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1. 发明授权

US5676928A Liposomes 失效
标题翻译：脂质体
公开(公告)号：US5676928A
公开(公告)日：1997-10-14
申请号：US468743
申请日：1995-06-06
申请人： Jo Klaveness , Arne Berg , Trond Vegard Jacobsen , Pal Rongved , Thorfinn Ege , Hiroshi Kikuchi , Kiyoto Yachi
发明人： Jo Klaveness , Arne Berg , Trond Vegard Jacobsen , Pal Rongved , Thorfinn Ege , Hiroshi Kikuchi , Kiyoto Yachi
IPC分类号： A61K49/04 , A61K49/18 , A61K49/22 , A61K51/12 , A61K9/127
CPC分类号： A61K49/227 , A61K49/0466 , A61K49/1812
摘要： The invention provides a diagnostic composition for administration to human or animal subjects, the composition containing multilamellar liposomes, optionally together with unilamellar liposomes, the liposomes containing at least one imaging agent and being suspended in an aqueous medium containing said imaging agent, wherein the liposomes comprise a neutral phospholipid and a charged phospholipid, the average particle diameter of the liposomes is 50-3000 nm and the concentration of imaging agent in any aqueous phase filling the interior of the liposomes is substantially the same as that in the aqueous medium in which the liposomes are suspended. The contrast agents concerned are typically X-ray, MRI or ultrasound contrast agents.
摘要翻译：本发明提供了一种用于向人或动物受试者施用的诊断组合物，所述组合物包含多层脂质体，任选地与单层脂质体一起，所述脂质体含有至少一种成像剂并悬浮在含有所述显像剂的水性介质中，其中所述脂质体包含中性磷脂和带电磷脂，脂质体的平均粒径为50-3000nm，填充脂质体内部的任何水相中显像剂的浓度基本上与脂质体的水性介质中相同被暂停。相关的造影剂通常是X射线，MRI或超声造影剂。

2. 发明授权

US5932190A Multinuclear complexes for X-ray imaging 失效
标题翻译：用于X射线成像的多核配合物
公开(公告)号：US5932190A
公开(公告)日：1999-08-03
申请号：US473574
申请日：1995-06-07
申请人： Torsten Almen , Arne Berg , Michael Droege , Harald Dugstad , Jere D. Fellman , Sook-Hui Kim , Jo Klaveness , Scott M. Rocklage , Pal Rongved , Brent Segal , Alan D. Watson
发明人： Torsten Almen , Arne Berg , Michael Droege , Harald Dugstad , Jere D. Fellman , Sook-Hui Kim , Jo Klaveness , Scott M. Rocklage , Pal Rongved , Brent Segal , Alan D. Watson
IPC分类号： A61K49/00 , A61K49/06 , C07C229/16 , C07C237/08 , C07F11/00 , C07F13/00 , C07F15/00 , C07F15/02 , A61K49/04
CPC分类号： C07F11/005 , A61K49/06 , C07F15/025 , Y10S514/836 , Y10S977/903 , Y10S977/928 , Y10S977/929
摘要： An x-ray contrast medium containing a multinuclear complex of the formula (M.sub.6 (.mu..sub.3 B).sub.8 A.sub.v).sub.x L.sub.w, wherein M is Mo, W, Re Tc, V, Nb, Ta, Ru, or Fe; .mu..sub.3 B represent a tridentate bridging atom; A is a non-bridging atom; L is a ligand coordinately bonded to at least one M atom; x is a positive integer; and v and w are independently zero or positive integers.
摘要翻译：含有式（M6（mu 3B）8Av）×Lw的多核配合物的X射线造影剂，其中M为Mo，W，Re Tc，V，Nb，Ta，Ru或Fe; mu 3B代表三齿桥接原子; A是非桥连原子; L是与至少一个M原子配位键合的配体; x是正整数; v和w分别为零或正整数。

3. 发明授权

US5348954A Heterocyclic chelating agents 失效
标题翻译：杂环螯合剂
公开(公告)号：US5348954A
公开(公告)日：1994-09-20
申请号：US690975
申请日：1991-07-24
申请人： Torsten Almen , Arne Berg , Harald Dugstad , Jo Klaveness , Klaus D. Krautwurst , Pal Rongved
发明人： Torsten Almen , Arne Berg , Harald Dugstad , Jo Klaveness , Klaus D. Krautwurst , Pal Rongved
IPC分类号： A61K47/48 , A61K49/00 , A61K49/04 , A61K49/06 , A61K51/00 , A61K51/04 , C07D207/14 , C07D211/42 , C07D211/46 , C07D211/56 , C07D241/04 , C07D241/20 , C07D265/30 , C07D265/32 , C07D279/12 , C07F3/00 , C07F5/00 , C07F9/94 , C07F13/00 , A61K31/15 , C07D211/08
CPC分类号： A61K47/48076 , A61K47/48023 , A61K49/06 , A61K51/0478 , A61K51/0482 , C07D207/14 , C07D211/56 , C07D241/04 , C07D265/30 , C07D279/12 , C07F13/005 , C07F3/003 , C07F5/003 , C07F9/94 , A61K2121/00 , A61K2123/00 , Y10S514/836 , Y10T436/24
摘要： Heterocylic chelating agents and salts thereof of formula I: ##STR1## wherein X represents a bond, O or S, or a group CHR.sup.1 or NR.sup.3 ; R.sup.1 represents H, a group OR.sup.3 or NR.sup.3 R.sup.3, or an alkyl or alkoxyalkyl group optionally substituted by a hydroxyl group or by a group NR.sup.3 R.sup.3 or CON.sup.3 R.sup.3 ;each R.sup.2 represents H, or an alkyl or alkoxy group optionally substituted by a hydroxyl or alkoxy group;each R.sup.3 represents H, an optionally hydroxylated alkyl group or a group CH.sub.2 Y;Y represents a group COZ, CON(OH)R.sup.4, POZ.sub.2 or SO.sub.2 Z;Z represents a group OR.sup.4, NR.sup.4 R.sup.4 or ##STR2## where each R.sup.11 is H, a hydroxyl group or an optionally hydroxylated alkyl group, s is 0, 1 or 2, and W is CHR.sup.11, NR.sup.11 or an oxygen atom; andeach R.sup.4 represents H, or an optionally mono- or poly-hydroxylated alkyl, alkoxyalkyl or polyalkoxyalkyl group;with the provisos that where s is 0 then W is CHR.sup.11 and that where X represents a bond or CHR.sup.1, at least one group R.sup.1 or R.sup.2 represents other than H or an unsubstituted alkyl group. A process for preparing these agents and methods of heavy metal detoxification using these agents are also described.
摘要翻译： PCT No.PCT / EP90 / 00079 Sec。 371日期1991年7月24日 102（e）日期1991年7月24日PCT 1990年1月15日PCT PCT。公开号WO90 / 08138 日本1990年7月26日。式I的杂环螯合剂及其盐：其中X表示键，O或S或CHR1或NR3基团; R1表示H，OR3或NR3R3，或任选被羟基或NR3R3或CON3R3基团取代的烷基或烷氧基烷基; 每个R 2表示H或任选被羟基或烷氧基取代的烷基或烷氧基; 每个R 3表示H，任选羟基化的烷基或基团CH 2 Y; Y代表基团COZ，CON（OH）R4，POZ2或SO2Z; Z表示OR4，NR4R4或，其中每个R11是H，羟基或任选羟基化的烷基，s是0,1或2，W是CHR 11，NR 11或氧原子; 并且每个R 4表示H或任选的单羟基化或多羟基化烷基，烷氧基烷基或聚烷氧基烷基; 条件是其中s为0，则W为CHR 11，并且其中X表示键或CHR，至少一个基团R 1或R 2表示不同于H或未取代的烷基。还描述了使用这些试剂制备这些试剂的方法和重金属解毒的方法。

4. 发明授权

US5198208A Aminopolycarboxylic acids and derivatives thereof 失效
标题翻译：氨基羟基羧酸及其衍生物
公开(公告)号：US5198208A
公开(公告)日：1993-03-30
申请号：US457717
申请日：1990-03-16
申请人： Arne Berg , Torsten Almen , Jo Klaveness , Pal Rongved , Terje Thomassen
发明人： Arne Berg , Torsten Almen , Jo Klaveness , Pal Rongved , Terje Thomassen
IPC分类号： A61K49/00 , A61K47/48 , A61K49/04 , A61K51/00 , A61K51/04 , C07C227/18 , C07C229/16 , C07C229/22 , C07C229/76 , C07C237/06 , C07D257/02 , C07D273/00 , C07D285/00 , C07F5/00 , C07F11/00 , C07F15/02 , C09K3/00
CPC分类号： A61K51/0482 , A61K47/48076 , A61K51/0478 , C07D257/02 , C07D273/00 , C07D285/00 , C07F5/003 , Y10S514/836 , Y10T436/24
摘要： There are provided chelating agents particularly useful for the preparations of diagnostic and therapeutic agents for magnetic resonance imaging, scintigraphy, ultrasound imaging, radiotherapy and heavy metal detoxification, said agents being compounds of formula X--CHR.sub.1 --NZ--(CHR.sub.1).sub.n --A--(CHR.sub.1).sub.m --NZ--CHR.sub.1 --X wherein (each of the groups Z is a group --CHR.sub.1 X or the groups Z together are a group --(CHR.sub.1).sub.q --A'--(CHR.sub.1).sub.r --, where A' is an oxygen or sulphur atom or a group --N--Y; A is a group --N--Y or A--(CHR.sub.1).sub.m -- represents a carbon-nitrogen bond or, when the groups Z together are a group --(CHR.sub.1).sub.q --A'--(CHR.sub.1).sub.r --, A may also represent an oxygen or sulphur atom; each Y, which may be the same or different, is a group --(CHR.sub.1).sub.p --N(CHR.sub.1 X).sub.2 or a group --CHR.sub.1 X; each X, which may be the same or different, is a carboxyl group or a derivative thereof or a group R.sub.1 ; each R.sub.1, which may be the same or different, is a hydrogen atom, a hydroxyalkyl group or an optionally hydroxylated alkoxy or alkoxyalkyl group; n, m, p, q and r are each 2, 3 or 4; with the provisos that at least two nitrogens carry a --CHR.sub.1 X moiety wherein X is a carboxyl group or a derivative thereof, that each --CHR.sub.1 X moiety is other than a methyl group, and that unless A' is oxygen or sulphur or A is N--(CHR.sub.1).sub.p --N(CHR.sub.1 X).sub.2 at least one R.sub.1 is other than hydrogen) and salts thereof.

5. 发明授权

US5716598A Contrast medium for magnetic resonance imaging using physiologically tolerable manganese compound 失效
标题翻译：使用生理可耐受锰化合物的磁共振成像对比剂
公开(公告)号：US5716598A
公开(公告)日：1998-02-10
申请号：US465100
申请日：1995-06-05
申请人： Klaes Golman , Goran Pettersson , Arne Berg , Jo Klaveness , Pal Rongved , Peter Leander
发明人： Klaes Golman , Goran Pettersson , Arne Berg , Jo Klaveness , Pal Rongved , Peter Leander
IPC分类号： A61K49/06 , A61K49/18 , A61K49/00 , A61B5/055
CPC分类号： A61K49/06 , A61K49/18
摘要： There is provided a contrast medium composition for magnetic resonance imaging comprising a physiologically tolerable manganese compound, a physiologically tolerable reducing compound containing an .alpha.-hydroxy ketone group, or salt thereof and a physiologically tolerable carrier or excipient, having a manganese concentration of at least 0.3 mM or being in a dosage unit form containing at least 300 .mu.mol manganese. Such compositions are particularly suitable for imaging of the liver.
摘要翻译：提供了一种用于磁共振成像的造影剂组合物，其包含生理上可耐受的锰化合物，含有α-羟基酮基团的生理上可耐受的还原化合物或其盐和生理上可耐受的载体或赋形剂，其锰浓度为至少0.3 或含有至少300μmol锰的剂量单位形式。这样的组合物特别适用于肝脏的成像。

6. 发明授权

US5531978A Aminopolycarboxylic acids and derivatives thereof 失效
标题翻译：氨基多羧酸及其衍生物
公开(公告)号：US5531978A
公开(公告)日：1996-07-02
申请号：US14569
申请日：1993-02-08
申请人： Arne Berg , Torsten Almen , Jo Klaveness , Pal Rongved , Terje Thomassen , Harald Dugstad
发明人： Arne Berg , Torsten Almen , Jo Klaveness , Pal Rongved , Terje Thomassen , Harald Dugstad
IPC分类号： A61K47/48 , A61K49/06 , A61K51/04 , C07C237/08 , C07D257/02 , C07D273/00 , C07D285/00 , C07D295/185 , C07F5/00 , C07F13/00 , A61K51/00 , A61K49/00
CPC分类号： A61K47/48076 , A61K49/06 , A61K51/0478 , C07C237/08 , C07D257/02 , C07D273/00 , C07D285/00 , C07D295/185 , C07F13/005 , C07F5/003 , A61K2123/00
摘要： There are provided chelating agents particularly useful for the preparation of diagnostic and therapeutic agents for magnetic resonance imaging, scintigraphy, ultrasound imaging, radiotherapy and heavy metal detoxification, said agents being compounds of formula IX--CHR.sub.1 --NZ--(CHR.sub.1).sub.n --A--(CHR.sub.1).sub.m --NZ--CHR.sub.1 --X (I)wherein n and m are 2, 3 or 4; and A, X, R.sub.1 and Z are as defined in the specification.
摘要翻译：提供特别可用于制备用于磁共振成像，闪烁扫描，超声成像，放射治疗和重金属解毒的诊断和治疗剂的螯合剂，所述药剂是式I的化合物X-CHR1-NZ-（CHR1）nA-（ CHR1）m-NZ-CHR1-X（I）其中n和m为2,3或4; A，X，R 1和Z如说明书中所定义。

7. 发明授权

US5458869A Multinuclear complexes for X-ray imaging 失效
标题翻译：用于X射线成像的多核配合物
公开(公告)号：US5458869A
公开(公告)日：1995-10-17
申请号：US927484
申请日：1992-11-24
申请人： Arne Berg , Torsten Almen , Klaus D. Krautwurst , Sook-Hui Kim , Pal Rongved , Jo Klaveness , Harald Dugstad
发明人： Arne Berg , Torsten Almen , Klaus D. Krautwurst , Sook-Hui Kim , Pal Rongved , Jo Klaveness , Harald Dugstad
IPC分类号： A61K20060101 , A61K49/00 , A61K49/04 , A61K51/02 , A61K51/04 , C07F11/00
CPC分类号： C07F11/005 , A61K49/04 , A61K51/02 , A61K51/04 , A61K51/0482 , A61K2123/00 , Y10S514/836
摘要： The invention relates to the use as contrast enhancing agents in medical imaging, especially X-ray imaging, of multinuclear complexes, i.e. complexes, such as those of W2O2 (u2O)2, in which the complexed entity comprises at least two contrast enhancing atoms.
摘要翻译： PCT No.PCT / EP91 / 00587 371日期：1992年11月24日 102（e）日期1992年11月24日PCT 1991年3月27日PCT公布。公开号WO91 / 14460 1991年10月3日的日期。本发明涉及在多核复合物（即W2O2（u2O）2）的复合物的医学成像，特别是X射线成像中用作对比增强剂的用途，其中复合实体包含至少两个对比度增强原子。

8. 发明授权

US5439668A Heterocyclic chelating agents 失效
标题翻译：杂环螯合剂
公开(公告)号：US5439668A
公开(公告)日：1995-08-08
申请号：US235882
申请日：1994-05-02
申请人： Torsten Almen , Arne Berg , Harald Dugstad , Jo Klaveness , Klaus D. Krautwurst , Pal Rongved
发明人： Torsten Almen , Arne Berg , Harald Dugstad , Jo Klaveness , Klaus D. Krautwurst , Pal Rongved
IPC分类号： A61K47/48 , A61K49/00 , A61K49/04 , A61K49/06 , A61K51/00 , A61K51/04 , C07D207/14 , C07D211/42 , C07D211/46 , C07D211/56 , C07D241/04 , C07D241/20 , C07D265/30 , C07D265/32 , C07D279/12 , C07F3/00 , C07F5/00 , C07F9/94 , C07F13/00 , A61B5/055
CPC分类号： A61K47/48076 , A61K47/48023 , A61K49/06 , A61K51/0478 , A61K51/0482 , C07D207/14 , C07D211/56 , C07D241/04 , C07D265/30 , C07D279/12 , C07F13/005 , C07F3/003 , C07F5/003 , C07F9/94 , A61K2121/00 , A61K2123/00 , Y10S514/836 , Y10T436/24
摘要： Heterocyclic chelating agents and salts thereof of formula I: ##STR1## wherein X represents a bond, O or S, or a group CHR.sup.1 or NR.sup.3, each R.sup.1 represents H, a group OR.sup.3 or NR.sup.3 R.sup.3, or an alkyl or alkoxyalkyl group optionally substituted by a hydroxyl group or by a group NR.sup.3 R.sup.3 or CON.sup.3 R.sup.3 ;each R.sup.2 represents H, or an alkyl or alkoxy group optionally substituted by a hydroxyl or aloxy group;each R.sup.3 represents H, an optionally hydroxylated alkyl group or a group CH.sub.2 Y;Y represents a group COZ, CON(OH)R.sup.4, POZ.sub.2 or SO.sub.2 Z; Z represents a group OR.sup.4, NR.sup.4 R.sup.4 or ##STR2## where each R.sup.11 is H, a hydroxyl group or an optionally hydroxylated alkyl group, s is 0, 1 or 2, and W is CHR.sup.11, NR.sup.11 or an oxygen atom; andeach R.sup.4 represents H, or an optionally mono- or poly-hydroxylated alkyl, alkoxyalkyl or polyalkoxyalkyl group;with the provisos that where s is O then W is CHR.sup.11 and that where X represents a bond or CHR.sup.1, at least one group R.sup.1 or R.sup.2 represents other than H or an unsubstituted alkyl group. A process for preparing these agents and methods of heavy metal detoxification using these agents are alo described.
摘要翻译：式I的杂环螯合剂及其盐：其中X表示键，O或S或基团CHR1或NR3，每个R1表示H，OR3或NR3R3，或烷基或烷氧基烷基任选被羟基或NR 3 R 3或CON 3 R 3基团取代; 每个R 2表示H或任选被羟基或氧基取代的烷基或烷氧基; 每个R 3表示H，任选羟基化的烷基或基团CH 2 Y; Y代表基团COZ，CON（OH）R4，POZ2或SO2Z; Z表示OR4，NR4R4或，其中每个R11是H，羟基或任选羟基化的烷基，s是0,1或2，W是CHR 11，NR 11或氧原子; 并且每个R 4表示H或任选的单羟基化或多羟基化烷基，烷氧基烷基或聚烷氧基烷基; 条件是其中s是O，则W是CHR 11，并且其中X代表键或CHR，至少有一个R 1或R 2基团不是H或未被取代的烷基。描述了使用这些试剂制备这些试剂的方法和重金属解毒方法。

9. 发明授权

US5419893A Aminopolycarboxylic acids and derivatives thereof for magnetic resonance imaging 失效
标题翻译：氨基多羧酸及其衍生物用于磁共振成像
公开(公告)号：US5419893A
公开(公告)日：1995-05-30
申请号：US5628
申请日：1993-01-19
申请人： Arne Berg , Torsten Almen , Jo Klaveness , Pal Rongved , Terje Thomassen
发明人： Arne Berg , Torsten Almen , Jo Klaveness , Pal Rongved , Terje Thomassen
IPC分类号： A61K49/00 , A61K47/48 , A61K49/04 , A61K51/00 , A61K51/04 , C07C227/18 , C07C229/16 , C07C229/22 , C07C229/76 , C07C237/06 , C07D257/02 , C07D273/00 , C07D285/00 , C07F5/00 , C07F11/00 , C07F15/02 , C09K3/00 , A61B5/055
CPC分类号： A61K51/0482 , A61K47/48076 , A61K51/0478 , C07D257/02 , C07D273/00 , C07D285/00 , C07F5/003 , Y10S514/836 , Y10T436/24
摘要： There are provided chelating agents particularly useful for the preparation of diagnostic and therapeutic agents for magnetic resonance imaging, scintigraphy, ultrasound imaging, radiotherapy and heavy metal detoxification, said agents being compounds of formula IX--CHR.sub.1 NZ--(CHR.sub.1).sub.n --A--(CHR.sub.1).sub.m --NZ--CHR.sub.1 --X (I)(wherein each of the groups Z is a group --CHR.sub.1 X or the groups Z together are a group --(CHR.sub.1).sub.q --A'--(CHR.sub.1).sub.r --, where A' is an oxygen or sulphur atom or a group --N--Y;A is a group --N--Y or A--(CHR.sub.1).sub.m -- represents a carbon-nitrogen bond or, when the groups Z together are a group --(CHR.sub.1).sub.q --A'--(CHR.sub.1).sub.r --, A may also represent an oxygen or sulphur atom;each Y, which may be the same or different, is a group --(CHR.sub.1).sub.p --N(CHR.sub.1 X).sub.2 or a group --CHR.sub.1 X;each X, which may be the same or different, is a carboxyl group or a derivative thereof or a group R.sub.1 ;each R.sub.1, which may be the same or different, is a hydrogen atom, a hydroxyalkyl group or an optionally hydroxylated alkoxy or alkoxyalkyl group;n,m,p,q and r are each 2,3 or 4; with the provisos that at least two nitrogens carry a --CHR.sub.1 X moiety wherein X is a carboxyl group or a derivative thereof, that each --CHR.sub.1 X moiety is other than a methyl group, and that unless A' is oxygen or sulphur or A is N--(CHR.sub.1).sub.p --N(CHR.sub.1 X).sub.2 at least one R.sub.1 is other than hydrogen) and salts thereof.
摘要翻译：提供了特别可用于制备用于磁共振成像，闪烁扫描，超声成像，放射治疗和重金属解毒的诊断和治疗剂的螯合剂，所述药剂是式I X-CHR1NZ-（CHR1）nA-（CHR1） m-NZ-CHR1-X（I）（其中基团Z为基团-CHR1X或基团Z一起为基团 - （CHR 1）q -A' - （CHR 1） - ，其中A'为氧或硫原子或基团-NY; A是基团-NY或A-（CHR1）m-表示碳 - 氮键，或者当基团Z一起为 - （CHR 1）q-A' - （ CHR1）r-，A也可以表示氧或硫原子;每个Y可以相同或不同，是基团 - （CHR1）pN（CHR1X）2或基团-CHR1X;每个X可以是相同或不同的是羧基或其衍生物或基团R 1;每个R 1可以相同或不同，是氢原子，羟烷基或任选羟基化的烷氧基或烷氧基烷基; n，m， p，q和r 分别为2,3或4; 条件是至少两个氮原子携带-CHR1X部分，其中X是羧基或其衍生物，每个-CHR1X部分不是甲基，除非A'是氧或硫或A是N- （CHR1）pN（CHR1X）2，至少一个R1不是氢）及其盐。

10. 发明授权

US5482699A Multinuclear complexes for x-ray imaging 失效
标题翻译：用于x射线成像的多核复合物
公开(公告)号：US5482699A
公开(公告)日：1996-01-09
申请号：US122461
申请日：1993-09-24
申请人： Torsten Almen , Arne Berg , C. Allen Chang , Michael Droege , Harald Dugstad , Jere D. Fellman , Sook-Hui Kim , Jo Klaveness , Scott M. Rocklage , Pal Rongved , Brent Segal , Alan D. Watson
发明人： Torsten Almen , Arne Berg , C. Allen Chang , Michael Droege , Harald Dugstad , Jere D. Fellman , Sook-Hui Kim , Jo Klaveness , Scott M. Rocklage , Pal Rongved , Brent Segal , Alan D. Watson
IPC分类号： A61K49/00 , A61K49/06 , C07C229/16 , C07C237/08 , C07F11/00 , C07F13/00 , C07F15/00 , C07F15/02 , A61K49/04
CPC分类号： C07F11/005 , A61K49/06 , C07F15/025 , Y10S514/836 , Y10S977/903 , Y10S977/928 , Y10S977/929
摘要： An imaging contrast medium comprising a physiologically tolerable multinuclear complex (as defined in claim 1) is disclosed. The multinuclear complex contains at least two, but preferably three or more contrast enhancing atoms. For X-ray or ultrasound imaging techniques heavy metal atoms are used to enhance contrast, whereas in Magnetic Resonance Imaging paramagnetic metal atoms are contrast enhancing. Molybdenum and tungsten are preferred contrast enhancing atoms. The medium may also be used therapeutically.
摘要翻译： PCT No.PCT / EP92 / 00698 Sec。 371日期：1993年9月24日 102（e）日期1993年11月24日PCT 1991年3月27日PCT公布。出版物WO92 / 17215 公开了包含生理上可耐受的多核复合物（如权利要求1所定义）的成像造影剂。多核络合物包含至少两个，但优选三个或更多对比增强原子。对于X射线或超声成像技术，重金属原子用于增强对比度，而在磁共振成像顺磁金属原子是对比度增强。钼和钨是优选的对比度增强原子。培养基也可以治疗使用。

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