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1. 发明申请

US20140054454A1 Electrostatic Gimbal for Correction of Errors in Time of Flight Mass Spectrometers 有权
标题翻译：用于校正飞行时间质谱误差的静电万向节
公开(公告)号：US20140054454A1
公开(公告)日：2014-02-27
申请号：US14004946
申请日：2012-03-13
申请人： John Brian Hoyes , David J. Langridge , Jason Wildgoose
发明人： John Brian Hoyes , David J. Langridge , Jason Wildgoose
IPC分类号： H01J49/40
CPC分类号： H01J49/403 , H01J49/40
摘要： A Time of Flight mass analyser is disclosed comprising one or more devices arranged and adapted to correct for tilt in an isochronous plane of ions and to adjust the isochronous plane of the ions so as to be parallel with the plane of detection in an ion detector.
摘要翻译：公开了一种飞行时间质量分析器，其包括一个或多个设备，其被配置并适于校正离子的等时平面中的倾斜，并且在离子检测器中调整离子的等时平面以与检测平面平行。

2. 发明授权

US08895920B2 Mass spectrometer with beam expander 有权
公开(公告)号：US08895920B2
公开(公告)日：2014-11-25
申请号：US13702931
申请日：2011-06-07
申请人： Jeffery Mark Brown , Anthony James Gilbert , John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
发明人： Jeffery Mark Brown , Anthony James Gilbert , John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/40 , H01J49/00 , H01J49/06
CPC分类号： H01J49/401 , H01J49/0031 , H01J49/0095 , H01J49/062 , H01J49/067 , H01J49/405
摘要： A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyzer. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyzer.

3. 发明授权

US08283628B2 Ion mobility spectrometer 有权
标题翻译：离子迁移谱仪
公开(公告)号：US08283628B2
公开(公告)日：2012-10-09
申请号：US13060100
申请日：2009-08-14
申请人： John Brian Hoyes , David J. Langridge
发明人： John Brian Hoyes , David J. Langridge
IPC分类号： B01D59/44
CPC分类号： H01J49/0081 , G01N27/622
摘要： An ion mobility spectrometer is disclosed wherein ions are passed through an ion mobility spectrometer (5) and become temporally separated. Ions having a relatively high ion mobility are transmitted by a non-destructive ion gate (6) but ions having a relatively low ion mobility are subsequently trapped within the ion mobility spectrometer (5) when the ion gate (6) is switched so as to prevent ions from being onwardly transmitted. Ions which are transmitted by the ion gate (6) are trapped in a downstream ion trap (7). The ions are then returned back upstream to a second upstream ion trap (4).
摘要翻译：公开了一种离子迁移谱仪，其中离子通过离子迁移谱仪（5）并在时间上分离。具有较高离子迁移率的离子通过非破坏性离子浇口（6）传输，但当离子浇道（6）被切换时，离子迁移谱仪（5）中随后将具有较低离子迁移率的离子捕获到离子迁移谱仪防止离子向上传播。由离子栅（6）传输的离子被捕获在下游离子阱（7）中。然后离子返回上游到第二上游离子阱（4）。

4. 发明申请

US20110291001A1 Ion Mobility Spectrometer 有权
标题翻译：离子流动光谱仪
公开(公告)号：US20110291001A1
公开(公告)日：2011-12-01
申请号：US13060100
申请日：2009-08-14
申请人： John Brian Hoyes , David J. Langridge
发明人： John Brian Hoyes , David J. Langridge
IPC分类号： H01J49/26
CPC分类号： H01J49/0081 , G01N27/622
摘要： An ion mobility spectrometer is disclosed wherein ions are passed through an ion mobility spectrometer (5) and become temporally separated. Ions having a relatively high ion mobility are transmitted by a non-destructive ion gate (6) but ions having a relatively low ion mobility are subsequently trapped within the ion mobility spectrometer (5) when the ion gate (6) is switched so as to prevent ions from being onwardly transmitted. Ions which are transmitted by the ion gate (6) are trapped in a downstream ion trap (7). The ions are then returned back upstream to a second upstream ion trap (4).
摘要翻译：公开了一种离子迁移谱仪，其中离子通过离子迁移谱仪（5）并在时间上分离。具有较高离子迁移率的离子通过非破坏性离子浇口（6）传输，但当离子浇道（6）被切换时，离子迁移谱仪（5）中随后将具有较低离子迁移率的离子捕获到离子迁移谱仪防止离子向上传播。由离子栅（6）传输的离子被捕获在下游离子阱（7）中。然后离子返回上游到第二上游离子阱（4）。

5. 发明授权

US09214328B2 Space focus time of flight mass spectrometer 有权
标题翻译：空间聚焦时间飞行质谱仪
公开(公告)号：US09214328B2
公开(公告)日：2015-12-15
申请号：US13996893
申请日：2011-12-22
申请人： John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
发明人： John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/40
CPC分类号： H01J49/403 , H01J49/0027 , H01J49/401
摘要： A Time of Flight mass spectrometer is disclosed wherein a fifth order spatial focusing device is provided. The device which may comprise an additional stage in the source region of the Time of Flight mass analyzer is arranged to introduce a non-zero fifth order spatial focusing term so that the combined effect of first, third and fifth order spatial focusing terms results in a reduction in the spread of ion arrival times ΔT of ions arriving at the ion detector.
摘要翻译：公开了一种提供五阶空间聚焦装置的飞行时间质谱仪。可以在飞行时间质量分析器的源区域中包括附加级的装置被布置成引入非零五阶空间聚焦项，使得第一，第三和第五阶空间聚焦项的组合效应导致减少到达离子检测器的离子到达时间和离子浓度Dgr。

6. 发明授权

US08921775B2 Electrostatic gimbal for correction of errors in time of flight mass spectrometers 有权
标题翻译：用于校正飞行时间质谱仪误差的静电万向架
公开(公告)号：US08921775B2
公开(公告)日：2014-12-30
申请号：US14004946
申请日：2012-03-13
申请人： David J. Langridge , Jason Lee Wildgoose , John Brian Hoyes
发明人： David J. Langridge , Jason Lee Wildgoose , John Brian Hoyes
IPC分类号： H01J49/00 , H01J49/40
CPC分类号： H01J49/403 , H01J49/40
摘要： A Time of Flight mass analyser is disclosed comprising one or more devices arranged and adapted to correct for tilt in an isochronous plane of ions and to adjust the isochronous plane of the ions so as to be parallel with the plane of detection in an ion detector.
摘要翻译：公开了一种飞行时间质量分析器，其包括一个或多个设备，其被配置并适于校正离子的等时平面中的倾斜，并且在离子检测器中调整离子的等时平面以与检测平面平行。

7. 发明申请

US20140014830A1 Space Focus Time of Flight Mass Spectrometer 有权
标题翻译：空间聚焦时间飞行质谱仪
公开(公告)号：US20140014830A1
公开(公告)日：2014-01-16
申请号：US13996893
申请日：2011-12-22
申请人： John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
发明人： John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/40
CPC分类号： H01J49/403 , H01J49/0027 , H01J49/401
摘要： A Time of Flight mass spectrometer is disclosed wherein a fifth order spatial focusing device is provided. The device which may comprise an additional stage in the source region of the Time of Flight mass analyser is arranged to introduce a non-zero fifth order spatial focusing term so that the combined effect of first, third and fifth order spatial focusing terms results in a reduction in the spread of ion arrival times ΔT of ions arriving at the ion detector.
摘要翻译：公开了一种提供五阶空间聚焦装置的飞行时间质谱仪。可以在飞行时间质量分析器的源区域中包括附加级的装置被布置成引入非零五阶空间聚焦项，使得第一，第三和第五阶空间聚焦项的组合效应导致降低到达离子检测器的离子到达时间ΔT的离子扩散。

8. 发明申请

US20130256524A1 Mass Spectrometer With Beam Expander 有权
公开(公告)号：US20130256524A1
公开(公告)日：2013-10-03
申请号：US13702931
申请日：2011-06-07
申请人： Jeffery Mark Brown , Anthony James Gilbert , John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
发明人： Jeffery Mark Brown , Anthony James Gilbert , John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/40
CPC分类号： H01J49/401 , H01J49/0031 , H01J49/0095 , H01J49/062 , H01J49/067 , H01J49/405
摘要： A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyser. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyser.

9. 发明授权

US09177776B2 Mass to charge ratio selective ejection from ion guide having supplemental RF voltage applied thereto 有权
标题翻译：离子导向器的质荷比选择性喷射具有施加到其上的补充RF电压
公开(公告)号：US09177776B2
公开(公告)日：2015-11-03
申请号：US13522888
申请日：2011-01-18
申请人： John Brian Hoyes , Daniel James Kenny , David Langridge
发明人： John Brian Hoyes , Daniel James Kenny , David Langridge
IPC分类号： H01J49/34 , H01J49/06 , H01J49/42
CPC分类号： H01J49/34 , H01J49/065 , H01J49/4235 , H01J49/4275 , H01J49/429
摘要： An ion guide is disclosed wherein an axial DC voltage barrier is created at the exit of the ion guide. A primary RF voltage is applied to the electrodes in order to confine ions radially within the ion guide. A supplemental RF voltage is also applied to the electrodes. The supplemental RF voltage has a greater axial repeat length than that of the primary RF voltage. The amplitude of the supplemental RF voltage is increased with time causing ions to become unstable and gain sufficient axial kinetic energy such that the ions overcome the axial DC voltage barrier. Ions emerge axially from the ion guide in mass to charge ratio order.
摘要翻译：公开了一种离子导向器，其中在离子导向器的出口处产生轴向DC电压屏障。将初级RF电压施加到电极，以便将离子径向限制在离子导向器内。补充的RF电压也被施加到电极。补充RF电压具有比初级RF电压更大的轴向重复长度。补充RF电压的幅度随时间增加，导致离子变得不稳定并获得足够的轴向动能，使得离子克服轴向DC电压屏障。离子以质量与电荷的比例顺序从离子导向器轴向出现。

10. 发明申请

US20130099110A1 Mass to Charge Ratio Selective Ejection from Ion Guide Having Supplemental RF Voltage Applied Thereto 有权
标题翻译：离子导向器的质量比充放电比例应用于补充RF电压
公开(公告)号：US20130099110A1
公开(公告)日：2013-04-25
申请号：US13522888
申请日：2011-01-18
申请人： John Brian Hoyes , Daniel James Kenny , David Langridge
发明人： John Brian Hoyes , Daniel James Kenny , David Langridge
IPC分类号： H01J49/34
CPC分类号： H01J49/34 , H01J49/065 , H01J49/4235 , H01J49/4275 , H01J49/429
摘要： An ion guide is disclosed wherein an axial DC voltage barrier is created at the exit of the ion guide. A primary RF voltage is applied to the electrodes in order to confine ions radially within the ion guide. A supplemental RF voltage is also applied to the electrodes. The supplemental RF voltage has a greater axial repeat length than that of the primary RF voltage. The amplitude of the supplemental RF voltage is increased with time causing ions to become unstable and gain sufficient axial kinetic energy such that the ions overcome the axial DC voltage barrier. Ions emerge axially from the ion guide in mass to charge ratio order.
摘要翻译：公开了一种离子导向器，其中在离子导向器的出口处产生轴向DC电压屏障。将初级RF电压施加到电极，以便将离子径向限制在离子导向器内。补充的RF电压也被施加到电极。补充RF电压具有比初级RF电压更大的轴向重复长度。补充RF电压的幅度随时间增加，导致离子变得不稳定并获得足够的轴向动能，使得离子克服轴向DC电压屏障。离子以质量与电荷的比例顺序从离子导向器轴向出现。

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