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1. 发明授权

US5755082A Manufacturing equipment for cushioning material 失效
公开(公告)号：US5755082A
公开(公告)日：1998-05-26
申请号：US784762
申请日：1997-01-16
申请人： Jiro Takahashi , Yukio Tahara , Tsuyoshi Mizutani , Itsuku Ohtawa , Akira Aoyama , Norikazu Yamagishi
发明人： Jiro Takahashi , Yukio Tahara , Tsuyoshi Mizutani , Itsuku Ohtawa , Akira Aoyama , Norikazu Yamagishi
IPC分类号： B29D22/00 , B31B21/26 , B31B21/74 , B31D5/00 , B65B9/20 , B65D81/07 , B65B31/00
CPC分类号： B31D5/0073 , B29D22/00 , B31D5/0086 , B29L2031/714 , B31D2205/0023 , B31D2205/0058 , B31D2205/007
摘要： Equipment which automatically manufactures cushioning material by filling air inside polyvinyl alcohol laminated paper and sealing the filled material into individual bags. The manufacturing equipment 1 is provided with a material roll 20 on which a sheet material of polyvinyl alcohol laminated paper is wound. The sheet material 10 is rolled out by a feeding roller 40 from the material roll 20, and the sheet material 10 in a known length, adjusted by a length adjusting device 50 having a roller 42 which goes up and down, is supplied intermittently to a bag forming device 100 located downstream thereof. The bag forming device 100 is provided with a pipe member 105 and a sailor 110, which is a guide plate to reverse the sheet material 10 and form it into a tubular shape, and the sheet material 10 is fed along the pipe member 105 after being formed into a tubular shape. Feed rollers 130 and auxiliary belt 120 are arranged at the periphery of the pipe member 105. The feed rollers 130 catch the superposed sections of both edges of the sheet material formed into a tubular shape and feed the material, inserting the superposed section into a center sealer 150. The center sealer 150 is provided with a heater and welds together the superposed sections. As a result of this welding, the sheet material is formed into a long tube. The center sealed tubular sheet material is further sent downstream from the lower end of the pipe member 105. Air is supplied from the top of the pipe member 105, and the air is filled inside the tubular sheet material. In such condition, the sheet material is sent to the end sealer/cutter. The end sealer/cutter 160 is provided with a pair of end sealers facing each other which weld the tubular sheet material into a bag shape and cut the material into individual bags with a cutter 165. At this time, the air amount is adjusted by the filled air amount adjusting device 170. The air filled cushioning material 200 is sent to the next process by a conveyor 210.

2. 发明授权

US5912058A Shock absorber and package with shock absorbers 失效
标题翻译：减震器和减震器包装
公开(公告)号：US5912058A
公开(公告)日：1999-06-15
申请号：US824306
申请日：1997-03-26
申请人： Jiro Takahashi , Itsuku Ohtawa , Norikazu Yamagishi , Tadayuki Ichiba , Mutsuharu Takesada , Akira Aoyama , Tsuyoshi Mizutani
发明人： Jiro Takahashi , Itsuku Ohtawa , Norikazu Yamagishi , Tadayuki Ichiba , Mutsuharu Takesada , Akira Aoyama , Tsuyoshi Mizutani
IPC分类号： B65D81/07 , B32B7/02 , B32B27/10 , B32B27/30 , B65D65/46 , B65D81/05 , C08L101/16 , B27N22/00 , B29D22/00 , B65D30/00 , B65D81/02
CPC分类号： B65D81/052 , B32B27/10 , B65D65/466 , Y02W30/801 , Y02W90/13 , Y10S206/814 , Y10T428/1303 , Y10T428/1307 , Y10T428/1341
摘要： Sheets of laminated paper are stacked and made into air-tight flat bags with air inlets. After air is supplied into the bags, the air inlets are air-tightly closed to form shock absorbers 50 encapsulating the air. The laminated paper is made by stacking on a paper base a water-soluble polyvinyl alcoholic layer, having a saponification of 80 to 90 mol % and a degree of polymerization of 500 to 2500, to a total thickness of 90 .mu.m or less and a gas permeability of 800 thousand seconds per 100 ml or more. The air is introduced into flat bags 51 to 50 to 80% of maximum inflation to ensure their shock absorbing function. A package 100 is made by putting an appropriate number of discrete shock absorbers 50, or a continuous series of shock absorbers 50, in gaps between a casing 10 and the package content 70. The shock absorbers 50 need not be spread all over the entire surface of the package, so long as they are sufficient to provide the needed contact area to ensure a maximum static load of 0.07 kgf/cm.sup.2 (around 20 kg in normal packages).
摘要翻译：将层压纸层叠并制成具有空气入口的气密平袋。将空气供给到袋中之后，空气入口气密地关闭，以形成密封空气的减震器50。层叠纸通过在纸基上堆叠皂化为80〜90摩尔％，聚合度为500〜2500的水溶性聚乙烯醇酸酯，总厚度为90μm以下，每100毫升或以上的气体渗透性为80万秒。将空气引入到最大充气量的50％至80％的扁平袋中，以确保其吸震功能。通过将适当数量的离散减震器50或连续系列的减震器50放置在壳体10和包装内容物70之间的间隙中来制造包装100.减震器50不需要遍及整个表面只要它们足以提供所需的接触面积，以确保最大静态载荷为0.07 kgf / cm2（正常包装中约为20 kg）。

3. 发明授权

US06967197B2 Thiazepinyl hydroxamic acid derivatives as matrix metalloproteinase inhibitors 失效
标题翻译：噻嗪基异羟肟酸衍生物作为基质金属蛋白酶抑制剂
公开(公告)号：US06967197B2
公开(公告)日：2005-11-22
申请号：US10203627
申请日：2001-02-20
申请人： Masahiro Neya , Hitoshi Yamazaki , Kazuhiko Ohne , Yuki Sawada , Tsuyoshi Mizutani , Yoshimasa Imamura , Noriko Mukai
发明人： Masahiro Neya , Hitoshi Yamazaki , Kazuhiko Ohne , Yuki Sawada , Tsuyoshi Mizutani , Yoshimasa Imamura , Noriko Mukai
IPC分类号： A61K31/554 , A61P1/02 , A61P1/04 , A61P9/10 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/08 , A61P19/10 , A61P25/08 , A61P29/00 , A61P29/02 , A61P31/00 , A61P31/04 , A61P31/18 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D281/06 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , A61K31/55
CPC分类号： C07D417/04 , C07D281/06 , C07D417/06 , C07D417/12 , C07D417/14
摘要： A compound of formula (I) in which R1 is halo, lower alkoxy, optionally substituted aryl, optionally substituted aryloxy, optionally substituted heterecyclic group or optionally substituted lower alkynyl, R2 is amidated carboxy, R3 is hydrogen or acyl, Ar is aryl or heterocyclic group, X is thia, sulfinyl or sulfonyl, Y and Z are each lower alkylene, m and n are each an integer of 0 to 2, and a salt thereof, useful as inhibitors of matrix metalloproteinases (MMP) or the production of tumor necrosis factor α (TNF α)
摘要翻译：式（I）的化合物，其中R 1是卤素，低级烷氧基，任选取代的芳基，任选取代的芳氧基，任选取代的羟基或任选取代的低级炔基，R 2 O >是酰胺基羧基，R 3是氢或酰基，Ar是芳基或杂环基，X是硫杂，亚磺酰基或磺酰基，Y和Z各自是低级亚烷基，m和n各自是 0至2及其盐，其可用作基质金属蛋白酶（MMP）的抑制剂或肿瘤坏死因子α（TNFα）的产生）

4. 发明授权

US06384080B1 Anthranilic acid derivatives as inhibitors of the cGMP-phosphodiesterase 失效
标题翻译：邻氨基苯甲酸衍生物作为cGMP-磷酸二酯酶的抑制剂
公开(公告)号：US06384080B1
公开(公告)日：2002-05-07
申请号：US09509541
申请日：2001-04-23
申请人： Teruo Oku , Kozo Sawada , Akio Kuroda , Takayuki Inoue , Natsuko Kayakiri , Yuki Sawada , Tsuyoshi Mizutani
发明人： Teruo Oku , Kozo Sawada , Akio Kuroda , Takayuki Inoue , Natsuko Kayakiri , Yuki Sawada , Tsuyoshi Mizutani
IPC分类号： A61K3118
CPC分类号： C07D213/40 , C07C227/30 , C07C227/32 , C07C2601/08 , C07C2601/14 , C07D207/14 , C07D207/48 , C07D211/58 , C07D231/12 , C07D233/56 , C07D235/14 , C07D249/08 , C07D307/22 , C07D317/58 , C07D333/20
摘要： Compounds of formula (I) where R1 is hydrogen; R2 is nitro, cyano or halo(lower)alkyl; R3 is phenyl substituted with one or more substituents selected from halogen, cyano and lower alkoxy; A is a lower alkylene group; R4 is a group CR6R7R8 wherein R6 and R7 form, together with the carbon atom to which they are attached a cycloalkyl group optionally substituted with hydroxy, lower alkoxy or a lower alkanoylamino; and R8 is hydrogen; its prodrug and a salt thereof.
摘要翻译：其中R1是氢的式（Ⅰ）化合物; R2是硝基，氰基或卤代（低级）烷基; R3是被一个或多个选自卤素，氰基和低级烷氧基的取代基取代的苯基; A是低级亚烷基; R4是基团CR6R7R8，其中R6和R7与它们所连接的碳原子一起形成任选被羟基，低级烷氧基或低级烷酰基氨基取代的环烷基; R8是氢; 其前药及其盐。

5. 发明授权

US06348474B1 Sulfonamide compounds and medicinal use thereof 失效
标题翻译：磺酰胺类化合物及其医药用途
公开(公告)号：US06348474B1
公开(公告)日：2002-02-19
申请号：US09446110
申请日：2000-02-14
申请人： Hiroshi Kayakiri , Yoshito Abe , Hitoshi Hamashima , Hitoshi Sawada , Tsuyoshi Mizutani , Teruo Oku , Noritsugu Yamasaki , Osamu Onomura , Masahiro Nishikawa , Takahiro Hiramura , Takafumi Imoto
发明人： Hiroshi Kayakiri , Yoshito Abe , Hitoshi Hamashima , Hitoshi Sawada , Tsuyoshi Mizutani , Teruo Oku , Noritsugu Yamasaki , Osamu Onomura , Masahiro Nishikawa , Takahiro Hiramura , Takafumi Imoto
IPC分类号： A61K31435
CPC分类号： C07D241/52 , C07D215/48 , C07D231/56 , C07D239/96 , C07D249/18 , C07D307/79 , C07D333/54 , C07D333/62 , C07D405/12 , C07D409/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： A sulfonamide compound of the formula (I): R1—SO2NHCO—A—R2 (I) wherein R1 is alkyl, alkenyl, alkynyl and the like; A is an optionally substituted heteropolycyclic group except benzimidazolyl, indolyl, 4,7-dihydrobenzimidazolyl and 2,3-dihydrobenzoxazinyl; X is alkylene, oxa, oxa(lower)alkylene and the like; and R2 is optionally substituted aryl, substituted biphenylyl and the like, a salt thereof and a pharmaceutical composition comprising the same. The sulfonamide compound is effective for the diseases treatable based on their blood sugar level-depressing activity, cGMP-PDE (especially PDE-V)-inhibiting activity, smooth muscle relaxing activity, bronchodilating activity, vasodilating activity, smooth muscle cell suppressing activity, and antiallergic activity.
摘要翻译：式（I）的磺酰胺化合物：其中R1是烷基，烯基，炔基等; A是任选取代的杂多环基团，除了苯并咪唑基，吲哚基，4,7-二氢苯并咪唑基和2,3-二氢苯并恶嗪基; X是亚烷基，氧杂，氧杂（低级）亚烷基等; 并且R 2是任选取代的芳基，取代的联苯基等，其盐和包含它们的药物组合物。磺胺类化合物可以基于其血糖降低活性，cGMP-PDE（特别是PDE-V）抑制活性，平滑肌松弛活性，支气管扩张活性，血管舒张活性，平滑肌细胞抑制活性，以及抗过敏活性。

6. 发明授权

US06787565B2 Sulfonamide compounds and pharmaceutical use thereof 失效
标题翻译：磺酰胺化合物及其药物用途
公开(公告)号：US06787565B2
公开(公告)日：2004-09-07
申请号：US10047093
申请日：2002-01-17
申请人： Hiroshi Kayakiri , Yoshito Abe , Hitoshi Hamashima , Hitoshi Sawada , Tsuyoshi Mizutani , Teruo Oku , Noritsugu Yamasaki , Osamu Onomura , Masahiro Nishikawa , Takahiro Hiramura , Takafumi Imoto
发明人： Hiroshi Kayakiri , Yoshito Abe , Hitoshi Hamashima , Hitoshi Sawada , Tsuyoshi Mizutani , Teruo Oku , Noritsugu Yamasaki , Osamu Onomura , Masahiro Nishikawa , Takahiro Hiramura , Takafumi Imoto
IPC分类号： A61K3134
CPC分类号： C07D241/52 , C07D215/48 , C07D231/56 , C07D239/96 , C07D249/18 , C07D307/79 , C07D333/54 , C07D333/62 , C07D405/12 , C07D409/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： A sulfonamide compound of the formula (I): R1—SO2NHCO—A—X—R2 (I) wherein R1 is alky, alkenyl, alkynyl and the like; A is an optionally substitutedheteropolycyclic group except benzimidazolyl, indolyl, 4,7-dihydrobenzimidazolyland 2,3-dihydrobenzoxazinyl; X is alkylene, oxa, oxa(lower)alkylene and the like; and R2 is optionally substituted aryl, substituted biphenylyl and the like, a salt thereof and a pharmaceutical composition comprising the same. The sulfonamide compound is effective for the diseases treatable based on their blood sugar level-depressing activity, cGMP-PDE (especially PDE-V)-inhibiting activity, smooth muscle relaxing activity, bronchodilating activity, vasodilating activity, smooth muscle cell suppressing activity, and antiallergic activity.
摘要翻译：式（I）的磺酰胺化合物：其中R 1是烷基，烯基，炔基等; A是任选取代的杂多环基团，除了苯并咪唑基，吲哚基，4,7-二氢苯并咪唑啉-2,3-二氢苯并恶嗪基; X是亚烷基，氧杂，氧杂（低级）亚烷基等; 和R 2是任选取代的芳基，取代的联苯基等，其盐和包含它们的药物组合物。磺胺类化合物可以基于其血糖降低活性，cGMP-PDE（特别是PDE-V）抑制活性，平滑肌松弛活性，支气管扩张活性，血管舒张活性，平滑肌细胞抑制活性，以及抗过敏活性。

7. 发明授权

US6015818A Quinoline derivatives as bradykinin agonists 有权
标题翻译：喹啉衍生物作为缓激肽激动剂
公开(公告)号：US6015818A
公开(公告)日：2000-01-18
申请号：US117453
申请日：1998-08-03
申请人： Teruo Oku , Hiroshi Kayakiri , Yoshito Abe , Yuki Sawada , Tsuyoshi Mizutani
发明人： Teruo Oku , Hiroshi Kayakiri , Yoshito Abe , Yuki Sawada , Tsuyoshi Mizutani
IPC分类号： A61K31/4439 , A61K31/4709 , A61P1/00 , A61P1/16 , A61P1/18 , A61P3/10 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P13/12 , A61P15/00 , A61P15/12 , A61P27/02 , A61P27/06 , A61P43/00 , C07D401/12 , C07D401/14 , C07D409/14 , A61K31/395
CPC分类号： C07D401/14 , C07D401/12 , C07D409/14
摘要： This invention relates to a compound of formula (1) wherein R.sup.1 is halogen, etc., R.sup.2 is halogen, etc., R.sup.3 is amino substituted with substituent(s) selected from the group consisting of lower alkyl and acyl, etc., R.sup.4 is heterocyclic (lower)alkyl, R.sup.5 is lower alkyl, and A.sup.1 is lower alkylene, and pharmaceutically acceptable salts thereof, to processes for preparation thereof, to a pharmaceutical composition comprising the same, and to methods of using the same therapeutically in the prevention and/or the treatment of hypertension or the like. ##STR1##
摘要翻译： PCT No.PCT / JP97 / 00233 Sec。 371日期1998年8月3日 102（e）1998年8月3日PCT PCT 1997年1月31日PCT公布。公开号WO97 / 28153 PCT 日期：1997年8月7日本发明涉及式（1）化合物，其中R 1为卤素等，R 2为卤素等，R 3为被选自下列基团的取代基取代的氨基：低级烷基和酰基等等，R4是杂环（低级）烷基，R5是低级烷基，并且A1是低级亚烷基及其制药方法的药学上可接受的盐，包括它们的药物组合物及其使用方法治疗性地预防和/或治疗高血压等。

8. 发明授权

US5818483A Actuator body structure for a piezoelectric ink ejecting printing apparatus 失效
标题翻译：用于压电喷墨打印装置的致动器主体结构
公开(公告)号：US5818483A
公开(公告)日：1998-10-06
申请号：US530423
申请日：1995-09-19
申请人： Tsuyoshi Mizutani
发明人： Tsuyoshi Mizutani
IPC分类号： B41J2/045 , B41J2/055 , B41J2/14 , B41J2/16
CPC分类号： B41J2/14209 , B41J2002/14379 , B41J2002/14491 , B41J2202/18
摘要： An ink ejecting print head includes an actuator having a plurality of grooves, and a plurality of partition walls separating the grooves. One conductor layer is provided at the center of each partition wall. Other conductor layers connect to conductive thin films provided in each of the ink channels. A voltage is applied to a driving electrode which is electrically connected to conductive thin film provided in one ink channel. The driving electrodes connected to the conductive thin films in the other ink channels and to the conductor layers in the partition walls are grounded. At this time, an electric field occurs in an area of an ink-channel side of each partition wall defining the ink channel, and each adjacent side of the partition wall is deformed. Therefore, the volume of the ink channel is decreased to produce pressure, so that ink is ejected from a nozzle intercommunicating with the ink channel. At this time, no electric field occurs in an area of the partition wall which is at the opposite side to the ink-channel side, so that the other ink channels adjacent to the ink channel are not affected by the deformation of the ink channel.
摘要翻译：喷墨打印头包括具有多个凹槽的致动器和分隔凹槽的多个分隔壁。一个导体层设置在每个分隔壁的中心。其他导体层连接到设置在每个墨水通道中的导电薄膜。电压施加到电连接到设置在一个墨通道中的导电薄膜的驱动电极。连接到其它墨水通道中的导电薄膜和分隔壁中的导体层的驱动电极接地。此时，在限定墨水通道的每个隔壁的墨通道侧的区域中发生电场，并且分隔壁的每个相邻侧变形。因此，墨通道的体积减小以产生压力，使得墨从与墨通道相通的喷嘴喷出。此时，在分隔壁的与油墨通道侧相反的一侧的区域中没有电场发生，使得与油墨通道相邻的其它油墨通道不受油墨通道变形的影响。

9. 发明申请

US20120034250A1 CONDENSED PYRROLOPYRIDINE DERIVATIVE 审中-公开
标题翻译：浓缩吡咯啉衍生物
公开(公告)号：US20120034250A1
公开(公告)日：2012-02-09
申请号：US13264008
申请日：2010-04-13
申请人： Shohei Shirakami , Yutaka Nakajima , Jun Maeda , Hiroaki Tominaga , Hiroaki Yamagishi , Takeshi Hondo , Masamichi Inami , Hiroki Morio , Takayuki Inoue , Tsuyoshi Mizutani , Hiroki Ishioka
发明人： Shohei Shirakami , Yutaka Nakajima , Jun Maeda , Hiroaki Tominaga , Hiroaki Yamagishi , Takeshi Hondo , Masamichi Inami , Hiroki Morio , Takayuki Inoue , Tsuyoshi Mizutani , Hiroki Ishioka
IPC分类号： A61K31/437 , A61K31/55 , A61P37/06 , A61K31/541 , A61K31/5377 , A61K31/496 , C07D471/14 , A61K31/497
CPC分类号： C07D471/14 , C07D519/00
摘要： [Problem]The present invention provides a condensed pyrrolopyridine derivative which is useful as an active ingredient for a pharmaceutical composition, in particular, a pharmaceutical composition for preventing or treating diseases caused by undesirable cytokine signal transduction or diseases caused by abnormal cytokine signal transduction.[Means for Solution]The present inventors have extensively studied a compound having a JAK inhibitory action, and as a result, they have found that a condensed pyrrolopyridine derivative which is the compound of the present invention has an excellent JAK inhibitory action, and is therefore useful as an agent for preventing or treating diseases caused by undesirable cytokine signal transduction or diseases caused by abnormal cytokine signal transduction, thereby completing the present invention.
摘要翻译：本发明提供可用作药物组合物的活性成分的特别是用于预防或治疗由不良细胞因子信号转导引起的疾病或由异常细胞因子信号转导引起的疾病的药物组合物的缩合吡咯并吡啶衍生物。 [解决方案]本发明人广泛研究了具有JAK抑制作用的化合物，结果发现，作为本发明化合物的缩合吡咯并吡啶衍生物具有优异的JAK抑制作用，因此可用作预防或治疗由不良细胞因子信号转导引起的疾病或由异常细胞因子信号转导引起的疾病的药剂，从而完成本发明。

10. 发明申请

US20060270678A1 Pyrrolopyridazine derivatives 失效
标题翻译：吡咯并哒嗪衍生物
公开(公告)号：US20060270678A1
公开(公告)日：2006-11-30
申请号：US11500293
申请日：2006-08-08
申请人： Yoshito Abe , Makoto Inoue , Tsuyoshi Mizutani , Kozo Sawada , Kazuhiko Ohne , Mitsuaki Okumura , Yuki Sawada , Kenichiro Imamura
发明人： Yoshito Abe , Makoto Inoue , Tsuyoshi Mizutani , Kozo Sawada , Kazuhiko Ohne , Mitsuaki Okumura , Yuki Sawada , Kenichiro Imamura
IPC分类号： A61K31/503 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-α mediated diseases.
摘要翻译：本发明涉及式（I）化合物或其盐，其中R 1，R 2，R 3和R 0 > 4 如说明书中所定义，它们作为药物的用途，其制备方法和用于治疗PDE-IV或TNF-α介导的疾病。

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