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    • 4. 发明授权
    • Method for screening for bacterial conjunctivitis
    • 筛选细菌性结膜炎的方法
    • US07727513B2
    • 2010-06-01
    • US11303001
    • 2005-12-15
    • John Gavin MacDonaldStephanie M. MartinJason Lye
    • John Gavin MacDonaldStephanie M. MartinJason Lye
    • A61K49/00C12Q1/20C12Q1/22C12Q1/04
    • C12Q1/04C12Q1/14
    • A method for rapidly detecting infectious conjunctivitis in a host is provided. The method includes contacting an ocular test sample with a chromogen (e.g., Reichardt's dye) that exhibits a color change in the presence of a microbe. The present inventors have discovered that the extent of the color change may vary depending on whether the microbe is a bacteria or virus. Without intending to be limited by theory, the present inventors believe that the chromogen interacts with the peptidoglycan-based cell wall structure of bacteria to induce a color change that is even more apparent at infectious levels. It is believed that this interaction occurs to a much greater extent in bacteria than in viruses. Accordingly, although the chromogen may still undergo a color change in the presence of the viruses, it is typically to a much lesser extent. In this manner, the degree of color change of the chromogen may be used in the present invention as a mechanism for differentiating between viral and bacterial conjunctivitis.
    • 提供了一种快速检测宿主感染性结膜炎的方法。 该方法包括使眼睛测试样品与在微生物存在下显示颜色变化的色原体(例如,Reichardt's染料)接触。 本发明人已经发现,颜色变化的程度可以根据微生物是细菌还是病毒而变化。 不期望受理论的限制,本发明人相信色原体与细菌的基于聚肽聚糖的细胞壁结构相互作用以诱导在感染水平上更加明显的颜色变化。 相信这种相互作用在细菌中比在病毒中更大程度地发生。 因此,虽然染色体在病毒存在的情况下仍可能发生颜色变化,但通常其程度要小得多。 以这种方式,在本发明中可以使用色原体的颜色变化程度作为区分病毒和细菌性结膜炎的机制。
    • 5. 发明申请
    • Thermochromic responsive elastic polymer substrate
    • 热变色响应弹性聚合物基材
    • US20090143516A1
    • 2009-06-04
    • US11998685
    • 2007-11-30
    • John Gavin MacDonaldStephanie M. Martin
    • John Gavin MacDonaldStephanie M. Martin
    • C08K5/17
    • A61M25/1027A41D13/11A41D19/0027A41D19/0055A61B5/015A61F6/04C08K5/0041G01K11/12G01K2207/00C08L21/00C08L13/02
    • A material composition including a flexible, polymeric matrix and a reverse-thermochromic colorant is described. When subjected to a heat source, the polymeric material can change color from a pale or neutral color to a darker or more vibrant color of a Delta E (ΔE) change of >3. The reverse-thermochromic colorant exhibits a color change when exposed to a heat source within a period of about 30 seconds, and is observable by an unaided human eye under either natural daylight or ambient artificial normal lighting conditions. One or more different reverse-thermochromic colorants in combination may be incorporated. The polymeric matrix surrounds or encapsulates a solvatochromic dye molecule with a phenolate betaine structure. The polymeric matrix includes a dipole orientating agent that induces said solvatochromic dye to express locally when subjected to a temperature change. Various uses for the composition and articles that incorporate the composition are also described, in addition to a method of indicating the temperature of an object or environmental condition.
    • 描述了包括柔性聚合物基质和反向热变色着色剂的材料组合物。 当经受热源时,聚合物材料可以将颜色从浅色或中性色变为Delta E(DeltaE)变化> 3的较暗或更鲜艳的颜色。 反向热变色着色剂在约30秒的时间内暴露于热源时显示颜色变化,并且在自然日光或环境人造正常照明条件下由肉眼观察到。 可并入一种或多种不同的反相热色素着色剂。 聚合物基质围绕或封装具有酚盐甜菜碱结构的溶剂化色素染料分子。 聚合物基质包括偶极取向剂,其在经受温度变化时诱导所述溶剂化色素染料局部表达。 除了指示物体的温度或环境条件的方法之外,还描述了包含组合物的组合物和制品的各种用途。
    • 7. 发明申请
    • Self-Indicating Wipe for Removing Bacteria from a Surface
    • 用于从表面去除细菌的自我指示擦拭
    • US20090155327A1
    • 2009-06-18
    • US11955696
    • 2007-12-13
    • Stephanie M. MartinJohn Gavin MacDonaldBao Trong Do
    • Stephanie M. MartinJohn Gavin MacDonaldBao Trong Do
    • A01N25/34A01N59/16A01N59/06A01P1/00
    • A61L2/28A47L13/16A61L2/238
    • A wipe that includes a bacteriostatic agent that contains cations having an affinity for the negatively charged cell walls of bacteria is provided. The affinity of the bacteriostatic agent for the bacteria allows the wipe to capture bacteria, thereby removing them from a surface and also inhibiting their spread to other surfaces that may contact the wipe. Of particular advantage, the bacteriostatic agent may help protect against the spread or infection of pathogens without the use of chemicals, such as antiseptics or antibiotics. Still further, the wipe of the present invention also contains a solvatochromatic indicator that undergoes a color change in the presence of a broad spectrum of bacteria. Thus, when the wipe captures bacteria, the indicator undergoes a color change that signals to the user that the wipe is functioning properly. The lack of a color change may likewise provide the user with the assurance that the area is generally free of bacteria and clean.
    • 提供了包含具有对细菌带负电荷的细胞壁具有亲和性的阳离子的抑菌剂的擦拭物。 抑菌剂对细菌的亲和力允许擦拭物捕获细菌,从而从表面除去它们,并且还抑制它们扩散到可能接触擦拭物的其它表面。 特别有利的是,抑菌剂可以帮助防止病原体的扩散或感染而不使用诸如防腐剂或抗生素的化学物质。 此外,本发明的擦拭物还含有在广谱细菌存在下经历颜色变化的溶剂色素指示剂。 因此,当擦拭物捕获细菌时,指示器经历颜色变化,向用户发出指示擦拭物正常工作的颜色变化。 缺少颜色变化也可以为用户提供该区域通常没有细菌和清洁的保证。
    • 8. 发明授权
    • Self-indicating wipe for removing bacteria from a surface
    • 自我指示擦拭从表面去除细菌
    • US08871232B2
    • 2014-10-28
    • US11955696
    • 2007-12-13
    • Stephanie M. MartinJohn Gavin MacDonaldBao Trong Do
    • Stephanie M. MartinJohn Gavin MacDonaldBao Trong Do
    • A01N59/06A01N59/16A01N25/34A01P1/00A61L2/28A47L13/16A61L2/238
    • A61L2/28A47L13/16A61L2/238
    • A wipe that includes a bacteriostatic agent that contains cations having an affinity for the negatively charged cell walls of bacteria is provided. The affinity of the bacteriostatic agent for the bacteria allows the wipe to capture bacteria, thereby removing them from a surface and also inhibiting their spread to other surfaces that may contact the wipe. Of particular advantage, the bacteriostatic agent may help protect against the spread or infection of pathogens without the use of chemicals, such as antiseptics or antibiotics. Still further, the wipe of the present invention also contains a solvatochromatic indicator that undergoes a color change in the presence of a broad spectrum of bacteria. Thus, when the wipe captures bacteria, the indicator undergoes a color change that signals to the user that the wipe is functioning properly. The lack of a color change may likewise provide the user with the assurance that the area is generally free of bacteria and clean.
    • 提供了包含具有对细菌带负电荷的细胞壁具有亲和性的阳离子的抑菌剂的擦拭物。 抑菌剂对细菌的亲和力允许擦拭物捕获细菌,从而从表面除去它们,并且还抑制它们扩散到可能接触擦拭物的其它表面。 特别有利的是,抑菌剂可以帮助防止病原体的扩散或感染而不使用诸如防腐剂或抗生素的化学物质。 此外,本发明的擦拭物还含有在广谱细菌存在下经历颜色变化的溶剂色素指示剂。 因此,当擦拭物捕获细菌时,指示器经历颜色变化,向用户发出指示擦拭物正常工作的颜色变化。 缺少颜色变化也可以为用户提供该区域通常没有细菌和清洁的保证。
    • 9. 发明授权
    • Method for detecting Candida on skin
    • 检测皮肤上假丝酵母的方法
    • US08361742B2
    • 2013-01-29
    • US12843922
    • 2010-07-27
    • Stephanie M. MartinAndrew M. Long, IIIJohn Gavin MacDonaldJason Lye
    • Stephanie M. MartinAndrew M. Long, IIIJohn Gavin MacDonaldJason Lye
    • C12Q1/22C12Q1/02
    • A61L15/56G01N2333/245G01N2333/31G01N2333/40
    • A method and system for rapidly detecting Candida on the skin of a host, such as an infant with diaper rash, is provided. The method includes contacting a dermal sample with a colorant that exhibits a certain spectral response (e.g., color change) in the presence of Candida. For example, the colorant may change from a first color to a second color, from colorless to a color, or from a color to colorless. The colorant is typically capable of differentiating between Candida (e.g., Candida albicans) and other microorganisms commonly associated with diaper rash, such as S. aureus and E. coli. Thus, when a dermal sample is placed into contact with the colorant, the color change may simply be observed to determine whether the infection is caused by Candida. If the color change occurs to a certain extent (e.g., from yellow to bright red), it may be determined that the test sample contains Candida. Likewise, if a color change occurs to a lesser extent (e.g., from yellow to faint orange) or not at all, it may be determined that the dermal sample contains other microorganisms (e.g., S. aureus or E. coli), no infection is present, or that the infection is simply due to other causes. Regardless, it will become readily apparent whether or not treatment for Candida is needed.
    • 提供了用于快速检测宿主皮肤上的假丝酵母的方法和系统,例如具有尿布疹的婴儿。 该方法包括使真皮样品与在假丝酵母存在下显示特定光谱响应(例如颜色变化)的着色剂接触。 例如,着色剂可以从第一颜色变为第二颜色,从无色到颜色,或从颜色变为无色。 着色剂通常能够区分假丝酵母(例如白色念珠菌)和通常与尿布疹相关的其它微生物,例如金黄色葡萄球菌和大肠杆菌。 因此,当真皮样品与着色剂接触时,可以简单地观察颜色变化以确定感染是否由念珠菌引起。 如果颜色变化发生一定程度(例如,从黄色到鲜红色),则可以确定测试样品含有念珠菌。 同样地,如果在较小程度上发生颜色变化(例如,从黄色到微弱橙色),或根本不发生变色,则可以确定真皮样品含有其他微生物(例如金黄色葡萄球菌或大肠杆菌),无感染 存在,或感染仅仅是由于其他原因。 无论是否需要对念珠菌的治疗,将变得显而易见。