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1. 发明申请

US20090090865A1 DEVICE FOR MONITORING EXPOSURE TO RADIATION, USE OF SUCH A DEVICE, AN ARTICLE AND A METHOD FOR MONITORING EXPOSURE TO RADIATION 审中-公开
标题翻译：用于监测辐射暴露的装置，这种装置的使用，文章和用于监测辐射暴露的方法
公开(公告)号：US20090090865A1
公开(公告)日：2009-04-09
申请号：US12282027
申请日：2007-02-28
申请人： Johan Lub , Eduard Meijer
发明人： Johan Lub , Eduard Meijer
IPC分类号： G02F1/13 , C09K19/00
CPC分类号： G01J1/50 , G01J1/429 , G02F1/13718
摘要： A device (1) for monitoring exposure to radiation (L), particularly ultraviolet radiation, at least comprising cholesteric liquid crystal material (3) having a photo-isomer sable compound, such that during use, a light reflection band of the cholesteric liquid crystal material (3) can be modified upon exposure to the radiation to be monitored. The invention also provides a method for monitoring exposure to radiation.
摘要翻译：一种用于监测暴露于辐射（L）的装置（1），特别是紫外线辐射，至少包括具有光异构化合物的胆固醇液晶材料（3），使得在使用期间胆甾型液晶的光反射带材料（3）可以在暴露于待监测的辐射之后进行修改。本发明还提供了一种监测辐射暴露的方法。

2. 发明授权

US09913921B2 Pretargeting kit for imaging or therapy comprising a trans-cyclooctene dienophile and a diene 有权
公开(公告)号：US09913921B2
公开(公告)日：2018-03-13
申请号：US14115455
申请日：2012-05-07
申请人： Marc Stefan Robillard , Johan Lub , Raffaella Rossin , Sandra Martina Van Ben Bosch , Ronny Mathieu Versteegen
发明人： Marc Stefan Robillard , Johan Lub , Raffaella Rossin , Sandra Martina Van Ben Bosch , Ronny Mathieu Versteegen
IPC分类号： A61K51/10 , A61K51/04 , B82Y5/00 , C07D207/46 , C07D235/02 , C07D245/02 , C07D249/16 , A61K47/68 , A61K49/10
CPC分类号： A61K51/1093 , A61K47/6897 , A61K49/106 , A61K51/041 , A61K51/0495 , A61K51/0497 , B82Y5/00 , C07D207/46 , C07D235/02 , C07D245/02 , C07D249/16
摘要： Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an E-cyclooctene which has a flattened structure as a result of the position of at least two exocyclic bonds.

3. 发明授权

US08409674B2 Alignment layer with reactive mesogens for aligning liquid crystal molecules 有权
标题翻译：具有用于对准液晶分子的反应性介晶的对准层
公开(公告)号：US08409674B2
公开(公告)日：2013-04-02
申请号：US10567552
申请日：2004-07-26
申请人： Richard Harding , Alison Linda May , Simon Greenfield , Johan Lub , Ciska Doornkamp , René Theodorus Wegh
发明人： Richard Harding , Alison Linda May , Simon Greenfield , Johan Lub , Ciska Doornkamp , René Theodorus Wegh
IPC分类号： C09K19/56 , G02F1/1337
CPC分类号： B82Y30/00 , G02F1/133711 , G02F1/133723 , G02F2001/133726 , Y10T428/1005 , Y10T428/1023 , Y10T428/31721
摘要： The invention relates to an alignment layer for aligning liquid crystal molecules, with improved adhesion to liquid crystal (LC) films, to a composition containing a precursor material used for the preparation of such a layer, to a laminate comprising such a layer and at least one LC polymer film, and to the use of the alignment layer and the laminate for optical, electrooptical, decorative or security uses and devices, wherein the alignment layer and the precursor material comprise at least one reactive mesogen in monomeric, oligomeric or polymeric form.
摘要翻译：本发明涉及一种用于将液晶分子对准的取向层与对液晶（LC）膜的粘合性提高到包含用于制备这种层的前体材料的组合物，一个LC聚合物膜，以及用于光学，电光，装饰或安全用途和装置的对准层和层压材料的使用，其中定向层和前体材料包含单体，低聚或聚合形式的至少一种反应性介晶。

4. 发明申请

US20120039803A1 PRETARGETING KIT, METHOD AND AGENTS USED THEREIN 审中-公开
标题翻译：预备套件，使用的方法和代理
公开(公告)号：US20120039803A1
公开(公告)日：2012-02-16
申请号：US13264526
申请日：2010-04-12
申请人： Marc Stefan Robillard , Raffaella Rossin , Johan Lub , Pascal Renart Verkerk , Dirk Burdinski
发明人： Marc Stefan Robillard , Raffaella Rossin , Johan Lub , Pascal Renart Verkerk , Dirk Burdinski
IPC分类号： A61K31/444 , A61K51/04 , A61K49/04 , A61K49/10 , A61K49/22 , A61K49/00 , C07D401/14
CPC分类号： B82Y5/00 , A61K47/6897 , A61K51/0495 , A61K51/1027 , A61K51/1045
摘要： Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an alkene or alkyne dienohile.
摘要翻译：描述了用于靶向医学成像和/或治疗剂的预靶向方法和相关试剂盒，其中使用对彼此显示出生物正交反应性的非生物反应性化学基团。本发明涉及使用[4 + 2]反电子需求（复古）Diels-Alder化学来提供预瞄准探针和效应探针之间的耦合。为此目的，这些探针中的一种包括电子缺乏四嗪或其它合适的二烯，另一种是烯烃或炔烃二酮。

5. 发明申请

US20110165074A1 CHELATING AMPHIPHILIC POLYMERS 有权
标题翻译：吸引人气聚合物
公开(公告)号：US20110165074A1
公开(公告)日：2011-07-07
申请号：US13062742
申请日：2009-09-08
申请人： Holger Gruell , Anke De Vries , Sander Langereis , Johan Lub , Erica M.G. Aussems-Custers
发明人： Holger Gruell , Anke De Vries , Sander Langereis , Johan Lub , Erica M.G. Aussems-Custers
IPC分类号： A61K51/12 , C08F8/32 , A61K47/34 , A61K49/12
CPC分类号： C08G81/025 , A61K9/107 , A61K9/1075 , A61K9/1273 , A61K9/5146 , A61K49/0414 , A61K49/126 , A61K49/1806 , A61K49/1812 , A61K49/1818 , A61K51/06 , A61K51/065 , A61K51/1217 , A61K51/1237 , A61K51/1251
摘要： Described are amphiphilic polymers that are provided with chelating moieties. The amphiphilic polymers are block copolymers comprising a hydrophilic block and a hydrophobic block, with the chelating moieties linked to the end-group of the hydrophilic block. The disclosed polymers are capable of self-assembly into structures such as micelles and polymersomes. With suitable metals present in the form of coordination complexes with 5 the chelating moieties, the chelating amphiphilic polymers of the invention are suitable for use in various imaging techniques requiring metal labeling, such as MRI (T 1/T 2 weighted contrast agents or CEST contrast agents) SPECT, PET or Spectral CT.
摘要翻译：描述的是具有螯合部分的两亲性聚合物。两亲聚合物是包含亲水嵌段和疏水嵌段的嵌段共聚物，螯合部分连接到亲水嵌段的端基。所公开的聚合物能够自组装成结构如胶束和聚合物囊泡。使用与5个螯合部分配位络合物形式的合适金属，本发明的螯合两亲性聚合物适用于需要金属标记的各种成像技术，例如MRI（T 1 / T 2加权造影剂或CEST对比度药剂）SPECT，PET或光谱CT。

6. 发明申请

US20060040068A1 Method of manufacturing a cholesteric layer 审中-公开
标题翻译：胆甾醇层的制造方法
公开(公告)号：US20060040068A1
公开(公告)日：2006-02-23
申请号：US10533059
申请日：2003-10-07
申请人： Rene Wegh , Johan Lub
发明人： Rene Wegh , Johan Lub
IPC分类号： C09K19/00
CPC分类号： C09K19/3857 , G02B5/3016 , G02F1/133536 , G02F2001/133543 , Y10T428/1005
摘要： The invention pertains to a method of manufacturing a layer of a cholesterically ordered polymer material, in which the material is oriented in such a way that the axis of the molecular helix of the cholesterically ordered material extends transversely to the layer, wherein the method comprises the steps: a) providing a layer comprising a cholesterically ordered mixture of a low-molecular weight polymerizable material and a high-molecular weight material, which high-molecular weight material comprises a quantity of a convertible group, which in its non-converted and in its converted state determines the pitch or the material to a different extent, the conversion of said high-molecular weight material being inducible by radiation, and the layer absorbs said radiation; b) irradiating the layer to convert at least a part of the convertible groups it the irradiated parts of the layer; c) letting at least the low-molecular weight material reorient to form the required helical structure; d) at least partially polymerizing and/or cross-linking the low-molecular weight material with itself and/or with the high-molecular weight material to freeze in the formed structure.
摘要翻译：本发明涉及一种制造胆甾醇有序聚合物材料层的方法，其中材料以这样一种方式取向，使得胆甾醇排序材料的分子螺旋轴线横向于该层延伸，其中该方法包括步骤：a）提供包含低分子量可聚合材料和高分子量材料的胆甾醇排序混合物的层，该高分子量材料包含一定量的可转化基团，其在其未转化和其转化状态决定了沥青或材料的不同程度，所述高分子量材料的转化可通过辐射诱导，并且该层吸收所述辐射; b）照射该层以将其所辐照的部分的至少一部分可转换基团转化; c）使至少低分子量材料重新取向以形成所需的螺旋结构; d）至少部分地将低分子量材料与其自身和/或与高分子量材料聚合和/或交联以在形成的结构中冷冻。

7. 发明申请

US20060022167A1 Chiral dopant with phenylethanediol functionality 失效
标题翻译：手性掺杂剂与苯乙二醇功能
公开(公告)号：US20060022167A1
公开(公告)日：2006-02-02
申请号：US10519604
申请日：2003-06-13
申请人： Johan Lub , Rene Wegh
发明人： Johan Lub , Rene Wegh
IPC分类号： C09K19/36 , C09K19/52 , C09K19/20 , C07C69/76
CPC分类号： C07D493/04 , C07C69/92 , C09K19/586 , Y10T428/10 , Y10T428/1036
摘要： The invention pertains to a phenylethanediol derivative having at least one polymerizable group, characterized in that the phenylethanediol derivative further comprises at least one photo-convertible group for adjusting the helical twisting power of the phenylethanediol derivative. According to a preferred embodiment the phenylethanediol has the formula wherein A stands for a bond or a p-phenylene group; B and B′ are independently (O)p—CoH2o—O—CO—CR′═CH2, o being 2-12, p being 0 or 1, and R′ being H or CH3; P stands for a CH2 or a C═O group; Q and Q′ are independently selected from H, C1-C3 alkyl, C1-C3 alkoxy, halogen, and CN; n is an integer from 1 to 3; and m is an integer from 0 to 2; and: wherein A stands for a bond or a p-phenylene group; B is (O)p—CoH2o—O—CO—CR′═CH2, o being 2-12, p is 1, and R′ being H or CH3; P stands for a CH2 or a C═O group; Q is selected from H, C1-C3 alkyl, C1-C3 alkoxy, halogen, and CN; and m is an integer from 0 to 2.
摘要翻译：本发明涉及具有至少一个可聚合基团的苯乙二醇衍生物，其特征在于所述苯乙二醇衍生物还包含至少一个用于调节苯乙二醇衍生物的螺旋扭转能力的光转化基团。根据优选的实施方案，苯乙二醇具有下式：其中A代表键或对亚苯基; B和B'独立地是（O）-O-CO-CR'-CH 2，-O-CO-CR'-CH 2， / SUB，o为2-12，p为0或1，R'为H或CH 3。 P代表CH 2或C-O基团; Q和Q'独立地选自H，C 1 -C 3烷基，C 1 -C 3烷氧基，卤素和CN; n为1〜3的整数， m为0〜2的整数。和：其中A代表键或对亚苯基; B是（O）-O-CO-CR'-CH 2，-O-CO-CR'-CH 2， o为2-12，p为1，R'为H或CH 3。 P代表CH 2或C-O基团; Q选自H，C 1 -C 3烷基，C 1 -C 3烷氧基，卤素和CN; m为0〜2的整数。

8. 发明授权

US09463256B2 Pretargeting kit, method and agents used therein 有权
标题翻译：预定位试剂盒，其中使用的方法和试剂
公开(公告)号：US09463256B2
公开(公告)日：2016-10-11
申请号：US13877725
申请日：2011-10-11
申请人： Johan Lub , Wolter Ten Hoeve , Raffaella Rossin , Sandra Martina Van Den Bosch , Marc Stefan Robillard
发明人： Johan Lub , Wolter Ten Hoeve , Raffaella Rossin , Sandra Martina Van Den Bosch , Marc Stefan Robillard
IPC分类号： A61K51/04 , A61K51/10 , A61K47/48 , A61K49/16 , B82Y5/00
CPC分类号： A61K51/1093 , A61K47/6889 , A61K47/6891 , A61K49/16 , A61K51/0495 , A61K51/10 , B82Y5/00
摘要： Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an E-cyclooctene which has one or more axial substituents.
摘要翻译：描述了用于靶向医学成像和/或治疗剂的预靶向方法和相关试剂盒，其中使用对彼此显示出生物正交反应性的非生物反应性化学基团。本发明涉及使用[4 + 2]反电子需求（复古）Diels-Alder化学来提供预瞄准探针和效应探针之间的耦合。为此目的，这些探针中的一个包括电子缺乏四嗪或其它合适的二烯，另一个是具有一个或多个轴取代基的E-环辛烯。

9. 发明授权

US09310050B2 Light-emitting arrangement with organic phosphor 有权
标题翻译：发光布置与有机磷光体
公开(公告)号：US09310050B2
公开(公告)日：2016-04-12
申请号：US13825701
申请日：2011-09-21
申请人： Johan Lub , Rifat Ata Mustafa Hikmet , Rene Theodorus Wegh
发明人： Johan Lub , Rifat Ata Mustafa Hikmet , Rene Theodorus Wegh
IPC分类号： C08G73/06 , F21V9/16 , C08G63/181 , C08G63/187 , C08G63/199 , C09K11/06 , H05B33/14 , H05B33/20
CPC分类号： F21V9/30 , C08G63/181 , C08G63/187 , C08G63/199 , C09K11/06 , C09K2211/1011 , C09K2211/1044 , F21K9/64 , F21Y2101/00 , F21Y2115/10 , H05B33/14 , H05B33/20
摘要： The invention provides a light-emitting arrangement (100) comprising a light source (105) adapted to emit light of a first wavelength, and a wavelength converting member (106) arranged to receive light of said first wavelength and adapted to convert at least part of the light of said first wavelength to light of a second wavelength, said wavelength converting member comprising i) a carrier polymeric material comprising a polyester backbone comprising an aromatic moiety, and ii) at least one wavelength converting material of a specified general formula. The perylene derived compounds have been found to have excellent stability when incorporated into said matrix material.
摘要翻译：本发明提供了一种包括适于发射第一波长的光的光源（105）的发光装置（100）和布置成接收所述第一波长的光的波长转换构件（106），并且适于将至少部分所述波长转换元件包括i）载体聚合物材料，其包含包含芳族部分的聚酯主链，和ii）至少一种具有特定通式的波长转换材料。已经发现苝衍生化合物在掺入所述基体材料中时具有优异的稳定性。

10. 发明授权

US08481130B2 Alignment layer with reactive mesogens for aligning liquid crystal molecules 有权
标题翻译：具有用于对准液晶分子的反应性介晶的对准层
公开(公告)号：US08481130B2
公开(公告)日：2013-07-09
申请号：US13614733
申请日：2012-09-13
申请人： Richard Harding , Alison Linda May , Simon Greenfield , Johan Lub , Ciska Doornkamp , Rene Theodorus Wegh
发明人： Richard Harding , Alison Linda May , Simon Greenfield , Johan Lub , Ciska Doornkamp , Rene Theodorus Wegh
IPC分类号： C09K19/56 , G02F1/1337
CPC分类号： B82Y30/00 , G02F1/133711 , G02F1/133723 , G02F2001/133726 , Y10T428/1005 , Y10T428/1023 , Y10T428/31721
摘要： The invention relates to an alignment layer with improved adhesion to liquid crystal (LC) films, to a precursor material used for the preparation of such a layer, to a laminate comprising such a layer and at least one LC polymer film, and to the use of the alignment layer and the laminate for optical, electrooptical, decorative or security uses and devices, wherein the alignment layer and the precursor material comprise at least one reactive mesogen in monomeric, oligomeric or polymeric form.
摘要翻译：本发明涉及一种对液晶（LC）膜的粘附性提高到用于制备这种层的前体材料的对准层，包括这种层和至少一个LC聚合物膜的层压体以及使用对准层和用于光学，电光，装饰或安全用途和装置的层压材料，其中取向层和前体材料包含单体，低聚或聚合形式的至少一种反应性介晶。

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