专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08598330B2 CC2D2A gene mutations associated with joubert syndrome and diagnostic methods for identifying the same 有权
标题翻译：与joubert综合征相关的CC2D2A基因突变和用于鉴定相同的诊断方法
公开(公告)号：US08598330B2
公开(公告)日：2013-12-03
申请号：US13346069
申请日：2012-01-09
申请人： John B. Vincent , Muhammad Ayub
发明人： John B. Vincent , Muhammad Ayub
IPC分类号： C12N15/12 , C12Q1/68
CPC分类号： C12Q1/6883 , C07K14/47 , C07K14/4728 , C07K16/18 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6893 , G01N2333/4727 , G01N2800/30
摘要： The present invention provides a method of screening a subject for mutations in the CC2D2A gene that are associated with Joubert syndrome, an autosomal recessive form of mental retardation. The present invention also provides proteins that are associated with Joubert syndrome including proteins that includes an amino acid sequence that terminates in DHEGGSGMES (SEQ ID NO: 1). Also provided are nucleotide sequences encoding such proteins and methods of screening subjects to identify nucleotide sequences or proteins associated with Joubert syndrome.
摘要翻译：本发明提供了一种筛选受试者与CCV2A基因突变相关的方法，该突变与Joubert综合征（常染色体隐性遗传性智力低下型）相关。本发明还提供与Joubert综合征相关的蛋白质，包括包含终止于DHEGGSGMES（SEQ ID NO：1）的氨基酸序列的蛋白质。还提供了编码这些蛋白质的核苷酸序列和筛选受试者以鉴定与Joubert综合征相关的核苷酸序列或蛋白质的方法。

2. 发明授权

US08119351B2 CC2D2A gene mutations associated with Joubert syndrome and diagnostic methods for identifying the same 有权
标题翻译：与Joubert综合征相关的CC2D2A基因突变和鉴定相同的诊断方法
公开(公告)号：US08119351B2
公开(公告)日：2012-02-21
申请号：US12681347
申请日：2008-10-03
申请人： John B. Vincent , Muhammad Ayub
发明人： John B. Vincent , Muhammad Ayub
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C07K14/47 , C07K14/4728 , C07K16/18 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6893 , G01N2333/4727 , G01N2800/30
摘要： The present invention provides a method of screening a subject for mutations in the CC2D2A gene that are associated with Joubert syndrome, an autosomal recessive form of mental retardation. The present invention also provides proteins that are associated with Joubert syndrome including proteins comprising an amino acid sequence that terminates in DHEGGSGMES (SEQ ID NO: 1). Also provided are nucleotide sequences encoding such proteins and methods of screening subjects to identify nucleotide sequences or proteins associated with Joubert syndrome.
摘要翻译：本发明提供了一种筛选受试者与CCV2A基因突变相关的方法，该突变与Joubert综合征（常染色体隐性遗传性智力低下型）相关。本发明还提供与Joubert综合征相关的蛋白质，其包括终止于DHEGGSGMES（SEQ ID NO：1）的氨基酸序列的蛋白质。还提供了编码这些蛋白质的核苷酸序列和筛选受试者以鉴定与Joubert综合征相关的核苷酸序列或蛋白质的方法。

3. 发明授权

US08716444B2 Method and apparatus for predicting susceptibility to a developmental disorder 有权
标题翻译：用于预测发育障碍易感性的方法和装置
公开(公告)号：US08716444B2
公开(公告)日：2014-05-06
申请号：US13258929
申请日：2010-03-26
申请人： John B. Vincent
发明人： John B. Vincent
IPC分类号： C07K1/00 , C12Q1/68
CPC分类号： G06Q10/06398 , C12Q1/6883 , C12Q2600/156 , G06Q10/063114 , G06Q10/0639 , G06Q10/06393
摘要： The present invention provides a method of screening a subject for mutations in the TRAPPC9 gene that are associated with developmental disabilities. The present invention also provides proteins that are associated with developmental disabilities including a truncation of NIBP. Also provided are nucleotide sequences encoding such proteins and methods of screening subjects to identify nucleotide sequences or proteins associated with developmental disabilities.
摘要翻译：本发明提供了筛选受试者与发育障碍相关的TRAPPC9基因突变的方法。本发明还提供与发育障碍相关的蛋白质，包括截断NIBP。还提供了编码这些蛋白质的核苷酸序列和筛选受试者以鉴定与发育障碍相关的核苷酸序列或蛋白质的方法。

4. 发明授权

US08637236B2 MECP2E1 gene 有权
标题翻译： MECP2E1基因
公开(公告)号：US08637236B2
公开(公告)日：2014-01-28
申请号：US12657559
申请日：2010-01-21
申请人： Berge A. Minassian , John B. Vincent
发明人： Berge A. Minassian , John B. Vincent
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , A61K38/00 , A61K38/1709 , A61K48/00 , C07K14/47 , C12Q2600/156 , G01N33/6896 , G01N2500/00 , G01N2800/28
摘要： The invention is a novel MECP2E1 splice variant and its corresponding polypeptide. The invention also includes methods of using these nucleic acid sequences and proteins in medical diagnosis and treatment of neuropsychiatric disorders or development disorders.
摘要翻译：本发明是一种新型的MECP2E1剪接变体及其相应的多肽。本发明还包括在神经精神障碍或发育障碍的医学诊断和治疗中使用这些核酸序列和蛋白质的方法。

5. 发明申请

US20130116149A1 Genetic Markers Associated with Intellectual Disability 审中-公开
标题翻译：遗传标记与智力障碍有关
公开(公告)号：US20130116149A1
公开(公告)日：2013-05-09
申请号：US13805884
申请日：2011-06-23
申请人： John B. Vincent
发明人： John B. Vincent
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C07H21/04 , C07K16/40 , C12N9/1007 , C12Q2600/156 , C12Y201/01203 , G01N2800/28
摘要： Genetic markers associated with intellectual disability as well as compositions, methods and kits for screening for genetic markers intellectual disability, diagnosing intellectual disability and identifying individuals with a predisposition for offspring suffering from intellectual disability are provided.
摘要翻译：提供与智力障碍相关的遗传标记，以及用于筛选遗传标记智力障碍，诊断智力障碍和识别患有智力障碍的后代倾向的个体的组合物，方法和试剂盒。

6. 发明申请

US20120100995A1 Biomarkers for Autism Spectrum Disorders 审中-公开
标题翻译：自闭症谱系障碍的生物标志物
公开(公告)号：US20120100995A1
公开(公告)日：2012-04-26
申请号：US13231467
申请日：2011-09-13
申请人： Stephen W. Scherer , John B. Vincent
发明人： Stephen W. Scherer , John B. Vincent
IPC分类号： C12Q1/68 , C40B20/00
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： Methods of determining the risk of ASD or ID in an individual are provided which comprise identifying the presence of one or more specific genomic mutations in, upstream of, or comprising the PTCHD1 gene. Additionally provided are methods of determining the risk of ASD or ID in an individual comprising analyzing genomic mutations in PTCHD1AS1 and/or PTCHD1AS2 and/or PTCHD1AS3.
摘要翻译：提供确定个体中ASD或ID风险的方法，其包括鉴定在PTCHD1基因的上游或包含PTCHD1基因中存在一个或多个特异性基因组突变。另外提供了确定个体中ASD或ID风险的方法，包括分析PTCHD1AS1和/或PTCHD1AS2和/或PTCHD1AS3中的基因组突变。

7. 发明申请

US20100248235A1 BIOMARKERS FOR AUTISM SPECTRUM DISORDERS 审中-公开
标题翻译：生物标志物用于非传染性疾病
公开(公告)号：US20100248235A1
公开(公告)日：2010-09-30
申请号：US12681229
申请日：2008-10-03
申请人： Stephen W. Scherer , John B. Vincent
发明人： Stephen W. Scherer , John B. Vincent
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
摘要： Methods of determining the risk of ASD in an individual are provided which comprise identifying the presence of one or more genomic mutations in one or more of the genes, PTCHD1, SHANK3, NFIA, DPP6, DPP10, DYPD, GPR98, PQBP1, ZNF41 and FTSJ1.
摘要翻译：提供确定个体中ASD风险的方法，其包括鉴定在一种或多种基因PTCHD1，SHANK3，NFIA，DPP6，DPP10，DYPD，GPR98，PQBP1，ZNF41和FTSJ1中存在一种或多种基因组突变。

8. 发明授权

US07354953B2 Time-release compositions for delivery of [Cr3O(carboxylate)6(H2O)3]+ 有权
标题翻译：用于递送[Cr 3 O（羧酸酯）6（H 2 O）3] +的时间释放组合物
公开(公告)号：US07354953B2
公开(公告)日：2008-04-08
申请号：US11392503
申请日：2006-03-30
申请人： John B. Vincent
发明人： John B. Vincent
IPC分类号： A61K31/28 , A61K33/24 , A61P3/10
CPC分类号： A61K31/28 , A61K31/555 , A61K33/24 , Y10S514/866
摘要： A time release composition is provided containing: a chromium complex having formula 3 [Cr3O(carboxylate)6(ligand)3]+ (3) wherein carboxylate is a C2-C5 alkyl carboxylate and wherein ‘ligand’ is a ligand that (i) renders the chromium complex insoluble or only slightly soluble in water and (ii) is acid labile, being readily displaced under acidic conditions below pH=4 and replaced by water to make the resulting water soluble complex 2 [Cr3O(carboxylate)6(H2O)3]+, (2) and the use of the time release composition for the time release delivery of complex 2.
摘要翻译：提供了一种时间释放组合物，其包含：具有式3的铬络合物<？in-line-formula description =“In-line formula”end =“lead”→[Cr 3 O（羧酸酯）（3）<？in-line-formula description =“In-line Formulas”end =“tail 其中羧酸酯是C 2 -C 5烷基羧酸酯，并且其中“配位体”是（i）使铬络合物不溶或仅微溶于水的配体，和（ii）酸不稳定，在酸性条件下易于置换 pH = 4并用水代替，得到的水溶性络合物2 <βin-line-formula description =“In-line Formulas”end =“lead”→[Cr 3 O（羧酸盐）（2）＆lt; 3＆gt;（2）＆lt;＆lt; 3＆gt;（2） =“在线公式”end =“tail”？>并且使用时间释放组合物来实现复制时间的传递2。

9. 发明授权

US06879424B2 Electrochromic display device and compositions useful in making such devices 失效
标题翻译：用于制造这种装置的电致变色显示装置和组合物
公开(公告)号：US06879424B2
公开(公告)日：2005-04-12
申请号：US10102236
申请日：2002-03-19
申请人： John B. Vincent , Susan J. Babinec , Daniel L. Dermody , Yu Chen
发明人： John B. Vincent , Susan J. Babinec , Daniel L. Dermody , Yu Chen
IPC分类号： C09K9/02 , G02F1/15 , G02F1/155 , G02F1/17 , G02B5/23
CPC分类号： C09K9/02 , G02F1/1523 , G02F1/155 , G02F1/176 , G02F2001/1519
摘要： The present invention relates to a composition and to a display device having the composition positioned between electrodes. The composition contains: (a) a compound that undergoes a reversible redox reaction to generate a pH gradient between the two electrodes, (b) an indicator dye, (c) a charge transport material, and optionally, (d) a matrix material and (e) an opacifier, and (f) secondary redox couple wherein components (a), (b), and (c) are different from one another and the standard reduction potential of component (a) is less than the standard reduction potential for the other components. Depending on the electric field present between the electrodes, a display image may be generated.
摘要翻译：本发明涉及具有位于电极之间的组合物和显示装置。组合物包含：（a）经历可逆氧化还原反应以在两个电极之间产生pH梯度的化合物，（b）指示剂染料，（c）电荷输送材料，和任选地（d）基质材料，（e）遮光剂，和（f）其中组分（a），（b）和（c）彼此不同的二次氧化还原对，并且组分（a）的标准还原电位小于其他组件。根据存在于电极之间的电场，可以产生显示图像。

10. 发明授权

US06744549B2 Electrochromic display device 失效
标题翻译：电致变色显示装置
公开(公告)号：US06744549B2
公开(公告)日：2004-06-01
申请号：US10102535
申请日：2002-03-19
申请人： John B. Vincent , Derrick W. Flick
发明人： John B. Vincent , Derrick W. Flick
IPC分类号： G02F1153
CPC分类号： G02F1/155 , G02F1/1523 , G02F2001/1557
摘要： The invention is a display device comprising a solid top transparent, charge conducting material, positioned below the transparent solid material is an active layer comprising an electrochromic material and an electrolyte, and positioned below the active layer is a working electrode and a counter-electrode arranged to be isolated from one another, wherein the distance between the working and the counter electrode is greater than two times the thickness of the active layer between the electrode and the conductive material.
摘要翻译：本发明是一种显示装置，其包括固体顶部透明的导电材料，其位于透明固体材料的下方，是包含电致变色材料和电解质的活性层，并且位于有源层下面的是工作电极和对置电极彼此隔离，其中工作电极和对电极之间的距离大于电极和导电材料之间的有源层的厚度的两倍。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式