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1. 发明授权

US09890351B2 Encapsulates 有权
公开(公告)号：US09890351B2
公开(公告)日：2018-02-13
申请号：US13569254
申请日：2012-08-08
申请人： Johan Smets , Susana Fernandez Prieto , Steven Daryl Smith , Todd Laurence Underiner , John August Wos , Wolfgang Edgar Huhn , Heath A. Frederick , Marta Giamberini , Bartosz Tylkowski
发明人： Johan Smets , Susana Fernandez Prieto , Steven Daryl Smith , Todd Laurence Underiner , John August Wos , Wolfgang Edgar Huhn , Heath A. Frederick , Marta Giamberini , Bartosz Tylkowski
IPC分类号： C11D17/00 , A61Q13/00 , A61K8/11 , C11D3/37 , C11D3/48 , C11D3/50 , A61Q5/02 , A61K8/81 , A61Q19/10 , A61Q5/12 , A61Q15/00 , A61Q19/00
CPC分类号： C11D17/0039 , A61K8/11 , A61K8/8129 , A61K8/8152 , A61K2800/412 , A61K2800/47 , A61K2800/81 , A61Q5/02 , A61Q5/12 , A61Q13/00 , A61Q15/00 , A61Q19/00 , A61Q19/10 , C11D3/373 , C11D3/48 , C11D3/505
摘要： The present application relates to encapsulates, compositions, products comprising such encapsulates, and processes for making and using such encapsulates. Such encapsulates comprise a core comprising a perfume and a shell that encapsulates said core, such encapsulates may optionally comprise a parametric balancing agent, such shell comprising one or more azobenzene moieties.

2. 发明申请

US20130039962A1 ENCAPSULATES 有权
标题翻译：包封
公开(公告)号：US20130039962A1
公开(公告)日：2013-02-14
申请号：US13569254
申请日：2012-08-08
申请人： Johan SMETS , Susana Fernandez Prieto , Steven Daryl Smith , Todd Laurence Underiner , John August Wos , Wolfgang Edgar Huhn , Heath A. Frederick , Marta Giamberini , Bartosz Tylkowski
发明人： Johan SMETS , Susana Fernandez Prieto , Steven Daryl Smith , Todd Laurence Underiner , John August Wos , Wolfgang Edgar Huhn , Heath A. Frederick , Marta Giamberini , Bartosz Tylkowski
IPC分类号： C11D3/50 , A61Q5/02 , A61Q15/00 , A61Q5/12 , A61Q19/00 , A61K8/11 , A61Q19/10
CPC分类号： C11D17/0039 , A61K8/11 , A61K8/8129 , A61K8/8152 , A61K2800/412 , A61K2800/47 , A61K2800/81 , A61Q5/02 , A61Q5/12 , A61Q13/00 , A61Q15/00 , A61Q19/00 , A61Q19/10 , C11D3/373 , C11D3/48 , C11D3/505
摘要： The present application relates to encapsulates, compositions, products comprising such encapsulates, and processes for making and using such encapsulates. Such encapsulates comprise a core comprising a perfume and a shell that encapsulates said core, such encapsulates may optionally comprise a parametric balancing agent, such shell comprising one or more azobenzene moieties.
摘要翻译：本申请涉及包含这些封装物的包封物，组合物，产品，以及制造和使用这种封装物的方法。这样的包封物包含包含香料和包封所述核心的壳的核心，这种包封物可任选地包含参与平衡剂，这种壳包含一个或多个偶氮苯部分。

3. 发明授权

US06541629B1 Enzyme inhibitors 失效
标题翻译：酶抑制剂
公开(公告)号：US06541629B1
公开(公告)日：2003-04-01
申请号：US09657963
申请日：2000-09-08
申请人： Scott Edward Osborne , Todd Laurence Underiner
发明人： Scott Edward Osborne , Todd Laurence Underiner
IPC分类号： C07D26526
CPC分类号： A61K47/60
摘要： The present invention relates to polymer conjugates having the formula: wherein T is a heterocyclic unit which is capable of inhibiting one or more proteolytic enzymes; L is a linking group; [Poly] is a polymeric unit, i indicates the number of said heterocyclic units which comprise said conjugate and has the value of from 1 to 100; z is 0 or 1, said polymer conjugates suitable for use in preventing skin irritation resulting from exposure of the skin to body fluids, inter alia, feces, menstrual fluid. The conjugates of the present invention are useful in diapers, dressings, sanitary napkins, and the like.
摘要翻译：本发明涉及具有下式的聚合物缀合物：其中T是能够抑制一种或多种蛋白水解酶的杂环单元; L是连接基团; [Poly]是聚合单元，i表示包含所述缀合物并且具有1至100的值的所述杂环单元的数目; z是0或1，所述聚合物共轭物适合用于防止皮肤暴露于体液，尤其是粪便，月经液引起的皮肤刺激。本发明的缀合物可用于尿布，敷料，卫生巾等。

4. 发明授权

US06504028B2 Process for preparing benzoxazin-4-one polymer conjugates 有权
标题翻译：制备苯并恶嗪-4-酮聚合物共轭物的方法
公开(公告)号：US06504028B2
公开(公告)日：2003-01-07
申请号：US09891475
申请日：2001-06-26
申请人： Renae Dianna Fossum , Todd Laurence Underiner
发明人： Renae Dianna Fossum , Todd Laurence Underiner
IPC分类号： C07D26512
CPC分类号： C08F8/30
摘要： The present invention relates to a process for forming polymer conjugates which are useful as enzyme inhibitors. The process of the present invention comprises the steps of: a) reacting a polymer or copolymer alcohol to form a chloroformate; b) combining a substituted or unsubstituted anthranilic acid comprising an enzyme interaction attenuating unit; and a base catalyst wherein the base catalyst is a supported base catalyst, to form a substrate reactive admixture; and c) adding to said chloroformate formed in step (a) said substrate reactive admixture formed in step (b) to form a benzoxazin-4-one conjugate.
摘要翻译：本发明涉及可用作酶抑制剂的聚合物缀合物的形成方法。本发明的方法包括以下步骤：a）使聚合物或共聚物醇反应形成氯甲酸酯; b）将包含酶相互作用衰减单元的取代或未取代的邻氨基苯甲酸组合; 和碱催化剂，其中所述碱催化剂是负载的碱催化剂，以形成底物反应性混合物; 和c）加入步骤（a）中形成的所述氯甲酸酯在步骤（b）中形成的所述底物反应性混合物以形成苯并恶嗪-4-酮缀合物。

5. 发明申请

US20090131890A1 PROTEASE INHIBITORS IN ABSORBENT ARTICLES 有权
标题翻译：吸收物质中的蛋白酶抑制剂
公开(公告)号：US20090131890A1
公开(公告)日：2009-05-21
申请号：US12358697
申请日：2009-01-23
申请人： Francis James Rourke , Scott Edward Osborne , Donald Carroll Roe , Todd Laurence Underiner , John McMillan Mciver , Timothy Bates
发明人： Francis James Rourke , Scott Edward Osborne , Donald Carroll Roe , Todd Laurence Underiner , John McMillan Mciver , Timothy Bates
IPC分类号： A61F13/40
CPC分类号： A61B5/441 , A61L15/44 , A61L2300/434
摘要： The invention provides an absorbent article, at least a portion of which has a protease inhibitor incorporated therein to decrease the activity of proteases that may otherwise initiate or contribute to inflammation of the skin of a wearer of the article resulting in skin irritation or dermatitis. The article can further comprise a delivery system for releasably containing and delivering the protease inhibitor to at least a portion of the skin of the wearer. The delivery system can comprise a skin care composition and at least a portion of the composition, including the protease inhibitor, is automatically transferred from the article to the wearer's skin without manual intervention during normal usage of the article to form a defense against protease activity. Most preferably, repeated application of similarly treated articles to the wearer's skin provides an available source from which the protease inhibitor continuously transfers onto the skin over time and accumulates to provide a proactive defense against protease activity for the reduction or prevention of skin irritation or dermatitis due to proteolytic enzymes.
摘要翻译：本发明提供一种吸收制品，其至少一部分具有并入其中的蛋白酶抑制剂以降低蛋白酶的活性，否则其可引起或促成造成皮肤刺激或皮炎的制品佩戴者的皮肤炎症。该制品还可包括用于将蛋白酶抑制剂可释放地包含并递送至穿戴者皮肤的至少一部分的递送系统。递送系统可以包含皮肤护理组合物，并且包括蛋白酶抑制剂在内的组合物的至少一部分在制品的正常使用期间被自动地从制品转移到穿着者的皮肤，而无需人工干预，以形成抗蛋白酶活性的防御。最优选地，将类似处理的物品重复应用于穿着者的皮肤提供了可用的来源，蛋白酶抑制剂从该蛋白酶抑制剂随时间连续转移到皮肤上并积聚以提供主动防御蛋白酶活性，以减少或预防皮肤刺激或皮炎到蛋白水解酶。

6. 发明授权

US07152809B2 Methods and personal protection devices for repelling insects 有权
公开(公告)号：US07152809B2
公开(公告)日：2006-12-26
申请号：US11248672
申请日：2005-10-12
申请人： Marcia Mary Ketcha , Pedro Antonio Rodriguez , Todd Laurence Underiner , Lowen Robert Morrison , Dennis Allen Beckholt , Robert Stanley Dirksing , David Burton Moore , Kendal William Kerr , James Douglas Still , Peter Blenkiron , Fernando Benvegnu , John Patrick Herlinger , Charles Winston Saunders , Andrew Wilson
发明人： Marcia Mary Ketcha , Pedro Antonio Rodriguez , Todd Laurence Underiner , Lowen Robert Morrison , Dennis Allen Beckholt , Robert Stanley Dirksing , David Burton Moore , Kendal William Kerr , James Douglas Still , Peter Blenkiron , Fernando Benvegnu , John Patrick Herlinger , Charles Winston Saunders , Andrew Wilson
IPC分类号： B05B1/24
CPC分类号： A01M1/2077 , A01M1/205 , A01M1/2072 , A01M29/12 , A01M2200/011 , A01M2200/012 , Y10S261/88
摘要： Methods and devices for repelling insects are disclosed. The methods and devices provide personal protection from insect bites and insect landings, particularly mosquito bites. The methods and devices employ insect repellents such as pyrethroids at low (parts per billion) levels. The methods and devices effectively minimize the number of mosquitoes landing on a subject properly using the devices.

7. 发明授权

US07007861B2 Methods and personal protection devices for repelling insects 有权
公开(公告)号：US07007861B2
公开(公告)日：2006-03-07
申请号：US09795420
申请日：2001-02-28
申请人： Marcia Mary Ketcha , Pedro Antonio Rodriguez , Todd Laurence Underiner , Lowen Robert Morrison , Dennis Allen Beckholt , Robert Stanley Dirksing , David Burton Moore , Kendal William Kerr , James Douglas Still , Peter Blenkiron , Fernando Benvegnu , John Patrick Herlinger , Charles Winston Saunders , Andrew Wilson
发明人： Marcia Mary Ketcha , Pedro Antonio Rodriguez , Todd Laurence Underiner , Lowen Robert Morrison , Dennis Allen Beckholt , Robert Stanley Dirksing , David Burton Moore , Kendal William Kerr , James Douglas Still , Peter Blenkiron , Fernando Benvegnu , John Patrick Herlinger , Charles Winston Saunders , Andrew Wilson
IPC分类号： B05B1/24
CPC分类号： A01M1/2077 , A01M1/205 , A01M1/2072 , A01M29/12 , A01M2200/011 , A01M2200/012 , Y10S261/88
摘要： Methods and devices for repelling insects are disclosed. The methods and devices provide personal protection from insect bites and insect landings, particularly mosquito bites. The methods and devices employ insect repellents such as pyrethroids at low (parts per billion) levels. The methods and devices effectively minimize the number of mosquitoes landing on a subject properly using the devices.

8. 发明授权

US06723788B1 Enzyme inhibitors 失效
标题翻译：酶抑制剂
公开(公告)号：US06723788B1
公开(公告)日：2004-04-20
申请号：US09658335
申请日：2000-09-08
申请人： Scott Edward Osborne , Todd Laurence Underiner
发明人： Scott Edward Osborne , Todd Laurence Underiner
IPC分类号： C08F832
CPC分类号： A61K47/60
摘要： The present invention relates to compositions which comprise one or more polymer conjugates having the formula: wherein T is a heterocyclic unit which is capable of inhibiting one or more proteolytic enzymes; L is a linking group; [Poly] is a polymeric unit, i indicates the number of said heterocyclic units which comprise said conjugate and has the value of from 1 to 100; z is 0 or 1, said polymer conjugates suitable for use in preventing skin irritation resulting from exposure of the skin to body fluids, inter alia, feces, menstrual fluid. The conjugates of the present invention are useful in diapers, dressings, sanitary napkins, and the like.
摘要翻译：本发明涉及包含一种或多种具有下式的聚合物缀合物的组合物：其中T是能够抑制一种或多种蛋白水解酶的杂环单元; L是连接基团; [聚]是聚合单元，i表示包含所述缀合物并且具有1至100的值的所述杂环单元的数目; z是0或1，所述聚合物共轭物适合用于防止皮肤暴露于体液，尤其是粪便，月经液引起的皮肤刺激。本发明的缀合物可用于尿布，敷料，卫生巾等。

9. 发明授权

US07168630B1 Methods and personal protection devices for repelling insects 有权
标题翻译：用于排斥昆虫的方法和个人防护装置
公开(公告)号：US07168630B1
公开(公告)日：2007-01-30
申请号：US11248532
申请日：2005-10-12
申请人： Marcia Mary Ketcha , Pedro Antonio Rodriguez , Todd Laurence Underiner , Lowen Robert Morrison , Dennis Allen Beckholt , Robert Stanley Dirksing , David Burton Moore , Kendal William Kerr , James Douglas Still , Peter Blenkiron , Fernando Benvegnu , John Patrick Herlinger , Charles Winston Saunders , Andrew Wilson
发明人： Marcia Mary Ketcha , Pedro Antonio Rodriguez , Todd Laurence Underiner , Lowen Robert Morrison , Dennis Allen Beckholt , Robert Stanley Dirksing , David Burton Moore , Kendal William Kerr , James Douglas Still , Peter Blenkiron , Fernando Benvegnu , John Patrick Herlinger , Charles Winston Saunders , Andrew Wilson
IPC分类号： B05B1/24
CPC分类号： A01M1/2077 , A01M1/205 , A01M1/2072 , A01M29/12 , A01M2200/011 , A01M2200/012 , Y10S261/88
摘要： Methods and devices for repelling insects are disclosed. The methods and devices provide personal protection from insect bites and insect landings, particularly mosquito bites. The methods and devices employ insect repellents such as pyrethroids at low (parts per billion) levels. The methods and devices effectively minimize the number of mosquitoes landing on a subject properly using the devices.
摘要翻译：公开了用于排斥昆虫的方法和装置。这些方法和设备提供个人防护，防止昆虫叮咬和昆虫着陆，特别是蚊子叮咬。方法和装置使用低（十亿分之一）级别的拟除虫菊酯的驱虫剂。这些方法和设备有效地将使用这些装置的蚊子落在对象上的次数有效地最小化。

10. 发明授权

US6066673A Enzyme inhibitors 失效
标题翻译：酶抑制剂
公开(公告)号：US6066673A
公开(公告)日：2000-05-23
申请号：US41196
申请日：1998-03-12
申请人： John McMillan McIver , Todd Laurence Underiner , Timothy Bates
发明人： John McMillan McIver , Todd Laurence Underiner , Timothy Bates
IPC分类号： A61K8/30 , A61K20060101 , A61K8/00 , A61K8/42 , A61K8/49 , A61K8/86 , A61K31/155 , A61K31/167 , A61K31/216 , A61K31/505 , A61K31/77 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/12 , A61P43/00 , A61Q17/00 , C07C257/14 , C07C257/18 , C07C277/08 , C07C279/18 , C07D233/04 , C07D239/06 , C08G20060101 , C08G65/329 , C08G65/48 , C12N20060101
CPC分类号： C08G65/333 , A61K31/155 , A61K31/77 , A61K8/0208 , A61K8/0216 , A61K8/86 , A61Q19/00 , C07C257/14 , C07C257/18 , C07C279/18 , C08G65/3326 , A61K2800/92 , Y10S514/844 , Y10S514/846
摘要： The present invention relates to compounds, compositions, and methods which are useful for the prevention and treatment of adverse health, skin, hair, and oral conditions. The compounds, compositions, and methods are also widely applicable for use in health, skin, hair, oral, beauty, and personal care applications.In particular, the present invention relates to compounds having the structure: ##STR1## and the tautomers, acceptable salts, and biohydrolyzable amides, esters, and imides thereof, wherein A, Q, n, P, L.sub.1, L.sub.2, L.sub.3, L.sub.4, Z, X, B.sub.1, and B.sub.2 are defined herein.
摘要翻译：本发明涉及可用于预防和治疗不良健康，皮肤，头发和口腔状况的化合物，组合物和方法。化合物，组合物和方法也广泛适用于健康，皮肤，头发，口腔，美容和个人护理用途。特别地，本发明涉及具有以下结构的化合物：和互变异构体，可接受的盐和可生物水解的酰胺，酯和酰亚胺，其中A，Q，n，P，L1，L2，L3，L4，Z，X ，B1和B2在本文中定义。

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