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1. 发明授权

US08755866B2 Method and apparatus for lymph node mapping 失效
标题翻译：淋巴结图谱的方法和装置
公开(公告)号：US08755866B2
公开(公告)日：2014-06-17
申请号：US11381443
申请日：2006-05-03
申请人： John F. Heanue , Joseph A. Heanue , Brian P. Wilfley , Augustus P. Lowell
发明人： John F. Heanue , Joseph A. Heanue , Brian P. Wilfley , Augustus P. Lowell
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/415 , A61B5/418 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/10 , G01J3/2823 , G01J3/4406 , G01N21/6408 , G01N2201/0826 , G01N2201/0833
摘要： A system and method for optical lymph node mapping. The system is useful for guiding sentinel lymph node biopsy surgeries. A contrast agent that includes a fluorescent dye is injected near the site of a malignancy. The contrast agent drains into the lymphatic system, collecting in a sentinel node or nodes. The system utilizes one or more low-power continuous-wave lasers or light-emitting diodes modulated with a digital code sequence to probe the tissue suspected of containing the sentinel node. When the light is incident near the sentinel node, it will excite fluorescence from the dye. A portion of the scattered fluorescent light is captured with one or more photo-detectors. A correlation of the photo-detector signal and the digital code sequence is calculated to produce an estimate of the distribution of flight times for photons traveling from a given source to a given detector. The flight time distributions are used along with the measured amplitudes to reconstruct a map of contrast agent location within the tissue.
摘要翻译：一种用于光学淋巴结图谱的系统和方法。该系统可用于引导前哨淋巴结活检。包含荧光染料的造影剂在恶性肿瘤部位附近注射。造影剂排入淋巴系统，收集在前哨节点或节点。该系统利用一个或多个低功率连续波激光器或用数字代码序列调制的发光二极管来探测怀疑含有前哨节点的组织。当光在哨兵节点附近入射时，它会激发染料的荧光。一部分散射的荧光被一个或多个光电探测器捕获。计算光检测器信号和数字码序列的相关性，以产生从给定源到给定检测器的光子的飞行时间分布的估计。飞行时间分布与测量的振幅一起使用以重建组织内造影剂位置的图。

2. 发明申请

US20120323109A1 Photon Measurement Method and Apparatus 审中-公开
标题翻译：光子测量方法和装置
公开(公告)号：US20120323109A1
公开(公告)日：2012-12-20
申请号：US13598324
申请日：2012-08-29
申请人： John F. Heanue , Joseph A. Heanue , Brian P. Wilfley , Augustus P. Lowell
发明人： John F. Heanue , Joseph A. Heanue , Brian P. Wilfley , Augustus P. Lowell
IPC分类号： A61B6/00
CPC分类号： G01N21/6456 , A61B5/0059 , A61B5/0071 , A61B5/0086 , G01N21/4795
摘要： A system and method for measuring photons utilizing a low-power light source modulated with a code sequence to interrogate a sample of interest. Preferably a portion of the scattered light from the sample is detected by a photo-detector. A correlation of the photo-detector signal and the code sequence produces an estimate of the distribution of flight times for photons traveling from the source to the detector.
摘要翻译：一种利用利用码序列调制的低功率光源来测量光子的系统和方法来询问感兴趣的样本。优选地，通过光检测器检测来自样品的一部分散射光。光检测器信号和代码序列的相关性产生从源到检测器的光子的飞行时间分布的估计。

3. 发明授权

US08269964B2 Photon measurement method and apparatus 有权
标题翻译：光子测量方法和装置
公开(公告)号：US08269964B2
公开(公告)日：2012-09-18
申请号：US11381450
申请日：2006-05-03
申请人： John F. Heanue , Joseph A. Heanue , Brian P. Wilfley , Augustus P. Lowell
发明人： John F. Heanue , Joseph A. Heanue , Brian P. Wilfley , Augustus P. Lowell
IPC分类号： G01J3/30
CPC分类号： G01N21/6456 , A61B5/0059 , A61B5/0071 , A61B5/0086 , G01N21/4795
摘要： A system and method for measuring photons utilizing a low-power light source modulated with a code sequence to interrogate a sample of interest. Preferably a portion of the scattered light from the sample is detected by a photo-detector. A correlation of the photo-detector signal and the code sequence produces an estimate of the distribution of flight times for photons traveling from the source to the detector.
摘要翻译：一种利用利用码序列调制的低功率光源来测量光子的系统和方法来询问感兴趣的样本。优选地，通过光检测器检测来自样品的一部分散射光。光检测器信号和代码序列的相关性产生从源到检测器的光子的飞行时间分布的估计。

4. 发明申请

US20120238897A1 SYSTEM AND METHOD FOR DETERMINING ELECTRODE-TISSUE CONTACT BASED ON AMPLITUDE MODULATION OF SENSED SIGNAL 有权
标题翻译：基于感应信号振幅调制的电极组织接触测定系统及方法
公开(公告)号：US20120238897A1
公开(公告)日：2012-09-20
申请号：US13423034
申请日：2012-03-16
申请人： Brian P. Wilfley , Joseph A. Heanue , Stuart L. Friedman
发明人： Brian P. Wilfley , Joseph A. Heanue , Stuart L. Friedman
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B18/1492 , A61B2090/065
摘要： Methods and systems for monitoring contact between a medical probe and tissue are provided. A medical probe is introduced into a patient adjacent the tissue. An electrical parameter, e.g., electrical admittance, is measuring between a first electrode located on the medical probe and a second electrode remote from the first electrode. The electrical parameter is amplitude modulated in response to a physiological cycle of the patient. Contact between the medical probe and the tissue is detected based on the amplitude modulation of the measured electrical parameter.
摘要翻译：提供了用于监测医疗探针和组织之间接触的方法和系统。将医用探针引入邻近组织的患者。诸如电导纳的电参数是在位于医用探针上的第一电极和远离第一电极的第二电极之间进行测量。电参数响应于患者的生理周期进行幅度调制。基于所测量的电参数的幅度调制来检测医用探针与组织之间的接触。

5. 发明授权

US08160690B2 System and method for determining electrode-tissue contact based on amplitude modulation of sensed signal 有权
标题翻译：基于感测信号的幅度调制确定电极 - 组织接触的系统和方法
公开(公告)号：US08160690B2
公开(公告)日：2012-04-17
申请号：US11762778
申请日：2007-06-14
申请人： Brian P. Wilfley , Joseph A. Heanue , Stuart L. Friedman
发明人： Brian P. Wilfley , Joseph A. Heanue , Stuart L. Friedman
IPC分类号： A61B5/05
CPC分类号： A61B5/053 , A61B18/1492 , A61B2090/065
摘要： Methods and systems for monitoring contact between a medical probe and tissue are provided. A medical probe is introduced into a patient adjacent the tissue. An electrical parameter, e.g., electrical admittance, is measured between a first electrode located on the medical probe and a second electrode remote from the first electrode. The electrical parameter is amplitude modulated in response to a physiological cycle of the patient. Contact between the medical probe and the tissue is detected based on the amplitude modulation of the measured electrical parameter.
摘要翻译：提供了用于监测医疗探针和组织之间接触的方法和系统。将医用探针引入邻近组织的患者。在位于医疗探针上的第一电极和远离第一电极的第二电极之间测量电参数，例如电导纳。电参数响应于患者的生理周期进行幅度调制。基于所测量的电参数的幅度调制来检测医用探针与组织之间的接触。

6. 发明授权

US08545517B2 Systems and methods for improving follicular unit harvesting 有权
标题翻译：改善滤泡单位收获的系统和方法
公开(公告)号：US08545517B2
公开(公告)日：2013-10-01
申请号：US12477444
申请日：2009-06-03
申请人： Mohan Bodduluri , Joseph A. Heanue , Kate L. Bechtel , Brian P. Wilfley
发明人： Mohan Bodduluri , Joseph A. Heanue , Kate L. Bechtel , Brian P. Wilfley
IPC分类号： A61B17/50 , A61B5/107 , G05B15/00
CPC分类号： A61B5/0066 , A61B5/446 , A61B34/25 , A61B34/30 , A61B90/30 , A61B90/361 , A61B2017/00106 , A61B2017/00752 , A61B2090/378 , G06T5/50 , G06T2207/20016
摘要： Tools and methods are provided for dissecting and/or removing biological units, such as hair follicles, from the body surface based on the images both above and below a body surface to reduce potential damage to the removed biological unit. The invention may be used in fully automated systems and also in a hand-held devices and systems. A system may produce a series of three-dimensional images of the body surface indicating follicular unit size, shape, position, and orientation both above and below the skin surface. The images may be utilized by an automated follicular unit harvesting tool, or maybe stored for later use. Imaging techniques include devices that sense light in the visible or infrared spectrums, optical coherence tomography, and ultrahigh frequency ultrasound.
摘要翻译：提供了工具和方法，用于基于身体表面上方和下方的图像从身体表面解剖和/或去除生物单位，例如毛囊，以减少对去除的生物单位的潜在损害。本发明可以用于全自动化系统中，也可用于手持设备和系统中。系统可以产生一系列身体表面的三维图像，指示皮肤表面上方和下方的滤泡单位尺寸，形状，位置和取向。图像可以由自动滤泡单元收获工具使用，或者可以存储以供以后使用。成像技术包括感知可见光或红外光谱中的光，光学相干断层扫描和超高频超声的装置。

7. 发明授权

US08489184B2 System and method for determining electrode-tissue contact based on amplitude modulation of sensed signal 有权
标题翻译：基于感测信号的幅度调制确定电极 - 组织接触的系统和方法
公开(公告)号：US08489184B2
公开(公告)日：2013-07-16
申请号：US13423034
申请日：2012-03-16
申请人： Brian P. Wilfley , Joseph A. Heanue , Stuart L. Friedman
发明人： Brian P. Wilfley , Joseph A. Heanue , Stuart L. Friedman
IPC分类号： A61B5/05
CPC分类号： A61B5/053 , A61B18/1492 , A61B2090/065
摘要： Methods and systems for monitoring contact between a medical probe and tissue are provided. A medical probe is introduced into a patient adjacent the tissue. An electrical parameter, e.g., electrical admittance, is measured between a first electrode located on the medical probe and a second electrode remote from the first electrode. The electrical parameter is amplitude modulated in response to a physiological cycle of the patient. Contact between the medical probe and the tissue is detected based on the amplitude modulation of the measured electrical parameter.
摘要翻译：提供了用于监测医疗探针和组织之间接触的方法和系统。将医用探针引入邻近组织的患者。在位于医疗探针上的第一电极和远离第一电极的第二电极之间测量电参数，例如电导纳。电参数响应于患者的生理周期进行幅度调制。基于所测量的电参数的幅度调制来检测医用探针与组织之间的接触。

8. 发明申请

US20090306498A1 Systems and Methods for Improving Follicular Unit Harvesting 有权
标题翻译：改善滤泡单位收获的系统与方法
公开(公告)号：US20090306498A1
公开(公告)日：2009-12-10
申请号：US12477444
申请日：2009-06-03
申请人： Mohan Bodduluri , Joseph A. Heanue , Kate L. Bechtel , Brian P. Wilfley
发明人： Mohan Bodduluri , Joseph A. Heanue , Kate L. Bechtel , Brian P. Wilfley
IPC分类号： A61B5/05 , A61B17/50 , A61B18/00
CPC分类号： A61B5/0066 , A61B5/446 , A61B34/25 , A61B34/30 , A61B90/30 , A61B90/361 , A61B2017/00106 , A61B2017/00752 , A61B2090/378 , G06T5/50 , G06T2207/20016
摘要： Tools and methods are provided for dissecting and/or removing biological units, such as hair follicles, from the body surface based on the images both above and below a body surface to reduce potential damage to the removed biological unit. The invention may be used in fully automated systems and also in a hand-held devices and systems. A system may produce a series of three-dimensional images of the body surface indicating follicular unit size, shape, position, and orientation both above and below the skin surface. The images may be utilized by an automated follicular unit harvesting tool, or maybe stored for later use. Imaging techniques include devices that sense light in the visible or infrared spectrums, optical coherence tomography, and ultrahigh frequency ultrasound.
摘要翻译：提供了工具和方法，用于基于身体表面上方和下方的图像从身体表面解剖和/或去除生物单位，例如毛囊，以减少对去除的生物单位的潜在损害。本发明可以用于全自动化系统中，也可用于手持设备和系统中。系统可以产生一系列身体表面的三维图像，指示皮肤表面上方和下方的滤泡单位尺寸，形状，位置和取向。图像可以由自动滤泡单元收获工具使用，或者可以存储以供以后使用。成像技术包括感知可见光或红外光谱中的光，光学相干断层扫描和超高频超声的装置。

9. 发明申请

US20080312713A1 SYSTEM AND METHOD FOR DETERMINING ELECTRODE-TISSUE CONTACT BASED ON AMPLITUDE MODULATION OF SENSED SIGNAL 有权
标题翻译：基于感应信号振幅调制的电极组织接触测定系统及方法
公开(公告)号：US20080312713A1
公开(公告)日：2008-12-18
申请号：US11762778
申请日：2007-06-14
申请人： Brian P. Wilfley , Joseph A. Heanue , Stuart L. Friedman
发明人： Brian P. Wilfley , Joseph A. Heanue , Stuart L. Friedman
IPC分类号： A61N1/02 , A61B18/14
CPC分类号： A61B5/053 , A61B18/1492 , A61B2090/065
摘要： Methods and systems for monitoring contact between a medical probe and tissue are provided. A medical probe is introduced into a patient adjacent the tissue. An electrical parameter, e.g., electrical admittance, is measuring between a first electrode located on the medical probe and a second electrode remote from the first electrode. The electrical parameter is amplitude modulated in response to a physiological cycle of the patient. Contact between the medical probe and the tissue is detected based on the amplitude modulation of the measured electrical parameter.
摘要翻译：提供了用于监测医疗探针和组织之间接触的方法和系统。将医用探针引入邻近组织的患者。诸如电导纳的电参数是在位于医用探针上的第一电极和远离第一电极的第二电极之间进行测量。电参数响应于患者的生理周期进行幅度调制。基于所测量的电参数的幅度调制来检测医用探针与组织之间的接触。

10. 发明授权

US07426260B2 Polychronic digital radiography detector with patterned mask for single-exposure energy-sensitive X-ray imaging 有权
标题翻译：具有用于单次曝光能量敏感X射线成像的图案化掩模的多时数字放射线检测器
公开(公告)号：US07426260B2
公开(公告)日：2008-09-16
申请号：US11250867
申请日：2005-10-14
申请人： Gary R. Cantu , Brian P. Wilfley , Joseph A. Heanue
发明人： Gary R. Cantu , Brian P. Wilfley , Joseph A. Heanue
IPC分类号： G21K3/00
CPC分类号： G01T1/295 , G01N23/04
摘要： A digital radiography system, having: a pixilated optical detector; and a mask positioned adjacent to the pixilated optical detector, the mask comprising a repeating pattern of first and second portions configured to pass different wavelengths of electromagnetic radiation therethrough such that a polychromic X-ray image can be taken using only a single X-ray exposure with a single imaging detector.
摘要翻译：一种数字放射照相系统，具有：像素化光学检测器; 以及与所述像素化光学检测器相邻定位的掩模，所述掩模包括被配置为通过不同波长的电磁辐射的第一和第二部分的重复图案，使得可以仅使用单次X射线曝光来获取多色X射线图像使用单个成像检测器。

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