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1. 发明授权

US4310505A Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances 失效
标题翻译：含有碳水化合物表面的脂质囊泡作为治疗和诊断物质的淋巴导向载体
公开(公告)号：US4310505A
公开(公告)日：1982-01-12
申请号：US92342
申请日：1979-11-08
申请人： John D. Baldeschwieler , Ronald C. Gamble , Marcia R. Mauk , Tsung-Ying Shen , Mitree M. Ponpipom
发明人： John D. Baldeschwieler , Ronald C. Gamble , Marcia R. Mauk , Tsung-Ying Shen , Mitree M. Ponpipom
IPC分类号： A61K51/00 , A61K9/127 , A61K47/00 , A61K49/00 , A61K43/00 , B01J13/00
CPC分类号： A61K9/1272 , A61K9/127 , A61K9/1271 , Y10T428/2984
摘要： Lipid vesicles comprising a lipid bilayer which includes analogs of cell-surface receptors such as dicetyl phosphate; stearylamine; 6-(5-cholesten-3.beta.-yloxy) hexyl 1-thio-.beta.-L-fucopyranoside; 6-(5-cholesten-3.beta.-yloxy) hexyl 1-thio-.beta.-D-galactopyranoside; 6-(5-cholesten-3.beta.-yloxy)hexyl 1-thio-.alpha.-D-mannopyranoside; 6-(5-cholesten-3-yloxy)hexyl 2-acetamido-2-deoxy-1-thio-.beta.-D-galactopyranoside; 6-(5-cholesten-3.beta.-yloxy)hexyl 6-amino-6-deoxy-1-thio-.beta.-D-galactopyranoside; or 6-(5-cholesten-3.beta.-yloxy)hexyl 6-amino-6-deoxy-1-thio-.alpha.-D-mannopyranoside; cholesterol and distearoyl phospatidylcholine, and an effective amount of physiologically compatible radioactive tracer, cytotoxic or therapeutic agent as a part of the vesicles. The vesicles of this invention can be administered to the human host and have been found to release the contents of the vesicles in a predetermined manner, i.e., controlled release, and in some cases, to be rapidly concentrated in the lymphatic system and/or liver, lungs or spleen of the host.
摘要翻译：包含脂质双层的脂质囊泡，其包括细胞表面受体的类似物，例如磷酸二鲸蜡酯; 硬脂胺 6-（5-胆甾烯-3β-氧代）己基1-硫代-β-L-吡喃葡萄糖苷; 6-（5-胆甾烯-3β-氧基）己基1-硫代-β-D-吡喃半乳糖苷; 6-（5-胆甾烯-3β-氧基）己基1-硫代-α-D-吡喃甘露糖苷; 6-（5-胆甾烯-3-基氧基）己基2-乙酰氨基-2-脱氧-1-硫代-β-D-吡喃半乳糖苷; 6-（5-胆甾烯-3β-氧基）己基6-氨基-6-脱氧-1-硫代-β-D-吡喃半乳糖苷; 或6-（5-胆甾烯-3β-氧基）己基6-氨基-6-脱氧-1-硫代-α-D-吡喃甘露糖苷; 胆固醇和二硬脂酰磷脂酰胆碱，以及有效量的生理相容的放射性示踪剂，细胞毒性剂或治疗剂作为囊泡的一部分。本发明的囊泡可以施用于人宿主，并且已经被发现以预定的方式（即控制释放）释放囊泡的内容物，并且在一些情况下快速浓缩在淋巴系统和/或肝脏中，肺或脾脏的主机。

2. 发明授权

US4310506A Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species 失效
标题翻译：含有高浓度包埋离子物质的脂质体的制备和应用方法
公开(公告)号：US4310506A
公开(公告)日：1982-01-12
申请号：US123162
申请日：1980-02-20
申请人： John D. Baldeschwieler , Ronald C. Gamble , Marcia R. Mauk
发明人： John D. Baldeschwieler , Ronald C. Gamble , Marcia R. Mauk
IPC分类号： A61K9/127 , A61K51/12 , A61K49/00 , A61K43/00 , B01J13/00
CPC分类号： A61K51/1234 , A61K9/1278 , A61K2123/00 , Y10T428/2984
摘要： Unilamellar vesicles comprising a lipid bilayer, an ionophore being incorporated in said lipid bilayer, a chelating agent entrapped within the vesicles, and an effective amount of physiologically compatible cation bound to said chelating agent within the vesicles. Unilamellar vesicles are loaded by incubating the vesicles with the cation, terminating the incubation and recovering the loaded vesicles by chromatography. In some applications of the invention, the cation may be a radioactive tracer, in which case the vesicles can be administered to the human host and observed by scintillation techniques to produce a radioimage which is useful for diagnostic purposes.
摘要翻译：包含脂质双层的单层囊泡，掺入所述脂质双层中的离子载体，包封在囊泡内的螯合剂，以及与囊泡内的所述螯合剂结合的有效量的生理上相容的阳离子。通过将囊泡与阳离子孵育来加载单层囊泡，终止孵育并通过色谱法回收加载的囊泡。在本发明的一些应用中，阳离子可以是放射性示踪剂，在这种情况下，囊泡可以施用于人宿主并通过闪烁技术观察以产生可用于诊断目的的放射性图像。

3. 发明授权

US5847105A Methods for performing multiple sequential reactions on a matrix 失效
标题翻译：在矩阵上执行多个连续反应的方法
公开(公告)号：US5847105A
公开(公告)日：1998-12-08
申请号：US910727
申请日：1997-08-13
申请人： John D. Baldeschwieler , Ronald C. Gamble , Thomas P. Theriault
发明人： John D. Baldeschwieler , Ronald C. Gamble , Thomas P. Theriault
IPC分类号： C12Q1/68 , B01J19/00 , C07H21/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , G01N33/53 , G01N37/00
CPC分类号： B82Y30/00 , B01J19/0046 , C07H21/00 , C07K1/042 , C07K1/047 , B01J2219/00369 , B01J2219/00378 , B01J2219/00475 , B01J2219/00513 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00675 , B01J2219/0068 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： A method and apparatus are provided for preparing a substrate upon which is located microdrop-sized loci at which chemical compounds are synthesized or diagnostic tests are conducted. The loci are formed by applying microdrops from a dispenser from which a microdrop is pulse fed onto the surface of the substrate.
摘要翻译：提供了一种用于制备基底的方法和装置，其上定位有微小尺寸的位置，在该位置处合成化合物或进行诊断测试。通过将微滴从脉冲馈送到基底表面上的分配器施加微滴而形成位点。

4. 发明授权

US5981733A Apparatus for the chemical synthesis of molecular arrays 失效
标题翻译：用于化学合成分子阵列的装置
公开(公告)号：US5981733A
公开(公告)日：1999-11-09
申请号：US714867
申请日：1996-09-16
申请人： Ronald C. Gamble , Thomas P. Theriault , John D. Baldeschwieler
发明人： Ronald C. Gamble , Thomas P. Theriault , John D. Baldeschwieler
IPC分类号： B01J19/00 , C40B40/06 , C40B60/14 , C07H21/00
CPC分类号： B01J19/0046 , B01J2219/00378 , B01J2219/00391 , B01J2219/00475 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00722 , C40B40/06 , C40B60/14 , Y02P20/582
摘要： An apparatus for the automated synthesis of molecular arrays. A jetting device is employed along with a reaction chamber to dispense reagents used in the synthesis onto the substrate. A positioning system moves the substrate from the jet to the reaction chamber. A controller controls the movement of the substrate and the application of the reagents so that the synthesis is carried out according to a pre-determined procedure. The apparatus will synthesize nucleotides in an array of micron-size spots according to a pattern selected by the operator immediately prior to synthesis.
摘要翻译：用于自动合成分子阵列的装置。喷射装置与反应室一起使用以将合成中使用的试剂分配到基材上。定位系统将基板从射流移动到反应室。控制器控制衬底的移动和试剂的应用，使得根据预定程序进行合成。该装置将根据在合成前立即由操作者选择的图案在微米级斑点的阵列中合成核苷酸。

5. 发明授权

US4581222A Membrane immune assay 失效
标题翻译：膜免疫测定
公开(公告)号：US4581222A
公开(公告)日：1986-04-08
申请号：US465360
申请日：1983-02-09
申请人： John D. Baldeschwieler , Ronald C. Gamble , Albert M. Lin , George W. Tin
发明人： John D. Baldeschwieler , Ronald C. Gamble , Albert M. Lin , George W. Tin
IPC分类号： G01N33/534 , A61K43/00 , G01T1/00
CPC分类号： G01N33/534 , Y10S436/804 , Y10S436/827
摘要： An immunoassay method for detection of antigen is disclosed. The method employs complement mediated lysis of vesicles loaded with In-111 or other gamma-emitting cation, and quantitative detection of the lysis by gamma-ray perturbed angular correlation (PAC) spectroscopy. The vesicles are labeled with a substance competitive to the antigen to be measured, and the concentration of the antigen in the sample measured by assessing the diminution in lysis due to the presence of the competing antigen.The method may also be used to assess the immunologic competence of a subject by injecting suitably sensitized vesicles and monitoring the in vivo lysis pattern by (PAC).
摘要翻译：公开了一种用于检测抗原的免疫测定方法。该方法使用负载有In-111或其他γ发射阳离子的囊泡的补体介导的裂解，以及通过γ射线扰动角度相关（PAC）光谱定量检测裂解。囊泡用与要测量的抗原竞争的物质标记，并且通过评估由于竞争性抗原的存在引起的裂解减少来测量样品中抗原的浓度。该方法还可以用于通过注射适当敏化的囊泡和通过（PAC）监测体内裂解模式来评估受试者的免疫能力。

6. 发明授权

US6015880A Method and substrate for performing multiple sequential reactions on a matrix 失效
标题翻译：在基质上进行多次连续反应的方法和底物
公开(公告)号：US6015880A
公开(公告)日：2000-01-18
申请号：US213857
申请日：1994-03-16
申请人： John D. Baldeschwieler , Ronald C. Gamble , Thomas P. Theriault
发明人： John D. Baldeschwieler , Ronald C. Gamble , Thomas P. Theriault
IPC分类号： C12Q1/68 , B01J19/00 , C07H21/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , G01N33/53 , G01N37/00 , A61K38/00
CPC分类号： B82Y30/00 , B01J19/0046 , C07H21/00 , C07K1/042 , C07K1/047 , B01J2219/00369 , B01J2219/00378 , B01J2219/00475 , B01J2219/00513 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00675 , B01J2219/0068 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： A method and apparatus are provided for preparing a substrate upon which is located microdrop-sized loci at which chemical compounds are synthesized or diagnostic tests are conducted. The loci are formed by applying microdrops from a dispenser from which a microdrop is pulse fed onto the surface of the substrate.
摘要翻译：提供了一种用于制备基底的方法和装置，其上定位有微小尺寸的位置，在该位置处合成化合物或进行诊断测试。通过将微滴从脉冲馈送到基底表面上的分配器施加微滴而形成位点。

7. 发明授权

US5824470A Method of preparing probes for sensing and manipulating microscopic environments and structures 失效
标题翻译：制备用于感测和操纵微观环境和结构的探针的方法
公开(公告)号：US5824470A
公开(公告)日：1998-10-20
申请号：US453958
申请日：1995-05-30
申请人： John D. Baldeschwieler , David Randall Baselt , Marc A. Unger , Stephen D. O'Connor
发明人： John D. Baldeschwieler , David Randall Baselt , Marc A. Unger , Stephen D. O'Connor
IPC分类号： C01B33/18 , C12Q1/68 , G01B21/30 , G01N33/543 , G01Q60/24 , G01Q70/16 , C01B25/00 , G01N21/00 , G01N33/53
CPC分类号： G01Q60/42 , B82Y35/00 , G01N33/54373 , Y10S977/732 , Y10S977/742 , Y10S977/842 , Y10S977/86 , Y10S977/875 , Y10S977/877 , Y10S977/881
摘要： Probes for sensing and manipulating microscopic environments and structures, their method of preparation and methods of use are disclosed.
摘要翻译：公开了用于感测和操纵微观环境和结构的探针，其制备方法和使用方法。

8. 发明授权

US5527538A Liposomal targeting of ischemic tissue 失效
标题翻译：缺血组织的脂质体靶向
公开(公告)号：US5527538A
公开(公告)日：1996-06-18
申请号：US83123
申请日：1993-06-25
申请人： John D. Baldeschwieler
发明人： John D. Baldeschwieler
IPC分类号： A61K9/127 , A61K9/133 , A61K47/24 , A61K51/12
CPC分类号： A61K51/1234 , A61K9/127 , A61K2123/00 , Y10S977/801 , Y10S977/808 , Y10S977/907 , Y10S977/915 , Y10S977/926 , Y10S977/927
摘要： Liposomes of a size of less than 200 nanometers target ischemic myocardial tissue and preferentially deliver active agents to infarcted areas in the absence of antibodies bound to the liposomes to effect the delivery.
摘要翻译：尺寸小于200纳米的脂质体靶向缺血性心肌组织，并且在不存在与脂质体结合的抗体以实现递送的情况下优先将活性剂递送至梗死区域。

9. 发明授权

US5593688A Liposomal targeting of ischemic tissue 失效
标题翻译：缺血组织的脂质体靶向
公开(公告)号：US5593688A
公开(公告)日：1997-01-14
申请号：US469292
申请日：1995-06-06
申请人： John D. Baldeschwieler
发明人： John D. Baldeschwieler
IPC分类号： A61K9/127 , A61K9/133
CPC分类号： A61K9/127 , Y10S977/808 , Y10S977/907 , Y10S977/915 , Y10S977/927 , Y10T428/2984
摘要： Liposomes of a size of less than 200 nanometers target ischemic myocardial tissue and preferentially deliver active agents to infarcted areas.
摘要翻译：尺寸小于200纳米的脂质体靶向缺血性心肌组织，并优先将活性剂递送至梗死区域。

10. 发明授权

US5071598A Cryoprotective reagent 失效
标题翻译：冷冻保护试剂
公开(公告)号：US5071598A
公开(公告)日：1991-12-10
申请号：US448803
申请日：1989-12-11
申请人： John D. Baldeschwieler , Raymond P. Goodrich, Jr.
发明人： John D. Baldeschwieler , Raymond P. Goodrich, Jr.
IPC分类号： A01N1/02 , C12N1/04
CPC分类号： A01N1/02 , A01N1/0221 , C12N1/04 , Y10S514/971
摘要： Compositions for cryopreservation of phosphoglyceride-containing biological and synthetic membranes are provided in which a lipophilic anchor molecule is modified by the attachment of a preferably carbohydrate moiety placed at a predetermined, variable distance from the hydrophobic portion of the molecule by means of a hydrophilic linker unit. A method for the use of the compositions is also provided.
摘要翻译：提供了含有磷酸甘油酯的生物和合成膜的低温保存组合物，其中亲脂性锚定分子通过借助于亲水连接体单元连接到位于与分子的疏水部分预定的可变距离的优选碳水化合物部分进行修饰。还提供了使用该组合物的方法。

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