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1. 发明申请

US20060110831A1 Automated clinical analyzer reagent formulation 失效
标题翻译：自动临床分析仪试剂配方
公开(公告)号：US20060110831A1
公开(公告)日：2006-05-25
申请号：US10996813
申请日：2004-11-24
申请人： Johan Kijlstra , Dieter Ruehle , Ralf Neigl , Paul Gherson , Germaine Tarcu
发明人： Johan Kijlstra , Dieter Ruehle , Ralf Neigl , Paul Gherson , Germaine Tarcu
IPC分类号： G01N33/00
CPC分类号： B01F13/0071 , B01L3/5027 , G01N2035/00544 , G01N2035/1058 , Y10T436/118339
摘要： This invention significantly reduces the frequency of hydraulic failure in the analytical line of a capsule chemistry sample liquid analysis system which can occur when the reagents required for the specific analytical test have an imperfect merger with the sample aliquot reagent in the vanish zone of the analytical line. It has been found that the dynamic surface tension of the sample aliquot reagent and the analytical reagent influence the merging process. It has also been found that optimum merging of these reagent capsules in the vanish zone can be obtained when the dynamic surface tension of the sample aliquot reagent and analytical reagent is different.
摘要翻译：本发明显着降低了胶囊化学样品液体分析系统的分析线中的液压故障频率，当分析试验所需的试剂与分析线的消失区域中的样品等分试剂不完全的合并时，。已经发现样品等分试剂和分析试剂的动态表面张力影响合并过程。还发现，当样品等分试剂和分析试剂的动态表面张力不同时，可以获得这些试剂胶囊在消失区域中的最佳合并。

2. 发明授权

US07338804B2 Automated clinical analyzer reagent formulation 失效
标题翻译：自动临床分析仪试剂配方
公开(公告)号：US07338804B2
公开(公告)日：2008-03-04
申请号：US10996813
申请日：2004-11-24
申请人： Johan Kijlstra , Dieter Rüehle , Ralf Niegl , Paul Gherson , Germaine Adriana Tarcu
发明人： Johan Kijlstra , Dieter Rüehle , Ralf Niegl , Paul Gherson , Germaine Adriana Tarcu
IPC分类号： G01N35/08
CPC分类号： B01F13/0071 , B01L3/5027 , G01N2035/00544 , G01N2035/1058 , Y10T436/118339
摘要： This invention significantly reduces the frequency of hydraulic failure in the analytical line of a capsule chemistry sample liquid analysis system which can occur when the reagents required for the specific analytical test have an imperfect merger with the sample aliquot reagent in the vanish zone of the analytical line. It has been found that the dynamic surface tension of the sample aliquot reagent and the analytical reagent influence the merging process. It has also been found that optimum merging of these reagent capsules in the vanish zone can be obtained when the dynamic surface tension of the sample aliquot reagent and analytical reagent is different.
摘要翻译：本发明显着降低了胶囊化学样品液体分析系统的分析线中的液压故障频率，当分析试验所需的试剂与分析线的消失区域中的样品等分试剂不完全的合并时，。已经发现样品等分试剂和分析试剂的动态表面张力影响合并过程。还发现，当样品等分试剂和分析试剂的动态表面张力不同时，可以获得这些试剂胶囊在消失区域中的最佳合并。

3. 发明授权

US5817955A Apparatus for simultaneous aspiration and dispensation of fluids 失效
标题翻译：用于同时抽吸和分配流体的装置
公开(公告)号：US5817955A
公开(公告)日：1998-10-06
申请号：US828969
申请日：1997-03-27
申请人： Paul Gherson , Carl Gebauer
发明人： Paul Gherson , Carl Gebauer
IPC分类号： G01N1/00 , B01L3/02 , F04B5/00 , F04B53/02 , G01F11/02 , G01N35/10 , F04B39/10
CPC分类号： B01L3/02 , F04B5/00 , F04B53/02 , G01F11/021 , G01N35/10 , B01L2400/0478
摘要： The apparatus for simultaneous aspiration and dispensation of fluids is in the form of a syringe with two chambers located end to end along the length of the syringe. Each syringe chamber includes a port. A piston inside the syringe includes a median section that is movable in both of the syringe chambers, a first end section movable only in one of the syringe chambers, and a second end section movable only in the other syringe chamber. Both end sections of the piston are of either less diameter than the median section of the piston or of greater diameter than the median section of the piston. When the piston is moved in a first direction, an aspiration or suction force is developed at one of the chamber ports and a dispensation pressure force is developed at the other chamber port. Reverse movement of the piston causes the opposite effect at the respective chamber ports. A compression seal is provided at the median section of the piston and at opposite non-adjacent end portions of the syringe chambers. The syringe housing can be formed in two separable sections to permit access to the compression seal at the median portion of the piston. Tandem compression seals can also be provided at the median section of the piston.
摘要翻译：用于同时抽吸和分配流体的装置是注射器的形式，其中两个腔室沿着注射器的长度位于一端。每个注射器室包括一个端口。注射器内的活塞包括可在两个注射器室中移动的中间部分，仅可在一个注射器室中移动的第一端部部分和仅可在另一注射器腔室中移动的第二端部部分。活塞的两个端部的直径都小于活塞的中间部分，或者比活塞的中间部分更大的直径。当活塞沿第一方向移动时，抽吸或抽吸力在腔室的一个端口处形成并且分配压力在另一腔室端口处形成。活塞的反向运动在相应的腔室端口产生相反的作用。压缩密封件设置在活塞的中间部分和注射器室的相对的非相邻端部处。注射器壳体可以形成在两个可分离部分中，以允许进入活塞中间部分处的压缩密封件。串联压缩密封件也可以在活塞的中间部分提供。

4. 发明授权

US5399497A Capsule chemistry sample liquid analysis system and method 失效
标题翻译：胶囊化学样品液体分析系统及方法
公开(公告)号：US5399497A
公开(公告)日：1995-03-21
申请号：US106254
申请日：1993-08-13
申请人： Anand Kumar , Paul Gherson , Milt Pelavin
发明人： Anand Kumar , Paul Gherson , Milt Pelavin
IPC分类号： G01N1/00 , B01F13/08 , G01N35/00 , G01N35/02 , G01N35/08 , G01N35/10
CPC分类号： B01F13/0809 , G01N35/0098 , G01N35/08 , G01N2035/1025 , Y10T436/117497 , Y10T436/118339
摘要： An analysis method and apparatus comprises feeding a stream of fluid capsules in a fluid conduit for flow therethrough by forming a film of isolating liquid on an inner surface of the conduit and randomly accessing each of a plurality of liquids selected from a sample liquid, reagents and a magnetic particle suspension to form a plurality of isolated segments from the plurality of liquids in each capsule in the conduit. The fluid capsules flow in at least one longitudinal direction of the conduit and the suspended magnetic particles are selectively magnetically retained from one segment in one capsule at a given location for placement of the magnetic particles in another segment in the one capsule during the flow of the one capsule through the conduit. The fluid capsules are then measured in the conduit.
摘要翻译：一种分析方法和装置包括：通过在导管的内表面上形成隔离液体的膜并随机接入选自样品液体，试剂和多种液体中的每一种液体，将流体胶囊流输送到流体导管中以流过其中; 一种磁性颗粒悬浮液，用于在管道中的每个胶囊中的多个液体中形成多个隔离区段。流体胶囊在导管的至少一个纵向方向上流动，并且悬浮的磁性颗粒从给定位置处的一个胶囊中的一个部分选择性地磁性地保持，用于将磁性颗粒放置在一个胶囊的另一个部分中，一个胶囊通过导管。然后在导管中测量流体胶囊。

5. 发明授权

US06872571B1 Method and apparatus for controlling a stream of liquid test packages in a capsule chemistry analysis system 失效
标题翻译：用于在胶囊化学分析系统中控制液体测试包装流的方法和装置
公开(公告)号：US06872571B1
公开(公告)日：2005-03-29
申请号：US09541663
申请日：2000-04-03
申请人： Robert Adolfsen , Paul Gherson , David Lightbody
发明人： Robert Adolfsen , Paul Gherson , David Lightbody
IPC分类号： G01N1/00 , G01N35/08 , G01N1/10 , G01N21/00 , G05B1/00 , B01N11/00
CPC分类号： G01N35/08 , Y10T436/117497 , Y10T436/118339 , Y10T436/119163 , Y10T436/2575
摘要： A method and apparatus for controlling a stream of liquid and air segments wherein the liquid and air segments are selectively aspirated into a first fluid conduit in a plurality of cycles, each cycle beginning with the aspiration of a first air segment and ending with the aspiration of a final air segment. The liquid and air segments are then transferred from the first fluid conduit to a second fluid conduit. The volume of the final air segment of each cycle is then adjusted after the final air segment has moved into the second fluid conduit. Next, the liquid segments and the air segments of each cycle are transferred from the second fluid conduit to a third fluid conduit. The volume of the first air segment of each cycle is then adjusted after the first air segment has moved into the third fluid conduit.
摘要翻译：一种用于控制液体和空气部分流的方法和装置，其中液体和空气部分以多个循环被选择性地吸入第一流体导管，每个循环以第一空气段的抽吸为开始，最后一个空气段。液体和空气段然后从第一流体导管转移到第二流体导管。然后在最终空气段已经移动到第二流体管道中之后调节每个循环的最终空气段的体积。接下来，每个循环的液体段和空气段从第二流体导管传送到第三流体导管。然后在第一空气段已经移动到第三流体管道中之后调节每个循环的第一空气段的体积。

6. 发明授权

US06485980B1 Method and apparatus for controlling a stream of liquid test packages in a capsule chemistry analysis system 失效
公开(公告)号：US06485980B1
公开(公告)日：2002-11-26
申请号：US09541664
申请日：2000-04-03
申请人： Robert H. Adolfsen , Paul Gherson , David Lightbody
发明人： Robert H. Adolfsen , Paul Gherson , David Lightbody
IPC分类号： G01N3565
CPC分类号： G01N35/08 , Y10T436/117497 , Y10T436/118339 , Y10T436/119163 , Y10T436/2575
摘要： A method and apparatus for controlling a stream of liquid and air segments wherein the liquid and air segments are selectively aspirated into a first fluid conduit in a plurality of cycles, each cycle beginning with the aspiration of a first air segment and ending with the aspiration of a final air segment. The liquid and air segments are then transferred from the first fluid conduit to a second fluid conduit. The volume of the final air segment of each cycle is then adjusted after the final air segment has moved into the second fluid conduit. Next, the liquid segments and the air segments of each cycle are transferred from the second fluid conduit to a third fluid conduit. The volume of the first air segment of each cycle is then adjusted after the first air segment has moved into the third fluid conduit.

7. 发明授权

US6022747A Blood clot detector 失效
标题翻译：血块检测器
公开(公告)号：US6022747A
公开(公告)日：2000-02-08
申请号：US113647
申请日：1998-07-10
申请人： Paul Gherson , Robert William Eherts , Theodore Pernicano
发明人： Paul Gherson , Robert William Eherts , Theodore Pernicano
IPC分类号： G01N1/00 , G01N33/49 , G01N35/10 , G01N27/416
CPC分类号： G01N33/4905 , G01N2035/1018
摘要： A blood clot detector includes a pressure transducer on an aspiration line to provide output voltage data to a microprocessor corresponding to the vacuum level during aspiration. The microprocessor integrates the vacuum readings over time during the aspiration cycle to provide a pressure integral for each test sample aspiration. A pressure integral is determined for an unclotted aspiration and used as a reference for comparison with the pressure integrals of each test sample aspiration to determine whether a blood clot has interfered with the test sample aspiration. A valve is provided across an analytical line and an aspiration line to provide selective communication between the aspiration line and the analytical line or to prevent such communication. Communication between the aspiration line and the analytical line permits transfer of a test sample from the aspiration line to the analytical line if the test sample is considered acceptable for sample analysis. Acceptability of the test sample for analysis is based upon a predetermined difference between the reference pressure integral and each test sample pressure integral.
摘要翻译：血液凝块检测器包括在抽吸线上的压力传感器，以在抽吸期间向微处理器提供对应于真空水平的输出电压数据。微处理器在抽吸循环期间随着时间的推移整合真空读数，为每个测试样品抽吸提供压力积分。确定未切开抽吸的压力积分，并用作与每个测试样品抽吸的压力积分进行比较的参考，以确定血块是否干扰了测试样品抽吸。在分析管线和抽吸管线之间提供阀，以在抽吸管线和分析管线之间提供选择性连通，或者防止这种连通。如果测试样品被认为可接受用于样品分析，则抽吸管线和分析管线之间的通信可将测试样品从抽吸管线转移到分析管线。用于分析的测试样品的可接受性基于参考压力积分和每个测试样品压力积分之间的预定差异。

8. 发明授权

US06426048B1 Sample dilution module with offset mixing chamber 失效
标题翻译：带偏置混合室的样品稀释模块
公开(公告)号：US06426048B1
公开(公告)日：2002-07-30
申请号：US09548152
申请日：2000-04-13
申请人： Robert W. Eherts , Paul Gherson , Carl R. Gebauer , Evandro S. Denunzio
发明人： Robert W. Eherts , Paul Gherson , Carl R. Gebauer , Evandro S. Denunzio
IPC分类号： B01L302
CPC分类号： B01F11/0071 , B01F11/0074 , G01N1/38 , G01N35/08 , Y10T436/117497 , Y10T436/118339 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： The sample dilution module includes an oil filled aspiration probe and mixing chamber that communicate with each other while the mixing chamber is maintained at an angle of approximately 5 to 45 degrees below a horizontal axis. The aspiration probe is maintained in a vertical orientation. A micro-bubble is aspirated between separate aspirations of test sample and diluent to prevent contact between the sample and diluent in the aspiration probe. The test sample and diluent are then drawn from the vertically oriented aspiration probe into the mixing chamber. After the sample and diluent are in the mixing chamber the micro-bubble of air can migrate away from the test sample and diluent to enable the test sample and diluent to contact each other. Mixing of the test sample and diluent is accomplished by moving the test sample and diluent back and forth in the mixing chamber without physical agitation of the mixing chamber and without any mixing element in the mixing chamber. Such movement is accomplished by alternate suction and vacuum forces imposed on the fluid in the mixing chamber.
摘要翻译：样品稀释模块包括充油抽吸探针和混合室，其在混合室保持在水平轴线以下约5至45度的角度的情况下相互连通。吸气探针保持垂直方向。在测试样品和稀释剂的单独吸气之间吸入微气泡，以防止抽吸探针中样品和稀释剂之间的接触。然后将测试样品和稀释剂从垂直取向的吸入探针中抽出到混合室中。在样品和稀释剂在混合室中之后，空气的微气泡可以离开测试样品和稀释剂迁移，以使测试样品和稀释剂彼此接触。测试样品和稀释剂的混合是通过在混合室中来回移动测试样品和稀释剂而没有混合室的物理搅拌并且在混合室中没有任何混合元件来实现的。这种移动通过施加在混合室中的流体上的交替抽吸和真空力来实现。

9. 发明授权

US06348354B1 Method and apparatus for controlling a stream of liquid test packages in a capsule chemistry analysis system 失效
标题翻译：用于在胶囊化学分析系统中控制液体测试包装流的方法和装置
公开(公告)号：US06348354B1
公开(公告)日：2002-02-19
申请号：US09111162
申请日：1998-07-06
申请人： Robert Adolfsen , Paul Gherson , David Lightbody
发明人： Robert Adolfsen , Paul Gherson , David Lightbody
IPC分类号： G01N3508
CPC分类号： G01N35/08 , Y10T436/117497 , Y10T436/118339 , Y10T436/119163 , Y10T436/2575
摘要： A method and apparatus for controlling a stream of liquid and air segments wherein the liquid and air segments are selectively aspirated into a first fluid conduit in a plurality of cycles, each cycle beginning with the aspiration of a first air segment and ending with the aspiration of a final air segment. The liquid and air segments are then transferred from the first fluid conduit to a second fluid conduit. The volume of the final air segment of each cycle is then adjusted after the final air segment has moved into the second fluid conduit. Next, the liquid segments and the air segments of each cycle are transferred from the second fluid conduit to a third fluid conduit. The volume of the first air segment of each cycle is then adjusted after the first air segment has moved into the third fluid conduit.
摘要翻译：一种用于控制液体和空气部分流的方法和装置，其中液体和空气部分以多个循环被选择性地吸入第一流体导管，每个循环以第一空气段的抽吸开始并以吸入最后一个空气段。液体和空气段然后从第一流体导管转移到第二流体导管。然后在最终空气段已经移动到第二流体管道中之后调节每个循环的最终空气段的体积。接下来，每个循环的液体段和空气段从第二流体导管传送到第三流体导管。然后在第一空气段已经移动到第三流体管道中之后调节每个循环的第一空气段的体积。

10. 发明授权

US6119533A Sampling system with selectable pumps to communicate with reading station 有权
标题翻译：采样系统，带可选择的泵与阅读台进行通讯
公开(公告)号：US6119533A
公开(公告)日：2000-09-19
申请号：US346404
申请日：1999-07-01
申请人： Paul Gherson , Robert William Eherts , Theodore Pernicano
发明人： Paul Gherson , Robert William Eherts , Theodore Pernicano
IPC分类号： G01N1/00 , G01N33/49 , G01N35/10
CPC分类号： G01N33/4905 , G01N2035/1018
摘要： A blood clot detector includes a pressure transducer on an aspiration line to provide output voltage data to a microprocessor corresponding to the vacuum level during aspiration. The microprocessor integrates the vacuum readings over time during the aspiration cycle to provide a pressure integral for each test sample aspiration. A pressure integral is determined for an unclotted aspiration and used as a reference for comparison with the pressure integrals of each test sample aspiration to determine whether a blood clot has interfered with the test sample aspiration. A valve is provided across an analytical line and an aspiration line to provide selective communication between the aspiration line and the analytical line or to prevent such communication. Communication between the aspiration line and the analytical line permits transfer of a test sample from the aspiration line to the analytical line if the test sample is considered acceptable for sample analysis. Acceptability of the test sample for analysis is based upon a predetermined difference between the reference pressure integral and each test sample pressure integral.
摘要翻译：血液凝块检测器包括在抽吸线上的压力传感器，以在抽吸期间向微处理器提供对应于真空水平的输出电压数据。微处理器在抽吸循环期间随着时间的推移整合真空读数，为每个测试样品抽吸提供压力积分。确定未切开抽吸的压力积分，并用作与每个测试样品抽吸的压力积分进行比较的参考，以确定血块是否干扰了测试样品抽吸。在分析管线和抽吸管线之间提供阀，以在抽吸管线和分析管线之间提供选择性连通，或者防止这种连通。如果测试样品被认为可接受用于样品分析，则抽吸管线和分析管线之间的通信可将测试样品从抽吸管线转移到分析管线。用于分析的测试样品的可接受性基于参考压力积分和每个测试样品压力积分之间的预定差异。

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