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1. 发明授权

US4310505A Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances 失效
标题翻译：含有碳水化合物表面的脂质囊泡作为治疗和诊断物质的淋巴导向载体
公开(公告)号：US4310505A
公开(公告)日：1982-01-12
申请号：US92342
申请日：1979-11-08
申请人： John D. Baldeschwieler , Ronald C. Gamble , Marcia R. Mauk , Tsung-Ying Shen , Mitree M. Ponpipom
发明人： John D. Baldeschwieler , Ronald C. Gamble , Marcia R. Mauk , Tsung-Ying Shen , Mitree M. Ponpipom
IPC分类号： A61K51/00 , A61K9/127 , A61K47/00 , A61K49/00 , A61K43/00 , B01J13/00
CPC分类号： A61K9/1272 , A61K9/127 , A61K9/1271 , Y10T428/2984
摘要： Lipid vesicles comprising a lipid bilayer which includes analogs of cell-surface receptors such as dicetyl phosphate; stearylamine; 6-(5-cholesten-3.beta.-yloxy) hexyl 1-thio-.beta.-L-fucopyranoside; 6-(5-cholesten-3.beta.-yloxy) hexyl 1-thio-.beta.-D-galactopyranoside; 6-(5-cholesten-3.beta.-yloxy)hexyl 1-thio-.alpha.-D-mannopyranoside; 6-(5-cholesten-3-yloxy)hexyl 2-acetamido-2-deoxy-1-thio-.beta.-D-galactopyranoside; 6-(5-cholesten-3.beta.-yloxy)hexyl 6-amino-6-deoxy-1-thio-.beta.-D-galactopyranoside; or 6-(5-cholesten-3.beta.-yloxy)hexyl 6-amino-6-deoxy-1-thio-.alpha.-D-mannopyranoside; cholesterol and distearoyl phospatidylcholine, and an effective amount of physiologically compatible radioactive tracer, cytotoxic or therapeutic agent as a part of the vesicles. The vesicles of this invention can be administered to the human host and have been found to release the contents of the vesicles in a predetermined manner, i.e., controlled release, and in some cases, to be rapidly concentrated in the lymphatic system and/or liver, lungs or spleen of the host.
摘要翻译：包含脂质双层的脂质囊泡，其包括细胞表面受体的类似物，例如磷酸二鲸蜡酯; 硬脂胺 6-（5-胆甾烯-3β-氧代）己基1-硫代-β-L-吡喃葡萄糖苷; 6-（5-胆甾烯-3β-氧基）己基1-硫代-β-D-吡喃半乳糖苷; 6-（5-胆甾烯-3β-氧基）己基1-硫代-α-D-吡喃甘露糖苷; 6-（5-胆甾烯-3-基氧基）己基2-乙酰氨基-2-脱氧-1-硫代-β-D-吡喃半乳糖苷; 6-（5-胆甾烯-3β-氧基）己基6-氨基-6-脱氧-1-硫代-β-D-吡喃半乳糖苷; 或6-（5-胆甾烯-3β-氧基）己基6-氨基-6-脱氧-1-硫代-α-D-吡喃甘露糖苷; 胆固醇和二硬脂酰磷脂酰胆碱，以及有效量的生理相容的放射性示踪剂，细胞毒性剂或治疗剂作为囊泡的一部分。本发明的囊泡可以施用于人宿主，并且已经被发现以预定的方式（即控制释放）释放囊泡的内容物，并且在一些情况下快速浓缩在淋巴系统和/或肝脏中，肺或脾脏的主机。

2. 发明授权

US4310506A Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species 失效
标题翻译：含有高浓度包埋离子物质的脂质体的制备和应用方法
公开(公告)号：US4310506A
公开(公告)日：1982-01-12
申请号：US123162
申请日：1980-02-20
申请人： John D. Baldeschwieler , Ronald C. Gamble , Marcia R. Mauk
发明人： John D. Baldeschwieler , Ronald C. Gamble , Marcia R. Mauk
IPC分类号： A61K9/127 , A61K51/12 , A61K49/00 , A61K43/00 , B01J13/00
CPC分类号： A61K51/1234 , A61K9/1278 , A61K2123/00 , Y10T428/2984
摘要： Unilamellar vesicles comprising a lipid bilayer, an ionophore being incorporated in said lipid bilayer, a chelating agent entrapped within the vesicles, and an effective amount of physiologically compatible cation bound to said chelating agent within the vesicles. Unilamellar vesicles are loaded by incubating the vesicles with the cation, terminating the incubation and recovering the loaded vesicles by chromatography. In some applications of the invention, the cation may be a radioactive tracer, in which case the vesicles can be administered to the human host and observed by scintillation techniques to produce a radioimage which is useful for diagnostic purposes.
摘要翻译：包含脂质双层的单层囊泡，掺入所述脂质双层中的离子载体，包封在囊泡内的螯合剂，以及与囊泡内的所述螯合剂结合的有效量的生理上相容的阳离子。通过将囊泡与阳离子孵育来加载单层囊泡，终止孵育并通过色谱法回收加载的囊泡。在本发明的一些应用中，阳离子可以是放射性示踪剂，在这种情况下，囊泡可以施用于人宿主并通过闪烁技术观察以产生可用于诊断目的的放射性图像。

3. 发明授权

US5981733A Apparatus for the chemical synthesis of molecular arrays 失效
标题翻译：用于化学合成分子阵列的装置
公开(公告)号：US5981733A
公开(公告)日：1999-11-09
申请号：US714867
申请日：1996-09-16
申请人： Ronald C. Gamble , Thomas P. Theriault , John D. Baldeschwieler
发明人： Ronald C. Gamble , Thomas P. Theriault , John D. Baldeschwieler
IPC分类号： B01J19/00 , C40B40/06 , C40B60/14 , C07H21/00
CPC分类号： B01J19/0046 , B01J2219/00378 , B01J2219/00391 , B01J2219/00475 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00722 , C40B40/06 , C40B60/14 , Y02P20/582
摘要： An apparatus for the automated synthesis of molecular arrays. A jetting device is employed along with a reaction chamber to dispense reagents used in the synthesis onto the substrate. A positioning system moves the substrate from the jet to the reaction chamber. A controller controls the movement of the substrate and the application of the reagents so that the synthesis is carried out according to a pre-determined procedure. The apparatus will synthesize nucleotides in an array of micron-size spots according to a pattern selected by the operator immediately prior to synthesis.
摘要翻译：用于自动合成分子阵列的装置。喷射装置与反应室一起使用以将合成中使用的试剂分配到基材上。定位系统将基板从射流移动到反应室。控制器控制衬底的移动和试剂的应用，使得根据预定程序进行合成。该装置将根据在合成前立即由操作者选择的图案在微米级斑点的阵列中合成核苷酸。

4. 发明授权

US4581222A Membrane immune assay 失效
标题翻译：膜免疫测定
公开(公告)号：US4581222A
公开(公告)日：1986-04-08
申请号：US465360
申请日：1983-02-09
申请人： John D. Baldeschwieler , Ronald C. Gamble , Albert M. Lin , George W. Tin
发明人： John D. Baldeschwieler , Ronald C. Gamble , Albert M. Lin , George W. Tin
IPC分类号： G01N33/534 , A61K43/00 , G01T1/00
CPC分类号： G01N33/534 , Y10S436/804 , Y10S436/827
摘要： An immunoassay method for detection of antigen is disclosed. The method employs complement mediated lysis of vesicles loaded with In-111 or other gamma-emitting cation, and quantitative detection of the lysis by gamma-ray perturbed angular correlation (PAC) spectroscopy. The vesicles are labeled with a substance competitive to the antigen to be measured, and the concentration of the antigen in the sample measured by assessing the diminution in lysis due to the presence of the competing antigen.The method may also be used to assess the immunologic competence of a subject by injecting suitably sensitized vesicles and monitoring the in vivo lysis pattern by (PAC).
摘要翻译：公开了一种用于检测抗原的免疫测定方法。该方法使用负载有In-111或其他γ发射阳离子的囊泡的补体介导的裂解，以及通过γ射线扰动角度相关（PAC）光谱定量检测裂解。囊泡用与要测量的抗原竞争的物质标记，并且通过评估由于竞争性抗原的存在引起的裂解减少来测量样品中抗原的浓度。该方法还可以用于通过注射适当敏化的囊泡和通过（PAC）监测体内裂解模式来评估受试者的免疫能力。

5. 发明授权

US5847105A Methods for performing multiple sequential reactions on a matrix 失效
标题翻译：在矩阵上执行多个连续反应的方法
公开(公告)号：US5847105A
公开(公告)日：1998-12-08
申请号：US910727
申请日：1997-08-13
申请人： John D. Baldeschwieler , Ronald C. Gamble , Thomas P. Theriault
发明人： John D. Baldeschwieler , Ronald C. Gamble , Thomas P. Theriault
IPC分类号： C12Q1/68 , B01J19/00 , C07H21/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , G01N33/53 , G01N37/00
CPC分类号： B82Y30/00 , B01J19/0046 , C07H21/00 , C07K1/042 , C07K1/047 , B01J2219/00369 , B01J2219/00378 , B01J2219/00475 , B01J2219/00513 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00675 , B01J2219/0068 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： A method and apparatus are provided for preparing a substrate upon which is located microdrop-sized loci at which chemical compounds are synthesized or diagnostic tests are conducted. The loci are formed by applying microdrops from a dispenser from which a microdrop is pulse fed onto the surface of the substrate.
摘要翻译：提供了一种用于制备基底的方法和装置，其上定位有微小尺寸的位置，在该位置处合成化合物或进行诊断测试。通过将微滴从脉冲馈送到基底表面上的分配器施加微滴而形成位点。

6. 发明授权

US6015880A Method and substrate for performing multiple sequential reactions on a matrix 失效
标题翻译：在基质上进行多次连续反应的方法和底物
公开(公告)号：US6015880A
公开(公告)日：2000-01-18
申请号：US213857
申请日：1994-03-16
申请人： John D. Baldeschwieler , Ronald C. Gamble , Thomas P. Theriault
发明人： John D. Baldeschwieler , Ronald C. Gamble , Thomas P. Theriault
IPC分类号： C12Q1/68 , B01J19/00 , C07H21/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , G01N33/53 , G01N37/00 , A61K38/00
CPC分类号： B82Y30/00 , B01J19/0046 , C07H21/00 , C07K1/042 , C07K1/047 , B01J2219/00369 , B01J2219/00378 , B01J2219/00475 , B01J2219/00513 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00675 , B01J2219/0068 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： A method and apparatus are provided for preparing a substrate upon which is located microdrop-sized loci at which chemical compounds are synthesized or diagnostic tests are conducted. The loci are formed by applying microdrops from a dispenser from which a microdrop is pulse fed onto the surface of the substrate.
摘要翻译：提供了一种用于制备基底的方法和装置，其上定位有微小尺寸的位置，在该位置处合成化合物或进行诊断测试。通过将微滴从脉冲馈送到基底表面上的分配器施加微滴而形成位点。

7. 发明申请

US20110178610A1 SYSTEMS AND METHODS FOR MANAGING UTILITY CONSUMPTION 审中-公开
标题翻译：用于管理实用消费的系统和方法
公开(公告)号：US20110178610A1
公开(公告)日：2011-07-21
申请号：US13120920
申请日：2009-10-15
申请人： Stephen D. O'Connor , Ronald C. Gamble , Richard A. Suchter
发明人： Stephen D. O'Connor , Ronald C. Gamble , Richard A. Suchter
IPC分类号： G05B13/04 , G06G7/48
CPC分类号： G06Q10/06
摘要： A system and method for monitoring and managing utility consumption includes use of (A) one or more sensors arranged to monitor an operating condition and/or utility consumption of at least one segment or appliance of a first facility; (B) a memory including at least one of (i) stored utility consumption information correlated or normalized to at least one designated parameter affecting utility consumption or (ii) hypothetical utility consumption; (C) a processor to compare the monitored information with the stored information, and (D) an output medium to store and/or display the comparison information. Stored consumption information may relate to the first facility or a second facility. Hypothetical utility consumption information may relate to a segment or appliance of the first facility operated according to optimized conditions, or an upgraded segment or appliance.
摘要翻译：一种用于监测和管理公用事业消耗的系统和方法包括使用（A）布置成监测第一设施的至少一个段或设备的运行状况和/或公用事业消耗的一个或多个传感器; （B）存储器，其包括以下至少一个：（i）存储的与至少一个影响公用事业消耗的指定参数相关或归一化的公用消费信息;（ii）假设的公用事业消费; （C）处理器，用于将所监视的信息与存储的信息进行比较，以及（D）存储和/或显示比较信息的输出介质。存储的消费信息可能与第一设施或第二设施有关。假设效用消耗信息可以涉及根据优化条件操作的第一设施的段或设备，或升级的段或设备。

8. 发明授权

US5958342A Jet droplet device 失效
标题翻译：喷射液滴装置
公开(公告)号：US5958342A
公开(公告)日：1999-09-28
申请号：US649535
申请日：1996-05-17
申请人： Ronald C. Gamble , Thomas P. Theriault , John Baldeschwieler
发明人： Ronald C. Gamble , Thomas P. Theriault , John Baldeschwieler
IPC分类号： C12N15/09 , B01J19/00 , B01L3/02 , C40B50/14 , C40B60/14 , G01N1/28 , G01N35/10 , G01N3/02
CPC分类号： B01L3/0268 , B01J19/0046 , B82Y30/00 , B01J2219/00378 , B01J2219/00531 , B01J2219/00533 , B01J2219/00536 , B01J2219/00605 , B01J2219/00612 , B01J2219/00637 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00691 , B01L2200/04 , C40B50/14 , C40B60/14 , G01N2001/282 , G01N2035/1041
摘要： Devices and methods are provided for precise production of arrays of microspots. A pulse jetting device is employed having a capillary of micron dimensions, with a portion of the capillary proximal to the jetting orifice circumferentially surrounded by a piezoelectric transducer. By appropriate design of the capillary, orifice and piezoelectric transducer, droplets can be formed on a surface, separated by as little as 80 microns center-to-center, and having at least about a 15 micron spacing at the border. The subject substrate arrays can be used for providing miniaturized arrays of reagents, such as nucleic acids, for detecting the presence of homologous sequences in a sample.
摘要翻译：提供了用于精确生产微孢子体阵列的装置和方法。使用脉冲喷射装置具有微米尺寸的毛细管，毛细管的一部分靠近喷射孔，周向地被压电换能器包围。通过毛细管，孔口和压电换能器的适当设计，液滴可以形成在中心至中心微小至80微米的表面上，并且在边界处具有至少约15微米的间距。主题衬底阵列可用于提供用于检测样品中同源序列的存在的小型试剂阵列，例如核酸。

9. 发明授权

US4497791A Method for labeling phagocytic cells 失效
标题翻译：标记吞噬细胞的方法
公开(公告)号：US4497791A
公开(公告)日：1985-02-05
申请号：US465502
申请日：1983-02-10
申请人： Ronald C. Gamble , George W. Tin , Lawrence E. Williams
发明人： Ronald C. Gamble , George W. Tin , Lawrence E. Williams
IPC分类号： G01N33/60 , A61K9/127 , A61K51/00 , A61K51/12 , C12N5/06 , C12Q1/00 , A61K43/00 , A61K49/00
CPC分类号： A61K9/1272 , A61K51/1203 , A61K51/1227 , A61K51/1234 , A61K2123/00
摘要： Described herein is a process for labeling leukocytes and other phagocytic cells with labeled micellular particles involving incubating the cells with the micellular particles. Also described is a process for detecting the locus of an infection by administering to a subject leukocytes radiolabeled by incubation with labeled micellular particles followed by scanning the subject to detect the locus of radiation emitted by the particles.
摘要翻译：本文描述的是用标记的微胶囊颗粒标记白细胞和其它吞噬细胞的方法，包括将细胞与微胶粒颗粒一起孵育。还描述了通过向受试者进行放射性标记的白细胞来检测感染的轨迹的方法，所述白细胞通过与标记的微粒颗粒孵育，随后扫描受试者以检测由颗粒发射的辐射的轨迹。

10. 发明申请

US20130245437A1 SYSTEM AND METHOD FOR FACILITATING REFLECTOMETRIC DETECTION OF PHYSIOLOGIC ACTIVITY 有权
标题翻译：用于促进生物活性反射检测的系统和方法
公开(公告)号：US20130245437A1
公开(公告)日：2013-09-19
申请号：US13827555
申请日：2013-03-14
申请人： Ronald C. Gamble , Lawrence Randolph Weill , Steve Perry Monacos
发明人： Ronald C. Gamble , Lawrence Randolph Weill , Steve Perry Monacos
IPC分类号： A61B5/05 , A61B5/024 , A61B5/00
CPC分类号： A61B5/725 , A61B5/0006 , A61B5/0205 , A61B5/024 , A61B5/02405 , A61B5/0507 , A61B5/7257 , A61B5/7275 , A61B5/742 , A61B5/746
摘要： A method for remotely sensing cardiac-related data of an animal subject includes transmitting a RF signal to impinge on tissue of the subject, receiving a reflected portion of the RF signal, generating baseband data, filtering baseband data (e.g., including high pass filtering), performing waveform phase position determination, performing at least one auto-correlation of the waveform phase position determined data, determining periodicity of the auto-correlated data, and (i) computing heart rate using a maximum periodicity of the periodicity, or (ii) identifying abnormalities in cardiac function, such as may be indicated by temporal variations in heart rate and/or signal amplitude corresponding to cardiac activity. Multiple bandpass filtering schemes may be employed.
摘要翻译：用于远程感测动物对象的心脏相关数据的方法包括：发送RF信号以撞击对象的组织，接收RF信号的反射部分，产生基带数据，滤波基带数据（例如，包括高通滤波）执行波形相位位置确定，执行波形相位位置确定数据的至少一个自相关，确定自动相关数据的周期性，以及（i）使用周期的最大周期来计算心率，或者（ii）识别心脏功能异常，例如可以通过对应于心脏活动的心率和/或信号幅度的时间变化来指示。可以采用多个带通滤波方案。

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