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1. 发明授权

US09754776B2 Luminescent converter for a phosphor-enhanced light source 有权
公开(公告)号：US09754776B2
公开(公告)日：2017-09-05
申请号：US13262873
申请日：2010-03-31
申请人： Cornelia Titia Staats , Gerardus Arnoldus Rita Van Dijk , Rene Theodorus Wegh , Willibrordus Hubertus Martinus Maria Van De Spijker , Martinus Petrus Joseph Peeters
发明人： Cornelia Titia Staats , Gerardus Arnoldus Rita Van Dijk , Rene Theodorus Wegh , Willibrordus Hubertus Martinus Maria Van De Spijker , Martinus Petrus Joseph Peeters
IPC分类号： H01J61/48 , H01J61/38 , H01J61/44 , C09K11/06 , C09K11/77 , H01L33/50
CPC分类号： H01J61/44 , C09K11/06 , C09K11/7774 , H01J61/48 , H01L33/504
摘要： The invention relates to a luminescent converter (10, 12) for a phosphor-enhanced light source (100, 102, 104). The luminescent converter comprises a first luminescent material (20) configured for absorbing at least a part of excitation light (hv0) emitted by a light emitter (40, 42) of the phosphor-enhanced light source, and for converting at least a part of the absorbed excitation light into first emission light (hv1) comprising a longer wavelength compared to the excitation light. The luminescent converter further comprising a second luminescent material (30) comprising organic luminescent material (30) and configured for absorbing at least a part of the first emission light emitted by the first luminescent material, and for converting at least a part of the absorbed first emission light into second emission light (hv2) having a longer wavelength compared to the first emission light.An effect of the luminescent converter according to the invention is that the two-step light conversion according to the invention generates a relatively small Stokes shift of the light emitted by the organic luminescent material. The inventors have found that by reducing the Stokes shift of the organic luminescent material, the width of the spectrum of the second emission light is limited to reduce an infrared part in the emission spectrum. As such, the efficiency is improved.

2. 发明授权

US08734761B2 Responsive MRI contrast agents 有权
标题翻译：响应性MRI造影剂
公开(公告)号：US08734761B2
公开(公告)日：2014-05-27
申请号：US11912694
申请日：2006-04-21
申请人： Nicolaas Petrus Willard , Rene Theodorus Wegh , Jeroen Alphons Pikkemaat , Holger Gruell
发明人： Nicolaas Petrus Willard , Rene Theodorus Wegh , Jeroen Alphons Pikkemaat , Holger Gruell
IPC分类号： A61B5/055
CPC分类号： A61K49/124 , A61K49/1812 , A61K49/1821
摘要： The invention provides MRI contrast agents which provide a high sensitivity and which have an optimised body retention time. These agents enable the mapping of the local pH, temperature, oxygen concentration or other metabolites in a patient's body by the use of Chemical Exchange Saturation Transfer (CEST). Particularly pH and temperature mapping are useful for the detection of small cancer lesions and localized inflammation respectively.
摘要翻译：本发明提供了提供高灵敏度并且具有优化的身体保留时间的MRI造影剂。这些试剂可以通过使用化学交换饱和转移（CEST）来测定患者体内的局部pH，温度，氧浓度或其他代谢物。特别是pH和温度映射可用于分别检测小癌病变和局部炎症。

3. 发明授权

US08310144B2 Illumination system and display device 有权
标题翻译：照明系统和显示设备
公开(公告)号：US08310144B2
公开(公告)日：2012-11-13
申请号：US12445467
申请日：2007-10-15
申请人： Christoph Gerard August Hoelen , Rene Theodorus Wegh , Jan Broere , Ludo Haenen
发明人： Christoph Gerard August Hoelen , Rene Theodorus Wegh , Jan Broere , Ludo Haenen
IPC分类号： H01J1/62
CPC分类号： G02F1/133603 , C09K11/0883 , C09K11/7774 , G02F2001/133614 , H05B33/14
摘要： A luminair and a display device including a light emitting diode, a light exit window and a luminescent layer arranged between the light emitting diode and the light exit window. The light emitting diode emits light of a first primary color. The luminescent layer is arranged between the light emitting diode and the light exit window for converting part of the light emitted by the light emitting diode into light of a second primary color. The luminescent layer includes a garnet luminescent material of one of at least Lutetium, Cerium, Silicon and Nitrogen, or a combination of a garnet luminescent material of at least Lutetium and Cerium and a garnet luminescent material of at least Cerium and at least one of Yttrium and Gadolinium.
摘要翻译：一种灯具和显示装置，包括发光二极管，光出射窗和布置在发光二极管和光出射窗之间的发光层。发光二极管发射第一基色的光。发光层布置在发光二极管和光出射窗之间，用于将由发光二极管发射的光的一部分转换为第二基色的光。发光层包括至少镥，铈，硅和氮中的至少一种的石榴石发光材料，或至少镥和铈的石榴石发光材料和至少铈的石榴石发光材料和至少一种钇的组合和钆。

4. 发明授权

US08306603B2 MRI involving contrast agent with time modulated contrast enhancement 有权
标题翻译：涉及造影剂的MRI与时间调制对比度增强
公开(公告)号：US08306603B2
公开(公告)日：2012-11-06
申请号：US11912674
申请日：2006-04-25
申请人： Nicolaas Petrus Willard , Rene Theodorus Wegh , Jeroen Alphons Pikkemaat , Holger Gruell , Tobias Schaeffter , Rudolf Mathias Johannes Nicolaas Lamerichs
发明人： Nicolaas Petrus Willard , Rene Theodorus Wegh , Jeroen Alphons Pikkemaat , Holger Gruell , Tobias Schaeffter , Rudolf Mathias Johannes Nicolaas Lamerichs
IPC分类号： A61B5/05
CPC分类号： G01R33/5601 , A61K49/124 , G01R33/5605
摘要： The present invention provides a method MRI imaging. By applying a time modulation to the contrast enhancement of an MRI contrast agent, the method according to the invention leads to images with improved signal-to-noise ratio in the contrast-enhanced areas, strongly suppressed unwanted signal in the unenhanced areas, and reduced artefacts, such as motion artefacts.
摘要翻译：本发明提供一种MRI成像方法。通过对MRI造影剂的对比度增强应用时间调制，根据本发明的方法导致对比度增强区域中具有改善的信噪比的图像，强烈地抑制未增强区域中的不需要的信号，并且减少人造物，如运动文物。

5. 发明申请

US20110210273A1 UV LAMP 审中-公开
标题翻译：紫外线灯
公开(公告)号：US20110210273A1
公开(公告)日：2011-09-01
申请号：US13128248
申请日：2009-11-06
申请人： Ralph Kurt , Elvira Johanna Maria Paulussen , Bastiaan Uitbeijerse , Marco Van As , Rene Theodorus Wegh
发明人： Ralph Kurt , Elvira Johanna Maria Paulussen , Bastiaan Uitbeijerse , Marco Van As , Rene Theodorus Wegh
IPC分类号： G01J3/10
CPC分类号： G02B19/0019 , F21V7/04 , F21V29/505 , G02B19/0023 , G02B19/0047 , G02B19/0095
摘要： The invention relates to an UV lamp (100) that may for example be used as a torch for crime inspection. The UV lamp (100) comprises a light source (50), e.g. an UV LED, and a reflector (30) which are designed such that a light spot comprising an inner region of a given minimal diameter D at an axial distance of about 8-D is produced which has an intensity variation of less than about 20%. The reflector (30) may preferably be a Compound Parabolic Concentrator (CPC) with a high aspect ratio. Moreover, the UV lamp (100) may comprise a luminescent indicator for making activity of the UV lamp visible to a user.
摘要翻译：本发明涉及一种UV灯（100），其可以例如用作用于犯罪检查的火炬。 UV灯（100）包括光源（50） UV LED和反射器（30），其被设计成使得包含在约8-D的轴向距离处的给定最小直径D的内部区域的光斑具有小于约20％的强度变化，。反射器（30）可以优选地是具有高纵横比的复合抛物面聚焦器（CPC）。此外，UV灯（100）可以包括用于使UV灯的活动对用户可见的发光指示器。

6. 发明申请

US20100327306A1 LED BASED LIGHT SOURCE FOR IMPROVED COLOR SATURATION 审中-公开
标题翻译：基于LED的光源改进色彩饱和度
公开(公告)号：US20100327306A1
公开(公告)日：2010-12-30
申请号：US12865872
申请日：2009-02-05
申请人： Petrus Johannes Mathijs Van Der Burgt , Rene Theodorus Wegh
发明人： Petrus Johannes Mathijs Van Der Burgt , Rene Theodorus Wegh
IPC分类号： H01L33/50 , H01L33/60
CPC分类号： H05B33/14 , C09K11/7774 , F21K9/64 , F21Y2115/10
摘要： There is provided a light emitting device comprising a light source comprising at least one light emitting diode emitting visible radiation. The light emitting device further comprises a wavelength converting body comprising a first wavelength converting material, which is arranged to receive light emitted by said light source and which has an emission maximum in the range of from 600 to 700 nm. The first wavelength converting material comprises the elements Mg, Ge, O and Mn. A light emitting device according to the invention produces light having increased saturation of red colors. Moreover, long life and good color stability is achieved.
摘要翻译：提供了一种发光装置，其包括光源，该光源包括发射可见光的至少一个发光二极管。发光装置还包括波长转换体，该波长转换体包括第一波长转换材料，该第一波长转换材料布置成接收由所述光源发射的光，其发射最大值在600-700nm的范围内。第一波长转换材料包括元素Mg，Ge，O和Mn。根据本发明的发光器件产生具有增加的红色饱和度的光。此外，实现了长寿命和良好的颜色稳定性。

7. 发明授权

US07667460B2 Distinguishing bound and unbound contrast agents using magnetic resonance 失效
标题翻译：使用磁共振区分绑定和未结合的造影剂
公开(公告)号：US07667460B2
公开(公告)日：2010-02-23
申请号：US12094270
申请日：2006-11-22
申请人： Rudolf Mathias Johannes Nicolaas Lamerichs , Rene Theodorus Wegh , Jeroen Alphons Pikkemaat , Holger Gruell
发明人： Rudolf Mathias Johannes Nicolaas Lamerichs , Rene Theodorus Wegh , Jeroen Alphons Pikkemaat , Holger Gruell
IPC分类号： G01V3/00
CPC分类号： G01R33/281 , G01R33/5601 , G01R33/56341
摘要： Magnetic resonance monitoring of a target (30) uses the detected magnetic resonance to determine movement such as diffusion of contrast agent relative to the object, and uses the movement to discriminate (50, 60) a part of the contrast agent which is bound to the target, from the rest of the contrast agent. The need for clearing agents can be avoided or reduced, and hence imaging is instantaneous. A “stationary spin map” of the object can be formed by comparing the movements in the different directions, and determining if the differences between them are less than a given threshold. Determining isotropic movement in this way for a number of locations on the object allows the map to be generated.
摘要翻译：目标（30）的磁共振监测使用检测到的磁共振来确定造影剂相对于物体的扩散的运动，并且使用该运动来区分（50,60）一部分与目标，从其余的造影剂。可以避免或减少对清除剂的需要，因此成像是瞬时的。可以通过比较不同方向的运动并确定它们之间的差异是否小于给定的阈值来形成物体的“固定自旋图”。以这种方式确定对象上多个位置的各向同性运动允许生成地图。

8. 发明申请

US20080258726A1 Distinguishing Bound and Unbound Contrast Agents Using Magnetic Resonance 失效
标题翻译：使用磁共振识别绑定和未绑定的对比剂
公开(公告)号：US20080258726A1
公开(公告)日：2008-10-23
申请号：US12094270
申请日：2006-11-22
申请人： Rudolf Mathias Johannes Nicolaas Lamerichs , Rene Theodorus Wegh , Jeroen Alphons Pikkemaat , Holger Gruell
发明人： Rudolf Mathias Johannes Nicolaas Lamerichs , Rene Theodorus Wegh , Jeroen Alphons Pikkemaat , Holger Gruell
IPC分类号： G01R33/563
CPC分类号： G01R33/281 , G01R33/5601 , G01R33/56341
摘要： Magnetic resonance monitoring of a target (30) uses the detected magnetic resonance to determine movement such as diffusion of contrast agent relative to the object, and uses the movement to discriminate (50, 60) a part of the contrast agent which is bound to the target, from the rest of the contrast agent. The need for clearing agents can be avoided or reduced, and hence imaging is instantaneous. A “stationary spin map” of the object can be formed by comparing the movements in the different directions, and determining if the differences between them are less than a given threshold. Determining isotropic movement in this way for a number of locations on the object allows the map to be generated.
摘要翻译：目标（30）的磁共振监测使用检测到的磁共振来确定造影剂相对于物体的扩散的运动，并且使用该运动来区分（50,60）一部分与目标，从其余的造影剂。可以避免或减少对清除剂的需要，因此成像是瞬时的。可以通过比较不同方向的运动并确定它们之间的差异是否小于给定的阈值来形成物体的“固定自旋图”。以这种方式确定对象上多个位置的各向同性运动允许生成地图。

9. 发明申请

US20080200799A1 Mri Involving Contrast Agent With Time Modulated Contrast Enhancement 有权
标题翻译： Mri涉及对比剂与时间调制对比度增强
公开(公告)号：US20080200799A1
公开(公告)日：2008-08-21
申请号：US11912674
申请日：2006-04-25
申请人： Nicolaas Petrus Willard , Rene Theodorus Wegh , Jeroen Alphons Pikkemaat , Holger Gruell , Tobias Schaeffter , Rudolf Mathias Johannes Nicolaas Lamerichs
发明人： Nicolaas Petrus Willard , Rene Theodorus Wegh , Jeroen Alphons Pikkemaat , Holger Gruell , Tobias Schaeffter , Rudolf Mathias Johannes Nicolaas Lamerichs
IPC分类号： A61B5/055
CPC分类号： G01R33/5601 , A61K49/124 , G01R33/5605
摘要： The present invention provides a method MRI imaging. By applying a time modulation to the contrast enhancement of an MRI contrast agent, the method according to the invention leads to images with improved signal-to-noise ratio in the contrast-enhanced areas, strongly suppressed unwanted signal in the unenhanced areas, and reduced artefacts, such as motion artefacts.
摘要翻译：本发明提供一种MRI成像方法。通过对MRI造影剂的对比度增强应用时间调制，根据本发明的方法导致对比度增强区域中具有改善的信噪比的图像，强烈地抑制未增强区域中的不需要的信号，并且减少人造物，如运动文物。

10. 发明授权

US07261836B2 Chiral dopant with phenylethanediol functionality 失效
标题翻译：手性掺杂剂与苯乙二醇功能
公开(公告)号：US07261836B2
公开(公告)日：2007-08-28
申请号：US10519604
申请日：2003-06-13
申请人： Johan Lub , Rene Theodorus Wegh
发明人： Johan Lub , Rene Theodorus Wegh
IPC分类号： C09K19/36 , C09K19/20 , C07C69/73
CPC分类号： C07D493/04 , C07C69/92 , C09K19/586 , Y10T428/10 , Y10T428/1036
摘要： The invention pertains to a phenylethanediol derivative having at least one polymerizable group, characterized in that the phenylethanediol derivative further comprises at least one photo-convertible group for adjusting the helical twisting power of the phenylethanediol derivative. According to a preferred embodiment the phenylethanediol has the formula wherein A stands for a bond or a p-phenylene group; B and B′ are independently (O)p—CoH2o—O—CO—CR′═CH2, o being 2-12, p being 0 or 1, and R′ being H or CH3; P stands for a CH2 or a C═O group; Q and Q′ are independently selected from H, C1-C3 alkyl, C1-C3 alkoxy, halogen, and CN; n is an integer from 1 to 3; and m is an integer from 0 to 2; and: wherein A stands for a bond or a p-phenylene group; B is (O)p—CoH2o—O—CO—CR′═CH2, o being 2-12, p is 1, and R′ being H or CH3; P stands for a CH2 or a C═O group; Q is selected from H, C1-C3 alkyl, C1-C3 alkoxy, halogen, and CN; and m is an integer from 0 to 2.
摘要翻译：本发明涉及具有至少一个可聚合基团的苯乙二醇衍生物，其特征在于所述苯乙二醇衍生物还包含至少一个用于调节苯乙二醇衍生物的螺旋扭转能力的光转化基团。根据优选的实施方案，苯乙二醇具有下式：其中A代表键或对亚苯基; B和B'独立地是（O）-O-CO-CR'-CH 2，-O-CO-CR'-CH 2， / SUB，o为2-12，p为0或1，R'为H或CH 3。 P代表CH 2或C-O基团; Q和Q'独立地选自H，C 1 -C 3烷基，C 1 -C 3烷氧基，卤素和CN; n为1〜3的整数， m为0〜2的整数。和：其中A代表键或对亚苯基; B是（O）-O-CO-CR'-CH 2，-O-CO-CR'-CH 2， o为2-12，p为1，R'为H或CH 3。 P代表CH 2或C-O基团; Q选自H，C 1 -C 3烷基，C 1 -C 3烷氧基，卤素和CN; m为0〜2的整数。

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