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1. 发明授权

US5876939A FAS associated proteins 失效
标题翻译： FAS相关蛋白
公开(公告)号：US5876939A
公开(公告)日：1999-03-02
申请号：US858311
申请日：1997-05-19
申请人： John C. Reed , Takaaki Sato
发明人： John C. Reed , Takaaki Sato
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61K48/00 , C07K14/47 , C12N5/10 , C12N9/16 , C12N15/00 , C12N15/10 , C12N15/55 , C12P21/08 , C12Q1/04 , C12Q1/68 , C12R1/91 , G01N33/53
CPC分类号： C07K14/4747 , C12N15/1055 , C12N9/16 , C12Q1/6897 , A61K38/00
摘要： The present invention provides mammalian protein tyrosine phosphatases, human PTP-BAS type 4, human PTP-BAS type 5a and mouse PTP-BAS type 5b, each of which is a Fas-associated protein (FAP), nucleic acid molecules encoding a PTP-BAS type 4 or a PTP-BAS type 5 and antibodies specific for a PTP-BAS type 4 or for a PTP-BAS type 5. The invention also provides methods for identifying FAP's, which can associate with Fas and can modulate apoptosis. The invention also provides screening assays for identifying an agent that can effectively alter the association of a FAP with Fas and, therefore, can increase or decrease the level of apoptosis in a cell. The invention further provides methods of modulating apoptosis in a cell by introducing into the cell a nucleic acid molecule encoding a PTP-BAS or fragment of a PTP-BAS or an antisense nucleotide sequence, which is complementary to a portion of a nucleic acid molecule encoding a PTP-BAS. The invention also provides a method of using a reagent that can specifically bind to a FAP to diagnose a pathology that is characterized by an increased or decreased level of apoptosis in a cell. The invention also provides methods of modulating apoptosis in a cell by contacting the cell with an agent that effectively alters the association of a FAP and Fas in a cell or alters the activity of a FAP in a cell.
摘要翻译：本发明提供哺乳动物蛋白酪氨酸磷酸酶，人PTP-BAS型4，人PTP-BAS型5a和小鼠PTP-BAS型5b，其各自是Fas相关蛋白（FAP），编码PTP- BAS型4或PTP-BAS型5和PTP-BAS型4或PTP-BAS型5特异性抗体。本发明还提供鉴定FAP的方法，其可与Fas结合并可调节细胞凋亡。本发明还提供用于鉴定能够有效改变FAP与Fas的缔合的试剂的筛选测定，因此可以增加或降低细胞凋亡水平。本发明还提供了通过向细胞中引入编码PTP-BAS或PTP-BAS或反义核苷酸序列片段的核酸分子来调节细胞凋亡的方法，所述核酸分子与编码的核酸分子的一部分互补一个PTP-BAS。本发明还提供了使用能够特异性结合FAP的试剂来诊断细胞凋亡水平升高或降低的病理学的方法。本发明还提供了通过使细胞与有效改变细胞中FAP和Fas的缔合的试剂接触而改变细胞凋亡的方法或改变细胞中FAP的活性的方法。

2. 发明授权

US5632994A Fas associated proteins 失效
标题翻译： Fas相关蛋白
公开(公告)号：US5632994A
公开(公告)日：1997-05-27
申请号：US410804
申请日：1995-03-27
申请人： John C. Reed , Takaaki Sato
发明人： John C. Reed , Takaaki Sato
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61K48/00 , C07K14/47 , C12N5/10 , C12N9/16 , C12N15/00 , C12N15/10 , C12N15/55 , C12P21/08 , C12Q1/04 , C12Q1/68 , C12R1/91 , A61K39/00 , C07K16/00 , G01N33/53
CPC分类号： C07K14/4747 , C12N15/1055 , C12N9/16 , C12Q1/6897 , A61K38/00
摘要： The present invention provides mammalian protein tyrosine phosphatases, human PTP-BAS type 4, human PTP-BAS type 5a and mouse PTP-BAS type 5b, each of which is a Fas-associated protein (FAP), nucleic acid molecules encoding a PTP-BAS type 4 or a PTP-BAS type 5 and antibodies specific for a PTP-BAS type 4 or for a PTP-BAS type 5. The invention also provides methods for identifying FAP's, which can associate with Fas and can modulate apoptosis. The invention also provides screening assays for identifying an agent that can effectively alter the association of a FAP with Fas and, therefore, can increase or decrease the level of apoptosis in a cell. The invention further provides methods of modulating apoptosis in a cell by introducing into the cell a nucleic acid molecule encoding a PTP-BAS or fragment of a PTP-BAS or an antisense nucleotide sequence, which is complementary to a portion of a nucleic acid molecule encoding a PTP-BAS. The invention also provides a method of using a reagent that can specifically bind to a FAP to diagnose a pathology that is characterized by an increased or decreased level of apoptosis in a cell. The invention also provides methods of modulating apoptosis in a cell by contacting the cell with an agent that effectively alters the association of a FAP and Fas in a cell or alters the activity of a FAP in a cell.
摘要翻译：本发明提供哺乳动物蛋白酪氨酸磷酸酶，人PTP-BAS型4，人PTP-BAS型5a和小鼠PTP-BAS型5b，其各自是Fas相关蛋白（FAP），编码PTP- BAS型4或PTP-BAS型5和PTP-BAS型4或PTP-BAS型5特异性抗体。本发明还提供鉴定FAP的方法，其可与Fas结合并可调节细胞凋亡。本发明还提供用于鉴定能够有效改变FAP与Fas的缔合的试剂的筛选测定，因此可以增加或降低细胞凋亡水平。本发明还提供了通过向细胞中引入编码PTP-BAS或PTP-BAS或反义核苷酸序列片段的核酸分子来调节细胞凋亡的方法，所述核酸分子与编码的核酸分子的一部分互补一个PTP-BAS。本发明还提供了使用能够特异性结合FAP的试剂来诊断细胞凋亡水平升高或降低的病理学的方法。本发明还提供了通过使细胞与有效改变细胞中FAP和Fas的缔合的试剂接触而改变细胞凋亡的方法或改变细胞中FAP的活性的方法。

3. 发明授权

US5747245A Nucleic acids encoding Fas associated proteins and screening assays using same 失效
标题翻译：编码Fas相关蛋白的核酸和使用其的筛选测定
公开(公告)号：US5747245A
公开(公告)日：1998-05-05
申请号：US259514
申请日：1994-06-14
申请人： John C. Reed , Takaaki Sato
发明人： John C. Reed , Takaaki Sato
IPC分类号： A61K38/00 , C12N9/16 , C12N15/10 , C12Q1/68 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6897 , C12N15/1055 , C12N9/16 , A61K38/00
摘要： The present invention provides mammalian protein tyrosine phosphatases, human PTP-BAS type 4, human PTP-BAS type 5a and mouse PTP-BAS type 5b, each of which is a Fas-associated protein (FAP), nucleic acid molecules encoding a PTP-BAS type 4 or a PTP-BAS type 5 and antibodies specific for a PTP-BAS type 4 or for a PTP-BAS type 5. The invention also provides methods for identifying FAP's, which can associate with Fas and can modulate apoptosis. The invention also provides screening assays for identifying an agent that can effectively alter the association of a FAP with Fas and, therefore, can increase or decrease the level of apoptosis in a cell. The invention further provides methods of modulating apoptosis in a cell by introducing into the cell a nucleic acid molecule encoding a PTP-BAS or an antisense nucleotide sequence, which is complementary to a portion of a nucleic acid molecule encoding a PTP-BAS. The invention also provides a method of using a reagent that can specifically bind to a FAP to diagnose a pathology that is characterized by an increased or decreased level of apoptosis in a cell. The invention also provides methods of modulating apoptosis in a cell by contacting the cell with an agent that effectively alters the association of a FAP and Fas in a cell or alters the activity of a FAP in a cell.
摘要翻译：本发明提供哺乳动物蛋白酪氨酸磷酸酶，人PTP-BAS型4，人PTP-BAS型5a和小鼠PTP-BAS型5b，其各自是Fas相关蛋白（FAP），编码PTP- BAS型4或PTP-BAS型5和PTP-BAS型4或PTP-BAS型5特异性抗体。本发明还提供鉴定FAP的方法，其可与Fas结合并可调节细胞凋亡。本发明还提供用于鉴定能够有效改变FAP与Fas的缔合的试剂的筛选测定，因此可以增加或降低细胞凋亡水平。本发明还提供了通过将编码PTP-BAS或反义核苷酸序列的核酸分子与编码PTP-BAS的核酸分子的一部分互补的细胞引入细胞来调节细胞凋亡的方法。本发明还提供了使用能够特异性结合FAP的试剂来诊断细胞凋亡水平升高或降低的病理学的方法。本发明还提供了通过使细胞与有效改变细胞中FAP和Fas的缔合的试剂接触而改变细胞凋亡的方法或改变细胞中FAP的活性的方法。

4. 发明授权

US5641866A Bcl-2-associated proteins 失效
公开(公告)号：US5641866A
公开(公告)日：1997-06-24
申请号：US463089
申请日：1995-06-05
申请人： John C. Reed , Shinichi Takayama , Takaaki Sato
发明人： John C. Reed , Shinichi Takayama , Takaaki Sato
IPC分类号： G01N33/53 , A61K38/00 , C07K14/47 , C07K14/82 , C07K16/18 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/02 , G01N33/566 , C07K16/00 , G01N33/574
CPC分类号： C07K16/18 , C07K14/47 , C07K14/82 , A61K38/00 , C07K2319/00 , C12N2799/026
摘要： The present invention provides nucleotide sequences encoding proteins and fragments thereof that bind to Bcl-2-related proteins. The invention also provides a Bcl-2-associated protein (BAP) such as Bcl-2-associated protein-1 (BAP-1), which binds to Bcl-2. The invention also provides antibodies that specifically bind to a BAP. The invention further provides methods for detecting agents such as drugs that alter the binding of a BAP such as BAP-1 or Raf-related protein with a Bcl-2-related protein and methods for detecting agents that induce dissociation of a bound complex formed by the association of a BAP and a Bcl-2-related protein. The invention further provides methods for modulating the activity of a Bcl-2-related protein in a cell by introducing into the cell a nucleic acid encoding a BAP or by introducing into the cell an antisense nucleotide sequence, which is complementary to a region of a gene encoding a BAP.

5. 发明授权

US06265556B1 Nucleic acid encoding CD40 associated proteins 失效
标题翻译：编码CD40相关蛋白的核酸
公开(公告)号：US06265556B1
公开(公告)日：2001-07-24
申请号：US08349357
申请日：1994-12-02
申请人： John C. Reed , Takaaki Sato
发明人： John C. Reed , Takaaki Sato
IPC分类号： C07H2102
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , C07K14/70578 , C07K16/28
摘要： The present invention provides a mammalian CD40-associated protein (CAP), a nucleic acid molecule encoding the CAP and antibodies specific for the CAP. The invention further provides a substantially purified human CAP-1 and a nucleic acid molecule encoding human CAP-1. The invention also provides screening assays for identifying an agent that effectively alters the association of a CAP with a second molecule, which can bind to the CAP. In addition, the invention provides methods for identify a CAP agonist or CAP antagonist that can increase or decrease, respectively, the level of expression of the CAP in a cell. Such an effective agent, agonist or antagonist can modulate a function of a cell such as a humoral immune response or cell growth. The invention also provides methods of detecting a CAP in a sample by detecting the CAP or a nucleic acid molecule encoding the CAP. Such methods can be used to diagnose a pathology that is characterized by an increased or decreased level of a CAP in a cell.
摘要翻译：本发明提供哺乳动物CD40相关蛋白（CAP），编码CAP的核酸分子和对CAP特异的抗体。本发明还提供了基本上纯化的人CAP-1和编码人CAP-1的核酸分子。本发明还提供了用于鉴定有效改变CAP与可与CAP结合的第二分子缔合的试剂的筛选试验。此外，本发明提供了鉴定CAP激动剂或CAP拮抗剂的方法，其可分别增加或减少CAP在细胞中的表达水平。这种有效的药剂，激动剂或拮抗剂可以调节细胞的功能，例如体液免疫应答或细胞生长。本发明还提供了通过检测CAP或编码CAP的核酸分子来检测样品中CAP的方法。这样的方法可用于诊断以细胞中CAP增加或降低水平为特征的病理学。

6. 发明授权

US06172187B2 CD40 associated proteins 失效
标题翻译： CD40相关蛋白
公开(公告)号：US06172187B2
公开(公告)日：2001-01-09
申请号：US08697610
申请日：1996-08-27
申请人： John C. Reed , Takaaki Sato
发明人： John C. Reed , Takaaki Sato
IPC分类号： C07K100
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , C07K14/70578 , C07K16/28
摘要： The present invention provides a mammalian CD40-associated protein (CAP), a nucleic acid molecule encoding the CAP and antibodies specific for the CAP. The invention further provides a substantially purified human CAP-1 and a nucleic acid molecule encoding human CAP-1. The invention also provides screening assays for identifying an agent that effectively alters the association of a CAP with a second molecule, which can bind to the CAP. In addition, the invention provides methods for identify a CAP agonist or CAP antagonist that can increase or decrease, respectively, the level of expression of the CAP in a cell. Such an effective agent, agonist or antagonist can modulate a function of a cell such as a humoral immune response or cell growth. The invention also provides methods of detecting a CAP in a sample by detecting the CAP or a nucleic acid molecule encoding the CAP. Such methods can be used to diagnose a pathology that is characterized by an increased or decreased level of a CAP in a cell.
摘要翻译：本发明提供哺乳动物CD40相关蛋白（CAP），编码CAP的核酸分子和对CAP特异的抗体。本发明还提供了基本上纯化的人CAP-1和编码人CAP-1的核酸分子。本发明还提供了用于鉴定有效改变CAP与可与CAP结合的第二分子缔合的试剂的筛选试验。此外，本发明提供了鉴定CAP激动剂或CAP拮抗剂的方法，其可分别增加或减少CAP在细胞中的表达水平。这种有效的药剂，激动剂或拮抗剂可以调节细胞的功能，例如体液免疫应答或细胞生长。本发明还提供了通过检测CAP或编码CAP的核酸分子来检测样品中CAP的方法。这样的方法可用于诊断以细胞中CAP增加或降低水平为特征的病理学。

7. 发明授权

US5539094A DNA encoding Bcl-2-associated proteins 失效
标题翻译：编码Bcl-2相关蛋白的DNA
公开(公告)号：US5539094A
公开(公告)日：1996-07-23
申请号：US152485
申请日：1993-11-12
申请人： John C. Reed , Shinichi Takayama , Takaaki Sato
发明人： John C. Reed , Shinichi Takayama , Takaaki Sato
IPC分类号： G01N33/53 , A61K38/00 , C07K14/47 , C07K14/82 , C07K16/18 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/02 , G01N33/566 , C07H21/00 , C12N15/12 , C12N15/63
CPC分类号： C07K16/18 , C07K14/47 , C07K14/82 , A61K38/00 , C07K2319/00 , C12N2799/026
摘要： The present invention provides nucleotide sequences encoding proteins and fragments thereof that bind to Bcl-2-related proteins. The invention also provides a Bcl-2-associated protein (BAP) such as Bcl-2-associated protein-1 (BAP-1), which binds to Bcl-2. The invention also provides antibodies that specifically bind to a BAP. The invention further provides methods for detecting agents such as drugs that alter the binding of a BAP such as BAP-1 or Raf-related protein with a Bcl-2-related protein and methods for detecting agents that induce dissociation of a bound complex formed by the association of a BAP and a Bcl-2-related protein. The invention further provides methods for modulating the activity of a Bcl-2-related protein in a cell by introducing into the cell a nucleic acid encoding a BAP or by introducing into the cell an antisense nucleotide sequence, which is complementary to a region of a gene encoding a BAP.
摘要翻译：本发明提供编码结合Bcl-2相关蛋白的蛋白质及其片段的核苷酸序列。本发明还提供了与Bcl-2结合的Bcl-2相关蛋白（BAP），例如Bcl-2相关蛋白-1（BAP-1）。本发明还提供特异性结合BAP的抗体。本发明还提供了用于检测试剂的方法，例如改变BAP（例如BAP-1或Raf-相关蛋白）与Bcl-2相关蛋白的结合的药物，以及用于检测诱导由 BAP和Bcl-2相关蛋白的结合。本发明还提供了通过向细胞中引入编码BAP的核酸或通过将反义核苷酸序列引入到与细胞内的区域互补的反义核苷酸序列来调节细胞中Bcl-2相关蛋白的活性的方法编码BAP的基因。

8. 发明授权

US5702897A Interaction of proteins involved in a cell death pathway 失效
标题翻译：参与细胞死亡途径的蛋白质的相互作用
公开(公告)号：US5702897A
公开(公告)日：1997-12-30
申请号：US607269
申请日：1996-02-20
申请人： John C. Reed , Takaaki Sato
发明人： John C. Reed , Takaaki Sato
IPC分类号： C07K14/47 , C12Q1/68 , G01N33/50 , G01N33/68
CPC分类号： G01N33/502 , C07K14/4747 , C12Q1/6897 , G01N33/5008 , G01N33/68 , G01N2510/00
摘要： The present invention provides methods for detecting an interaction among proteins involved in regulating cell death. The invention also provides a drug screening assay useful for identifying agents that alter an interaction among proteins involved in controlling cell death. The invention further provides a method for identifying novel proteins that are involved in a cell death pathway.
摘要翻译：本发明提供了检测涉及调节细胞死亡的蛋白质之间相互作用的方法。本发明还提供了用于鉴定改变参与控制细胞死亡的蛋白质之间的相互作用的试剂的药物筛选测定法。本发明还提供了鉴定参与细胞死亡途径的新蛋白质的方法。

9. 发明授权

US5686595A Bcl-2-associated proteins 失效
标题翻译： Bcl-2相关蛋白
公开(公告)号：US5686595A
公开(公告)日：1997-11-11
申请号：US461359
申请日：1995-06-05
申请人： John C. Reed , Shinichi Takayama , Takaaki Sato
发明人： John C. Reed , Shinichi Takayama , Takaaki Sato
IPC分类号： G01N33/53 , A61K38/00 , C07K14/47 , C07K14/82 , C07K16/18 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/02 , G01N33/566 , C12N15/00 , C07H21/02 , C07H21/04
CPC分类号： C07K16/18 , C07K14/47 , C07K14/82 , A61K38/00 , C07K2319/00 , C12N2799/026
摘要： The present invention provides nucleotide sequences encoding proteins and fragments thereof that bind to Bcl-2-related proteins. The invention also provides a Bcl-2-associated protein (BAP) such as Bcl-2-associated protein-1 (BAP-1), which binds to Bcl-2. The invention also provides antibodies that specifically bind to a BAP. The invention further provides methods for detecting agents such as drugs that alter the binding of a BAP such as BAP-1 or Raf-related protein with a Bcl-2-related protein and methods for detecting agents that induce dissociation of a bound complex formed by the association of a BAP and a Bcl-2-related protein. The invention further provides methods for modulating the activity of a Bcl-2-related protein in a cell by introducing into the cell a nucleic acid encoding a BAP or by introducing into the cell an antisense nucleotide sequence, which is complementary to a region of a gene encoding a BAP.
摘要翻译：本发明提供编码结合Bcl-2相关蛋白的蛋白质及其片段的核苷酸序列。本发明还提供了与Bcl-2结合的Bcl-2相关蛋白（BAP），例如Bcl-2相关蛋白-1（BAP-1）。本发明还提供特异性结合BAP的抗体。本发明还提供了用于检测试剂的方法，例如改变BAP（例如BAP-1或Raf-相关蛋白）与Bcl-2相关蛋白的结合的药物，以及用于检测诱导由 BAP和Bcl-2相关蛋白的结合。本发明还提供了通过向细胞中引入编码BAP的核酸或通过向细胞中引入反义核苷酸序列来调节细胞中Bcl-2相关蛋白的活性的方法，所述反义核苷酸序列与编码BAP的基因。

10. 发明授权

US5650491A BCL-2-associated proteins 失效
标题翻译： BCL-2相关蛋白
公开(公告)号：US5650491A
公开(公告)日：1997-07-22
申请号：US461360
申请日：1995-06-05
申请人： John C. Reed , Shinichi Takayama , Takaaki Sato
发明人： John C. Reed , Shinichi Takayama , Takaaki Sato
IPC分类号： G01N33/53 , A61K38/00 , C07K14/47 , C07K14/82 , C07K16/18 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/02 , G01N33/566 , C07K2/00
CPC分类号： C07K16/18 , C07K14/47 , C07K14/82 , A61K38/00 , C07K2319/00 , C12N2799/026
摘要： The present invention provides nucleotide sequences encoding proteins and fragments thereof that bind to Bcl-2-related proteins. The invention also provides a Bcl-2-associated protein (BAP) such as Bcl-2-associated protein-1 (BAP-1), which binds to Bcl-2. The invention also provides antibodies that specifically bind to a BAP. The invention further provides methods for detecting agents such as drugs that alter the binding of a BAP such as BAP-1 or Raf-related protein with a Bcl-2-related protein and methods for detecting agents that induce dissociation of a bound complex formed by the association of a BAP and a Bcl-2-related protein. The invention further provides methods for modulating the activity of a Bcl-2-related protein in a cell by introducing into the cell a nucleic acid encoding a BAP or by introducing into the cell an antisense nucleotide sequence, which is complementary to a region of a gene encoding a BAP.
摘要翻译：本发明提供编码结合Bcl-2相关蛋白的蛋白质及其片段的核苷酸序列。本发明还提供了与Bcl-2结合的Bcl-2相关蛋白（BAP），例如Bcl-2相关蛋白-1（BAP-1）。本发明还提供特异性结合BAP的抗体。本发明还提供了用于检测试剂的方法，例如改变BAP（例如BAP-1或Raf-相关蛋白）与Bcl-2相关蛋白的结合的药物，以及用于检测诱导由 BAP和Bcl-2相关蛋白的结合。本发明还提供了通过向细胞中引入编码BAP的核酸或通过将反义核苷酸序列引入到与细胞内的区域互补的反义核苷酸序列来调节细胞中Bcl-2相关蛋白的活性的方法编码BAP的基因。

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