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1. 发明授权

US5177221A Chromogenic hemispherands and their preparation 失效
标题翻译：显色半球及其制备
公开(公告)号：US5177221A
公开(公告)日：1993-01-05
申请号：US564203
申请日：1990-08-08
申请人： Donald J. Cram , Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Roger C. Helgeson , Anand Kumar , Koon-Wah Leong
发明人： Donald J. Cram , Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Roger C. Helgeson , Anand Kumar , Koon-Wah Leong
IPC分类号： C07D323/00 , C07D493/08 , C07D498/08 , G01N27/333
CPC分类号： C07D493/08 , C07D323/00 , G01N27/3335
摘要： The present invention resides in the discovery of a new class of compounds defined herein as "chromogenic hemispherands" useful for the measurement of ions, in particular, ions in aqueous solution, which have the structure ##STR1## wherein: R, same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;R', same or different, is lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;R", same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;Q is a chromogenic moiety capable of providing the appearance of or change in color, or which is otherwise capable of providing a detectable response in the presence of a particular cation;m is 1 to about 3;n is 0 to about 3;A is an aliphatic or aromatic subunit, e.g., ##STR2##
摘要翻译：本发明在于发现本文中定义的可用于测量离子，特别是水溶液中的离子的“显色半球”，其具有以下结构：其中：R相同或不同，是氢，低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; R'相同或不同，为低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; R“相同或不同，为氢，低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; Q是能够提供颜色出现或变化的发色部分，或者否则能够在特定阳离子存在下提供可检测的响应; m为1〜3; n为0至约3; A是脂肪族或芳香族亚基，例如

2. 发明授权

US5011924A Chromogenic cryptahemispherands and their preparation 失效
标题翻译：显色隐窝和它们的制备
公开(公告)号：US5011924A
公开(公告)日：1991-04-30
申请号：US349465
申请日：1989-05-09
申请人： Donald J. Cram , Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Roger C. Helgeson , Anand Kumar , Koon-Wah Leong
发明人： Donald J. Cram , Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Roger C. Helgeson , Anand Kumar , Koon-Wah Leong
IPC分类号： C07D498/08 , G01N33/84
CPC分类号： C07D498/08 , G01N33/84
摘要： The present invention resides in the discovery of a new class of compounds defined herein as "chromogenic cryptahemispherands" useful for the measurement of ions, in particular, ions in aqueous solution, which have the structure ##STR1## wherein: R, same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;R', same or different, is lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;R", same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;Q is a chromogenic moiety capable of providing the appearance of or change in color, or which is otherwise capable of providing a detectable response in the presence of a particular cation;a, b, m and n, same or different, are 1 to about 3; and x, y, same or different, are 1 to about 4.A test device utilizing one or more of the compounds for performing such measurements is also disclosed.
摘要翻译：本发明在于在本文定义的一类新的化合物的发现，其可用于测量离子，特别是水溶液中的离子，其具有以下结构：其中：R相同或不同，是氢，低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; R'相同或不同，为低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; R“相同或不同，为氢，低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; Q是能够提供颜色出现或变化的发色部分，或者否则能够在特定阳离子存在下提供可检测的响应; a，b，m和n相同或不同，为1〜3; x，y相同或不同，为1至约4.还公开了利用一种或多种化合物进行这种测量的测试装置。

3. 发明授权

US4994395A Chromogenic cryptand reagents and methods for determining cation concentrations in test samples containing interfering cations 失效
标题翻译：显色穴位试剂和测定含有干扰阳离子的试样中的阳离子浓度的方法
公开(公告)号：US4994395A
公开(公告)日：1991-02-19
申请号：US038741
申请日：1987-04-15
申请人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
发明人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
IPC分类号： G01N31/00 , C07D498/08 , C07D498/18 , G01N33/52 , G01N33/84
CPC分类号： C07D498/08 , G01N33/525 , G01N33/84 , Y10S436/805
摘要： The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent comprising(a) one or more chromogenic cryptand compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5;m and n, either same or different, are equal to 0 to about 4;a and e, either same or different, are equal to 0 to about 2;b and d, either same or different, are equal to 0 to about 5;R, either same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and--Q-- is ##STR2## wherein X is CH, N, or COH; andY includes ##STR3## and (b) one or more interfering cation complexing compound masks.

4. 发明授权

US4808539A Compounds, reagents and procedures for determining cations 失效
标题翻译：用于确定阳离子的化合物，试剂和程序
公开(公告)号：US4808539A
公开(公告)日：1989-02-28
申请号：US38843
申请日：1987-04-15
申请人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
发明人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
IPC分类号： G01N31/00 , C07D498/08 , C07D498/18 , G01N33/52 , G01N33/84 , G01N33/20
CPC分类号： C07D498/08 , C07D498/18 , G01N33/521 , G01N33/84
摘要： The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent comprising one or more chromogenic cryptand compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5;m and n, either same or different, are equal to 0 to about 4;a and e, either same or different, are equal to 0 to about 2;b and d, either same or different, are equal to 0 to about 5;R, either same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and-Q- is ##STR2## wherein X is CH, N, or COH; andY includes ##STR3## except that when Q is ##STR4## wherein Y is selected from the group consisting of p-nitrophenylazo, 3-phenylisothiazalyl -5-azo, isothiazolyl-5-azo, thiazolyl-5-azo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino and bis-(p-dimethylaminophenyl)hydroxymethyl, then the following condition cannot be present: that simultaneously b is equal to 0 or 1, d is equal to 0 or 1, j is equal to 1, n is equal to 1 or 2, a is equal to 1, e is equal to 1, k is equal to 1 and m is equal to 2.

5. 发明授权

US6117391A Cup handling subsystem for an automated clinical chemistry analyzer system 失效
标题翻译：用于自动化临床化学分析仪系统的杯子处理子系统
公开(公告)号：US6117391A
公开(公告)日：2000-09-12
申请号：US99739
申请日：1998-06-18
申请人： Frederick E. Mootz , Carl R. Gebauer , Frank Bakonyi , Nicolae Dumitrescu
发明人： Frederick E. Mootz , Carl R. Gebauer , Frank Bakonyi , Nicolae Dumitrescu
IPC分类号： G01N35/02 , B65G59/06 , B65G59/10 , G01N35/04 , G01N35/00
CPC分类号： G01N35/04 , B65G59/062 , B65G59/105 , G01N2035/0427 , G01N2035/0465 , Y10T436/113332
摘要： The present invention relates to a cup handling subsystem for an automated clinical chemistry analyzer system which includes a nestable sample cup for holding sample mixtures, a cup dispenser mechanism for holding and dispensing a supply of the cups into a sample shuttle for transporting them, and an incubator for controlling the temperature of the cup and its contents. In one embodiment, the cups include a conical lower portion and a cylindrical upper portion having a top flange, a bottom flange and a groove formed therebetween. An apparatus is provided for holding and dispensing a plurality of such cups including a supply tube for holding the cups in a stack wherein the stack has a bottom-most cup and a next-bottom-most cup located above the bottom-most cup. The apparatus also includes an escapement located at a lower end of the supply tube which includes a disk having an aperture formed therein, a first leaf attached to a top side of the disk and a second leaf attached to a bottom side of the disk. The disk is movable between a first position in which the second leaf engages the bottom flange of the bottom-most cup and a second position in which the first leaf is inserted into the groove of the next-bottom-most cup and engages the top flange of the next-bottom-most cup and in which the second leaf no longer engages the bottom flange of the bottom-most cup. In the second position, the bottom-most cup is free to fall through the aperture formed in the disk.
摘要翻译：本发明涉及一种用于自动临床化学分析仪系统的杯子处理子系统，其包括用于保持样品混合物的可嵌套样品杯，用于保持和分配杯子供应到用于运输它们的样品梭中的杯分配器机构，以及用于控制杯子及其内容物的温度的培养箱。在一个实施例中，杯包括锥形下部和具有顶部凸缘，底部凸缘和在其间形成的凹槽的圆柱形上部。提供了一种用于保持和分配多个这样的杯子的装置，其包括用于将杯子保持在堆叠中的供给管，其中所述烟囱具有最底部的杯子和位于最下面的杯子上方的下一个最下面的杯子。该装置还包括位于供应管的下端处的擒纵机构，其包括具有形成在其中的孔的盘，附接到盘的顶侧的第一叶片和附接到盘的底侧的第二叶片。盘可以在其中第二叶片接合最底部杯的底部凸缘的第一位置和第二位置之间移动，第二位置中第一叶片插入下一个最下面的杯子的凹槽中并且接合顶部凸缘的下一个最下面的杯子，其中第二个叶子不再接合最底部的杯子的底部凸缘。在第二位置，最下面的杯子可自由地落入通过形成在盘中的孔。

6. 发明授权

US5096831A Reagents for determining cations 失效
标题翻译：用于确定阳离子的试剂
公开(公告)号：US5096831A
公开(公告)日：1992-03-17
申请号：US699188
申请日：1991-05-13
申请人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
发明人： Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Koon-Wah Leong , Anand Kumar
IPC分类号： C07D498/08 , C07D498/18 , G01N33/52 , G01N33/84
CPC分类号： C07D498/08 , C07D498/18 , G01N33/521 , G01N33/84
摘要： The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent including one or more chromogenic cryptand compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5;m and n, either same or different, are equal to 0 to about 4;a and e, either same or different, are equal to 0 to about 2;b and d, either same or different, are equal to 0 to about 5;R, either same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and ##STR2## wherein X is CH, N or COH; andY includes ##STR3## except that when Q is ##STR4## wherein Y is p-nitrophenylazo, 3-phenylisothiazolyl-5-azo, isothiazolyl-5-azo, thiazolyl-5-azo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino or bis-(p-dimethylaminophenyl)hydroxymethyl, then the following condition cannot be present: that simultaneously b is equal to 0 or 1, d is equal to 0 or 1, j is equal to 1, n is equal to 1 or 2, a is equal to 1, e is equal to 1, k is equal to 1 and m is equal to 2.
摘要翻译：本发明是用于测定样品中存在的阳离子量的试剂和方法，该试剂包括一种或多种式I（I）的显色隐窝化合物，其中相同或不同的k和j相同或不同，约5; m和n相同或不同，等于0至约4; a和e相同或不同，等于0至约2; b和d相同或不同，等于0至约5; R，相同或不同，为氢，低级烷基，低级亚烷基，低级烯基，烯丙基或芳基; 和，其中X是CH，N或COH; 并且Y包括，不同之处在于Q是，其中Y是对硝基苯基偶氮，3-苯基异噻唑-5-偶氮，异噻唑-5-偶氮，噻唑基-5 （2,4,6-三硝基苯基偶氮），对硝基苯乙烯基，对苯醌二亚氨基亚氨基或双 - （对二甲基氨基苯基）羟甲基，则不能存在以下条件：同时b等于0或1，d等于 0或1，j等于1，n等于1或2，a等于1，e等于1，k等于1，m等于2。

7. 发明授权

US4992381A Method of detecting electrolytes in an aqueous test sample using chromogenic hemispherands and test device therefor 失效
标题翻译：使用显色半球及其测试装置检测含水测试样品中的电解质的方法
公开(公告)号：US4992381A
公开(公告)日：1991-02-12
申请号：US38679
申请日：1987-04-15
申请人： Donald J. Cram , Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Roger C. Helgeson , Anand Kumar , Koon-Wah Leong
发明人： Donald J. Cram , Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Roger C. Helgeson , Anand Kumar , Koon-Wah Leong
IPC分类号： C07D323/00 , C07D493/08 , C07D498/08 , C09B57/00 , G01N27/333 , G01N31/00 , G01N31/22
CPC分类号： C07D493/08 , C07D323/00 , G01N27/3335
摘要： The present invention resides in the discovery of a new class of compounds defined herein as "chromogenic hemispherands" useful for the measurement of ions, in particular, ions in aqueous solution, methods of using the chromogenic hemispherands and test devices containing the chromogenic hemispherands. The chromogenic hemispherands of the invention have the structure ##STR1## wherein: R, same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;R', same or different, is lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;R", same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;Q is a chromogenic moiety capable of providing the appearance of or change in color, or which is otherwise capable of providing a detectable response in the presence of a particular cation;m is 1 to about 3;n is 0 to about 3;P is an aliphatic or aromatic subunit, e.g., --CR.sub.2 CR.sub.2 OCR.sub.2 CR.sub.2 --, ##STR2##

8. 发明授权

US4859606A Method for detecting cations in a test sample utilizing chromogenic cryptahemispherands 失效
标题翻译：使用显色隐孢子虫检测试样中阳离子的方法
公开(公告)号：US4859606A
公开(公告)日：1989-08-22
申请号：US38681
申请日：1987-04-15
申请人： Donald J. Cram , Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Roger C. Helgeson , Anand Kumar , Koon-Wah Leong
发明人： Donald J. Cram , Eddy Chapoteau , Bronislaw P. Czech , Carl R. Gebauer , Roger C. Helgeson , Anand Kumar , Koon-Wah Leong
IPC分类号： G01N27/333 , C07D498/08 , C09B57/00 , G01N27/416 , G01N31/00 , G01N31/22 , G01N33/84
CPC分类号： C07D498/08 , G01N33/84
摘要： The present invention resides in the discovery of a class of compounds defined herein as "chromogenic cryptahemispherands" useful for the measurement of ions, in particular, ions in aqueous solution, which have the structure ##STR1## wherein: R, same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;R', same or different, is lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;R", same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl or aryl;Q is a chromogenic moiety capable of providing the appearance of or change in color, or which is otherwise capable of providing a detectable response in the presence of a particular cation;a, b, m and n, same or different, are 1 to about 3; and x, y, same or different, are 1 to about 4.A test device utilizing one or more of the compounds for performing such measurements is also disclosed.

9. 发明授权

US06881380B1 Cup handling subsystem for an automated clinical chemistry analyzer system 失效
标题翻译：用于自动化临床化学分析仪系统的杯子处理子系统
公开(公告)号：US06881380B1
公开(公告)日：2005-04-19
申请号：US09626066
申请日：2000-07-26
申请人： Frederick E. Mootz , Carl R. Gebauer , Frank Bakonyi , Nicolae Dumitrescu
发明人： Frederick E. Mootz , Carl R. Gebauer , Frank Bakonyi , Nicolae Dumitrescu
IPC分类号： B65G59/06 , B65G59/10 , G01N35/04 , G01N29/00
CPC分类号： G01N35/04 , B65G59/062 , B65G59/105 , G01N2035/0427 , G01N2035/0465 , Y10T436/11 , Y10T436/113332
摘要： The present invention relates to a cup handling subsystem for an automated clinical chemistry analyzer system which includes a nestable sample cup for holding sample mixtures, a cup dispenser mechanism for holding and dispensing a supply of the cups into a sample shuttle for transporting them, and an incubator for controlling the temperature of the cup and its contents. In one embodiment, the cups include a conical lower portion and a cylindrical upper portion having a top flange, a bottom flange and a groove formed therebetween. An apparatus is provided for holding and dispensing a plurality of such cups including a supply tube for holding the cups in a stack wherein the stack has a bottom-most cup and a next-bottom-most cup located above the bottom-most cup. The apparatus also includes an escapement located at a lower end of the supply tube which includes a disk having an aperture formed therein, a first leaf attached to a top side of the disk and a second leaf attached to a bottom side of the disk. The disk is movable between a first position in which the second leaf engages the bottom flange of the bottom-most cup and a second position in which the first leaf is inserted into the groove of the next-bottom-most cup and engages the top flange of the next-bottom-most cup and in which the second leaf no longer engages the bottom flange of the bottom-most cup. In the second position, the bottom-most cup is free to fall through the aperture formed in the disk.
摘要翻译：本发明涉及一种用于自动临床化学分析仪系统的杯子处理子系统，其包括用于保持样品混合物的可嵌套样品杯，用于保持和分配杯子供应到用于运输它们的样品梭中的杯分配器机构，以及用于控制杯子及其内容物的温度的培养箱。在一个实施例中，杯包括锥形下部和具有顶部凸缘，底部凸缘和在其间形成的凹槽的圆柱形上部。提供了一种用于保持和分配多个这样的杯子的装置，其包括用于将杯子保持在堆叠中的供给管，其中所述烟囱具有最底部的杯子和位于最下面的杯子上方的下一个最下面的杯子。该装置还包括位于供应管的下端处的擒纵机构，其包括具有形成在其中的孔的盘，附接到盘的顶侧的第一叶片和附接到盘的底侧的第二叶片。盘可以在其中第二叶片接合最底部杯的底部凸缘的第一位置和第二位置之间移动，第二位置中第一叶片插入下一个最下面的杯子的凹槽中并且接合顶部凸缘的下一个最下面的杯子，其中第二个叶子不再接合最底部的杯子的底部凸缘。在第二位置，最下面的杯子可自由地落入通过形成在盘中的孔。

10. 发明授权

US06426048B1 Sample dilution module with offset mixing chamber 失效
标题翻译：带偏置混合室的样品稀释模块
公开(公告)号：US06426048B1
公开(公告)日：2002-07-30
申请号：US09548152
申请日：2000-04-13
申请人： Robert W. Eherts , Paul Gherson , Carl R. Gebauer , Evandro S. Denunzio
发明人： Robert W. Eherts , Paul Gherson , Carl R. Gebauer , Evandro S. Denunzio
IPC分类号： B01L302
CPC分类号： B01F11/0071 , B01F11/0074 , G01N1/38 , G01N35/08 , Y10T436/117497 , Y10T436/118339 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： The sample dilution module includes an oil filled aspiration probe and mixing chamber that communicate with each other while the mixing chamber is maintained at an angle of approximately 5 to 45 degrees below a horizontal axis. The aspiration probe is maintained in a vertical orientation. A micro-bubble is aspirated between separate aspirations of test sample and diluent to prevent contact between the sample and diluent in the aspiration probe. The test sample and diluent are then drawn from the vertically oriented aspiration probe into the mixing chamber. After the sample and diluent are in the mixing chamber the micro-bubble of air can migrate away from the test sample and diluent to enable the test sample and diluent to contact each other. Mixing of the test sample and diluent is accomplished by moving the test sample and diluent back and forth in the mixing chamber without physical agitation of the mixing chamber and without any mixing element in the mixing chamber. Such movement is accomplished by alternate suction and vacuum forces imposed on the fluid in the mixing chamber.
摘要翻译：样品稀释模块包括充油抽吸探针和混合室，其在混合室保持在水平轴线以下约5至45度的角度的情况下相互连通。吸气探针保持垂直方向。在测试样品和稀释剂的单独吸气之间吸入微气泡，以防止抽吸探针中样品和稀释剂之间的接触。然后将测试样品和稀释剂从垂直取向的吸入探针中抽出到混合室中。在样品和稀释剂在混合室中之后，空气的微气泡可以离开测试样品和稀释剂迁移，以使测试样品和稀释剂彼此接触。测试样品和稀释剂的混合是通过在混合室中来回移动测试样品和稀释剂而没有混合室的物理搅拌并且在混合室中没有任何混合元件来实现的。这种移动通过施加在混合室中的流体上的交替抽吸和真空力来实现。

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