专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07317009B2 Pyrrolopyridazine derivatives 失效
标题翻译：吡咯并哒嗪衍生物
公开(公告)号：US07317009B2
公开(公告)日：2008-01-08
申请号：US11500293
申请日：2006-08-08
申请人： Yoshito Abe , Makoto Inoue , Tsuyoshi Mizutani , Kozo Sawada , Kazuhiko Ohne , Mitsuaki Okumura , Yuki Sawada , Kenichiro Imamura
发明人： Yoshito Abe , Makoto Inoue , Tsuyoshi Mizutani , Kozo Sawada , Kazuhiko Ohne , Mitsuaki Okumura , Yuki Sawada , Kenichiro Imamura
IPC分类号： C07D487/04 , A61K31/5025
CPC分类号： C07D487/04
摘要： The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-α mediated diseases
摘要翻译：本发明涉及式（I）化合物或其盐，其中R 1，R 2，R 3和R 0 > 4 如说明书中所定义，它们作为药物的用途，其制备方法和用于治疗PDE-IV或TNF-α介导的疾病

2. 发明授权

US07153854B2 Pyrrolopyridazine derivatives 失效
标题翻译：吡咯并哒嗪衍生物
公开(公告)号：US07153854B2
公开(公告)日：2006-12-26
申请号：US10747079
申请日：2003-12-30
申请人： Yoshito Abe , Makoto Inoue , Tsuyoshi Mizutani , Kozo Sawada , Kazuhiko Ohne , Mitsuaki Okumura , Yuki Sawada , Kenichiro Imamura
发明人： Yoshito Abe , Makoto Inoue , Tsuyoshi Mizutani , Kozo Sawada , Kazuhiko Ohne , Mitsuaki Okumura , Yuki Sawada , Kenichiro Imamura
IPC分类号： C07D487/04 , A61K31/5025
CPC分类号： C07D487/04
摘要： The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-α mediated diseases
摘要翻译：本发明涉及式（I）化合物或其盐，其中R 1，R 2，R 3和R 0 > 4 如说明书中所定义，它们作为药物的用途，其制备方法和用于治疗PDE-IV或TNF-α介导的疾病

3. 发明申请

US20050075342A1 Pyrrolopyridazine derivatives 失效
标题翻译：吡咯并哒嗪衍生物
公开(公告)号：US20050075342A1
公开(公告)日：2005-04-07
申请号：US10747079
申请日：2003-12-30
申请人： Yoshito Abe , Makoto Inoue , Tsuyoshi Mizutani , Kozo Sawada , Kazuhiko Ohne , Mitsuaki Okumura , Yuki Sawada , Kenichiro Imamura
发明人： Yoshito Abe , Makoto Inoue , Tsuyoshi Mizutani , Kozo Sawada , Kazuhiko Ohne , Mitsuaki Okumura , Yuki Sawada , Kenichiro Imamura
IPC分类号： A61P31/00 , C07D487/04 , A61K31/503
CPC分类号： C07D487/04
摘要： The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-α mediated diseases.
摘要翻译：本发明涉及式（I）化合物或其盐，其中R 1，R 2，R 3和R 4如说明书中所定义，它们作为药物的用途，其制备和用途用于治疗PDE-IV或TNF-α介导的疾病。

4. 发明申请

US20060270678A1 Pyrrolopyridazine derivatives 失效
标题翻译：吡咯并哒嗪衍生物
公开(公告)号：US20060270678A1
公开(公告)日：2006-11-30
申请号：US11500293
申请日：2006-08-08
申请人： Yoshito Abe , Makoto Inoue , Tsuyoshi Mizutani , Kozo Sawada , Kazuhiko Ohne , Mitsuaki Okumura , Yuki Sawada , Kenichiro Imamura
发明人： Yoshito Abe , Makoto Inoue , Tsuyoshi Mizutani , Kozo Sawada , Kazuhiko Ohne , Mitsuaki Okumura , Yuki Sawada , Kenichiro Imamura
IPC分类号： A61K31/503 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-α mediated diseases.
摘要翻译：本发明涉及式（I）化合物或其盐，其中R 1，R 2，R 3和R 0 > 4 如说明书中所定义，它们作为药物的用途，其制备方法和用于治疗PDE-IV或TNF-α介导的疾病。

5. 发明授权

US06384080B1 Anthranilic acid derivatives as inhibitors of the cGMP-phosphodiesterase 失效
标题翻译：邻氨基苯甲酸衍生物作为cGMP-磷酸二酯酶的抑制剂
公开(公告)号：US06384080B1
公开(公告)日：2002-05-07
申请号：US09509541
申请日：2001-04-23
申请人： Teruo Oku , Kozo Sawada , Akio Kuroda , Takayuki Inoue , Natsuko Kayakiri , Yuki Sawada , Tsuyoshi Mizutani
发明人： Teruo Oku , Kozo Sawada , Akio Kuroda , Takayuki Inoue , Natsuko Kayakiri , Yuki Sawada , Tsuyoshi Mizutani
IPC分类号： A61K3118
CPC分类号： C07D213/40 , C07C227/30 , C07C227/32 , C07C2601/08 , C07C2601/14 , C07D207/14 , C07D207/48 , C07D211/58 , C07D231/12 , C07D233/56 , C07D235/14 , C07D249/08 , C07D307/22 , C07D317/58 , C07D333/20
摘要： Compounds of formula (I) where R1 is hydrogen; R2 is nitro, cyano or halo(lower)alkyl; R3 is phenyl substituted with one or more substituents selected from halogen, cyano and lower alkoxy; A is a lower alkylene group; R4 is a group CR6R7R8 wherein R6 and R7 form, together with the carbon atom to which they are attached a cycloalkyl group optionally substituted with hydroxy, lower alkoxy or a lower alkanoylamino; and R8 is hydrogen; its prodrug and a salt thereof.
摘要翻译：其中R1是氢的式（Ⅰ）化合物; R2是硝基，氰基或卤代（低级）烷基; R3是被一个或多个选自卤素，氰基和低级烷氧基的取代基取代的苯基; A是低级亚烷基; R4是基团CR6R7R8，其中R6和R7与它们所连接的碳原子一起形成任选被羟基，低级烷氧基或低级烷酰基氨基取代的环烷基; R8是氢; 其前药及其盐。

6. 发明授权

US06582351B1 Imidazopyridinone derivatives and their use as phosphodiesterase inhibitors 失效
标题翻译：咪唑并吡啶酮衍生物及其作为磷酸二酯酶抑制剂的用途
公开(公告)号：US06582351B1
公开(公告)日：2003-06-24
申请号：US10030979
申请日：2002-01-16
申请人： Kozo Sawada , Takayuki Inoue , Yuki Sawada , Tsuyoshi Mizutani
发明人： Kozo Sawada , Takayuki Inoue , Yuki Sawada , Tsuyoshi Mizutani
IPC分类号： A61K31435
CPC分类号： C07D401/04 , C07D235/26 , C07D235/28 , C07D401/12 , C07D403/04 , C07D405/04 , C07D405/12 , C07D471/04
摘要： A compound (Ia): wherein the variables are defined in the specification, its prodrug or a pharmaceutically acceptable salt thereof useful in the treatment of angina, hypertension etc.
摘要翻译：化合物（Ia）：其中变量在说明书中定义，其前药或其药学上可接受的盐可用于治疗心绞痛，高血压等。

7. 发明授权

US6069156A Indole derivatives as cGMP-PDE inhibitors 失效
标题翻译：吲哚衍生物作为cGMP-PDE抑制剂
公开(公告)号：US6069156A
公开(公告)日：2000-05-30
申请号：US930597
申请日：1997-12-10
申请人： Teruo Oku , Kozo Sawada , Akio Kuroda , Kazuhiko Ohne , Atsushi Nomoto , Naomi Hosogai , Yoshimitsu Nakajima , Akira Nagashima , Keizo Sogabe , Kouichi Tamura , Masakazu Kobayashi
发明人： Teruo Oku , Kozo Sawada , Akio Kuroda , Kazuhiko Ohne , Atsushi Nomoto , Naomi Hosogai , Yoshimitsu Nakajima , Akira Nagashima , Keizo Sogabe , Kouichi Tamura , Masakazu Kobayashi
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/425 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/535 , A61P3/08 , A61P3/10 , A61P9/00 , A61P11/00 , A61P13/02 , A61P15/00 , A61P27/02 , A61P27/14 , A61P37/08 , A61P43/00 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/16 , C07D209/30 , C07D209/42 , C07D209/52 , C07D209/88 , C07D209/94 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D417/06 , A01N43/40 , C07D209/04
CPC分类号： C07D401/06 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/16 , C07D209/30 , C07D209/42 , C07D209/52 , C07D209/88 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D417/06
摘要： Compounds of the formula (I): ##STR1## and their pharmaceutically acceptable compositions are useful in inhibiting the activity of cyclic guanosine 3',5'-monophosphate phosphodiesterase.
摘要翻译： PCT No.PCT / JP96 / 00892 Sec。 371 1997年12月10日第 102（e）日期1997年12月10日PCT提交1996年4月2日PCT公布。公开号WO96 / 32379 日期：1996年10月17日式（I）化合物及其药学上可接受的组合物可用于抑制环鸟苷3'，5'-单磷酸磷酸二酯酶的活性。

8. 发明授权

US4436849A Aqueous resin composition 失效
标题翻译：水性树脂组合物
公开(公告)号：US4436849A
公开(公告)日：1984-03-13
申请号：US431080
申请日：1982-09-30
申请人： Tetsuo Aihara , Yasuharu Nakayama , Koichi Umeyama , Kozo Sawada , Masaaki Shinohara
发明人： Tetsuo Aihara , Yasuharu Nakayama , Koichi Umeyama , Kozo Sawada , Masaaki Shinohara
IPC分类号： C08F2/26 , C08G63/685 , C09D167/08 , C08L67/08 , C09D3/68
CPC分类号： C08G63/6854 , C09D167/08
摘要： An aqueous resin composition comprising a neutralization product of an isocyanurate group-containing maleinized alkyd resin having an acid value of 5 to 65 in an aqueous medium, said maleinized alkyd resin being prepared by maleinizing an alkyd resin having an acid value of not more than 10 and a hydroxyl value of not more than 10 which is the product of condensation reaction of(A) 20 to 60% by weight of at least one of drying or semi-drying oils and fatty acids,(B) 10 to 45% by weight of at least one tris(hydroxyalkyl) isocyanurate,(C) 0 to 45% by weight of at least one polyhydric alcohol other than the component (B),(D) 10 to 45% by weight of at least one polybasic acid, and(E) 0 to 15% by weight of at least one monobasic acidand an aqueous emulsion resin composition obtained by emulsion polymerization of a radical polymerizable unsaturated monomer in an aqueous medium in the presence of the aforesaid neutralization product. The above aqueous resin compositions can give a coating having excellent corrosion resistance and fast-drying property.
摘要翻译：一种含水树脂组合物，其包含在水性介质中含有酸值为5〜65的含异氰脲酸酯基的马来酸化醇酸树脂的中和产物，所述马来酸化的醇酸树脂通过使酸值不大于10的醇酸树脂和（A）20至60重量％的干燥或半干性油和脂肪酸中的至少一种的缩合反应的产物的羟值为10以下，（B）10〜45重量％的至少一种三（羟烷基）异氰脲酸酯，（C）0至45重量％的除（B）成分以外的至少一种多元醇，（D）10至45重量％的至少一种多元酸，以及（E）0〜15重量％的至少一种一元酸和通过自由基聚合性不饱和单体在水性介质中在上述中和产物的存在下乳液聚合得到的水性乳液树脂组合物。上述水性树脂组合物可以得到具有优异的耐腐蚀性和快干性能的涂层。

9. 发明授权

US5312829A Indole derivatives 失效
标题翻译：吲哚衍生物
公开(公告)号：US5312829A
公开(公告)日：1994-05-17
申请号：US956579
申请日：1992-10-06
申请人： Satoshi Okada , Kozo Sawada , Natsuko Kayakiri , Yuki Saitoh , Hirokazu Tanaka , Masashi Hashimoto
发明人： Satoshi Okada , Kozo Sawada , Natsuko Kayakiri , Yuki Saitoh , Hirokazu Tanaka , Masashi Hashimoto
IPC分类号： C07D209/12 , C07D209/14 , C07D209/18 , C07D403/10 , C07D413/10 , C07D417/10 , C07D209/10 , A61K31/405 , C07D405/04
CPC分类号： C07D403/10 , C07D209/12 , C07D209/14 , C07D209/18 , C07D413/10 , C07D417/10
摘要： A compound of the formula: ##STR1## wherein R.sup.1 is carboxy or pharmaceutically acceptable salts and esters thereof;R.sup.2 is hydrogen, lower alkyl or halogen;R.sup.3 is phenyl, naphthyl, phenyl or naphthyl each substituted by from one to three C.sub.1-6 alkyl groups, mono-, di- or triphenyl (C.sub.1-6)alkyl; or substituted mono-, di- or triphenyl (C.sub.1-6) alkyl;A is lower alkylene which may be substituted by oxo or lower alkenylene,Q is carbonyl or lower alkylene,X is ##STR2## in which R.sup.4 is hydrogen or C.sub.1-6 alkyl, andR.sup.5 is hydrogen, C.sub.1-6 alkyl or Y--Z--R.sup.3,Y is a bond or lower alkylene,Z is lower alkylene ##STR3## in which R.sup.6 is hydrogen, (C.sub.1 -C.sub.6) alkyl, mono-, di- or triphenyl(C.sub.1-10) alkyl, C.sub.1-6 alkyl or lower alkoxycarbonyl substituted mono-, di- or triphenyl(C.sub.1-6)alkyl or pharmaceutically acceptable carboxylic acid acyl, and pharmaceutically acceptable salts thereof. The compound is useful as a testosterone 5.alpha.-reductase inhibitor.
摘要翻译：下式的化合物：其中R 1是羧基或其药学上可接受的盐和酯; R2是氢，低级烷基或卤素; R 3为苯基，萘基，苯基或萘基，各自被一至三个C 1-6烷基，单 - ，二 - 或三苯基（C 1-6）烷基取代; 或取代的单 - ，二 - 或三苯基（C 1-6）烷基; A是可被氧代或低级亚烯基取代的低级亚烷基，Q是羰基或低级亚烷基，X是其中R 4是氢或C 1-6烷基，R 5是氢，C 1-6烷基或YZ-R 3 ，Y为键或低级亚烷基，Z为低级亚烷基，其中R6为氢，（C1-C6）烷基，单 - ，二 - 或三苯基（C1-10）烷基，C1-6烷基或低级烷氧基羰基取代的单 - ，二 - 或三苯基（C 1-6）烷基或药学上可接受的羧酸酰基及其药学上可接受的盐。该化合物可用作睾酮5α-还原酶抑制剂。

10. 发明授权

US5037866A Air-drying aqueous coating composition for electro-deposition based on fatty acid modified acrylic copolymers 失效
标题翻译：基于脂肪酸改性丙烯酸共聚物的电沉积空气干燥水性涂料组合物
公开(公告)号：US5037866A
公开(公告)日：1991-08-06
申请号：US581991
申请日：1990-09-10
申请人： Tetsuo Aihara , Yasuharu Nakayama , Shigeki Matsubara , Kozo Sawada
发明人： Tetsuo Aihara , Yasuharu Nakayama , Shigeki Matsubara , Kozo Sawada
IPC分类号： C08F8/08 , C09D5/44 , C09D163/00
CPC分类号： C09D5/4473 , C09D163/00 , C09D5/4434
摘要： An air-drying aqueous coating composition for electrodeposition comprising[A] a water-solubilized product or a water-dispersed product obtained by reacting (A-1) an epoxy resin and (A-2) a (semi)drying oil fatty acid-modified vinyl polymer having an acid value of 10 to 200 in such proportions that the solids weight ratio of the component (A-1) to the component (A-2) is from 90/10 to 5/95, and[B] an amphoteric organic solvent having affinity for component [A].
摘要翻译：一种用于电沉积的风干水性涂料组合物，其包含[A]通过使（A-1）环氧树脂和（A-2）a（半）干燥油脂肪酸 - 水溶液反应而获得的水溶性产物或水分散产物，（A-1）与成分（A-2）的固体重量比为90/10〜5/95的比例的酸值为10〜200的改性乙烯基聚合物，[B] 对组分[A]具有亲和性的两性有机溶剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式