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1. 发明授权

US4133951A Vitamin B-12 cobalt-57 and process 失效
标题翻译：维生素B-12钴-57和工艺
公开(公告)号：US4133951A
公开(公告)日：1979-01-09
申请号：US667619
申请日：1976-03-17
申请人： John C. Charlton , Alan L. Hamilton
发明人： John C. Charlton , Alan L. Hamilton
IPC分类号： C07H23/00 , G01N33/60 , A61K31/68
CPC分类号： C07H23/00 , G01N33/60 , Y10S514/917
摘要： A method of making radioactively labelled vitamin B-12 by reacting .alpha.-(5,6-dimethylbenzimidazolyl)hydrogenobamide with cobaltous ion Co-57, or with another radioactive cobalt isotope. The method enables vitamin B-12 of high specific activity to be made, which is useful for in vitro and in vivo analysis.
摘要翻译：通过使α-（5,6-二甲基苯并咪唑基）氢溴酸盐与钴离子Co-57或与另一种放射性钴同位素反应制备放射性标记的维生素B-12的方法。该方法能够制备具有高比活性的维生素B-12，其可用于体外和体内分析。

2. 发明授权

US06828116B1 Energy transfer assay method and reagent 失效
标题翻译：能量转移测定法和试剂
公开(公告)号：US06828116B1
公开(公告)日：2004-12-07
申请号：US09719016
申请日：2001-02-15
申请人： Alan L. Hamilton , Martyn N. Birch , Malcolm J. Hatcher , Nigel Bosworth , Brian Scott
发明人： Alan L. Hamilton , Martyn N. Birch , Malcolm J. Hatcher , Nigel Bosworth , Brian Scott
IPC分类号： C12Q137
CPC分类号： G01N33/533 , C07H21/00 , C09B23/02 , G01N33/542 , Y10S435/968
摘要： Disclosed is a non-fluorescent cyanine dye that may be used as an acceptor in fluorescence energy transfer assays involving the detection of binding and/or cleavage events in reactions involving biological molecules, and assay methods utilising such dyes. The non-fluorescent cyanine dye is a compound of formula (I), wherein the linker group Q contains at least one double bond and forms a conjugated system with the rings containing X and Y; groups R3, R4, R5 and R6 are attached to the rings containing X and Y, or optionally, are attached to atoms of the Z1 and Z2 ring structures; Z1 and Z2 each represent a bond or the atoms necessary to complete one or two fused aromatic rings each ring having five or six atoms, selected from carbon atoms and, optionally, no more than two oxygen, nitrogen and sulphur atoms; at least one of groups R1, R2, R3, R4, R5, R6and R7 is a target bonding group; any remaining groups R3, R4, R5, R6 and R7 groups are independently selected from the group consisting of hydrogen, C1-C4 alkyl, OR9, COOR9, nitro, amino, acylamino, quaternary ammonium, phosphate sulphonate and sulphate, where R9 is selected from H and C1-C4 alkyl; any remaining R1 and R2 are selected from C1-C10 alkyl which may be unsubstituted or substituted with phenyl, the phenyl being optionally substituted by up to two substituents selected from carboxyl, sulphonate and nitro groups; characterised in that at least one of the groups R1, R2, R3, R4, R5, R6 and R7 comprises a substituent which reduces the fluorescence emission of said dye such that it is essentially non-fluorescent.
摘要翻译：公开了一种非荧光花青染料，其可用作荧光能量转移测定中的受体，涉及检测涉及生物分子的反应中的结合和/或切割事件，以及使用这种染料的测定方法。非荧光花青染料是式（I）化合物，其中连接基团Q含有至少一个双键并与含有X和Y的环形成共轭体系; 基团R 3，R 4，R 5和R 6连接到含有X和Y的环上，或任选地连接到Z 1和Z 2环结构的原子上 ; Z 1和Z 2各自表示一个键或完成一个或两个稠合芳环所必需的原子，每个环具有五个或六个原子，选自碳原子和任选不超过两个氧，氮和硫原子基团R 1，R 2，R 3，R 4，R 5，R 6和R 7中的至少一个是目标键合基团; 任何剩余的基团R 3，R 4，R 5，R 6和R 7基团独立地选自氢，C 1 -C 4烷基，OR 9， 9，硝基，氨基，酰氨基，季铵，磷酸酯磺酸盐和硫酸盐，其中R 9选自H和C 1 -C 4烷基; 任何剩余的R 1和R 2选自可以是未取代的或被苯基取代的C 1 -C 10烷基，所述苯基任选被至多两个选自羧基，磺酸根和硝基的取代基取代; 其特征在于R 1，R 2，R 3，R 4，R 5，R 6和R 7基团中的至少一个包含降低荧光的取代基所述染料的发射使得其基本上不发荧光。

3. 发明授权

US11338184B2 Golf game 有权
公开(公告)号：US11338184B2
公开(公告)日：2022-05-24
申请号：US16226880
申请日：2018-12-20
申请人： Alan L. Hamilton , Lesa D. Hamilton
发明人： Alan L. Hamilton , Lesa D. Hamilton
IPC分类号： A63B67/02
摘要： A golf game having an elongated mat with a first end, a second end, sides, a top surface, and a bottom surface. Adjacent each end are a plurality of holes with each hole having a removable plug. Along the sides, the first end, and the second end are rails that preferably fold up from the edges of the mat by remaining interconnected by male/female slots.

4. 发明申请

US20190184254A1 GOLF GAME 审中-公开
公开(公告)号：US20190184254A1
公开(公告)日：2019-06-20
申请号：US16226880
申请日：2018-12-20
申请人： Alan L. Hamilton , Lesa D. Hamilton
发明人： Alan L. Hamilton , Lesa D. Hamilton
IPC分类号： A63B67/02
CPC分类号： A63B67/02
摘要： A golf game having an elongated mat with a first end, a second end, sides, a top surface, and a bottom surface. Adjacent each end are a plurality of holes with each hole having a removable plug. Along the sides, the first end, and the second end are rails that preferably fold up from the edges of the mat by remaining interconnected by male/female slots.

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