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    • 1. 发明申请
    • Synthetic process, and crystalline forms of a pyrrolotriazine compound
    • 合成方法和吡咯并三嗪化合物的结晶形式
    • US20060014741A1
    • 2006-01-19
    • US11149525
    • 2005-06-10
    • John DiMarcoJack GougoutasBharat Patel
    • John DiMarcoJack GougoutasBharat Patel
    • A61K31/5377C07D487/04
    • C07D487/04
    • The present invention provides a process for preparing pyrrolotriazine compounds of formula (I) or a pharmaceutically acceptable salt thereof. Also provided are crystalline forms of the pyrrolotriazine compound [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methyl-pyrrolo[2, 1-f][1,2,4]triazin-6-yl]-carbamic acid, (3S)-3-morpholinylmethyl ester and pharmaceutical compositions comprising at least one crystalline form, as well of methods of using the crystalline forms in the treatment of a proliferative disease, and methods for obtaining such crystalline forms. The compounds of formula (I), including [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamic acid, (3S)-3-morpholinylmethyl ester, are useful for inhibiting tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.
    • 本发明提供了制备式(I)的吡咯并三嗪化合物或其药学上可接受的盐的方法。 还提供了吡咯并三嗪化合物[4 - [[1-(3-氟苯基)甲基] -1H-吲唑-5-基氨基] -5-甲基 - 吡咯并[2,1-f] [1,2, 4]三嗪-6-基] - 氨基甲酸,(3S)-3-吗啉基甲酯和包含至少一种结晶形式的药物组合物,以及使用结晶形式治疗增殖性疾病的方法,以及用于 获得这样的结晶形式。 式(I)化合物包括[4 - [[1-(3-氟苯基)甲基] -1H-吲唑-5-基氨基] -5-甲基 - 吡咯并[2,1-f] 4]三嗪-6-基] - 氨基甲酸,(3S)-3-吗啉基甲基酯可用于抑制生长因子受体如HER1,HER2和HER4的酪氨酸激酶活性,从而使其可用作抗增殖剂,用于治疗 癌症等疾病。
    • 3. 发明申请
    • Cell size enlargers for polystyrene foams
    • 聚苯乙烯泡沫的泡孔尺寸放大器
    • US20070299152A1
    • 2007-12-27
    • US11472772
    • 2006-06-22
    • Bharat PatelYadollah DelavizRaymond M. BreindelMitchell Z. WeekleyRoland R. LohManoj K. Choudhary
    • Bharat PatelYadollah DelavizRaymond M. BreindelMitchell Z. WeekleyRoland R. LohManoj K. Choudhary
    • C08J9/00
    • C08J9/0061C08J9/0014C08J2325/06C08J2423/00C08J2471/00
    • Polymer extruded foams that contain cell size enlarging agents are provided. The inventive composition includes a foamable polymer material, at least one blowing agent, and at least one cell size enlarging agent. The blowing agent utilized in the inventive composition is preferably selected such that the composition has a zero ozone depletion and low global warming potential. Examples include any inorganic blowing agents and/or non-hydrogenated chlorofluorocarbons (non-HCFCs). The foamable polymer material is preferably polystyrene. The cell size enlarging agent may be chosen from ethylene vinyl acetate (EVA) and/or ethylene methyl acrylate (EMA). The cell size enlarging agent permits the formation of a foam with large cell sizes that are desirable to achieve a high insulation value and to optimize the physical properties of the foamed product. In addition, the cell size enlarging agent provides an increased cell size to the foamed product without detracting from the physical and thermal properties.
    • 提供了含有电池尺寸扩大剂的聚合物挤出泡沫体。 本发明的组合物包括可发泡聚合物材料,至少一种发泡剂和至少一种细胞尺寸扩大剂。 本发明组合物中使用的发泡剂优选地选择成使得组合物具有零臭氧消耗和低的全球变暖潜能。 实例包括任何无机发泡剂和/或非氢化氯氟烃(非HCFC)。 可发泡聚合物材料优选为聚苯乙烯。 电池尺寸扩大剂可以选自乙烯乙酸乙烯酯(EVA)和/或乙烯丙烯酸甲酯(EMA)。 电池尺寸扩大剂允许形成具有大电池尺寸的泡沫,这是希望达到高绝缘值并优化发泡产品的物理性能的泡沫。 此外,电池尺寸扩大剂为发泡产品提供增加的电池尺寸,而不会降低物理和热性能。