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1. 发明授权

US06936056B2 Intravascular system for occluded blood vessels and guidewire for use therein 失效
公开(公告)号：US06936056B2
公开(公告)日：2005-08-30
申请号：US10355754
申请日：2003-01-31
申请人： John E. Nash , William T. Fisher , Charles W. Dodson, Jr. , John Michael Henderson , Joseph W. Kaufmann
发明人： John E. Nash , William T. Fisher , Charles W. Dodson, Jr. , John Michael Henderson , Joseph W. Kaufmann
IPC分类号： A61B17/00 , A61B17/22 , A61B17/32 , A61D1/02 , A61M1/00 , A61M31/00
CPC分类号： A61B17/320758 , A61B2017/00845 , A61B2017/00853 , A61B2017/22038 , A61B2217/005 , A61B2217/007 , A61M1/0058
摘要： A system and method for opening a lumen in an occluded blood vessel, e.g., a coronary bypass graft, of a living being. The system comprises an atherectomy catheter having a working head, e.g., a rotary impacting impeller, and a debris extraction sub-system. The atherectomy catheter is located within a guide catheter. The working head is arranged to operate on, e.g., impact, the occlusive material in the occluded vessel to open a lumen therein, whereupon some debris may be produced. The debris extraction sub-system introduces an infusate liquid at a first flow rate adjacent the working head and withdraws that liquid and some blood at a second and higher flow rate, through the guide catheter to create a differential flow adjacent the working head, whereupon the debris is withdrawn in the infusate liquid and blood for collection outside the being's body. The introduction of the infusate liquid may also be used to establish an unbalanced flow adjacent the working head to enable the atherectomy catheter to be steered hydrodynamically. A guide wire having an inflatable balloon on its distal end may be used with the atherectomy catheter to block the flow of debris distally, while enabling distal tissues to be perfused with an oxygenating liquid. At least one flow control port may be provided in the guide catheter to prevent collapse of the vessel being revascularized. A cradle is provided to fix the guide catheter and guide wire in position within the body of the being while enabling the atherectomy catheter to be advanced along the guide wire and through the guide catheter. The guide catheter includes a wear resistant coating and is constructed so that its distal end includes plural sections of different outside diameters, with the distal most section being of the smallest outside diameter. A control console is provided to establish various modes of operation of the system based on manual inputs via switches or voice commands via voice recognition circuitry. A video panel displays the various modes of operation and instructions to the operator.

2. 发明授权

US06652546B1 System and method of use for revascularizing stenotic bypass grafts and other occluded blood vessels 有权
公开(公告)号：US06652546B1
公开(公告)日：2003-11-25
申请号：US09690976
申请日：2000-10-18
申请人： John E. Nash , William T. Fisher , Charles W. Dodson, Jr. , John Michael Henderson , Joseph W. Kaufmann
发明人： John E. Nash , William T. Fisher , Charles W. Dodson, Jr. , John Michael Henderson , Joseph W. Kaufmann
IPC分类号： A61D102
CPC分类号： A61B17/320758 , A61B2017/00845 , A61B2017/00853 , A61B2017/22038 , A61B2217/005 , A61B2217/007 , A61M1/0058
摘要： A system and method for opening a lumen in an occluded blood vessel, e.g., a coronary bypass graft, of a living being. The system comprises an atherectomy catheter having a working head, e.g., a rotary impacting impeller, and a debris extraction sub-system. The atherectomy catheter is located within a guide catheter. The working head is arranged to operate on, e.g., impact, the occlusive material in the occluded vessel to open a lumen therein, whereupon some debris may be produced. The debris extraction sub-system introduces an infusate liquid at a first flow rate adjacent the working head and withdraws that liquid and some blood at a second and higher flow rate, through the guide catheter to create a differential flow adjacent the working head, whereupon the debris is withdrawn in the infusate liquid and blood for collection outside the being's body. The introduction of the infusate liquid may also be used to establish an unbalanced flow adjacent the working head to enable the atherectomy catheter to be steered hydrodynamically. A guide wire having an inflatable balloon on its distal end may be used with the atherectomy catheter to block the flow of debris distally, while enabling distal tissues to be perfused with an oxygenating liquid. At least one flow control port may be provided in the guide catheter to prevent collapse of the vessel being revascularized. A cradle is provided to fix the guide catheter and guide wire in position within the body of the being while enabling the atherectomy catheter to be advanced along the guide wire and through the guide catheter. The guide catheter includes a wear resistant coating and is constructed so that its distal end includes plural sections of different outside diameters, with the distal most section being of the smallest outside diameter. A control console is provided to establish various modes of operation of the system based on manual inputs via switches or voice commands via voice recognition circuitry. A video panel displays the various modes of operation and instructions to the operator.

3. 发明授权

US07981129B2 System for opening a lumen in an occluded blood vessel 有权
标题翻译：用于打开闭塞血管内腔的系统
公开(公告)号：US07981129B2
公开(公告)日：2011-07-19
申请号：US11925191
申请日：2007-10-26
申请人： John E. Nash , William T. Fisher , Charles W. Dodson, Jr.
发明人： John E. Nash , William T. Fisher , Charles W. Dodson, Jr.
IPC分类号： A61B17/22
CPC分类号： A61B17/32037 , A61B17/22 , A61B17/320758 , A61B2017/22048 , A61B2017/22067 , A61B2017/320775 , A61B2217/005 , A61B2217/007 , A61M1/0058 , A61M1/0084 , A61M5/14232 , A61M2025/1095 , A61M2205/05
摘要： A system for opening a lumen in an occluded blood vessel, e.g.., a coronary bypass graft, of a living being. The method entails using an instrument to deploy the stent at occlusive material within the blood vessel to open the lumen, whereupon some debris may be produced. Operating a debris extraction system for removing debris during deployment of the stent.
摘要翻译：用于打开活体的封闭血管例如冠状动脉旁路移植物的内腔的系统。该方法需要使用仪器将支架部署在血管内的封闭材料上以打开内腔，于是可能产生一些碎屑。操作碎片提取系统，用于在展开支架期间去除碎屑。

4. 发明授权

US08226673B2 System and method of use for agent delivery and revascularizing of grafts and vessels 有权
标题翻译：用于药剂递送和移植物和血管血运重建的系统和方法
公开(公告)号：US08226673B2
公开(公告)日：2012-07-24
申请号：US12468753
申请日：2009-05-19
申请人： John E. Nash , William T. Fisher , Charles W. Dodson, Jr.
发明人： John E. Nash , William T. Fisher , Charles W. Dodson, Jr.
IPC分类号： A61B17/22
CPC分类号： A61B17/320758 , A61B17/32037 , A61B2017/22048 , A61B2017/22067 , A61B2217/005 , A61B2217/007 , A61M1/0058 , A61M1/0084 , A61M5/14232 , A61M2025/1095 , A61M2205/05
摘要： A system and method for opening a lumen in an occluded blood vessel, e.g., a coronary bypass graft, of a living being. The system comprises an atherectomy catheter having a working head, e.g., a rotary impacting impeller, and a debris extraction sub\-system. The atherectomy catheter is located within a guide catheter. The working head is arranged to operate on, e.g., impact, the occlusive material in the occluded vessel to open a lumen therein, whereupon some debris may be produced. The debris extraction sub\-system introduces an infusate liquid at a first flow rate adjacent the working head and withdraws that liquid and some blood at a second and higher flow rate, through the guide catheter to create a differential flow adjacent the working head, whereupon the debris is withdrawn in the infusate liquid and blood for collection outside the being's body.
摘要翻译：一种用于打开活体的封闭血管（例如冠状动脉旁路移植物）中的内腔的系统和方法。该系统包括具有工作头的动脉粥样硬化切除术导管，例如旋转冲击叶轮和碎片提取子系统。粥样斑块切除术导管位于引导导管内。工作头被布置成操作例如冲击闭塞的容器中的封闭材料以在其中打开内腔，于是可能产生一些碎屑。碎片提取子系统以邻近工作头的第一流速引入输注液体，并通过引导导管以第二和较高流速抽出该液体和一些血液，以在工作头附近形成差动流，残留的液体和血液中的碎屑被收集在身体外部。

5. 发明授权

US06524323B1 System and method of use for revascularizing stenotic bypass grafts and other occluded blood vessels 有权
公开(公告)号：US06524323B1
公开(公告)日：2003-02-25
申请号：US09594131
申请日：2000-06-14
申请人： John E. Nash , William T. Fisher , Charles W. Dodson, Jr.
发明人： John E. Nash , William T. Fisher , Charles W. Dodson, Jr.
IPC分类号： A61B1722
CPC分类号： A61B17/32037 , A61B17/22 , A61B17/320758 , A61B2017/22048 , A61B2017/22067 , A61B2017/320775 , A61B2217/005 , A61B2217/007 , A61M1/0058 , A61M1/0084 , A61M5/14232 , A61M2025/1095 , A61M2205/05
摘要： A system and method for opening a lumen in an occluded blood vessel, e.g., a coronary bypass graft, of a living being. The system comprises an atherectomy catheter having a working head, e.g., a rotary impacting impeller, and a debris extraction sub-system. The atherectomy catheter is located within a guide catheter. The working head is arranged to operate on, e.g., impact, the occlusive material in the occluded vessel to open a lumen therein, whereupon some debris may be produced. The debris extraction sub-system introduces an infusate liquid at a first flow rate adjacent the working head and withdraws that liquid and some blood at a second and higher flow rate, through the guide catheter to create a differential flow adjacent the working head, whereupon the debris is withdrawn in the infusate liquid and blood for collection outside the being's body. The introduction of the infusate liquid may also be used to establish an unbalanced flow adjacent the working head to enable the atherectomy catheter to be steered hydrodynamically. A guide wire having an inflatable balloon on its distal end may be used with the atherectomy catheter to block the flow of debris distally, while enabling distal tissues to be perfused with an oxygenating liquid. At least one flow control port may be provided in the guide catheter to prevent collapse of the vessel being revascularized. A cradle is provided to fix the guide catheter and guide wire in position within the body of the being while enabling the atherectomy catheter to be advanced along the guide wire and through the guide catheter.

6. 发明授权

US6080170A System and method of use for revascularizing stenotic bypass grafts and other occluded blood vessels 有权
公开(公告)号：US6080170A
公开(公告)日：2000-06-27
申请号：US233712
申请日：1999-01-19
申请人： John E. Nash , William T. Fisher , Charles W. Dodson, Jr.
发明人： John E. Nash , William T. Fisher , Charles W. Dodson, Jr.
IPC分类号： A61B17/22 , A61B17/32 , A61D1/02 , A61F2/06 , A61M1/00 , A61M29/02 , A61M31/00
CPC分类号： A61B17/32037 , A61B17/22 , A61B17/320758 , A61B2017/22048 , A61B2017/22067 , A61B2017/320775 , A61B2217/005 , A61B2217/007 , A61M1/0058 , A61M1/0084 , A61M2025/1095 , A61M2205/05 , A61M5/14232
摘要： A system and method for opening a lumen in an occluded blood vessel, e.g., a coronary bypass graft, of a living being. The system comprises an atherectomy catheter having a working head, e.g., a rotary impacting impeller, and a debris extraction sub-system. The atherectomy catheter is located within a guide catheter. The working head is arranged to operate on, e.g., impact, the occlusive material in the occluded vessel to open a lumen therein, whereupon some debris may be produced. The debris extraction sub-system introduces an infusate liquid at a first flow rate adjacent the working head and withdraws that liquid and some blood at a second and higher flow rate, through the guide catheter to create a differential flow adjacent the working head, whereupon the debris is withdrawn in the infusate liquid and blood for collection outside the being's body. The introduction of the infusate liquid may also be used to establish an unbalanced flow adjacent the working head to enable the atherectomy catheter to be steered hydrodynamically. A guide wire having an inflatable balloon on its distal end may be used with the atherectomy catheter to block the flow of debris distally, while enabling distal tissues to be perfused with an oxygenating liquid. At least one flow control port may be provided in the guide catheter to prevent collapse of the vessel being revascularized. A cradle is provided to fix the guide catheter and guide wire in position within the body of the being while enabling the atherectomy catheter to be advanced along the guide wire and through the guide catheter.

7. 发明授权

US06843797B2 System and method of use for revascularizing stenotic bypass grafts and other occluded blood vessels 有权
标题翻译：用于血管狭窄性旁路移植物和其他闭塞血管的系统和方法
公开(公告)号：US06843797B2
公开(公告)日：2005-01-18
申请号：US10339688
申请日：2003-01-09
申请人： John E. Nash , William T. Fisher , Charles W. Dodson, Jr.
发明人： John E. Nash , William T. Fisher , Charles W. Dodson, Jr.
IPC分类号： A61B17/22 , A61B17/32 , A61D1/02 , A61F2/06 , A61M1/00 , A61M29/02 , A61M31/00
CPC分类号： A61B17/32037 , A61B17/22 , A61B17/320758 , A61B2017/22048 , A61B2017/22067 , A61B2017/320775 , A61B2217/005 , A61B2217/007 , A61M1/0058 , A61M1/0084 , A61M5/14232 , A61M2025/1095 , A61M2205/05
摘要： A system and method for opening a lumen in an occluded blood vessel, e.g., a coronary bypass graft, of a living being. The system comprises an atherectomy catheter having a working head, e.g., a rotary impacting impeller, and a debris extraction sub-system. The atherectomy catheter is located within a guide catheter. The working head is arranged to operate on, e.g., impact, the occlusive material in the occluded vessel to open a lumen therein, whereupon some debris may be produced. The debris extraction sub-system introduces an infusate liquid at a first flow rate adjacent the working head and withdraws that liquid and some blood at a second and higher flow rate, through the guide catheter to create a differential flow adjacent the working head, whereupon the debris is withdrawn in the infusate liquid and blood for collection outside the being's body. The introduction of the infusate liquid may also be used to establish an unbalanced flow adjacent the working head to enable the atherectomy catheter to be steered hydrodynamically. A guide wire having an inflatable balloon on its distal end may be used with the atherectomy catheter to block the flow of debris distally, while enabling distal tissues to be perfused with an oxygenating liquid. At least one flow control port may be provided in the guide catheter to prevent collapse of the vessel being revascularized. A cradle is provided to fix the guide catheter and guide wire in position within the body of the being while enabling the atherectomy catheter to be advanced along the guide wire and through the guide catheter.
摘要翻译：一种用于打开活体的封闭血管（例如冠状动脉旁路移植物）中的内腔的系统和方法。该系统包括具有工作头的动脉粥样硬化切除术导管，例如旋转冲击叶轮和碎片提取子系统。粥样斑块切除术导管位于引导导管内。工作头被布置成操作例如冲击闭塞的容器中的封闭材料以在其中打开内腔，于是可能产生一些碎屑。碎片提取子系统以邻近工作头的第一流速引入输注液体，并通过引导导管以第二和较高流速抽出该液体和一些血液，以在工作头附近形成差动流，残留的液体和血液被收集在身体外部。输注液体的引入也可用于在工作头附近建立不平衡的流动，以使动脉粥样硬化切除术导管能够流体动力学转向。在其远端具有可膨胀气囊的导丝可以与粥样斑块切除术导管一起使用，以阻止碎片向远处流动，同时使远端组织能够用含氧液体灌注。可以在引导导管中设置至少一个流量控制端口，以防止血运重建的血管的塌陷。提供支架以将引导导管和导丝固定在身体内的适当位置，同时使得粥样斑块切除导管能够沿导丝并通过引导导管前进。

8. 发明授权

US07534249B2 System and method of use for agent delivery and revascularizing of grafts and vessels 失效
公开(公告)号：US07534249B2
公开(公告)日：2009-05-19
申请号：US10665337
申请日：2003-09-18
申请人： John E. Nash , William T. Fisher , Charles W. Dodson, Jr.
发明人： John E. Nash , William T. Fisher , Charles W. Dodson, Jr.
IPC分类号： A61B17/22
CPC分类号： A61B17/320758 , A61B17/32037 , A61B2017/22048 , A61B2017/22067 , A61B2217/005 , A61B2217/007 , A61M1/0058 , A61M1/0084 , A61M5/14232 , A61M2025/1095 , A61M2205/05
摘要： A system and method for opening a lumen in an occluded blood vessel, e.g., a coronary bypass graft, of a living being. The system comprises an atherectomy catheter having a working head, e.g., a rotary impacting impeller, and a debris extraction sub-system. The atherectomy catheter is located within a guide catheter. The working head is arranged to operate on, e.g., impact, the occlusive material in the occluded vessel to open a lumen therein, whereupon some debris may be produced. The debris extraction sub-system introduces an infusate liquid at a first flow rate adjacent the working head and withdraws that liquid and some blood at a second and higher flow rate, through the guide catheter to create a differential flow adjacent the working head, whereupon the debris is withdrawn in the infusate liquid and blood for collection outside the being's body. The introduction of the infusate liquid may also be used to establish an unbalanced flow adjacent the working head to enable the atherectomy catheter to be steered hydrodynamically. A guide wire having an inflatable balloon on its distal end may be used with the atherectomy catheter to block the flow of debris distally, while enabling distal tissues to be perfused with an oxygenating liquid. At least one flow control port may be provided in the guide catheter to prevent collapse of the vessel being revascularized. A cradle is provided to fix the guide catheter and guide wire in position within the body of the being while enabling the atherectomy catheter to be advanced along the guide wire and through the guide catheter.

9. 发明授权

US07367982B2 Method for opening a lumen in an occluded blood vessel 有权
标题翻译：打开闭塞血管内腔的方法
公开(公告)号：US07367982B2
公开(公告)日：2008-05-06
申请号：US10978984
申请日：2004-11-01
申请人： John E. Nash , William T. Fisher , Charles W. Dodson, Jr.
发明人： John E. Nash , William T. Fisher , Charles W. Dodson, Jr.
IPC分类号： A61B17/22
CPC分类号： A61B17/32037 , A61B17/22 , A61B17/320758 , A61B2017/22048 , A61B2017/22067 , A61B2017/320775 , A61B2217/005 , A61B2217/007 , A61M1/0058 , A61M1/0084 , A61M5/14232 , A61M2025/1095 , A61M2205/05
摘要： A method for opening a lumen in an occluded blood vessel, e.g., a coronary bypass graft, of a living being. The method entails using an instrument to deploy the stent at occlusive material within the blood vessel to open the lumen, whereupon some debris may be produced. Operating a debris extraction system for removing debris during deployment of the stent.
摘要翻译：一种用于打开活体的闭塞血管例如冠状动脉搭桥移植物的内腔的方法。该方法需要使用仪器将支架部署在血管内的封闭材料上以打开内腔，于是可能产生一些碎屑。操作碎片提取系统，用于在展开支架期间去除碎屑。

10. 发明申请

US20090292276A1 SYSTEM AND METHOD OF USE FOR AGENT DELIVERY AND REVASCULARIZING OF GRAFTS AND VESSELS 有权
标题翻译：用于送货和运输的货物和船只的系统和方法
公开(公告)号：US20090292276A1
公开(公告)日：2009-11-26
申请号：US12468753
申请日：2009-05-19
申请人： John E. Nash , William T. Fisher , Charles W. Dodson, JR.
发明人： John E. Nash , William T. Fisher , Charles W. Dodson, JR.
IPC分类号： A61B17/22 , A61M37/00 , A61B18/20
CPC分类号： A61B17/320758 , A61B17/32037 , A61B2017/22048 , A61B2017/22067 , A61B2217/005 , A61B2217/007 , A61M1/0058 , A61M1/0084 , A61M5/14232 , A61M2025/1095 , A61M2205/05
摘要： A system and method for opening a lumen in an occluded blood vessel, e.g., a coronary bypass graft, of a living being. The system comprises an atherectomy catheter having a working head, e.g., a rotary impacting impeller, and a debris extraction sub-system. The atherectomy catheter is located within a guide catheter. The working head is arranged to operate on, e.g., impact, the occlusive material in the occluded vessel to open a lumen therein, whereupon some debris may be produced. The debris extraction sub-system introduces an infusate liquid at a first flow rate adjacent the working head and withdraws that liquid and some blood at a second and higher flow rate, through the guide catheter to create a differential flow adjacent the working head, whereupon the debris is withdrawn in the infusate liquid and blood for collection outside the being's body. The introduction of the infusate liquid may also be used to establish an unbalanced flow adjacent the working head to enable the atherectomy catheter to be steered hydrodynamically. A guide wire having an inflatable balloon on its distal end may be used with the atherectomy catheter to block the flow of debris distally, while enabling distal tissues to be perfused with an oxygenating liquid. At least one flow control port may be provided in the guide catheter to prevent collapse of the vessel being revascularized. A cradle is provided to fix the guide catheter and guide wire in position within the body of the being while enabling the atherectomy catheter to be advanced along the guide wire and through the guide catheter.
摘要翻译：一种用于打开活体的封闭血管（例如冠状动脉旁路移植物）中的内腔的系统和方法。该系统包括具有工作头的动脉粥样硬化切除术导管，例如旋转冲击叶轮和碎片提取子系统。粥样斑块切除术导管位于引导导管内。工作头被布置成操作例如冲击闭塞的容器中的封闭材料以在其中打开内腔，于是可能产生一些碎屑。碎片提取子系统以邻近工作头的第一流速引入输注液体，并通过引导导管以第二和较高流速抽出该液体和一些血液，以在工作头附近形成差动流，残留的液体和血液被收集在身体外部。输注液体的引入也可用于在工作头附近建立不平衡的流动，以使动脉粥样硬化切除术导管能够流体动力学转向。在其远端具有可膨胀气囊的导丝可以与粥样斑块切除术导管一起使用，以阻止碎片向远处流动，同时使远端组织能够用含氧液体灌注。可以在引导导管中设置至少一个流量控制端口，以防止血运重建的血管的塌陷。提供支架以将引导导管和导丝固定在身体内的适当位置，同时使得粥样斑块切除导管能够沿导丝并通过引导导管前进。

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