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1. 发明授权

US08598330B2 CC2D2A gene mutations associated with joubert syndrome and diagnostic methods for identifying the same 有权
标题翻译：与joubert综合征相关的CC2D2A基因突变和用于鉴定相同的诊断方法
公开(公告)号：US08598330B2
公开(公告)日：2013-12-03
申请号：US13346069
申请日：2012-01-09
申请人： John B. Vincent , Muhammad Ayub
发明人： John B. Vincent , Muhammad Ayub
IPC分类号： C12N15/12 , C12Q1/68
CPC分类号： C12Q1/6883 , C07K14/47 , C07K14/4728 , C07K16/18 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6893 , G01N2333/4727 , G01N2800/30
摘要： The present invention provides a method of screening a subject for mutations in the CC2D2A gene that are associated with Joubert syndrome, an autosomal recessive form of mental retardation. The present invention also provides proteins that are associated with Joubert syndrome including proteins that includes an amino acid sequence that terminates in DHEGGSGMES (SEQ ID NO: 1). Also provided are nucleotide sequences encoding such proteins and methods of screening subjects to identify nucleotide sequences or proteins associated with Joubert syndrome.
摘要翻译：本发明提供了一种筛选受试者与CCV2A基因突变相关的方法，该突变与Joubert综合征（常染色体隐性遗传性智力低下型）相关。本发明还提供与Joubert综合征相关的蛋白质，包括包含终止于DHEGGSGMES（SEQ ID NO：1）的氨基酸序列的蛋白质。还提供了编码这些蛋白质的核苷酸序列和筛选受试者以鉴定与Joubert综合征相关的核苷酸序列或蛋白质的方法。

2. 发明授权

US08119351B2 CC2D2A gene mutations associated with Joubert syndrome and diagnostic methods for identifying the same 有权
标题翻译：与Joubert综合征相关的CC2D2A基因突变和鉴定相同的诊断方法
公开(公告)号：US08119351B2
公开(公告)日：2012-02-21
申请号：US12681347
申请日：2008-10-03
申请人： John B. Vincent , Muhammad Ayub
发明人： John B. Vincent , Muhammad Ayub
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C07K14/47 , C07K14/4728 , C07K16/18 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6893 , G01N2333/4727 , G01N2800/30
摘要： The present invention provides a method of screening a subject for mutations in the CC2D2A gene that are associated with Joubert syndrome, an autosomal recessive form of mental retardation. The present invention also provides proteins that are associated with Joubert syndrome including proteins comprising an amino acid sequence that terminates in DHEGGSGMES (SEQ ID NO: 1). Also provided are nucleotide sequences encoding such proteins and methods of screening subjects to identify nucleotide sequences or proteins associated with Joubert syndrome.
摘要翻译：本发明提供了一种筛选受试者与CCV2A基因突变相关的方法，该突变与Joubert综合征（常染色体隐性遗传性智力低下型）相关。本发明还提供与Joubert综合征相关的蛋白质，其包括终止于DHEGGSGMES（SEQ ID NO：1）的氨基酸序列的蛋白质。还提供了编码这些蛋白质的核苷酸序列和筛选受试者以鉴定与Joubert综合征相关的核苷酸序列或蛋白质的方法。

3. 发明申请

US20120258887A1 CC2D2A GENE MUTATIONS ASSOCIATED WITH JOUBERT SYNDROME AND DIAGNOSTIC METHODS FOR IDENTIFYING THE SAME 有权
标题翻译：与JOUBERT综合征相关的CC2D2A基因突变和鉴别其的诊断方法
公开(公告)号：US20120258887A1
公开(公告)日：2012-10-11
申请号：US13346069
申请日：2012-01-09
申请人： John B. Vincent , Muhammad Ayub
发明人： John B. Vincent , Muhammad Ayub
IPC分类号： C07K14/00 , C12Q1/68 , C40B40/06 , C07H21/04 , C07K16/00
CPC分类号： C12Q1/6883 , C07K14/47 , C07K14/4728 , C07K16/18 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6893 , G01N2333/4727 , G01N2800/30
摘要： The present invention provides a method of screening a subject for mutations in the CC2D2A gene that are associated with Joubert syndrome, an autosomal recessive form of mental retardation. The present invention also provides proteins that are associated with Joubert syndrome including proteins that includes an amino acid sequence that terminates in DHEGGSGMES (SEQ ID NO: 1). Also provided are nucleotide sequences encoding such proteins and methods of screening subjects to identify nucleotide sequences or proteins associated with Joubert syndrome.
摘要翻译：本发明提供了一种筛选受试者与CCV2A基因突变相关的方法，该突变与Joubert综合征（常染色体隐性遗传性智力低下型）相关。本发明还提供与Joubert综合征相关的蛋白质，包括包含终止于DHEGGSGMES（SEQ ID NO：1）的氨基酸序列的蛋白质。还提供了编码这些蛋白质的核苷酸序列和筛选受试者以鉴定与Joubert综合征相关的核苷酸序列或蛋白质的方法。

4. 发明申请

US20100297636A1 CC2D2A GENE MUTATIONS ASSOCIATED WITH JOUBERT SYNDROME AND DIAGNOSTIC METHODS FOR IDENTIFYING THE SAME 有权
标题翻译：与JOUBERT综合征相关的CC2D2A基因突变和鉴别其的诊断方法
公开(公告)号：US20100297636A1
公开(公告)日：2010-11-25
申请号：US12681347
申请日：2008-10-03
申请人： John B. Vincent , Muhammad Ayub
发明人： John B. Vincent , Muhammad Ayub
IPC分类号： C12Q1/68 , C07K14/435 , C07K11/00 , C07H21/00 , G01N33/68 , C07K16/18
CPC分类号： C12Q1/6883 , C07K14/47 , C07K14/4728 , C07K16/18 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6893 , G01N2333/4727 , G01N2800/30
摘要： The present invention provides a method of screening a subject for mutations in the CC2D2A gene that are associated with Joubert syndrome, an autosomal recessive form of mental retardation. The present invention also provides proteins that are associated with Joubert syndrome including proteins comprising an amino acid sequence that terminates in DHEGGSGMES (SEQ ID NO: 1). Also provided are nucleotide sequences encoding such proteins and methods of screening subjects to identify nucleotide sequences or proteins associated with Joubert syndrome.
摘要翻译：本发明提供了一种筛选受试者与CCV2A基因突变相关的方法，该突变与Joubert综合征（常染色体隐性遗传性智力低下型）相关。本发明还提供与Joubert综合征相关的蛋白质，其包括终止于DHEGGSGMES（SEQ ID NO：1）的氨基酸序列的蛋白质。还提供了编码这些蛋白质的核苷酸序列和筛选受试者以鉴定与Joubert综合征相关的核苷酸序列或蛋白质的方法。

5. 发明申请

US20080064894A1 Method for the synthesis of basic chromium carboxylates 有权
标题翻译：碱性铬羧酸盐的合成方法
公开(公告)号：US20080064894A1
公开(公告)日：2008-03-13
申请号：US11519883
申请日：2006-09-13
申请人： John B. Vincent
发明人： John B. Vincent
IPC分类号： C07F11/00
CPC分类号： C07F11/005
摘要： A method for the synthesis of a chromium complex 2, [Cr3O(carboxylate)6(H2O)3]+ (2), wherein carboxylate is a substituted or unsubstituted C2-C5 alkyl carboxylate, is provided, including the step of: heating an aqueous reaction mixture of a Cr(III) salt, a substituted or unsubstituted C2-C5 alkyl carboxylic acid and a metal hydroxide for a time period and at a temperature sufficient to generate an aqueous product mixture comprising chromium complex 2 and non-toxic byproducts.
摘要翻译：合成铬络合物2，[Cr 3 O（羧酸酯）6（H 2 O）3）的方法，（2），其中羧酸酯是取代或未取代的C 2 -C 5烷基羧酸酯，其包括以下步骤：加热Cr（III）盐的水性反应混合物，取代或未取代的C 2 -C 5烷基羧酸和金属氢氧化物，其时间和温度足以产生包含铬络合物2和无毒副产物的含水产物混合物。

6. 发明授权

US06881752B2 USE OF TRIAQUA-μ3-OXOHEXAKIS-μ-PROPIONATOTRICHROMIUM(1+), [CR3O(O2CCH2CH3)6(H2O)3]+, AS A NUTRITIONAL SUPPLEMENT OR IN TREATMENT OF MEDICAL CONDITIONS 有权
标题翻译：使用TRIAQUA-mu3-OXOHEXAKIS-mu-PROPIONATOTRICHROMIUM（1+），[CR3O（O2CCH2CH3）6（H2O）3] +，作为营养补充或治疗医疗条件
公开(公告)号：US06881752B2
公开(公告)日：2005-04-19
申请号：US10179700
申请日：2002-06-26
申请人： John B. Vincent , Catherine M. Davis
发明人： John B. Vincent , Catherine M. Davis
IPC分类号： A23K1/175 , A61K31/28 , A61K33/24 , A01N25/00 , A61K47/00
CPC分类号： A61K33/24 , A23K20/30 , A61K31/28 , Y10S514/866
摘要： Methods of using the chromium(III) complex represented by the formula [Cr3O(O2CCH2CH3)6(H2O)3]+ as a nutritional supplement, and for treating medical disorders associated with chromium deficiency, nutritive and pharmaceutical compositions containing this chromium(III) complex are also provided.
摘要翻译：使用由式[Cr 3 N 2 O（O 2 CH 2 CH 3）3表示的铬（III）络合物的方法，作为营养补充剂和用于治疗医学病症的药物（例如，作为营养补充剂）和/或作为营养补充剂还提供与铬缺乏相关的营养物质和含有该铬（III）络合物的药物组合物。

7. 发明授权

US06639709B2 Matrix addressable electrochromic display device 有权
标题翻译：矩阵可寻址电致变色显示装置
公开(公告)号：US06639709B2
公开(公告)日：2003-10-28
申请号：US10102491
申请日：2002-03-19
申请人： John B. Vincent , Derrick W. Flick
发明人： John B. Vincent , Derrick W. Flick
IPC分类号： G02F115
CPC分类号： C09K9/02 , G02F1/1523 , G02F1/155 , G02F1/176 , G02F2001/1519
摘要： The invention is a matrix addressable electrochromic display device comprising a top electrode structure comprising at least one transparent or semi-transparent and substantially ionically isolative, electrically conductive electrode, a bottom electrode structure comprising at least one substantially ionically isolative, electrically conductive electrode, wherein at least one of the top or bottom electrode structures comprises two or more of said electrodes and the top and bottom electrode structures are positioned to form at least two separate regions where the top electrodes are positioned above the bottom electrodes and between the top electrode structure and the bottom electrode structure is positioned an active layer comprising an electrolyte and an electrochromic material.
摘要翻译：本发明是一种矩阵可寻址电致变色显示装置，其包括顶电极结构，其包括至少一个透明或半透明且基本上离子隔离的导电电极，底电极结构包括至少一个基本上离子隔离的导电电极，其中在顶部或底部电极结构中的至少一个包括两个或更多个所述电极，并且顶部和底部电极结构被定位成形成至少两个分开的区域，其中顶部电极位于底部电极之上并且位于顶部电极结构和底部电极结构被定位成包括电解质和电致变色材料的活性层。

8. 发明授权

US06197816B1 Use of triaqua-mu3-oxohexakis-mu-propionatotrichromium (1+), [CR3O(O2CCH2CH3)6(H2O) 3]+, as a nutritional supplement or in treatment of medical conditions 有权
标题翻译：使用triaqua-mu3-oxohexakis-mu-propionatotrichromium（1+），[CR3O（O2CCH2CH3）6（H2O）3] +作为营养补充剂或治疗医疗条件
公开(公告)号：US06197816B1
公开(公告)日：2001-03-06
申请号：US09163005
申请日：1998-09-30
申请人： John B. Vincent , Catherine M. Davis
发明人： John B. Vincent , Catherine M. Davis
IPC分类号： A61K3128
CPC分类号： A61K33/24 , A23K20/30 , A61K31/28 , Y10S514/866
摘要： Methods of using the chromium(III) complex represented by the formula [Cr3O(O2CCH2CH3)6(H2O)3]+ as a nutritional supplement.
摘要翻译：使用由式[Cr 3 O（O 2 CCH 2 CH 3）6（H 2 O）3] +表示的铬（III）络合物作为营养补充剂的方法。

9. 发明授权

US5441643A Process for recovering metals from solution utilizing metalloprotein affinity chromatography 失效
标题翻译：使用金属蛋白亲和层析从溶液中回收金属的方法
公开(公告)号：US5441643A
公开(公告)日：1995-08-15
申请号：US158553
申请日：1993-11-29
申请人： Dennis R. Spears , John B. Vincent
发明人： Dennis R. Spears , John B. Vincent
IPC分类号： B01D15/00 , B01J20/32 , G01N30/02 , B01D15/08
CPC分类号： B01D15/3828 , B01J20/286 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3274 , B01J2220/54 , B01J2220/58 , G01N30/02
摘要： A process for recovering metals from an aqueous metal-ion bearing solution includes the steps of:(a) forming an affinity chromatography matrix by providing a metal bearing protein bound to an insoluble support material to form an immobilized metalloprotein material;(b) introducing into the affinity chromatography matrix a quantity of aqueous metal-containing solution having a pH, redox potential or other property properly adjusted to cause ions of a selected metal entrained within the solution to bind to the immobilized metalloprotein material;(c) washing the matrix with a first buffer which does not elute the metal ions of interest but does remove other species of metal entrained in the solution; and(d) applying a second buffer or solution of appropriate pH, redox potential or other property to the affinity chromatography matrix to elute the metal ions of interest from the immobilized metalloprotein material.
摘要翻译：从含金属离子载体溶液中回收金属的方法包括以下步骤：（a）通过提供与不溶性载体材料结合的金属担载蛋白形成固定的金属蛋白材料形成亲和层析基质; （b）向所述亲和层析基质中引入一定量的具有适当调节pH值，氧化还原电位或其它特性的含水金属溶液，使得所述溶液中夹带的选定金属的离子与固定的金属蛋白材料结合; （c）用不洗涤感兴趣的金属离子的第一缓冲液洗涤基质，但是除去夹带在溶液中的其它物质的金属; 和（d）将适当的pH，氧化还原电位或其他性质的第二缓冲液或溶液施加到亲和层析基质上以从固定的金属蛋白材料中洗脱所关注的金属离子。

10. 发明授权

US09568484B2 MECP2E1 gene 有权
标题翻译： MECP2E1基因
公开(公告)号：US09568484B2
公开(公告)日：2017-02-14
申请号：US12313251
申请日：2008-11-18
申请人： Berge A. Minassian , John B. Vincent
发明人： Berge A. Minassian , John B. Vincent
IPC分类号： C12Q1/68 , G01N33/68 , C07K14/47 , A61K38/00 , A61K48/00
CPC分类号： C12Q1/6883 , A61K38/00 , A61K48/00 , C07K14/47 , C12Q2600/156 , C12Q2600/158 , G01N33/6896 , G01N2500/00 , G01N2800/28
摘要： The invention is a novel MECP2E1 splice variant and its corresponding polypeptide. The invention also includes methods of using these nucleic acid sequences and proteins in medical diagnosis and treatment of neuropsychiatric disorders or development disorders.
摘要翻译：本发明是一种新型的MECP2E1剪接变体及其相应的多肽。本发明还包括在神经精神障碍或发育障碍的医学诊断和治疗中使用这些核酸序列和蛋白质的方法。

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