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1. 发明授权

US06325973B1 Methods and apparatus for improved luminescence assays 有权
标题翻译：用于改善发光测定的方法和装置
公开(公告)号：US06325973B1
公开(公告)日：2001-12-04
申请号：US09253558
申请日：1999-02-19
申请人： John K. Leland , Haresh P. Shah , John H. Kenten , Jack E. Goodman , George E. Lowke , Yuzaburo Namba , Gary F. Blackburn , Richard J. Massey
发明人： John K. Leland , Haresh P. Shah , John H. Kenten , Jack E. Goodman , George E. Lowke , Yuzaburo Namba , Gary F. Blackburn , Richard J. Massey
IPC分类号： G01N2726
摘要： An apparatus for performing a binding assay for an analyte of interest in a sample based upon measurement of clectrochemiluminescence at an electrode surface comprising: (a) a cell defining a sample; (b) an electrode adjacent a portion of the sample containing volume; (c) a voltage control device for impressing electrochemical energy upon the electrode sufficient to generate luminescence; (d) means for magnetically collecting particles along the electrode surface; and (e) a light detection device for measuring the luminescence.
摘要翻译：一种用于基于电极表面上的电化学发光测量来对样品中感兴趣的分析物进行结合测定的装置，包括：（a）限定样品的细胞; （b）邻近样品容纳体积的一部分的电极; （c）电压控制装置，用于在足以产生发光的电极上施加电化学能; （d）沿着电极表面磁性收集颗粒的装置; 和（e）用于测量发光的光检测装置。

2. 发明授权

US6078782A Methods for improved particle electrochemiluminescence assays 失效
标题翻译：改进粒子电化学发光测定方法
公开(公告)号：US6078782A
公开(公告)日：2000-06-20
申请号：US473313
申请日：1995-06-07
申请人： John K. Leland , Haresh P. Shah , John H. Kenten , Jack E. Goodman , George E. Lowke , Yuzaburo Namba , Gary F. Blackburn , Richard J. Massey
发明人： John K. Leland , Haresh P. Shah , John H. Kenten , Jack E. Goodman , George E. Lowke , Yuzaburo Namba , Gary F. Blackburn , Richard J. Massey
IPC分类号： C07H21/00 , C12Q1/68 , G01N1/40 , G01N21/66 , G01N21/69 , G01N21/76 , G01N33/543 , G01N33/58 , G01N33/553
CPC分类号： C07H21/00 , C12Q1/6816 , C12Q1/6825 , C12Q1/686 , G01N21/66 , G01N21/69 , G01N21/76 , G01N33/54313 , G01N33/54326 , G01N33/54366 , G01N33/5438 , G01N33/582 , G01N1/40 , G01N2458/30
摘要： The invention relates to methods of performing a binding assay for an analyte of interest present in a sample based upon electrochemiluminescence at an electrode of interest. Particles are employed in the method, which are then collected in a zone at which electrochemiluminescence can be induced, wherein the amount of induced electrochemiluminescence is related to the amount of analyte in the sample.
摘要翻译：本发明涉及基于感兴趣的电极处的电化学发光对样品中存在的感兴趣分析物进行结合测定的方法。在该方法中使用颗粒，然后将其收集在可以诱导电化学发光的区域中，其中诱导的电化学发光的量与样品中分析物的量相关。

3. 发明授权

US06881589B1 Electrochemiluminescent localizable complexes for assay compositions 失效
标题翻译：用于测定组合物的电化学发光可定位的复合物
公开(公告)号：US06881589B1
公开(公告)日：2005-04-19
申请号：US08465443
申请日：1995-06-05
申请人： John K. Leland , Haresh P. Shah , John H. Kenten , Jack E. Goodman , George E. Lowke , Yuzaburo Namba , Gary F. Blackburn , Richard J. Massey
发明人： John K. Leland , Haresh P. Shah , John H. Kenten , Jack E. Goodman , George E. Lowke , Yuzaburo Namba , Gary F. Blackburn , Richard J. Massey
IPC分类号： C07H21/00 , C12Q1/68 , G01N1/40 , G01N21/66 , G01N21/76 , G01N33/543 , G01N33/58 , G01N33/53 , G01N21/00 , G01N33/544 , G01N33/566
CPC分类号： C12Q1/6825 , C07H21/00 , C12Q1/6816 , C12Q1/686 , G01N1/40 , G01N21/66 , G01N21/76 , G01N33/54313 , G01N33/54326 , G01N33/54366 , G01N33/5438 , G01N33/582 , G01N2458/30 , Y10S436/805 , Y10S436/806 , C12Q2565/628 , C12Q2563/113 , C12Q2563/103
摘要： The invention provides compositions and kits for performing a binding assay for an analyte of interest present in a sample based upon electrochemiluminescence. The compositions and kits comprise an electrochemiluminescent label, collectable particles, binding reagents, and an electrolyte.
摘要翻译：本发明提供了基于电化学发光对样品中存在的感兴趣分析物进行结合测定的组合物和试剂盒。组合物和试剂盒包括电化学发光标记，可收集颗粒，结合试剂和电解质。

4. 发明授权

US07462322B2 Methods and apparatus for improved luminescence assays 失效
标题翻译：用于改善发光测定的方法和装置
公开(公告)号：US07462322B2
公开(公告)日：2008-12-09
申请号：US10912574
申请日：2004-08-06
申请人： John K. Leland , Haresh P. Shah , John H. Kenten , Jack E. Goodman , George E. Lowke , Yuzaburo Namba , Gary F. Blackburn , Richard J. Massey
发明人： John K. Leland , Haresh P. Shah , John H. Kenten , Jack E. Goodman , George E. Lowke , Yuzaburo Namba , Gary F. Blackburn , Richard J. Massey
IPC分类号： G01N21/76 , G01N33/553 , G01N27/26 , C12M1/00
CPC分类号： G01N33/582 , C07H21/00 , G01N1/40 , G01N21/66 , G01N21/76 , G01N33/54313 , G01N33/54326 , G01N33/54366 , G01N33/5438
摘要： An apparatus for performing a binding assay for an analyte of interest present in a sample based upon measurement of electrochemiluminescence at an electrode surface comprising a cell defining a sample containing volume intersecting with inlet and outlet means, an electrode having a substantially horizontally positioned surface exposed to and positioned below a portion of the sample containing volume, means for impressing electrochemical energy upon said electrode sufficient to generate luminescence, means for magnetically collecting particles along said surface and means for measuring the luminescence generated at said electrode.
摘要翻译：基于在包括限定与入口和出口装置相交的体积的样品的细胞的电极表面上测量电化学发光，对样品中存在的感兴趣分析物进行结合测定的装置，具有暴露于并且位于所述样品容纳体积的一部分下方，用于在所述电极上施加足以产生发光的电化学能量的装置，用于沿着所述表面磁性收集颗粒的装置和用于测量在所述电极处产生的发光的装置。

5. 发明授权

US5935779A Methods for improved particle electrochemiluminescence assay 失效
标题翻译：改进粒子电化学发光测定方法
公开(公告)号：US5935779A
公开(公告)日：1999-08-10
申请号：US346832
申请日：1994-11-30
申请人： Richard J. Massey , Jonathan K. Leland , Haresh P. Shah , John H. Kenten , Jack E. Goodman , George E. Lowke , Yuzaburo Namba , Gary F. Blackburn
发明人： Richard J. Massey , Jonathan K. Leland , Haresh P. Shah , John H. Kenten , Jack E. Goodman , George E. Lowke , Yuzaburo Namba , Gary F. Blackburn
IPC分类号： C07H21/00 , C12Q1/68 , G01N1/40 , G01N21/66 , G01N21/69 , G01N21/76 , G01N33/543 , G01N33/58
CPC分类号： C07H21/00 , C12Q1/6816 , C12Q1/6825 , C12Q1/686 , G01N21/66 , G01N21/69 , G01N21/76 , G01N33/54313 , G01N33/54326 , G01N33/54366 , G01N33/5438 , G01N33/582 , G01N1/40 , G01N2458/30
摘要： The invention relates to methods of performing a binding assay for an analyte of interest present in a sample based upon electrochemiluminescence at an electrode of interest. Particles are employed in the method, which are then collected in a zone at which electrochemiluminescence can be induced, wherein the amount of induced electrochemilurninescence is related to the amount of analyte in the sample.
摘要翻译：本发明涉及基于感兴趣的电极处的电化学发光对样品中存在的感兴趣分析物进行结合测定的方法。在该方法中使用颗粒，然后将其收集在可以诱导电化学发光的区域中，其中诱导的电化学发光的量与样品中分析物的量相关。

6. 发明授权

US5705402A Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets 失效
标题翻译：包括多个磁体的基于磁性微粒的发光测定方法和装置
公开(公告)号：US5705402A
公开(公告)日：1998-01-06
申请号：US255824
申请日：1994-06-08
申请人： Jonathan K. Leland , Haresh P. Shah , John H. Kenten , Jack E. Goodman , George E. Lowke , Yuzaburo Namba , Gary F. Blackburn , Richard J. Massey
发明人： Jonathan K. Leland , Haresh P. Shah , John H. Kenten , Jack E. Goodman , George E. Lowke , Yuzaburo Namba , Gary F. Blackburn , Richard J. Massey
IPC分类号： C12Q1/68 , G01N1/40 , G01N21/66 , G01N21/69 , G01N21/76 , G01N33/543 , G01N33/58
CPC分类号： G01N21/69 , C12Q1/6825 , G01N21/76 , G01N33/54313 , G01N33/54326 , G01N33/54366 , G01N33/5438 , G01N33/582 , G01N1/40 , G01N2458/30
摘要： Disclosed and claimed are methods and apparatus for performing a binding assay for an analyte of interest present in a sample based upon measurement of electrochemiluminescence at an electrode. The method uses magnetically responsive particles. The method and apparatus call for a plurality of electromagnets or permanent magnets in north-south orientation for imposing a magnetic field so as to collect the particles.
摘要翻译：公开并要求保护的是基于电极上的电化学发光测量，对样品中存在的感兴趣分析物进行结合测定的方法和装置。该方法使用磁响应颗粒。所述方法和装置要求用于施加磁场以收集颗粒的南北取向的多个电磁体或永磁体。

7. 发明授权

US5779976A Apparatus for improved luminescence assays 失效
标题翻译：用于改善发光测定的装置
公开(公告)号：US5779976A
公开(公告)日：1998-07-14
申请号：US461395
申请日：1995-06-05
申请人： Jonathan K. Leland , Haresh P. Shah , John Henry Kenten , Jack E. Goodman , George E. Lowke , Yuzaburo Namba , Gary F. Blackburn , Richard J. Massey
发明人： Jonathan K. Leland , Haresh P. Shah , John Henry Kenten , Jack E. Goodman , George E. Lowke , Yuzaburo Namba , Gary F. Blackburn , Richard J. Massey
IPC分类号： C07H21/00 , C12Q1/68 , G01N1/40 , G01N21/66 , G01N21/69 , G01N21/76 , G01N33/543 , G01N33/58
CPC分类号： G01N21/69 , C07H21/00 , C12Q1/6816 , C12Q1/6825 , C12Q1/686 , G01N21/66 , G01N21/76 , G01N33/54313 , G01N33/54326 , G01N33/54366 , G01N33/5438 , G01N33/582 , G01N1/40 , G01N2458/30
摘要： An apparatus for performing a binding assay for an analyte of interest present in a sample based upon measurement of electrochemiluminescence at an electrode surface comprising a cell defining a sample containing volume intersecting with inlet and outlet means, an electrode having a substantially horizontally positioned surface exposed to and positioned below a portion of the sample containing volume, means for impressing electrochemical energy upon said electrode sufficient to generate luminescence, means for magnetically collecting particles along said surface and means for measuring the luminescence generated at said electrode.
摘要翻译：基于在包括限定与入口和出口装置相交的体积的样品的细胞的电极表面上测量电化学发光，对样品中存在的感兴趣分析物进行结合测定的装置，具有暴露于并且位于所述样品容纳体积的一部分下方，用于在所述电极上施加足以产生发光的电化学能量的装置，用于沿着所述表面磁性收集颗粒的装置和用于测量在所述电极处产生的发光的装置。

8. 发明授权

US5962218A Methods and apparatus for improved luminescence assays 失效
标题翻译：用于改善发光测定的方法和装置
公开(公告)号：US5962218A
公开(公告)日：1999-10-05
申请号：US160063
申请日：1993-11-24
申请人： Jonathan K. Leland , Haresh P. Shah , John H. Kenten , Jack E. Goodman , George E. Lowke , Gary F. Blackburn , Richard J. Massey
发明人： Jonathan K. Leland , Haresh P. Shah , John H. Kenten , Jack E. Goodman , George E. Lowke , Gary F. Blackburn , Richard J. Massey
IPC分类号： C12Q1/68 , G01N1/40 , G01N21/69 , G01N21/76 , G01N33/543 , G01N33/553
CPC分类号： G01N21/69 , C12Q1/6825 , G01N21/76 , G01N33/5438 , G01N1/40
摘要： The invention relates to methods, apparatus, reagents, and kits for performing a binding assay for an analyte of interest present in a sample based upon electrochemiluminescence at an electrode of interest. In the method, reagents and kits particles can be employed; for instance, for settling upon the electrode surface by gravity, centrifugation or magnetic attraction. The apparatus can include a magnet for generating a magnetic field in a region proximate the electrode.
摘要翻译：本发明涉及用于基于感兴趣的电极处的电化学发光对样品中存在的感兴趣分析物进行结合测定的方法，装置，试剂和试剂盒。在该方法中，可以使用试剂和试剂盒颗粒; 例如，通过重力，离心或磁吸引来沉积在电极表面上。该装置可以包括用于在靠近电极的区域中产生磁场的磁体。

9. 发明授权

US4576916A Electro-optical apparatus for microbial identification and enumeration 失效
标题翻译：用于微生物识别和计数的电光装置
公开(公告)号：US4576916A
公开(公告)日：1986-03-18
申请号：US629641
申请日：1984-07-11
申请人： George E. Lowke , Robert J. Meltzer
发明人： George E. Lowke , Robert J. Meltzer
IPC分类号： C12M1/34 , G01N21/23 , G01N21/33 , C12M1/36 , C12Q1/04 , C12Q1/06 , C12Q1/18
CPC分类号： G01N21/33 , C12M41/36 , G01N21/23 , Y10S435/808
摘要： Rapid and accurate identifying and enumerating of microorganisms is carried out with an apparatus having an electrical cell, an optical sensing assembly, an automated microbial sample delivery means and an electrical signal processing means. The electrical cell contains a chamber having an inlet and outlet and paired electrodes located adjacent walls of the chamber. The optical sensing assembly has a laser light source to pass a beam of laser light through the electrical cell and between the electrodes, and a laser light detector in alignment with the light source to receive laser light emerging from the electrical cell. The electrical signal processing means translates variations in birefringence caused by a microbial sample into quantitative data. In operation of the apparatus, a polarized beam of laser light passes through a microbial sample containing an inhibiting reagent while the sample is in an electrical field between the electrodes, and the extend of birefringence is measured.
摘要翻译：使用具有电池，光学感测组件，自动微生物样品传送装置和电信号处理装置的装置来进行微生物的快速和准确的识别和列举。电池包含具有入口和出口的腔室和位于腔室壁附近的成对电极。光学传感组件具有激光光源，以将激光束通过电池和电极之间，以及与光源对准的激光检测器，以接收从电池发出的激光。电信号处理装置将由微生物样品引起的双折射变化转换为定量数据。在该装置的操作中，当样品处于电极之间的电场中时，激光的偏振光束通过含有抑制试剂的微生物样品，并且测量双折射的延伸。

10. 发明授权

US4467032A Identification and enumeration of microbial cells 失效
标题翻译：微生物细胞的鉴定和计数
公开(公告)号：US4467032A
公开(公告)日：1984-08-21
申请号：US371906
申请日：1982-04-26
申请人： George E. Lowke , Robert J. Meltzer
发明人： George E. Lowke , Robert J. Meltzer
IPC分类号： C12M1/34 , C12Q1/04 , G01N21/23 , G01N21/33 , C12Q1/06
CPC分类号： G01N21/33 , C12M41/36 , G01N21/23
摘要： A process and apparatus is disclosed for rapid and accurate identifying and enumerating of microorganisms. A sample believed to contain a certain microorganism is combined with an inhibiting reagent having a known specificity for the microorganism. The combined sample and inhibiting reagent is placed in an alternating current electrical field having a frequency sufficiently high to cause alignment of microbial cells in the sample. A polarized beam of laser light is then passed through the sample and the extent of birefringence is measured. The measured birefringence is compared with that of a control sample known to contain the microorganism under investigation to determine the microorganism in the sample.
摘要翻译：公开了用于快速和准确地识别和列举微生物的方法和装置。认为含有某种微生物的样品与对微生物具有已知特异性的抑制剂组合。将组合的样品和抑制试剂置于具有足够高的频率的交流电场中以引起样品中微生物细胞的排列。然后将偏光的激光束通过样品，并测量双折射的程度。将测量的双折射率与已知含有正在研究的微生物的对照样品的比较进行比较，以确定样品中的微生物。

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