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1. 发明授权

US09177776B2 Mass to charge ratio selective ejection from ion guide having supplemental RF voltage applied thereto 有权
标题翻译：离子导向器的质荷比选择性喷射具有施加到其上的补充RF电压
公开(公告)号：US09177776B2
公开(公告)日：2015-11-03
申请号：US13522888
申请日：2011-01-18
申请人： John Brian Hoyes , Daniel James Kenny , David Langridge
发明人： John Brian Hoyes , Daniel James Kenny , David Langridge
IPC分类号： H01J49/34 , H01J49/06 , H01J49/42
CPC分类号： H01J49/34 , H01J49/065 , H01J49/4235 , H01J49/4275 , H01J49/429
摘要： An ion guide is disclosed wherein an axial DC voltage barrier is created at the exit of the ion guide. A primary RF voltage is applied to the electrodes in order to confine ions radially within the ion guide. A supplemental RF voltage is also applied to the electrodes. The supplemental RF voltage has a greater axial repeat length than that of the primary RF voltage. The amplitude of the supplemental RF voltage is increased with time causing ions to become unstable and gain sufficient axial kinetic energy such that the ions overcome the axial DC voltage barrier. Ions emerge axially from the ion guide in mass to charge ratio order.
摘要翻译：公开了一种离子导向器，其中在离子导向器的出口处产生轴向DC电压屏障。将初级RF电压施加到电极，以便将离子径向限制在离子导向器内。补充的RF电压也被施加到电极。补充RF电压具有比初级RF电压更大的轴向重复长度。补充RF电压的幅度随时间增加，导致离子变得不稳定并获得足够的轴向动能，使得离子克服轴向DC电压屏障。离子以质量与电荷的比例顺序从离子导向器轴向出现。

2. 发明申请

US20130099110A1 Mass to Charge Ratio Selective Ejection from Ion Guide Having Supplemental RF Voltage Applied Thereto 有权
标题翻译：离子导向器的质量比充放电比例应用于补充RF电压
公开(公告)号：US20130099110A1
公开(公告)日：2013-04-25
申请号：US13522888
申请日：2011-01-18
申请人： John Brian Hoyes , Daniel James Kenny , David Langridge
发明人： John Brian Hoyes , Daniel James Kenny , David Langridge
IPC分类号： H01J49/34
CPC分类号： H01J49/34 , H01J49/065 , H01J49/4235 , H01J49/4275 , H01J49/429
摘要： An ion guide is disclosed wherein an axial DC voltage barrier is created at the exit of the ion guide. A primary RF voltage is applied to the electrodes in order to confine ions radially within the ion guide. A supplemental RF voltage is also applied to the electrodes. The supplemental RF voltage has a greater axial repeat length than that of the primary RF voltage. The amplitude of the supplemental RF voltage is increased with time causing ions to become unstable and gain sufficient axial kinetic energy such that the ions overcome the axial DC voltage barrier. Ions emerge axially from the ion guide in mass to charge ratio order.
摘要翻译：公开了一种离子导向器，其中在离子导向器的出口处产生轴向DC电压屏障。将初级RF电压施加到电极，以便将离子径向限制在离子导向器内。补充的RF电压也被施加到电极。补充RF电压具有比初级RF电压更大的轴向重复长度。补充RF电压的幅度随时间增加，导致离子变得不稳定并获得足够的轴向动能，使得离子克服轴向DC电压屏障。离子以质量与电荷的比例顺序从离子导向器轴向出现。

3. 发明申请

US20140054454A1 Electrostatic Gimbal for Correction of Errors in Time of Flight Mass Spectrometers 有权
标题翻译：用于校正飞行时间质谱误差的静电万向节
公开(公告)号：US20140054454A1
公开(公告)日：2014-02-27
申请号：US14004946
申请日：2012-03-13
申请人： John Brian Hoyes , David J. Langridge , Jason Wildgoose
发明人： John Brian Hoyes , David J. Langridge , Jason Wildgoose
IPC分类号： H01J49/40
CPC分类号： H01J49/403 , H01J49/40
摘要： A Time of Flight mass analyser is disclosed comprising one or more devices arranged and adapted to correct for tilt in an isochronous plane of ions and to adjust the isochronous plane of the ions so as to be parallel with the plane of detection in an ion detector.
摘要翻译：公开了一种飞行时间质量分析器，其包括一个或多个设备，其被配置并适于校正离子的等时平面中的倾斜，并且在离子检测器中调整离子的等时平面以与检测平面平行。

4. 发明授权

US08389933B2 Mass analyzer utilizing a plurality of axial pseudo-potential wells 有权
标题翻译：使用多个轴向伪势阱的质量分析器
公开(公告)号：US08389933B2
公开(公告)日：2013-03-05
申请号：US13157021
申请日：2011-06-09
申请人： John Brian Hoyes
发明人： John Brian Hoyes
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： H01J49/36 , H01J49/0031 , H01J49/4235
摘要： A mass analyser is provided comprising a plurality of electrodes having apertures through which ions are transmitted in use. A plurality of pseudo-potential corrugations are created along the axis of the mass analyser. The amplitude or depth of the pseudo-potential corrugations is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages are applied to the electrodes of the mass analyser in order to urge ions along the length of the mass analyser. The amplitude of the transient DC voltages applied to the electrodes is increased with time and ions are caused to be emitted from the mass analyser in reverse order of their mass to charge ratio. A first AC or RF voltage is arranged to provide optimal pseudo-potential corrugations while a second AC or RF voltage is arranged to provide optimal radial confinement of ions within the mass analyser.
摘要翻译：提供质量分析器，其包括具有孔的多个电极，在使用中离子通过该孔传输。沿着质量分析器的轴线产生多个伪电位波纹。伪电位波纹的振幅或深度与离子的质荷比成反比。一个或多个瞬态直流电压被施加到质量分析器的电极，以沿着质量分析器的长度推动离子。施加到电极的瞬态DC电压的幅度随时间增加，并且使离子从质量分析器以其质荷比的相反顺序发射。布置第一AC或RF电压以提供最佳伪电位波纹，同时布置第二AC或RF电压以在质量分析器内提供离子的最佳径向约束。

5. 发明申请

US20110168882A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20110168882A1
公开(公告)日：2011-07-14
申请号：US12528454
申请日：2008-02-26
申请人： John Brian Hoyes
发明人： John Brian Hoyes
IPC分类号： H01J49/26
CPC分类号： H01J49/062 , H01J49/408 , H01J49/42
摘要： A mass spectrometer is disclosed comprising an ion guide (1) or ion mobility spectrometer having helical, toroidal, part-toroidal, hemitoroidal, semitoroidal or spiral ion guiding region (4). The ion guide (1) may comprise a tube made from a leaky dielectric wherein an RF voltage is applied to outer electrodes in order to confine ions radially within the ion guide (1). A DC voltage is applied to a resistive inner layer in order to urge ions along the ion guide (1). Alternatively, the ion guide may comprise a plurality of electrodes each having an aperture through which ions are transmitted.
摘要翻译：公开了一种质谱仪，其包括具有螺旋，环形，部分环形，椭圆形，半形或螺旋离子导向区域（4）的离子导向器（1）或离子迁移谱仪。离子导向器（1）可以包括由泄漏电介质制成的管，其中将RF电压施加到外部电极以将离子径向限制在离子导向器（1）内。 DC电压被施加到电阻内层，以促使沿离子导向器（1）的离子。或者，离子导向器可以包括多个电极，每个电极都具有一个孔，通过该孔可传输离子。

6. 发明授权

US06906319B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06906319B2
公开(公告)日：2005-06-14
申请号：US10274949
申请日：2002-10-22
申请人： John Brian Hoyes
发明人： John Brian Hoyes
IPC分类号： H01J49/16 , H01J49/40 , H01J49/42
CPC分类号： H01J49/004 , H01J49/401 , H01J49/42 , H01J49/429
摘要： A mass spectrometer is disclosed wherein ions having a particular desired charge state are selected by operating an ion mobility spectrometer in combination with a quadrupole mass filter. Precursor ions are fragmented or reacted to form product ions in a collision cell ion trap and sent back upstream to an upstream ion trap. The fragment or product ions are then passed through the ion mobility spectrometer wherein they become temporally separated according to their ion mobility. Fragment or product ions are then re-trapped in the collision cell ion trap before being released therefrom in packets. A pusher electrode of a time of flight mass analyzer is energized a predetermined period of time after a packet of ions is released from the collision cell ion trap. Accordingly, it is possible to select multiply charged precursor ions from a background of singly charged ions, fragment them, and mass analyze the fragment ions with a near 100% duty cycle across the whole mass range.
摘要翻译：公开了一种质谱仪，其中通过与四极质量过滤器结合操作离子迁移谱仪来选择具有特定所需电荷状态的离子。前体离子被碎裂或反应以在碰撞细胞离子阱中形成产物离子，并在上游返回到上游离子阱。然后将片段或产物离子通过离子迁移谱仪，其中它们根据其离子迁移率暂时分离。然后将碎片或产物离子重新捕获在碰撞细胞离子阱中，然后从包中释放。飞行时间质量分析器的推动器电极在从碰撞池离子阱中释放离子束之后经过预定的时间段通电。因此，可以从单电荷离子的背景中选择多电荷的前体离子，使其分裂，并且在整个质量范围内以近100％的占空比质量分析碎片离子。

7. 发明授权

US08895920B2 Mass spectrometer with beam expander 有权
公开(公告)号：US08895920B2
公开(公告)日：2014-11-25
申请号：US13702931
申请日：2011-06-07
申请人： Jeffery Mark Brown , Anthony James Gilbert , John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
发明人： Jeffery Mark Brown , Anthony James Gilbert , John Brian Hoyes , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/40 , H01J49/00 , H01J49/06
CPC分类号： H01J49/401 , H01J49/0031 , H01J49/0095 , H01J49/062 , H01J49/067 , H01J49/405
摘要： A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyzer. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyzer.

8. 发明授权

US08283628B2 Ion mobility spectrometer 有权
标题翻译：离子迁移谱仪
公开(公告)号：US08283628B2
公开(公告)日：2012-10-09
申请号：US13060100
申请日：2009-08-14
申请人： John Brian Hoyes , David J. Langridge
发明人： John Brian Hoyes , David J. Langridge
IPC分类号： B01D59/44
CPC分类号： H01J49/0081 , G01N27/622
摘要： An ion mobility spectrometer is disclosed wherein ions are passed through an ion mobility spectrometer (5) and become temporally separated. Ions having a relatively high ion mobility are transmitted by a non-destructive ion gate (6) but ions having a relatively low ion mobility are subsequently trapped within the ion mobility spectrometer (5) when the ion gate (6) is switched so as to prevent ions from being onwardly transmitted. Ions which are transmitted by the ion gate (6) are trapped in a downstream ion trap (7). The ions are then returned back upstream to a second upstream ion trap (4).
摘要翻译：公开了一种离子迁移谱仪，其中离子通过离子迁移谱仪（5）并在时间上分离。具有较高离子迁移率的离子通过非破坏性离子浇口（6）传输，但当离子浇道（6）被切换时，离子迁移谱仪（5）中随后将具有较低离子迁移率的离子捕获到离子迁移谱仪防止离子向上传播。由离子栅（6）传输的离子被捕获在下游离子阱（7）中。然后离子返回上游到第二上游离子阱（4）。

9. 发明申请

US20110291001A1 Ion Mobility Spectrometer 有权
标题翻译：离子流动光谱仪
公开(公告)号：US20110291001A1
公开(公告)日：2011-12-01
申请号：US13060100
申请日：2009-08-14
申请人： John Brian Hoyes , David J. Langridge
发明人： John Brian Hoyes , David J. Langridge
IPC分类号： H01J49/26
CPC分类号： H01J49/0081 , G01N27/622
摘要： An ion mobility spectrometer is disclosed wherein ions are passed through an ion mobility spectrometer (5) and become temporally separated. Ions having a relatively high ion mobility are transmitted by a non-destructive ion gate (6) but ions having a relatively low ion mobility are subsequently trapped within the ion mobility spectrometer (5) when the ion gate (6) is switched so as to prevent ions from being onwardly transmitted. Ions which are transmitted by the ion gate (6) are trapped in a downstream ion trap (7). The ions are then returned back upstream to a second upstream ion trap (4).
摘要翻译：公开了一种离子迁移谱仪，其中离子通过离子迁移谱仪（5）并在时间上分离。具有较高离子迁移率的离子通过非破坏性离子浇口（6）传输，但当离子浇道（6）被切换时，离子迁移谱仪（5）中随后将具有较低离子迁移率的离子捕获到离子迁移谱仪防止离子向上传播。由离子栅（6）传输的离子被捕获在下游离子阱（7）中。然后离子返回上游到第二上游离子阱（4）。

10. 发明授权

US07960694B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07960694B2
公开(公告)日：2011-06-14
申请号：US12373204
申请日：2007-07-09
申请人： John Brian Hoyes
发明人： John Brian Hoyes
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： H01J49/36 , H01J49/0031 , H01J49/4235
摘要： A mass analyser (2) is provided comprising a plurality of electrodes having apertures through which ions are transmitted in use. A plurality of pseudo-potential corrugations are created along the axis of the mass ((analyser 2). The amplitude or depth of the pseudo-potential corrugations is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages are applied to the electrodes of the mass analyser (2) in order to urge ions along the length of the mass analyser (2). The amplitude of the transient DC voltages applied to the electrodes is increased with time and ions are caused to be emitted from the mass analyser (2) in reverse order of their mass to charge ratio. Two AC or RF voltages are applied to the electrodes. The first AC or RF voltage is arranged to provide optimal pseudo-potential corrugations whilst the second AC′ or RF voltage is arranged to provide optimal radial confinement of ions within the mass analyser (2).
摘要翻译：提供质量分析器（2），其包括具有孔的多个电极，在使用中通过该孔具有离子。沿着质量轴（（分析仪2））产生多个伪电位波纹，伪电位波纹的振幅或深度与离子的质荷比成反比，一个或多个瞬态直流电压被施加到质量分析器（2）的电极，以沿着质量分析器（2）的长度推动离子，施加到电极的瞬态DC电压的幅度随时间增加并且离子被发射从质量分析器（2）以其质量与电荷比的相反顺序将两个AC或RF电压施加到电极上，第一AC或RF电压被布置成提供最佳伪电位波纹，而第二AC'或RF 电压被布置成在质量分析器（2）内提供离子的最佳径向约束。

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