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1. 发明授权

US08367706B2 Inhibitors of janus kinases 有权
公开(公告)号：US08367706B2
公开(公告)日：2013-02-05
申请号：US12665045
申请日：2008-06-16
申请人： Michael Altman , Matthew Christopher , Jonathan B. Grimm , Andrew Haidle , Kaleen Konrad , Jongwon Lim , Rachel N. MacCoss , Michelle Machacek , Ekundayo Osimboni , Ryan D. Otte , Tony Siu , Kerrie Spencer , Brandon Taoka , Paul Tempest , Kevin Wilson , Hyun Chong Woo , Jonathan Young , Anna Zabierek
发明人： Michael Altman , Matthew Christopher , Jonathan B. Grimm , Andrew Haidle , Kaleen Konrad , Jongwon Lim , Rachel N. MacCoss , Michelle Machacek , Ekundayo Osimboni , Ryan D. Otte , Tony Siu , Kerrie Spencer , Brandon Taoka , Paul Tempest , Kevin Wilson , Hyun Chong Woo , Jonathan Young , Anna Zabierek
IPC分类号： A61K31/4436 , C07D409/12
CPC分类号： C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D498/10 , C07F9/65586 , C07F9/65685
摘要： The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.

2. 发明申请

US20100256097A1 INHIBITORS OF JANUS KINASES 有权
公开(公告)号：US20100256097A1
公开(公告)日：2010-10-07
申请号：US12665045
申请日：2008-06-16
申请人： Michael Altman , Matthew Christopher , Jonathan B. Grimm , Andrew Haidle , Kaleen Konrad , Jongwon Lim , Rachel N. MacCoss , Michelle Machacek , Ekundayo Osimboni , Ryan D. Otte , Tony Siu , Kerrie Spencer , Brandon Taoka , Paul Tempest , Kevin Wilson , Hyan Chong Woo , Jonathan Young , Anna Zabierek
发明人： Michael Altman , Matthew Christopher , Jonathan B. Grimm , Andrew Haidle , Kaleen Konrad , Jongwon Lim , Rachel N. MacCoss , Michelle Machacek , Ekundayo Osimboni , Ryan D. Otte , Tony Siu , Kerrie Spencer , Brandon Taoka , Paul Tempest , Kevin Wilson , Hyan Chong Woo , Jonathan Young , Anna Zabierek
IPC分类号： A61K31/675 , C07D409/14 , A61K31/4439 , A61K31/4436 , C07D413/14 , A61K31/5377 , C07D409/12 , A61K31/501 , C07F9/28 , C07D417/14 , A61K31/541
CPC分类号： C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D498/10 , C07F9/65586 , C07F9/65685
摘要： The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.

3. 发明授权

US08329722B2 Inhibitors of janus kinases and/or 3-phosphoinositide-dependent protein kinase-1 有权
标题翻译：甘油激酶和/或3-磷酸肌醇依赖性蛋白激酶-1的抑制剂
公开(公告)号：US08329722B2
公开(公告)日：2012-12-11
申请号：US12530648
申请日：2008-03-10
申请人： Tony Siu , Jonathan Young , Michael Altman , Alan Northrup , Ekaterina Kozina , Christopher Dinsmore , David J. Guerin , Kevin A. Keenan , Joon O. Jung , Solomon Kattar , Rachel N. MacCoss
发明人： Tony Siu , Jonathan Young , Michael Altman , Alan Northrup , Ekaterina Kozina , Christopher Dinsmore , David J. Guerin , Kevin A. Keenan , Joon O. Jung , Solomon Kattar , Rachel N. MacCoss
IPC分类号： C07D487/14 , A61K31/4375
CPC分类号： C07D471/04 , C07D471/14
摘要： The instant invention provides for compounds that inhibit JAK2 tyrosine kinase and/or PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting JAK2 tyrosine kinase activity and/or PDK1 kinase inhibitory activity by administering the compound to a patient in need of treatment or prevention of myeloproliferative disorders or cancer.
摘要翻译：本发明提供抑制JAK2酪氨酸激酶和/或PDK1的化合物。本发明还提供了包含这种抑制化合物的组合物以及通过将该化合物给予需要治疗或预防骨髓增生性疾病或癌症的患者来抑制JAK2酪氨酸激酶活性和/或PDK1激酶抑制活性的方法。

4. 发明申请

US20120264735A1 TYROSINE KINASE INHIBITORS 审中-公开
标题翻译：酪氨酸激酶抑制剂
公开(公告)号：US20120264735A1
公开(公告)日：2012-10-18
申请号：US13517321
申请日：2010-12-14
申请人： Jonathan Young , Barbara Czako , Michael Altman , David Guerin , Michelle Martinez , Alexey Rivkin , Kevin Wilson , Kathryn Lipford , Catherine White , Laura Surdi , Stephanie Chichetti , Matthew H. Daniels , Sean P. Ahearn , Danielle Falcone , Ekundayo Osimboni
发明人： Jonathan Young , Barbara Czako , Michael Altman , David Guerin , Michelle Martinez , Alexey Rivkin , Kevin Wilson , Kathryn Lipford , Catherine White , Laura Surdi , Stephanie Chichetti , Matthew H. Daniels , Sean P. Ahearn , Danielle Falcone , Ekundayo Osimboni
IPC分类号： A61K31/501 , A61K31/506 , C07D413/12 , A61P35/00 , C07D413/14 , C07D417/14 , A61K31/541 , C07D403/04 , A61K31/5377
CPC分类号： C07D403/04 , C07D237/14 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/10 , C07D417/14 , C07D471/04
摘要： The present invention relates to pyridazin-4(1H)-one derivatives, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译：本发明涉及哒嗪-4（1H） - 酮衍生物，其可用于治疗细胞增殖性疾病，用于治疗与MET活性相关的疾病，以及用于抑制受体酪氨酸激酶MET。本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。

5. 发明授权

US08349865B2 Inhibitors of janus kinases 有权
标题翻译：痛风激酶抑制剂
公开(公告)号：US08349865B2
公开(公告)日：2013-01-08
申请号：US12677375
申请日：2008-09-08
申请人： Tony Siu , Jonathan Young , Michael Altman , Alan Northrup , Matthew Katcher , Ellalahewage Sathyajith Kumarasinghe , Ekaterina Kozina , Scott Peterson , Matthew Childers
发明人： Tony Siu , Jonathan Young , Michael Altman , Alan Northrup , Matthew Katcher , Ellalahewage Sathyajith Kumarasinghe , Ekaterina Kozina , Scott Peterson , Matthew Childers
IPC分类号： C07D471/06 , A61K31/4375
CPC分类号： C07D471/04 , C07D471/14
摘要： The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
摘要翻译：本发明提供抑制四种已知的哺乳动物JAK激酶（JAK1，JAK2，JAK3和TYK2）和PDK1的化合物。本发明还提供了包含这种抑制化合物的组合物和通过向需要治疗骨髓增生性疾病或癌症的患者施用化合物来抑制JAK1，JAK2，JAK3 TYK2和PDK1的活性的方法。

6. 发明申请

US20100197634A1 INHIBITORS OF JANUS KINASES 有权
公开(公告)号：US20100197634A1
公开(公告)日：2010-08-05
申请号：US12677375
申请日：2008-09-08
申请人： Tony Siu , Jonathan Young , Michael Altman , Alan Northrup , Matthew Katcher , Ellalahewage Sathyajith Kumarasinghe , Ekaterina Kozina , Scott Peterson , Matthew Childers
发明人： Tony Siu , Jonathan Young , Michael Altman , Alan Northrup , Matthew Katcher , Ellalahewage Sathyajith Kumarasinghe , Ekaterina Kozina , Scott Peterson , Matthew Childers
IPC分类号： A61K31/69 , C07D471/02 , A61K31/4375 , C07D413/14 , A61K31/5377 , C07F5/02 , C07D401/14 , A61K31/506 , C07D471/12 , A61K31/496 , A61P35/00
CPC分类号： C07D471/04 , C07D471/14
摘要： The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.

7. 发明申请

US20110130393A1 INHIBITORS OF JANUS KINASES 有权
公开(公告)号：US20110130393A1
公开(公告)日：2011-06-02
申请号：US13056180
申请日：2009-07-21
申请人： Michael Altman , Kevin Wilson
发明人： Michael Altman , Kevin Wilson
IPC分类号： A61K31/541 , C07D231/38 , A61K31/415 , A61P35/00 , C07D413/12 , A61K31/5377 , C07D403/12 , A61K31/496 , C07D417/12
CPC分类号： C07D231/38 , C07D401/12
摘要： The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2). The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 and TYK2 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.

8. 发明申请

US20130116231A1 TYROSINE KINASE INHIBITORS 审中-公开
标题翻译：酪氨酸激酶抑制剂
公开(公告)号：US20130116231A1
公开(公告)日：2013-05-09
申请号：US13809436
申请日：2011-07-07
申请人： Kevin Wilson , Michael Altman , Kathryn Lipford , Catherine White , Matthew Daniels
发明人： Kevin Wilson , Michael Altman , Kathryn Lipford , Catherine White , Matthew Daniels
IPC分类号： C07D411/14 , C07D403/14 , C07D403/04 , C07D401/14 , C07D401/12
CPC分类号： C07D411/14 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14
摘要： The present invention relates to 1,4-dihydropyridazinone derivatives, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译：本发明涉及1,4-二氢哒嗪酮衍生物，其可用于治疗细胞增殖性疾病，用于治疗与MET活性相关的疾病，以及用于抑制受体酪氨酸激酶MET。本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。

9. 发明授权

US08415346B2 Inhibitors of Janus kinases 有权
标题翻译： Janus激酶抑制剂
公开(公告)号：US08415346B2
公开(公告)日：2013-04-09
申请号：US13056180
申请日：2009-07-21
申请人： Michael Altman , Kevin Wilson
发明人： Michael Altman , Kevin Wilson
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , C07D231/38 , C07D413/12 , C07D403/12 , C07D417/12
CPC分类号： C07D231/38 , C07D401/12
摘要： The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2). The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 and TYK2 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
摘要翻译：本发明提供抑制四种已知的哺乳动物JAK激酶（JAK1，JAK2，JAK3和TYK2）的化合物。本发明还提供了包含这种抑制化合物的组合物和通过将该化合物施用于需要治疗骨髓增生性疾病或癌症的患者的JAK1，JAK2，JAK3和TYK2的活性的方法。

10. 发明授权

US09439525B1 Stackable cup with plate cut-out 有权
标题翻译：可堆叠杯与板切口
公开(公告)号：US09439525B1
公开(公告)日：2016-09-13
申请号：US15130099
申请日：2016-04-15
申请人： Michael Altman
发明人： Michael Altman
IPC分类号： B65D6/28 , A47G19/23 , A47G19/08
CPC分类号： A47G19/23 , A47G19/04 , A47G23/0225
摘要： A cup includes two compartments in a unitary structure: an upper compartment that holds the liquid drink and a lower compartment that has a configured slot to slide onto the edge of a plate. The upper compartment has an open top-end and a closed bottom-end just like any other cup. The open top-end is larger than the closed bottom-end so as to permit stacking multiple cups together. The lower compartment is connected below the closed bottom-end of the first compartment. The second compartment defines a configured slot or cut-out that is shaped to receive the edge of a plate and contact the bottom of the plate. The cut-out starts with a wide slot at the wall of the cup that transitions to a narrow slot within the cup. The narrow slot is intended for the edge of the plate. The wider slot contacts the bottom of the plate.
摘要翻译：一个杯子包括一个整体结构的两个隔间：一个保持液体饮料的上部隔间和一个具有配置的槽以滑动到板的边缘的下隔室。上部隔间具有敞开的顶端和封闭的底端，就像任何其他杯子一样。打开的顶端大于封闭的底端，以便允许将多个杯子堆叠在一起。下隔室连接在第一隔间的封闭底端下方。第二隔室限定了一个配置的狭槽或切口，其被成形为接收板的边缘并接触板的底部。切口开始于在杯壁处的宽槽，其过渡到杯内的狭窄狭缝。窄槽适用于板的边缘。较宽的槽接触板的底部。

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