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1. 发明授权

US06875182B2 Electrosurgical specimen-collection system 失效
标题翻译：电外科标本采集系统
公开(公告)号：US06875182B2
公开(公告)日：2005-04-05
申请号：US10136700
申请日：2002-04-30
申请人： John L. Wardle , Fred H. Burbank , Paul Lubock
发明人： John L. Wardle , Fred H. Burbank , Paul Lubock
IPC分类号： A61B20060101 , A61B10/00 , A61B10/02 , A61B10/04 , A61B17/22 , A61B17/32 , A61B17/34 , A61B18/14 , A61B19/00
CPC分类号： A61B10/0233 , A61B10/02 , A61B10/0266 , A61B10/0275 , A61B10/0283 , A61B10/04 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/14 , A61B18/148 , A61B18/1482 , A61B18/1487 , A61B18/1492 , A61B90/37 , A61B2010/0208 , A61B2010/0225 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00291 , A61B2018/00333 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1412 , A61B2018/1425 , A61B2018/1455 , A61B2018/1475 , A61B2018/162 , A61B2090/3908
摘要： Devices, methods and systems for obtaining biopsy tissue samples are provided. Flexible hollow tubes with a rail and a tip cutting element advance within a shaft with an aperture and a bore having a ramp, so that the cutting element emerges from the aperture and cuts tissue as it moves over the ramp. Either or both shaft and bore may have guides, which may engage each other to guide the tube along a tissue cutting pathway. A tube may have a rail and the bore a channel which engages the rail and guides the tube. Cut tissue may be acquired and transported proximally within the tube by suction to a tissue collection chamber. Multiple tissue samples may be obtained from a single insertion point by rotation and/or translation of the shaft between biopsies.
摘要翻译：提供了用于获得活检组织样本的装置，方法和系统。具有导轨和尖端切割元件的柔性中空管在具有孔的轴内延伸并且具有斜坡的孔，使得切割元件从孔中露出并且在组织移动通过斜坡时切割组织。轴和孔中的一个或两个可以具有引导件，其可以彼此接合以沿着组织切割路径引导管。管可以具有轨道并且孔具有与轨道接合并引导管的通道。可以通过抽吸将组织收集并在管内向近端运送到组织收集室。可以通过在活组织检查之间的轴的旋转和/或平移从单个插入点获得多个组织样本。

2. 发明授权

US6017316A Vacuum control system and method for automated biopsy device 失效
标题翻译：真空控制系统及自动活检装置的方法
公开(公告)号：US6017316A
公开(公告)日：2000-01-25
申请号：US878468
申请日：1997-06-18
申请人： Mark A. Ritchart , Fred H. Burbank , Seth A. Foerster , John L. Wardle
发明人： Mark A. Ritchart , Fred H. Burbank , Seth A. Foerster , John L. Wardle
IPC分类号： A61B10/02 , A61B1/00 , A61B10/00 , A61B17/00 , A61B19/00
CPC分类号： A61B10/0275 , A61B10/0283 , A61B2010/0208 , A61B2017/00017 , A61B2090/0811
摘要： An automatic control system for a vacuum-assisted automatic core biopsy device (10) is provided, wherein the automatic core biopsy device (10) comprises a housing (12), out of which extends a needle assembly (14) including a hollow outer piercing needle (16), an inner cutter (18) having a lumen (20), a probe housing (22), and a tissue receiving notch (24). The automatic control system (92) is computerized to move the hollow outer piercing needle (16) automatically to the target tissue lesion, as was true in the prior art, but also is programmed to automatically control the rotational orientation of the piercing needle (16), and its associated tissue receiving notch (24), as well as the axial positioning and rotation of the cutting cannula (18). Consequently, a clinician user need only mark the desired locations within the target location from which tissue samples are desired and the automatic control system will operate the device to retrieve samples from the marked locations.
摘要翻译：提供了一种用于真空辅助自动核心活检装置（10）的自动控制系统，其中所述自动核心活检装置（10）包括壳体（12），所述壳体（12）从所述壳体（12）延伸出针组件（14），所述针组件包括中空外穿孔针（16），具有内腔（20）的内切割器（18），探针外壳（22）和组织接收凹口（24）。自动控制系统（92）被计算机化以将空心外穿刺针（16）自动移动到目标组织损伤，如现有技术中所述，但也被编程为自动控制穿刺针（16）的旋转取向）和其相关联的组织接收凹口（24）以及切割套管（18）的轴向定位和旋转。因此，临床医师用户仅需要在目标位置标记期望的位置，从该组织样本期望的位置，自动控制系统将操作该装置以从标记的位置检索样本。

3. 发明授权

US08626270B2 Cavity-filling biopsy site markers 有权
标题翻译：腔填充活检部位标记
公开(公告)号：US08626270B2
公开(公告)日：2014-01-07
申请号：US13495408
申请日：2012-06-13
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones
IPC分类号： A61B8/00 , A61B8/14 , A61B8/08 , A61B8/12
CPC分类号： A61B8/481 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/3908 , A61B2090/392 , A61B2090/3925 , A61B2090/395 , A61B2090/3954 , A61B2090/3966 , A61B2090/3987 , A61B2090/3995 , A61K49/006 , A61K49/222 , A61M37/0069
摘要： The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome® or SenoCor 360™ cannula.
摘要翻译：本发明提供用于在有限时间内标记活检部位的材料，装置和方法。活检标记材料是可超声检测的生物可再吸收粉末，粉末颗粒通常在最大尺寸为约20微米至约800微米之间，更优选为约300微米至约500微米。粉末可以由含有大约10微米至约500微米的空腔的聚合材料形成，并且还可以含有粘合剂，麻醉剂，止血剂和不透射线的标记物。用于递送粉末的装置包括被配置为容纳粉末并且装配在活检插管内的管，粉末通过注射器的作用喷射。系统可以包括含有粉末的管和含有无菌盐水的注射器。管可以被配置成装配在活检插管内，例如Mammotome或SenoCor 360 TM插管。

4. 发明授权

US08447386B2 Marker or filler forming fluid 有权
标题翻译：标记或填料成型液
公开(公告)号：US08447386B2
公开(公告)日：2013-05-21
申请号：US12967639
申请日：2010-12-14
申请人： Fred H. Burbank , Michael L. Jones , Frank Louw , Paul Lubock
发明人： Fred H. Burbank , Michael L. Jones , Frank Louw , Paul Lubock
IPC分类号： A61B6/00 , A61B10/00
CPC分类号： A61B90/39 , A61B2090/3908 , A61B2090/3925 , A61B2090/3933 , A61B2090/3987 , A61K49/226
摘要： A system for at least partially filling and marking a cavity at a site within a patient's body includes a marker delivery device having a chamber configured to contain a marking substance and having a mechanism configured to expel the marking substance. A quantity of the marking substance is contained within the chamber of the marker delivery device. The marking substance is configured to at least partially fill the cavity and form therein a porous bioabsorbable body. A delivery tube is coupled in fluid communication with the chamber of the marker delivery device. The delivery tube has a distal end with a discharge port through which the marking substance is expelled. A releasable remotely detectable distal tip is coupled to the distal end of the delivery tube and is configured to be released to remain within the porous bioabsorbable body within the cavity upon the formation thereof.
摘要翻译：一种用于至少部分地填充和标记患者体内的部位的空腔的系统包括标记物输送装置，其具有被配置为容纳标记物质并具有被构造成排出标记物质的机构的室。标记物质的量被容纳在标记物输送装置的室内。标记物质构造成至少部分地填充空腔并在其中形成多孔生物可吸收体。输送管与标记物递送装置的腔室流体连通地联接。输送管具有远端，其具有排出口，排出标记物质。可释放的可远程检测的远侧末端联接到输送管的远端，并且构造成在其形成时被释放以保持在腔内的多孔生物可吸收体内。

5. 发明申请

US20090131825A1 Imageable biopsy site marker 审中-公开
标题翻译：可成像的活检部位标记
公开(公告)号：US20090131825A1
公开(公告)日：2009-05-21
申请号：US12317100
申请日：2008-12-18
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Nancy Forcier
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Nancy Forcier
IPC分类号： A61B17/34
CPC分类号： A61B90/39 , A61B10/02 , A61B2017/00004 , A61B2090/3788 , A61B2090/3908 , A61B2090/3925 , A61B2090/3929 , A61B2090/3933 , A61B2090/395 , A61B2090/3975 , A61B2090/3987 , A61B2090/3995 , A61K49/006 , A61M37/0069
摘要： A biopsy site marker having at least one small marker body or pellet of bioresorbable material such as gelatin, collagen, polylactic acid, polyglycolic acid which has a radiopaque object, preferably with a non-biological configuration. The at least one bioresorbable body or pellet with a radiopaque object is deposited into the biopsy site, by a delivery device that includes an elongated tubular body with a piston slidable within the tubular body. One end of the tube is placed into the biopsy site. At least one but preferably several marker bodies or pellets are deposited sequentially into the biopsy site through the tube. At least the bioresorbable materials of the detectable markers remain present in sufficient quantity to permit detection and location of the biopsy site at a first time point (e.g., 2 weeks) after introduction but clear from the biopsy site or otherwise do not interfere with imaging of tissues adjacent the biopsy site at a second time point (e.g., 5-7 months) after introduction.
摘要翻译：活检部位标记物，其具有至少一个生物可再吸收材料的小标记体或颗粒，例如具有不透射线对象的明胶，胶原，聚乳酸，聚乙醇酸，优选具有非生物构型。具有不透射线物体的至少一个生物可吸收体或丸粒通过包括细长管状体的递送装置沉积到活检部位中，所述细长管状体具有可在管状体内滑动的活塞。将管的一端放入活检部位。至少一个但优选几个标记体或丸粒通过管子依次沉积到活检部位。至少可检测标记的生物可吸收材料保持足够的量，以允许在引入之后的第一时间点（例如2周）检测和定位活检部位，但是从活组织检查部位清除，否则不干扰成像导入后的第二时间点（如5-7个月）附近的组织组织。

6. 发明授权

US07322940B2 Breast biopsy system and methods 有权
标题翻译：乳腺活检系统及方法
公开(公告)号：US07322940B2
公开(公告)日：2008-01-29
申请号：US10790661
申请日：2004-03-01
申请人： Fred H. Burbank , Michael L. Jones , Paul Lubock
发明人： Fred H. Burbank , Michael L. Jones , Paul Lubock
IPC分类号： A61B10/00 , A61B18/18
CPC分类号： A61B10/0266 , A61B10/02 , A61B17/00491 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/14 , A61B18/1487 , A61B18/1492 , A61B90/17 , A61B90/37 , A61B2017/3488 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00333 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1475 , A61B2018/162 , A61B2090/3908
摘要： An instrument assembly and method are described for isolating a target lesion in a patient's body tissue, resulting in a high likelihood of “clean” margins about the lesion when it is removed for diagnosis and/or therapy. This approach advantageously will often result in the ability to both diagnose and treat a malignant lesion with only a single percutaneous procedure, with no follow-up percutaneous or surgical procedure required. In particular, the instrument assembly has a distal end adapted for entry into the patient's body, a longitudinal shaft, and a cutting element disposed along a distal portion of the shaft. The cutting element is actuatable between a retracted position within an electrically insulating recess and a radially extended position and is rotatable about its axis in the radially extended position to isolate a desire tissue specimen from surrounding tissue by defining a peripheral margin about the tissue specimen.
摘要翻译：描述了用于分离患者身体组织中的靶病变的器械组件和方法，导致当其被去除以用于诊断和/或治疗时，对病变的“清洁”边缘的高可能性。这种方法有利地经常导致仅用单一经皮手术诊断和治疗恶性病变的能力，而不需要随访的经皮或外科手术。特别地，仪器组件具有适于进入患者身体的远端，纵向轴和沿着轴的远端部分设置的切割元件。切割元件可以在电绝缘凹槽中的缩回位置和径向延伸的位置之间致动，并且可以在其径向延伸的位置绕其轴线旋转，以通过围绕组织样本限定周边边缘来隔离期望的组织样本与周围组织。

7. 发明授权

US06958044B2 Methods and apparatus for securing medical instruments to desired locations in a patient's body 有权
公开(公告)号：US06958044B2
公开(公告)日：2005-10-25
申请号：US10004987
申请日：2001-12-04
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones , Richard L. Quick
IPC分类号： A61B10/02 , A61B10/00 , A61B17/00 , A61B17/22 , A61B17/32 , A61B17/34 , A61B18/12 , A61B18/14 , A61B19/00 , A61F2/82
CPC分类号： A61B10/04 , A61B10/02 , A61B10/0241 , A61B10/0266 , A61B17/00491 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/12 , A61B18/14 , A61B18/1477 , A61B18/1487 , A61B18/1492 , A61B90/17 , A61B90/37 , A61B90/39 , A61B2017/320064 , A61B2017/3488 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00333 , A61B2018/00577 , A61B2018/00601 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1425 , A61B2018/1475 , A61B2018/162 , A61B2019/5487 , A61B2019/5491 , A61B2090/3908 , A61B2090/3991
摘要： Devices and methods are provided for securely affixing a medical instrument to desired tissue in a patient's body, using a fixation agent. Such medical instruments may comprise localization wires or tissue acquisition instruments, such as biopsy instruments, for example. In the case of tissue acquisition instruments, the inventors have discovered significant advantages for securely affixing the distal end of the tissue acquisition instrument to a particular tissue target area. For example, such an approach permits the imaging environment to be uncoupled from the procedural environment so that expensive and often unavailable imaging equipment, such as stereotactic imaging equipment, need not be used. In a preferred embodiment, a bonding agent, such as adhesive, surgical glue, or a solvent, is used as the fixation agent.

8. 发明授权

US06862470B2 Cavity-filling biopsy site markers 有权
标题翻译：腔填充活检部位标记
公开(公告)号：US06862470B2
公开(公告)日：2005-03-01
申请号：US10124757
申请日：2002-04-16
申请人： Fred H. Burbank , Paul Lubock , Michael L. Jones
发明人： Fred H. Burbank , Paul Lubock , Michael L. Jones
IPC分类号： A61B6/00 , A61B6/12 , A61B8/08 , A61B8/12 , A61B10/00 , A61B10/02 , A61B17/00 , A61B19/00 , A61K49/00 , A61K49/04 , A61K49/22
CPC分类号： A61B8/481 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B90/39 , A61B2017/00004 , A61B2090/3908 , A61B2090/392 , A61B2090/3925 , A61B2090/395 , A61B2090/3954 , A61B2090/3966 , A61B2090/3987 , A61B2090/3995 , A61K49/006 , A61K49/222 , A61M37/0069
摘要： The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome® or SenoCor 360™ cannula.
摘要翻译：本发明提供用于在有限时间内标记活检部位的材料，装置和方法。活检标记材料是可超声检测的生物可再吸收粉末，粉末颗粒通常在最大尺寸为约20微米至约800微米之间，更优选为约300微米至约500微米。粉末可以由含有大约10微米至约500微米的空腔的聚合材料形成，并且还可以含有粘合剂，麻醉剂，止血剂和不透射线的标记物。用于递送粉末的装置包括被配置为容纳粉末并且装配在活检插管内的管，粉末通过注射器的作用喷射。系统可以包括含有粉末的管和含有无菌盐水的注射器。管可以被配置成装配在活检插管内，例如Mammotome或SenoCor 360 TM插管。

9. 发明授权

US06676658B2 Tissue specimen isolating and damaging device and method 有权
公开(公告)号：US06676658B2
公开(公告)日：2004-01-13
申请号：US09884349
申请日：2001-06-18
申请人： Fred H. Burbank , Paul Lubock
发明人： Fred H. Burbank , Paul Lubock
IPC分类号： A61B1818
CPC分类号： A61B10/0266 , A61B10/0041 , A61B10/02 , A61B10/0233 , A61B17/00234 , A61B17/00491 , A61B17/221 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/0206 , A61B18/06 , A61B18/14 , A61B18/148 , A61B18/1482 , A61B18/1487 , A61B18/1492 , A61B18/20 , A61B90/37 , A61B2010/0208 , A61B2017/00287 , A61B2017/2212 , A61B2017/320733 , A61B2017/3488 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00333 , A61B2018/00577 , A61B2018/00601 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1425 , A61B2018/144 , A61B2018/1475 , A61B2018/162 , A61B2018/1861 , A61B2090/3908 , A61N5/1007 , A61N5/1027
摘要： A device and method for treatment of a tissue specimen disposed in surrounding tissue has a tissue specimen isolating tool and a tissue specimen damager. The tissue specimen isolating tool isolates the tissue specimen from the surrounding tissue. The tissue specimen damager damages the tissue, with a possible end result being necrosis. The severing tool may have a cutting member that is extendable to an outwardly radially bowed position about device. The tissue specimen is isolated by rotating the cutting member about the tissue specimen. The cutting member may be functionally connected to a cutting member radio frequency generation source. The tissue specimen damager may damage the tissue specimen using ionizing radiation, cutting devices, thermal treatment devices, chemical treatment devices, or sealing an outer boundary of the tissue specimen.

10. 发明授权

US06638234B2 Sentinel node location and biopsy 有权
标题翻译：前哨淋巴结位置和活检
公开(公告)号：US06638234B2
公开(公告)日：2003-10-28
申请号：US09727112
申请日：2000-11-29
申请人： Fred H. Burbank , Paul Lubock
发明人： Fred H. Burbank , Paul Lubock
IPC分类号： A61B1000
CPC分类号： A61B10/0266 , A61B6/4258 , A61B10/02 , A61B17/00491 , A61B18/1477 , A61B18/1482 , A61B18/1487 , A61B18/1815 , A61B90/39 , A61B2010/0208 , A61B2017/3488 , A61B2018/00208 , A61B2018/00273 , A61B2018/00333 , A61B2018/00577 , A61B2018/00916 , A61B2018/1407 , A61B2018/1425 , A61B2018/1475 , A61B2090/378 , A61B2090/3904 , A61B2090/3908 , A61B2090/392
摘要： A method and apparatus for locating and accessing a patient's sentinel lymph nodes which are associated with a lesion site of the patient. A radiopharmaceutical is injected at or near a lesion site within a patient's body. The migration of the radiopharmaceutical and accumulation of the radiopharmaceutical in a sentinel node of the patient is monitored with a gamma camera or radiation energy detector from outside the patient's body. The sentinel node can then be accessed with a cannula having an RF energy electrode on the distal end of the cannula which is activated during insertion of the cannula. Once the distal end of the cannula is positioned adjacent the sentinel node, an anchor device is inserted through the cannula. The distal end of the anchor device is then positioned in the sentinel node and secured to the sentinel node to be used as a locator for subsequent procedures.
摘要翻译：一种用于定位和访问与患者的病变部位相关联的患者前哨淋巴结的方法和装置。在患者体内的病变部位处或附近注射放射性药物。放射性药物的迁移和放射性药物的积聚在患者的前哨淋巴结中用伽马照相机或辐射能量检测器从患者身体外部监测。然后可以使用在插管的远端处具有RF能量电极的插管来访问前哨节点，其在插管期间被激活。一旦套管的远端定位成邻近前哨节点，锚定装置就插入插管中。然后将锚装置的远端定位在前哨节点中并固定到前哨节点，以用作后续步骤的定位器。

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