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1. 发明授权

US08201662B2 Electric motor driven lubrication pump control system and method for turbomachine windmill operation 有权
标题翻译：电机驱动润滑泵控制系统及涡轮机风车运行方法
公开(公告)号：US08201662B2
公开(公告)日：2012-06-19
申请号：US12174553
申请日：2008-07-16
申请人： Jim Delaloye , Matthew Christopher
发明人： Jim Delaloye , Matthew Christopher
IPC分类号： F01D25/18 , F01D17/06 , F01D21/02 , F01M9/00 , F01B25/06 , F03B15/06 , F04D15/00 , F04D27/00 , F03D3/06
CPC分类号： F01D25/20 , F02C7/06 , F05D2220/34 , F05D2270/09 , F05D2270/304
摘要： A system and method are provided to selectively control lubricant supply flow to a rotating machine that is installed in an aircraft having ram air turbine that is movable between at least a deployed position and a stowed position. A controller determines at least when the ram air turbine is in the deployed position, and determining when rotational speed of the rotating machine exceeds a predetermined value. The electric motor driven lubrication pump is at least selectively energized to control the measured lubricant pressure to a predetermined minimum pressure at least when the ram air turbine is deployed and the rotational speed exceeds the predetermined value.
摘要翻译：提供了一种系统和方法，用于选择性地控制向安装在具有可在至少展开位置和收起位置之间移动的冲压式空气涡轮机的飞行器中的旋转机器的润滑剂供应流。控制器至少确定冲压式空气涡轮机处于展开位置时，确定旋转机械的转速何时超过预定值。所述电动机驱动的润滑泵至少选择性地通电以至少在所述冲压式空气涡轮机展开并且所述转速超过所述预定值时将所测量的润滑剂压力控制到预定的最小压力。

2. 发明申请

US20100018806A1 ELECTRIC MOTOR DRIVEN LUBRICATION PUMP STARTUP CONTROL SYSTEM AND METHOD 有权
标题翻译：电动马达驱动润滑泵启动控制系统及方法
公开(公告)号：US20100018806A1
公开(公告)日：2010-01-28
申请号：US12181195
申请日：2008-07-28
申请人： Jim Delaloye , Matthew Christopher
发明人： Jim Delaloye , Matthew Christopher
IPC分类号： F01M5/00
CPC分类号： F01M5/025 , F01M2001/0215
摘要： A system and method are provided for controlling an electric motor driven lubrication supply pump that is supplied with electrical power from a power bus, and that supplies lubricant to a rotating machine that is at least part of a vehicle subsystem. A determination is made that the subsystem is being started-up. Moreover, one or more lubricant parameters, power bus electrical state, and one or more lubricant load states are determined. The electrical power supplied from the power bus to the electric motor is varied, based on the one or more lubricant parameters, the power bus electrical state, and the one or more lubricant load states.
摘要翻译：提供了一种系统和方法，用于控制从电力总线提供电力的电动机驱动的润滑供给泵，并且向作为车辆子系统的至少一部分的旋转机械供应润滑剂。确定子系统正在启动。此外，确定一个或多个润滑剂参数，功率总线电状态和一个或多个润滑剂负载状态。基于一个或多个润滑剂参数，电力总线电气状态和一个或多个润滑剂负载状态，从电力总线供应到电动机的电力是不同的。

3. 发明授权

US09151193B2 Electric motor driven lubrication pump startup control system and method 有权
标题翻译：电机驱动润滑泵起动控制系统及方法
公开(公告)号：US09151193B2
公开(公告)日：2015-10-06
申请号：US12181195
申请日：2008-07-28
申请人： Jim Delaloye , Matthew Christopher
发明人： Jim Delaloye , Matthew Christopher
IPC分类号： F01M5/00 , F01M5/02 , F01M1/02
CPC分类号： F01M5/025 , F01M2001/0215
摘要： A system and method are provided for controlling an electric motor driven lubrication supply pump that is supplied with electrical power from a power bus, and that supplies lubricant to a rotating machine that is at least part of a vehicle subsystem. A determination is made that the subsystem is being started-up. Moreover, one or more lubricant parameters, power bus electrical state, and one or more lubricant load states are determined. The electrical power supplied from the power bus to the electric motor is varied, based on the one or more lubricant parameters, the power bus electrical state, and the one or more lubricant load states.
摘要翻译：提供了一种系统和方法，用于控制从电力总线提供电力的电动机驱动的润滑供给泵，并且向作为车辆子系统的至少一部分的旋转机械供应润滑剂。确定子系统正在启动。此外，确定一个或多个润滑剂参数，功率总线电状态和一个或多个润滑剂负载状态。基于一个或多个润滑剂参数，电力总线电气状态和一个或多个润滑剂负载状态，从电力总线供应到电动机的电力是不同的。

4. 发明申请

US20090045014A1 ELECTRIC MOTOR DRIVEN LUBRICATION PUMP CONTROL SYSTEM AND METHOD FOR TURBOMACHINE WINDMILL OPERATION 有权
标题翻译：电动马达驱动润滑泵控制系统及涡轮机风机运行方法
公开(公告)号：US20090045014A1
公开(公告)日：2009-02-19
申请号：US12174553
申请日：2008-07-16
申请人： Jim Delaloye , Matthew Christopher
发明人： Jim Delaloye , Matthew Christopher
IPC分类号： F01M9/00
CPC分类号： F01D25/20 , F02C7/06 , F05D2220/34 , F05D2270/09 , F05D2270/304
摘要： A system and method are provided to selectively control lubricant supply flow to a rotating machine that is installed in an aircraft having ram air turbine that is movable between at least a deployed position and a stowed position. A controller determines at least when the ram air turbine is in the deployed position, and determining when rotational speed of the rotating machine exceeds a predetermined value. The electric motor driven lubrication pump is at least selectively energized to control the measured lubricant pressure to a predetermined minimum pressure at least when the ram air turbine is deployed and the rotational speed exceeds the predetermined value.
摘要翻译：提供了一种系统和方法，用于选择性地控制向安装在具有可在至少展开位置和收起位置之间移动的冲压式空气涡轮机的飞行器中的旋转机器的润滑剂供应流。控制器至少确定冲压式空气涡轮机处于展开位置时，确定旋转机械的转速何时超过预定值。所述电动机驱动的润滑泵至少选择性地通电以至少在所述冲压式空气涡轮机展开并且所述转速超过所述预定值时将所测量的润滑剂压力控制到预定的最小压力。

5. 发明申请

US20200237817A1 METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER 审中-公开
公开(公告)号：US20200237817A1
公开(公告)日：2020-07-30
申请号：US16774425
申请日：2020-01-28
申请人： Matthew Christopher , John F. DiPersio , Timothy J. Ley , Allegra Petti , Michael P. Rettig
发明人： Matthew Christopher , John F. DiPersio , Timothy J. Ley , Allegra Petti , Michael P. Rettig
IPC分类号： A61K35/14 , A61K38/21 , C12N5/0783 , A61P35/02
摘要： Among the various aspects of the present disclosure is the provision of methods and compositions for upregulating MHC class II in cancer cells (e.g., a hematological cancer cell). Also provided are methods of treatment for subjects suffering from hematological cancers, comprising administration of interferon-γ (IFN-γ). The methods of treatment provided herein may be particularly suitable for subjects who have received an allogenic transplant or have suffered a relapse.

6. 发明授权

US08367706B2 Inhibitors of janus kinases 有权
公开(公告)号：US08367706B2
公开(公告)日：2013-02-05
申请号：US12665045
申请日：2008-06-16
申请人： Michael Altman , Matthew Christopher , Jonathan B. Grimm , Andrew Haidle , Kaleen Konrad , Jongwon Lim , Rachel N. MacCoss , Michelle Machacek , Ekundayo Osimboni , Ryan D. Otte , Tony Siu , Kerrie Spencer , Brandon Taoka , Paul Tempest , Kevin Wilson , Hyun Chong Woo , Jonathan Young , Anna Zabierek
发明人： Michael Altman , Matthew Christopher , Jonathan B. Grimm , Andrew Haidle , Kaleen Konrad , Jongwon Lim , Rachel N. MacCoss , Michelle Machacek , Ekundayo Osimboni , Ryan D. Otte , Tony Siu , Kerrie Spencer , Brandon Taoka , Paul Tempest , Kevin Wilson , Hyun Chong Woo , Jonathan Young , Anna Zabierek
IPC分类号： A61K31/4436 , C07D409/12
CPC分类号： C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D498/10 , C07F9/65586 , C07F9/65685
摘要： The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.

7. 发明授权

US11696926B2 Methods and compositions for treatment of cancer 有权
公开(公告)号：US11696926B2
公开(公告)日：2023-07-11
申请号：US16774425
申请日：2020-01-28
申请人： Matthew Christopher , John F. DiPersio , Timothy J. Ley , Allegra Petti , Michael P. Rettig
发明人： Matthew Christopher , John F. DiPersio , Timothy J. Ley , Allegra Petti , Michael P. Rettig
IPC分类号： A61K35/14 , A61P35/02 , C12N5/0783 , A61K38/21
CPC分类号： A61K35/14 , A61K38/217 , A61P35/02 , C12N5/0636
摘要： Among the various aspects of the present disclosure is the provision of methods and compositions for upregulating MHC class II in cancer cells (e.g., a hematological cancer cell). Also provided are methods of treatment for subjects suffering from hematological cancers, comprising administration of interferon-γ (IFN-γ). The methods of treatment provided herein may be particularly suitable for subjects who have received an allogenic transplant or have suffered a relapse.

8. 发明申请

US20050286073A1 Image forming device diagnostics using served applets 有权
标题翻译：使用服务小程序的图像形成设备诊断
公开(公告)号：US20050286073A1
公开(公告)日：2005-12-29
申请号：US10879946
申请日：2004-06-28
申请人： Matthew Christopher
发明人： Matthew Christopher
IPC分类号： G06F15/00 , H04N1/00
CPC分类号： G06F11/273 , H04N1/00244 , H04N1/00344 , H04N2201/0074 , H04N2201/0082 , H04N2201/0091
摘要： An image forming device includes a web server, and serves applets to a communicatively coupled computer. The applets execute on the computer, and control one or more operations and/or monitor one or more conditions or sensors in the image forming device. An applet may provide detailed instructions to the computer user as a diagnostic program executes on the image forming device. A list of available applets may be served to the computer, and one or more applets served in response to a user's selection from the list. A decision tree may be served, and one or more applets served as the user advances through the decision tree. Serving the diagnostic applets from the image forming device alleviates the need for a field repair technician to carry a large suite of diagnostic software to diagnose and repair a plurality of models, years, and configurations of image forming devices.
摘要翻译：图像形成装置包括网络服务器，并且向通信耦合的计算机提供小应用程序。该小程序在计算机上执行，并且控制一个或多个操作和/或监视图像形成装置中的一个或多个条件或传感器。作为在图像形成装置上执行的诊断程序，小程序可以向计算机用户提供详细的指令。可以向计算机提供可用小程序的列表，并且响应于用户从列表中的选择而服务的一个或多个小程序。可以提供决策树，并且用作用户的一个或多个小程序通过决策树进行。从图像形成装置提供诊断小程序减轻了现场维修技术人员携带大量诊断软件来诊断和修复图像形成装置的多个型号，年数和配置的需要。

9. 发明申请

US20050121315A1 System for generating hydrogen and method thereof 审中-公开
标题翻译：用于产生氢的系统及其方法
公开(公告)号：US20050121315A1
公开(公告)日：2005-06-09
申请号：US11004185
申请日：2004-12-03
申请人： Justin Baltrucki , A. Speranza , Michael Spaner , Curt Ebner , Ken Dreier , Stephen Goyette , Lawrence Moulthrop , Matthew Christopher
发明人： Justin Baltrucki , A. Speranza , Michael Spaner , Curt Ebner , Ken Dreier , Stephen Goyette , Lawrence Moulthrop , Matthew Christopher
IPC分类号： C25B15/00 , H01M8/04 , H01M8/24 , B23H7/04
CPC分类号： C25B15/02 , C25B15/00 , C25B15/08 , H01M8/04291 , H01M8/04462 , H01M8/04671 , H01M8/04761 , H01M8/04932 , H01M8/241 , H01M8/2457
摘要： An electrochemical system having a plurality of discrete electrochemical cell stacks is described. The system includes a water-oxygen management system fluidly coupled to the plurality of electrochemical cell stacks and a hydrogen management system fluidly coupled to the plurality of electrochemical cells. A means for ventilating the system and a control system for monitoring and operating said electrochemical system, said control system including a means for detecting abnormal operating conditions and a means for degrading the performance of said electrochemical system in response to said abnormal condition.
摘要翻译：描述了具有多个分立的电化学电池组的电化学系统。该系统包括流体耦合到多个电化学电池堆的水氧管理系统和与多个电化学电池流体耦合的氢管理系统。一种用于使系统通风的装置和用于监测和操作所述电化学系统的控制系统，所述控制系统包括用于检测异常操作条件的装置和用于响应于所述异常状况降低所述电化学系统的性能的装置。

10. 发明授权

US08151573B2 Turbomachine flameout confirmation 失效
标题翻译：涡轮机熄火确认
公开(公告)号：US08151573B2
公开(公告)日：2012-04-10
申请号：US12266279
申请日：2008-11-06
申请人： Matthew Christopher , Hanif Vhora
发明人： Matthew Christopher , Hanif Vhora
IPC分类号： F02C7/00
CPC分类号： F02C9/28 , F05D2270/07 , F05D2270/08 , F05D2270/092 , Y02T50/677
摘要： Methods and apparatus are provided for detecting a flameout of an operating turbomachine that is configured to receive a controlled flow of bleed air from a bleed air source and a controlled flow of fuel from a fuel source. A value of an operational parameter within the turbomachine is detected and a determination is made as to whether it has varied by a predetermined amount. If the operational parameter has varied by the predetermined amount, a flameout confirmation test is triggered. The flameout confirmation test includes holding the controlled flow of bleed air constant, commanding an increase in turbomachine speed, and confirming that a flameout has occurred by detecting that the controlled fuel flow to the turbomachine is at a maximum fuel flow limit and that actual turbomachine speed differs from the commanded turbomachine speed by a predetermined speed error.
摘要翻译：提供了用于检测操作涡轮机的熄火的方法和装置，其构造成从放气空间源和来自燃料源的受控流动的燃料中接收受控流出的空气。检测涡轮机内的操作参数的值，并确定其是否变化了预定量。如果操作参数变化了预定量，则触发熄火确认测试。熄火确认测试包括保持受控的排气流量恒定，指示涡轮机速度的增加，并且通过检测到涡轮机的受控燃料流量处于最大燃料流量极限并确定实际的涡轮机速度来确认已经发生熄火与指定的涡轮机速度相差预定的速度误差。

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