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1. 发明授权

US09890351B2 Encapsulates 有权
公开(公告)号：US09890351B2
公开(公告)日：2018-02-13
申请号：US13569254
申请日：2012-08-08
申请人： Johan Smets , Susana Fernandez Prieto , Steven Daryl Smith , Todd Laurence Underiner , John August Wos , Wolfgang Edgar Huhn , Heath A. Frederick , Marta Giamberini , Bartosz Tylkowski
发明人： Johan Smets , Susana Fernandez Prieto , Steven Daryl Smith , Todd Laurence Underiner , John August Wos , Wolfgang Edgar Huhn , Heath A. Frederick , Marta Giamberini , Bartosz Tylkowski
IPC分类号： C11D17/00 , A61Q13/00 , A61K8/11 , C11D3/37 , C11D3/48 , C11D3/50 , A61Q5/02 , A61K8/81 , A61Q19/10 , A61Q5/12 , A61Q15/00 , A61Q19/00
CPC分类号： C11D17/0039 , A61K8/11 , A61K8/8129 , A61K8/8152 , A61K2800/412 , A61K2800/47 , A61K2800/81 , A61Q5/02 , A61Q5/12 , A61Q13/00 , A61Q15/00 , A61Q19/00 , A61Q19/10 , C11D3/373 , C11D3/48 , C11D3/505
摘要： The present application relates to encapsulates, compositions, products comprising such encapsulates, and processes for making and using such encapsulates. Such encapsulates comprise a core comprising a perfume and a shell that encapsulates said core, such encapsulates may optionally comprise a parametric balancing agent, such shell comprising one or more azobenzene moieties.

2. 发明申请

US20130039962A1 ENCAPSULATES 有权
标题翻译：包封
公开(公告)号：US20130039962A1
公开(公告)日：2013-02-14
申请号：US13569254
申请日：2012-08-08
申请人： Johan SMETS , Susana Fernandez Prieto , Steven Daryl Smith , Todd Laurence Underiner , John August Wos , Wolfgang Edgar Huhn , Heath A. Frederick , Marta Giamberini , Bartosz Tylkowski
发明人： Johan SMETS , Susana Fernandez Prieto , Steven Daryl Smith , Todd Laurence Underiner , John August Wos , Wolfgang Edgar Huhn , Heath A. Frederick , Marta Giamberini , Bartosz Tylkowski
IPC分类号： C11D3/50 , A61Q5/02 , A61Q15/00 , A61Q5/12 , A61Q19/00 , A61K8/11 , A61Q19/10
CPC分类号： C11D17/0039 , A61K8/11 , A61K8/8129 , A61K8/8152 , A61K2800/412 , A61K2800/47 , A61K2800/81 , A61Q5/02 , A61Q5/12 , A61Q13/00 , A61Q15/00 , A61Q19/00 , A61Q19/10 , C11D3/373 , C11D3/48 , C11D3/505
摘要： The present application relates to encapsulates, compositions, products comprising such encapsulates, and processes for making and using such encapsulates. Such encapsulates comprise a core comprising a perfume and a shell that encapsulates said core, such encapsulates may optionally comprise a parametric balancing agent, such shell comprising one or more azobenzene moieties.
摘要翻译：本申请涉及包含这些封装物的包封物，组合物，产品，以及制造和使用这种封装物的方法。这样的包封物包含包含香料和包封所述核心的壳的核心，这种包封物可任选地包含参与平衡剂，这种壳包含一个或多个偶氮苯部分。

3. 发明申请

US20120142969A1 Process for the Preparation of 2-Methoxymethyl-1,4-Benzenediamine, Its Derivatives Thereof and the Salts Thereof 有权
标题翻译： 2-甲氧基甲基-1,4-苯二胺及其衍生物及其盐的制备方法
公开(公告)号：US20120142969A1
公开(公告)日：2012-06-07
申请号：US13016272
申请日：2011-01-28
申请人： John Michael GARDLIK , Garry Steven Garrett , Bryan Patrick Murphy , John Michael Janusz , John August Wos
发明人： John Michael GARDLIK , Garry Steven Garrett , Bryan Patrick Murphy , John Michael Janusz , John August Wos
IPC分类号： C07C213/02
CPC分类号： C07C213/02 , C07C217/76
摘要： A process for synthesizing 2-methoxymethyl-1,4-benzenediamine, its derivatives of formula (IV) and the salts thereof, which comprises a reductive amination step. The preferred final product is 2-methoxymethyl-1,4-benzenediamine of formula (IV-a). These compounds may be used as primary intermediates in compositions for dyeing keratin fibers.
摘要翻译：一种合成2-甲氧基甲基-1,4-苯二胺的方法，其式（Ⅳ）的衍生物及其盐，其包括还原胺化步骤。优选的最终产物是式（IV-a）的2-甲氧基甲基-1,4-苯二胺。这些化合物可用作用于染色角蛋白纤维的组合物中的主要中间体。

4. 发明授权

US07041696B2 Interleukin-1β converting enzyme inhibitors 失效
标题翻译：白细胞介素-1β转换酶抑制剂
公开(公告)号：US07041696B2
公开(公告)日：2006-05-09
申请号：US10457181
申请日：2003-06-09
申请人： John August Wos , David Lindsey Soper , Steven Victor O'Neil , Yili Wang , Kofi Abeka Oppong , Michael Christopher Laufersweiler , Jian Chen , Biswanath De , Thomas Prosser Demuth, Jr.
发明人： John August Wos , David Lindsey Soper , Steven Victor O'Neil , Yili Wang , Kofi Abeka Oppong , Michael Christopher Laufersweiler , Jian Chen , Biswanath De , Thomas Prosser Demuth, Jr.
IPC分类号： C07D487/04 , A61K31/403 , A61P29/00
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to interleukin-1β converting enzyme inhibitors having the formula: R is a carbocyclic or heterocyclic ring; R1 is a cysteine trap; R2a, R2a′, R2b, and R2b′ are each independently hydrogen, C1–C4 alkyl, C1–C4 alkoxy, and mixtures thereof; or R2a′ and R2b′ can taken together to form a double bond; L and L1 are linking groups having the formula: T is selected from the group consisting of: i) —NR6—; ii) —O—; iii) —NR6S(O)2—; iv) —S(O)2NR6—; and v) mixtures thereof; R6 is hydrogen, substituted or unsubstituted C1–C20 linear, branched, or cyclic alkyl, C6–C20 aryl, C7–C20 alkylenearyl, and mixtures thereof; the indices w, w1, and w2 are each independently 0 or 1; i) hydrogen; ii) C1–C4 linear, branched, and cyclic alkyl; iii) R3a and R3b or R4a, and R4b can be taken together to form a carbonyl unit; iv) two R3a or two R3b units from adjacent carbon atoms or two R4a or two R4b units from adjacent carbon atoms can be taken together to form a double bond; and v) mixtures thereof; the index m is from 0 to 5; the index n is from 0 to 5.
摘要翻译：本发明涉及具有下式的白细胞介素-1β转换酶抑制剂：R是碳环或杂环; R 1是半胱氨酸阱; R 2a，R 2a，R 2b和R 2b'各自独立地为氢，C

5. 发明授权

US06372730B1 2-decarboxy-2-phosphinico Prostaglandin F analogs 有权
标题翻译： 2-decarboxy-2-phosphinico前列腺素F类似物
公开(公告)号：US06372730B1
公开(公告)日：2002-04-16
申请号：US09632256
申请日：2000-08-03
申请人： Mitchell Anthony deLong , John August Wos , Biswanath De , Frank Hallock Ebetino
发明人： Mitchell Anthony deLong , John August Wos , Biswanath De , Frank Hallock Ebetino
IPC分类号： A61K3166
CPC分类号： C07F9/303
摘要： The invention provides novel Prostaglandin F analogs. In particular, the present invention is directed to compounds having a structure according to the following formula: wherein R1, R2, X, Y, V, a, b, W, and Z are defined below. This invention also includes optical isomers, diastereomers and enantiomers of the formula above, and pharmaceutically—acceptable salts, biohydrolyzable amides, esters, and imides thereof. The compounds of the present invention are useful for the treatment of a variety of diseases and conditions, such as bone disorders and glaucoma. Accordingly, the invention further provides pharmaceutical compositions comprising these compounds. The invention still further provides methods of treatment for bone disorders and glaucoma using these compounds or the compositions containing them.
摘要翻译：本发明提供了新型前列腺素F类似物。特别地，本发明涉及具有下式结构的化合物：其中R1，R2，X，Y，V，a，b，W和Z定义如下。本发明还包括光学异构体，非对映异构体和上式的对映异构体及其药学上可接受的盐，生物可水解的酰胺，酯和酰亚胺。本发明的化合物可用于治疗多种疾病和病症，例如骨骼疾病和青光眼。因此，本发明还提供包含这些化合物的药物组合物。本发明还提供了使用这些化合物或含有它们的组合物治疗骨病和青光眼的方法。

6. 发明授权

US08592631B2 Process for the preparation of 2-methoxymethy1-1,4-benzenediamine, its derivatives thereof and the salts thereof 有权
标题翻译： 2-甲氧基甲基-1,4-苯二胺及其衍生物及其盐的制备方法
公开(公告)号：US08592631B2
公开(公告)日：2013-11-26
申请号：US13016272
申请日：2011-01-28
申请人： John Michael Gardlik , Garry Steven Garrett , Bryan Patrick Murphy , John Michael Janusz , John August Wos
发明人： John Michael Gardlik , Garry Steven Garrett , Bryan Patrick Murphy , John Michael Janusz , John August Wos
IPC分类号： C07C209/00
CPC分类号： C07C213/02 , C07C217/76
摘要： A process for synthesizing 2-methoxymethyl-1,4-benzenediamine, its derivatives of formula (IV) and the salts thereof, which comprises a reductive amination step. The preferred final product is 2-methoxymethyl-1,4-benzenediamine of formula (IV-a). These compounds may be used as primary intermediates in compositions for dyeing keratin fibers.
摘要翻译：一种合成2-甲氧基甲基-1,4-苯二胺的方法，其式（Ⅳ）的衍生物及其盐，其包括还原胺化步骤。优选的最终产物是式（IV-a）的2-甲氧基甲基-1,4-苯二胺。这些化合物可用作用于染色角蛋白纤维的组合物中的主要中间体。

7. 发明授权

US07026335B2 Melanocortin receptor ligands 失效
标题翻译：黑皮质素受体配体
公开(公告)号：US07026335B2
公开(公告)日：2006-04-11
申请号：US10410775
申请日：2003-04-09
申请人： Frank Hallock Ebetino , Xuewei Liu , Mark Gregory Solinsky , John August Wos
发明人： Frank Hallock Ebetino , Xuewei Liu , Mark Gregory Solinsky , John August Wos
IPC分类号： A61K31/445 , C07D401/04
CPC分类号： C07D401/06 , C07D211/26
摘要： The present invention relates to compounds which comprise a 4-substituted piperidine ring linked to a substituted or unsubstituted hydrocarbyl ring. The compounds, including all enatiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the formula: wherein preferably R is substituted aryl, W is a pendant unit having the formula: -L-Q L is a linking unit, Q is preferably a cyclic hydrocarbyl unit; W1 is preferably a carbocyclic unit and W2 is a heteroatom comprising unit.
摘要翻译：本发明涉及包含与取代或未取代的烃基环连接的4-取代的哌啶环的化合物。化合物，包括所有对映异构体和非对映体形式及其药学上可接受的盐，具有下式：其中优选R是取代的芳基，W是具有下式的侧链单元：<？in-line-formula description =“In-line Formulas” - =“lead”？> - LQ <？in-line-formula description =“In-line Formulas”end =“tail”？> L是连接单元，Q优选为环状烃基单元; W 1优选是碳环单元，W 2是含杂原子的单元。

8. 发明授权

US6066751A Process for making epoxide intermediates 失效
标题翻译：制备环氧化物中间体的方法
公开(公告)号：US6066751A
公开(公告)日：2000-05-23
申请号：US148539
申请日：1998-09-04
申请人： John August Wos , Jack Snyder Amburgey, Jr. , Mitchell Anthony deLong , Yili Wang , Haiyan George Dai , Biswanath De
发明人： John August Wos , Jack Snyder Amburgey, Jr. , Mitchell Anthony deLong , Yili Wang , Haiyan George Dai , Biswanath De
IPC分类号： C07D301/14 , C07C405/00 , C07D303/12
CPC分类号： C07C405/00
摘要： It has been surprisingly discovered that the disadvantages of the lengthy literature procedures to synthesize 13,14-dihydro prostaglandin A, E, and F derivatives can be overcome using a novel Methyl 7-(2-hydroxy-5-(2-(2-oxiranyl)ethyl)-4-(1,1,2,2 tetramethyl-1-silapropoxy)cyclopentyl) heptanoate intermediate, which can be synthesized from commercially available Methyl 7-[3-(R)-hydroxy-5-oxo-1-cyclopent-1-yl] heptanoate. This novel intermediate can be coupled with oxygen, carbon, sulfur, and nitrogen nucleophiles, in the presence of a base or a Lewis acid, in a ring-opening process to provide 13,14-dihydro prostaglandin A, E, and F derivatives.
摘要翻译：已经令人惊讶地发现，使用新的7-（2-羟基-5-（2-（2-（2-甲氧基乙氧基）苯基）甲基丙烯酸甲酯，可以克服长时间合成13,14-二氢前列腺素A，E和F衍生物的文献程序的缺点，环氧乙烷基）乙基）-4-（1,1,2,2-四甲基-1-硅基丙氧基）环戊基）庚酸酯中间体，其可以从市售的7- [3-（R） - 羟基-5-氧代-1 环戊-1-基]庚酸乙酯。这种新型中间体可以在碱或路易斯酸的存在下与氧，碳，硫和氮亲核试剂在开环过程中偶联，得到13,14-二氢前列腺素A，E和F衍生物。

9. 再颁专利

USRE43372E1 C16 unsaturated FP-selective prostaglandins analogs 有权
标题翻译： C16不饱和FP选择性前列腺素类似物
公开(公告)号：USRE43372E1
公开(公告)日：2012-05-08
申请号：US12479532
申请日：2009-06-05
申请人： Mitchell Anthony deLong , David Lindsey Soper , John August Wos , Biswanath De
发明人： Mitchell Anthony deLong , David Lindsey Soper , John August Wos , Biswanath De
IPC分类号： C07C405/00 , A61K31/5575
CPC分类号： C07C405/0041 , C07C405/00 , C07C405/0016
摘要： Compounds having the general structure: which are useful for the treatment of a variety of diseases and conditions, such as bone disorders.
摘要翻译：具有一般结构的化合物：其可用于治疗各种疾病和病症，例如骨骼疾病。

10. 发明授权

US06451859B1 C16 unsaturated FP-selective prostaglandins analogs 有权
标题翻译： C16不饱和FP选择性前列腺素类似物
公开(公告)号：US06451859B1
公开(公告)日：2002-09-17
申请号：US09914531
申请日：2001-08-29
申请人： Mitchell Anthony deLong , David Lindsey Soper , John August Wos , Biswanath De
发明人： Mitchell Anthony deLong , David Lindsey Soper , John August Wos , Biswanath De
IPC分类号： C07C40500
CPC分类号： C07D333/36 , C07C59/215 , C07C59/56 , C07C59/72 , C07C235/26 , C07C251/06 , C07C259/06 , C07C311/51 , C07C327/22 , C07C405/00 , C07C2601/08 , C07D277/64 , C07D307/46 , C07D307/66 , C07D307/80 , C07D333/56
摘要： Compounds having a structure according to the following formula: are effective in treating disorders such as bone disorders and glaucoma in a subject in need thereof.
摘要翻译：具有根据下式的结构的化合物在有需要的受试者中有效治疗诸如骨病和青光眼的疾病。

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