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1. 发明授权

US07029444B2 Real time self-adjusting calibration algorithm 有权
公开(公告)号：US07029444B2
公开(公告)日：2006-04-18
申请号：US10926319
申请日：2004-08-25
申请人： John J. Shin , Kris R. Holtzclaw , Nandita D. Dangui , Sami Kanderian, Jr. , John J. Mastrototaro , Peter I. Hong
发明人： John J. Shin , Kris R. Holtzclaw , Nandita D. Dangui , Sami Kanderian, Jr. , John J. Mastrototaro , Peter I. Hong
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1495 , A61B5/6848 , A61B5/6849 , A61M2005/1726 , G06F19/00
摘要： A method of calibrating glucose monitor data includes collecting the glucose monitor data over a period of time at predetermined intervals. It also includes obtaining at least two reference glucose values from a reference source that temporally correspond with the glucose monitor data obtained at the predetermined intervals. Also included is calculating the calibration characteristics using the reference glucose values and the corresponding glucose monitor data to regress the obtained glucose monitor data. And calibrating the obtained glucose monitor data using the calibration characteristics is included. In preferred embodiments, the reference source is a blood glucose meter, and the at least two reference glucose values are obtained from blood tests. In additional embodiments, the calculation of the calibration characteristics is obtained using linear regression and in particular embodiments, least squares linear regression. Alternatively, the calculation of the calibration characteristics is obtained using non-linear regression.

2. 发明授权

US06895263B2 Real time self-adjusting calibration algorithm 有权
公开(公告)号：US06895263B2
公开(公告)日：2005-05-17
申请号：US10141375
申请日：2002-05-08
申请人： John J. Shin , Kris R. Holtzclaw , Nandita D. Dangui , Sami Kanderian, Jr. , John J. Mastrototaro , Peter I. Hong
发明人： John J. Shin , Kris R. Holtzclaw , Nandita D. Dangui , Sami Kanderian, Jr. , John J. Mastrototaro , Peter I. Hong
IPC分类号： G01N33/66 , A61B5/00 , A61B5/145 , A61B5/1468 , A61B5/1486 , A61B5/1495
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1495 , A61B5/6848 , A61B5/6849 , A61M2005/1726 , G06F19/00
摘要： A method of calibrating glucose monitor data includes collecting the glucose monitor data over a period of time at predetermined intervals. It also includes obtaining at least two reference glucose values from a reference source that temporally correspond with the glucose monitor data obtained at the predetermined intervals. Also included is calculating the calibration characteristics using the reference glucose values and the corresponding glucose monitor data to regress the obtained glucose monitor data. And calibrating the obtained glucose monitor data using the calibration characteristics is included. In preferred embodiments, the reference source is a blood glucose meter, and the at least two reference glucose values are obtained from blood tests. In additional embodiments, the calculation of the calibration characteristics is obtained using linear regression and in particular embodiments, least squares linear regression. Alternatively, the calculation of the calibration characteristics is obtained using non-linear regression.

3. 发明申请

US20100010330A1 WIRELESS MONITOR FOR A PERSONAL MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：用于个人医疗设备系统的无线监视器
公开(公告)号：US20100010330A1
公开(公告)日：2010-01-14
申请号：US12564830
申请日：2009-09-22
申请人： Ulrich Rankers , Bradley J. Enegren , Rebecca K. Gottlieb , Jino Han , Kris R. Holtzclaw , Peter I. Hong , Emilian Istoc , John J. Mastrototaro , Sheldon B. Moberg , Cary Talbot , Gary L. Williams , Arieh S. Halpern
发明人： Ulrich Rankers , Bradley J. Enegren , Rebecca K. Gottlieb , Jino Han , Kris R. Holtzclaw , Peter I. Hong , Emilian Istoc , John J. Mastrototaro , Sheldon B. Moberg , Cary Talbot , Gary L. Williams , Arieh S. Halpern
IPC分类号： A61B5/145
CPC分类号： A61B5/4839 , A61B5/14532 , A61B5/411 , A61B5/7275 , A61M5/142 , A61M5/14244 , A61M5/172 , A61M2205/18 , A61M2205/3561 , A61M2205/3569 , A61M2205/3592 , A61M2205/502 , A61M2205/505 , A61M2209/01 , G06F19/3418 , G06F19/3468 , G16H40/63
摘要： A monitor device for a fluid infusion system and its operating, display, and data processing characteristics are described herein. One embodiment of the monitor device is used in an insulin infusion system having an insulin infusion pump and a continuous glucose sensor transmitter. The monitor device is configured as a wireless bedside monitor that wirelessly receives status data from a device in the fluid infusion system, such as the infusion pump or the sensor transmitter. The monitor device supports a number of user interface features, alarm/alert features, and graphical display features, where such features enhance the overall operation and user-friendliness of the monitor device. For example, the monitor device can generate status icons that graphically indicate the time remaining for an exhaustible operating quantity of a device in the infusion system (e.g., a battery charge, a fluid reservoir volume, or a calibration or replacement period). The monitor device can also estimate future measurements of a physiological characteristic of a monitored patient, based upon empirical measurement data received by the monitor device.
摘要翻译：本文描述了用于流体输注系统的监视器装置及其操作，显示和数据处理特性。监测装置的一个实施例用于具有胰岛素输注泵和连续葡萄糖传感器发射器的胰岛素输注系统中。监视器装置被配置为无线床边监视器，其从诸如输液泵或传感器发射器的流体输注系统中的装置无线地接收状态数据。监视器设备支持许多用户界面功能，警报/警报功能和图形显示功能，其中这些功能可提高监视器设备的整体操作和用户友好性。例如，监视器设备可以生成状态图标，其图形地指示输注系统中的设备的可耗费操作量（例如，电池充电，流体存储器容积，或校准或更换周期）的剩余时间。监视器装置还可以基于由监视器装置接收的经验测量数据来估计被监视患者的生理特征的未来测量。

4. 发明申请

US20080300572A1 WIRELESS MONITOR FOR A PERSONAL MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：用于个人医疗设备系统的无线监视器
公开(公告)号：US20080300572A1
公开(公告)日：2008-12-04
申请号：US11757153
申请日：2007-06-01
申请人： Ulrich Rankers , Bradley J. Enegren , Rebecca K. Gottlieb , Jino Han , Kris R. Holtzclaw , Peter I. Hong , Emilian Istoc , John J. Mastrototaro , Sheldon B. Moberg , Cary Talbot , Gary L. Williams , Arieh S. Halpern
发明人： Ulrich Rankers , Bradley J. Enegren , Rebecca K. Gottlieb , Jino Han , Kris R. Holtzclaw , Peter I. Hong , Emilian Istoc , John J. Mastrototaro , Sheldon B. Moberg , Cary Talbot , Gary L. Williams , Arieh S. Halpern
IPC分类号： A61M37/00
CPC分类号： A61B5/4839 , A61B5/14532 , A61B5/411 , A61B5/7275 , A61M5/142 , A61M5/14244 , A61M5/172 , A61M2205/18 , A61M2205/3561 , A61M2205/3569 , A61M2205/3592 , A61M2205/502 , A61M2205/505 , A61M2209/01 , G06F19/3418 , G06F19/3468 , G16H40/63
摘要： A monitor device for a fluid infusion system and its operating, display, and data processing characteristics are described herein. One embodiment of the monitor device is used in an insulin infusion system having an insulin infusion pump and a continuous glucose sensor transmitter. The monitor device is configured as a wireless bedside monitor that wirelessly receives status data from a device in the fluid infusion system, such as the infusion pump or the sensor transmitter. The monitor device supports a number of user interface features, alarm/alert features, and graphical display features, where such features enhance the overall operation and user-friendliness of the monitor device. For example, the monitor device can generate status icons that graphically indicate the time remaining for an exhaustible operating quantity of a device in the infusion system (e.g., a battery charge, a fluid reservoir volume, or a calibration or replacement period). The monitor device can also estimate future measurements of a physiological characteristic of a monitored patient, based upon empirical measurement data received by the monitor device.
摘要翻译：本文描述了用于流体输注系统的监视器装置及其操作，显示和数据处理特性。监测装置的一个实施例用于具有胰岛素输注泵和连续葡萄糖传感器发射器的胰岛素输注系统中。监视器装置被配置为无线床边监视器，其从诸如输液泵或传感器发射器的流体输注系统中的装置无线地接收状态数据。监视器设备支持许多用户界面功能，警报/警报功能和图形显示功能，其中这些功能可提高监视器设备的整体操作和用户友好性。例如，监视器设备可以生成状态图标，其图形地指示输注系统中的设备的可耗费的操作量的剩余时间（例如，电池充电，流体存储器容积，或校准或更换周期）。监视器装置还可以基于由监视器装置接收的经验测量数据来估计被监视患者的生理特征的未来测量。

5. 发明授权

US06558351B1 Closed loop system for controlling insulin infusion 有权
标题翻译：用于控制胰岛素输注的闭环系统
公开(公告)号：US06558351B1
公开(公告)日：2003-05-06
申请号：US09586175
申请日：2000-06-01
申请人： Garry M. Steil , Kerstin Rebrin , Paul V. Goode, Jr. , John J. Mastrototaro , Richard E. Purvis , William P. Van Antwerp , John J. Shin , Cary D. Talbot
发明人： Garry M. Steil , Kerstin Rebrin , Paul V. Goode, Jr. , John J. Mastrototaro , Richard E. Purvis , William P. Van Antwerp , John J. Shin , Cary D. Talbot
IPC分类号： A61M3700
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/14539 , A61B5/1495 , A61B5/4839 , A61B5/6849 , A61B5/7242 , A61M5/14244 , A61M5/158 , A61M5/1582 , A61M5/1723 , A61M2005/1581 , A61M2005/1726 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： A closed loop infusion system controls the rate that fluid is infused into the body of a user. The closed loop infusion system includes a sensor system, a controller, and a delivery system. The sensor system includes a sensor for monitoring a condition of the user. The sensor produces a sensor signal, which is representative of the condition of the user. The sensor signal is used to generate a controller input. The controller uses the controller input to generate commands to operate the delivery system. The delivery system infuses a liquid into the user at a rate dictated by the commands from the controller. Preferably, the sensor system monitors the glucose concentration in the body of the user, and the liquid infused by the delivery system into the body of the user includes insulin. The sensor system uses the sensor signal to generate a message that is sent to the delivery system. The message includes the information used to generate the controller input. The sensor may be a subcutaneous sensor in contact with interstitial fluid. Also, two or more sensors may be used by the sensor system.
摘要翻译：闭环输注系统控制流体注入使用者身体的速度。闭环输注系统包括传感器系统，控制器和输送系统。传感器系统包括用于监测用户状况的传感器。传感器产生一个传感器信号，代表用户的状态。传感器信号用于生成控制器输入。控制器使用控制器输入来生成操作传送系统的命令。输送系统以由控制器的命令指示的速率将液体注入用户。优选地，传感器系统监测用户体内的葡萄糖浓度，并且由输送系统输入到使用者体内的液体包括胰岛素。传感器系统使用传感器信号来产生发送到传送系统的消息。该消息包括用于生成控制器输入的信息。传感器可以是与间质液接触的皮下传感器。此外，传感器系统可以使用两个或更多个传感器。

6. 发明授权

US06424847B1 Glucose monitor calibration methods 有权
标题翻译：葡萄糖监测仪校准方法
公开(公告)号：US06424847B1
公开(公告)日：2002-07-23
申请号：US09511580
申请日：2000-02-23
申请人： John J. Mastrototaro , Todd M. Gross , John J. Shin
发明人： John J. Mastrototaro , Todd M. Gross , John J. Shin
IPC分类号： A61B500
CPC分类号： A61B5/14532 , A61M2005/1726
摘要： A method of calibrating glucose monitor data includes collecting the glucose monitor data over a period of time at predetermined intervals. It also includes obtaining at least two reference glucose values from a reference source that temporally correspond with the glucose monitor data obtained at the predetermined intervals. Also included is calculating the calibration characteristics using the reference glucose values and the corresponding glucose monitor data to regress the obtained glucose monitor data. And calibrating the obtained glucose monitor data using the calibration characteristics is included. In preferred embodiments, the reference source is a blood glucose meter, and the at least two reference glucose values are obtained from blood tests. In additional embodiments, the calculation of the calibration characteristics is obtained using linear regression and in particular embodiments, least squares linear regression. Alternatively, the calculation of the calibration characteristics is obtained using non-linear regression.
摘要翻译：校准葡萄糖监测数据的方法包括以预定间隔在一段时间内收集葡萄糖监测数据。它还包括从参考源获得至少两个参考葡萄糖值，所述参考源在时间上对应于以预定间隔获得的葡萄糖监测数据。还包括使用参考葡萄糖值和相应的葡萄糖监测数据计算校准特性以回归所获得的葡萄糖监测数据。并且包括使用校准特性来校准所获得的葡萄糖监测数据。在优选实施例中，参考源是血糖仪，并且从血液测试获得至少两个参考葡萄糖值。在另外的实施例中，使用线性回归和特定实施例，最小二乘线性回归来获得校准特性的计算。或者，使用非线性回归获得校准特性的计算。

7. 发明授权

US08660628B2 Analyte sensors comprising blended membrane compositions and methods for making and using them 有权
标题翻译：分析物传感器包括混合膜组合物和制备和使用它们的方法
公开(公告)号：US08660628B2
公开(公告)日：2014-02-25
申请号：US12643790
申请日：2009-12-21
申请人： Jenn-Hann Larry Wang , Tri T. Dang , Brooks B. Cochran , John J. Mastrototaro , Rajiv Shah
发明人： Jenn-Hann Larry Wang , Tri T. Dang , Brooks B. Cochran , John J. Mastrototaro , Rajiv Shah
IPC分类号： A61B5/05
CPC分类号： G01N33/5438 , G01N27/307 , G01N33/54393
摘要： Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes an analyte modulating membrane that comprises a blended mixture of a linear polyurethane/polyurea polymer, and a branched acrylate polymer.
摘要翻译：本发明的实施例提供了分析物传感器，其具有被设计成调节其化学反应的元件以及用于制造和使用这些传感器的方法。在本发明的某些实施方案中，传感器包括分析物调节膜，其包含线性聚氨酯/聚脲聚合物和支化丙烯酸酯聚合物的共混混合物。

8. 发明申请

US20120259278A1 Algorithm Sensor Augmented Bolus Estimator for Semi-Closed Loop Infusion System 审中-公开
标题翻译：用于半闭环输注系统的算法传感器增强螺栓估计器
公开(公告)号：US20120259278A1
公开(公告)日：2012-10-11
申请号：US13529278
申请日：2012-06-21
申请人： Andrew C. Hayes , John J. Mastrototaro , Sheldon B. Moberg , John C. Mueller, JR. , H. Bud Clark , Mike Charles Vallet Tolle , Gary L. Williams , Bihong Wu , Garry M. Steil
发明人： Andrew C. Hayes , John J. Mastrototaro , Sheldon B. Moberg , John C. Mueller, JR. , H. Bud Clark , Mike Charles Vallet Tolle , Gary L. Williams , Bihong Wu , Garry M. Steil
IPC分类号： A61M5/168
CPC分类号： A61B5/7239 , A61B5/14532 , A61M5/1723 , A61M2005/14208 , A61M2205/18 , A61M2205/35 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H40/63 , G16H50/50 , A61M2230/005
摘要： An infusion system is for infusing a fluid into the body of a patient. The infusion system includes at least one sensor for monitoring blood glucose concentration of the patient and an infusion device for delivering fluid to the patient. The sensor produces at least one sensor signal input. The infusion device uses the at least one sensor signal input and a derivative predicted algorithm to determine future blood glucose levels. The infusion device delivers fluid to the patient when future blood glucose levels are in a patient's target range. The infusion device is capable of suspending and resuming fluid delivery based on future blood glucose levels and a patient's low shutoff threshold. The infusion device suspends fluid delivery when future blood glucose levels falls below the low shutoff threshold. The infusion device resumes fluid delivery when a future blood glucose level is above the low shutoff threshold.
摘要翻译：输液系统用于将流体注入患者体内。输注系统包括至少一个用于监测患者的血糖浓度的传感器和用于将流体输送给患者的输注装置。传感器产生至少一个传感器信号输入。输注装置使用至少一个传感器信号输入和导数预测算法来确定未来的血糖水平。当未来的血糖水平处于患者的目标范围内时，输注装置向患者输送流体。输液装置能够基于将来的血糖水平和患者的低关闭阈值来暂停和恢复流体输送。当未来的血糖水平低于低关闭阈值时，输液装置暂停流体输送。当未来的血糖水平高于低关闭阈值时，输注装置恢复流体输送。

9. 发明申请

US20120179015A1 TELEMETERED CHARACTERISTIC MONITOR SYSTEM AND METHOD OF USING THE SAME 审中-公开
标题翻译：电流特性监测系统及其使用方法
公开(公告)号：US20120179015A1
公开(公告)日：2012-07-12
申请号：US13424698
申请日：2012-03-20
申请人： ALFRED E. MANN , Richard E. Purvis , John J. Mastrototaro , James D. Causey , James Henke , Peter Hong , John H. Livingston , Clifford W. Hague , Brad T. Hite
发明人： ALFRED E. MANN , Richard E. Purvis , John J. Mastrototaro , James D. Causey , James Henke , Peter Hong , John H. Livingston , Clifford W. Hague , Brad T. Hite
IPC分类号： A61B5/145
CPC分类号： A61B5/1495 , A61B5/0002 , A61B5/14532 , A61B5/14865 , A61B5/6848 , A61B5/6849 , A61B2560/0214 , A61B2560/0223 , A61M2005/1726
摘要： A telemetered characteristic monitor system includes a remotely located data receiving device, a sensor for producing signal indicative of a characteristic of a user, and a transmitter device. The transmitter device includes a housing, a sensor connector, a processor, and a transmitter. The transmitter receives the signals from the sensor and wirelessly transmits the processed signals to the remotely located data receiving device. The processor coupled to the sensor processes the signals from the sensor for transmission to the remotely located data receiving device. The data receiving device may be a characteristic monitor, a data receiver that provides data to another device, an RF programmer for a medical device, a medication delivery device (such as an infusion pump), or the like.
摘要翻译：遥测特征监视器系统包括远程定位的数据接收装置，用于产生指示用户特征的信号的传感器和发射机装置。发射器装置包括壳体，传感器连接器，处理器和发射器。发射机接收来自传感器的信号，并将经处理的信号无线发送到位于远程的数据接收装置。耦合到传感器的处理器处理来自传感器的信号以传输到位于远程的数据接收装置。数据接收装置可以是特征监视器，向另一设备提供数据的数据接收器，用于医疗装置的RF编程器，药物输送装置（例如输液泵）等。

10. 发明申请

US20100191087A1 SENSING SYSTEM WITH AUXILIARY DISPLAY 审中-公开
标题翻译：带辅助显示器的感应系统
公开(公告)号：US20100191087A1
公开(公告)日：2010-07-29
申请号：US12758391
申请日：2010-04-12
申请人： Cary D. Talbot , John J. Mastrototaro , Rajiv Shah , Edward Chernoff , John C. Mueller, JR. , Varaz Shahmirian , Richard E. Purvis , Wayne A. Morgan , Rebecca K. Gottlieb
发明人： Cary D. Talbot , John J. Mastrototaro , Rajiv Shah , Edward Chernoff , John C. Mueller, JR. , Varaz Shahmirian , Richard E. Purvis , Wayne A. Morgan , Rebecca K. Gottlieb
IPC分类号： A61B5/145
CPC分类号： A61B5/0002 , A61B5/145 , A61B5/14532 , A61B5/412 , A61B2560/0209 , A61B2560/0443 , A61B2560/0456
摘要： A system is provided for sensing blood glucose data of a patient. The system includes a sensor, user interface, and an optional auxiliary device. If the connection between the sensor and user interface is by a wire, the sensor remains powered when the wire is disconnected. The communication between the sensor and the user interface may be wireless. The auxiliary device can be a patient monitor or other display or signal device, which displays information about the blood glucose data collected by the sensor. The sensor is connected to sensor electronics, which include a sensor power supply, a voltage regulator, and optionally a memory and processor.
摘要翻译：提供了一种用于感测患者血糖数据的系统。该系统包括传感器，用户界面和可选的辅助设备。如果传感器和用户界面之间的连接是通过导线连接的，那么当导线断开时，传感器保持供电。传感器和用户界面之间的通信可能是无线的。辅助装置可以是患者监视器或其他显示器或信号装置，其显示关于由传感器收集的血糖数据的信息。传感器连接到传感器电子设备，其中包括传感器电源，电压调节器以及可选的存储器和处理器。

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