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    • 5. 发明申请
    • METHODS OF PREPARING METAL-MODIFIED SILICA NANOPARTICLES
    • 制备金属改性二氧化硅纳米粒子的方法
    • US20100150859A1
    • 2010-06-17
    • US12335176
    • 2008-12-15
    • Bao Trong DoThomas David EhlertRobert Allen JanssenJohn Gavin MacDonaldPaul Warren RasmussenShiming Zhuang
    • Bao Trong DoThomas David EhlertRobert Allen JanssenJohn Gavin MacDonaldPaul Warren RasmussenShiming Zhuang
    • A61L2/23B01F11/02
    • B01F11/0258A61L9/014
    • A method of preparing metal-modified silica particles is disclosed. Specifically, a treatment chamber is provided in which a first and a second formulation are ultrasonically mixed to prepare metal-modified silica particles. The treatment chamber has an elongate housing through which the first and second formulations flow longitudinally from a first inlet port and a second inlet port, respectively, to an outlet port thereof. An elongate ultrasonic waveguide assembly extends within the housing and is operable at a predetermined ultrasonic frequency to ultrasonically energize the formulations within the housing. An elongate ultrasonic horn of the waveguide assembly is disposed at least in part intermediate the inlet and outlet ports, and has a plurality of discrete agitating members in contact with and extending transversely outward from the horn intermediate the inlet and outlet ports in longitudinally spaced relationship with each other. The horn and agitating members are constructed and arranged for dynamic motion of the agitating members relative to the horn at the predetermined frequency and to operate in an ultrasonic cavitation mode of the agitating members corresponding to the predetermined frequency and the formulations being mixed in the chamber.
    • 公开了一种制备金属改性二氧化硅颗粒的方法。 具体地说,提供一种处理室,其中第一和第二制剂被超声波混合以制备金属改性的二氧化硅颗粒。 处理室具有细长的外壳,第一和第二配方通过该外壳从第一入口端口和第二入口端口分别纵向流到其出口。 细长的超声波波导组件在壳体内延伸并且可以预定的超声频率操作以超声波地激励壳体内的配方。 波导组件的细长的超声波喇叭至少部分地设置在入口和出口的中间,并且具有多个离散的搅拌构件,其与入口和出口端口处的喇叭的横向外部接触并向外延伸,与纵向间隔开的关系 彼此。 喇叭和搅拌构件被构造和布置成用于搅动构件相对于喇叭以预定频率的动态运动,并且在对应于预定频率的搅拌构件的超声空化模式下操作,并且配方在腔室中混合。
    • 8. 发明授权
    • Self-indicating wipe for removing bacteria from a surface
    • 自我指示擦拭从表面去除细菌
    • US08871232B2
    • 2014-10-28
    • US11955696
    • 2007-12-13
    • Stephanie M. MartinJohn Gavin MacDonaldBao Trong Do
    • Stephanie M. MartinJohn Gavin MacDonaldBao Trong Do
    • A01N59/06A01N59/16A01N25/34A01P1/00A61L2/28A47L13/16A61L2/238
    • A61L2/28A47L13/16A61L2/238
    • A wipe that includes a bacteriostatic agent that contains cations having an affinity for the negatively charged cell walls of bacteria is provided. The affinity of the bacteriostatic agent for the bacteria allows the wipe to capture bacteria, thereby removing them from a surface and also inhibiting their spread to other surfaces that may contact the wipe. Of particular advantage, the bacteriostatic agent may help protect against the spread or infection of pathogens without the use of chemicals, such as antiseptics or antibiotics. Still further, the wipe of the present invention also contains a solvatochromatic indicator that undergoes a color change in the presence of a broad spectrum of bacteria. Thus, when the wipe captures bacteria, the indicator undergoes a color change that signals to the user that the wipe is functioning properly. The lack of a color change may likewise provide the user with the assurance that the area is generally free of bacteria and clean.
    • 提供了包含具有对细菌带负电荷的细胞壁具有亲和性的阳离子的抑菌剂的擦拭物。 抑菌剂对细菌的亲和力允许擦拭物捕获细菌,从而从表面除去它们,并且还抑制它们扩散到可能接触擦拭物的其它表面。 特别有利的是,抑菌剂可以帮助防止病原体的扩散或感染而不使用诸如防腐剂或抗生素的化学物质。 此外,本发明的擦拭物还含有在广谱细菌存在下经历颜色变化的溶剂色素指示剂。 因此,当擦拭物捕获细菌时,指示器经历颜色变化,向用户发出指示擦拭物正常工作的颜色变化。 缺少颜色变化也可以为用户提供该区域通常没有细菌和清洁的保证。
    • 9. 发明授权
    • Methods of preparing metal-modified silica nanoparticles
    • 制备金属改性二氧化硅纳米粒子的方法
    • US08685178B2
    • 2014-04-01
    • US12335176
    • 2008-12-15
    • Bao Trong DoThomas David EhlertRobert Allen JanssenJohn Gavin MacDonaldPaul Warren RasmussenShiming Zhuang
    • Bao Trong DoThomas David EhlertRobert Allen JanssenJohn Gavin MacDonaldPaul Warren RasmussenShiming Zhuang
    • B06B3/00B22F9/16
    • B01F11/0258A61L9/014
    • A method of preparing metal-modified silica particles is disclosed. Specifically, a treatment chamber is provided in which a first and a second formulation are ultrasonically mixed to prepare metal-modified silica particles. The treatment chamber has an elongate housing through which the first and second formulations flow longitudinally from a first inlet port and a second inlet port, respectively, to an outlet port thereof. An elongate ultrasonic waveguide assembly extends within the housing and is operable at a predetermined ultrasonic frequency to ultrasonically energize the formulations within the housing. An elongate ultrasonic horn of the waveguide assembly is disposed at least in part intermediate the inlet and outlet ports, and has a plurality of discrete agitating members in contact with and extending transversely outward from the horn intermediate the inlet and outlet ports in longitudinally spaced relationship with each other. The horn and agitating members are constructed and arranged for dynamic motion of the agitating members relative to the horn at the predetermined frequency and to operate in an ultrasonic cavitation mode of the agitating members corresponding to the predetermined frequency and the formulations being mixed in the chamber.
    • 公开了一种制备金属改性二氧化硅颗粒的方法。 具体地说,提供一种处理室,其中第一和第二制剂被超声波混合以制备金属改性的二氧化硅颗粒。 处理室具有细长的外壳,第一和第二配方通过该外壳从第一入口端口和第二入口端口分别纵向流到其出口。 细长的超声波波导组件在壳体内延伸并且可以预定的超声频率操作以超声波地激励壳体内的配方。 波导组件的细长超声波喇叭至少部分地设置在入口和出口的中间,并且具有多个离散的搅拌构件,其与入口和出口端口处的喇叭中的接触并横向向外延伸,与纵向间隔开的关系 彼此。 喇叭和搅拌构件被构造和布置成用于搅动构件相对于喇叭以预定频率的动态运动,并且在对应于预定频率的搅拌构件的超声空化模式下操作,并且配方在腔室中混合。