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1. 发明授权

US06726673B1 Methods and apparatus for improved administration of testosterone pharmaceuticals 失效
标题翻译：用于改善睾丸激素药物施用的方法和装置
公开(公告)号：US06726673B1
公开(公告)日：2004-04-27
申请号：US09317313
申请日：1999-05-24
申请人： Jie Zhang , Hao Zhang , Wade A. Hull , Larry Rigby
发明人： Jie Zhang , Hao Zhang , Wade A. Hull , Larry Rigby
IPC分类号： A61M3100
CPC分类号： A61K9/0024 , A61F7/032 , A61K9/0009 , A61K9/7023 , A61M31/002 , A61M2037/0007 , A61N1/30
摘要： The present invention relates to a method and apparatus for increasing the delivery rate of an androgen transdermal therapeutic system through the skin. An androgen transdermal therapeutic system can be applied to a patient's skin for delivery of the androgen. A temperature modification apparatus which is capable of generating controlled heat is applied approximate to the androgen transdermal therapeutic system. The heating from the temperature modification apparatus raises the temperature of the androgen transdermal therapeutic system and raises the temperature of the patient's skin to achieve an increased rate of delivery of androgen through the skin. The controlled heat can also be used to adjust dosage rates of the androgen transdermal therapeutic system and to mimic natural circadian patterns. The controlled heating may also be used to improve or regulate the release of androgen from injected/implanted extended/controlled release systems.
摘要翻译：本发明涉及通过皮肤增加雄激素透皮治疗系统的递送率的方法和装置。雄激素透皮治疗系统可以应用于患者的皮肤以递送雄激素。接近于雄激素透皮治疗系统的是能产生受控热量的温度调节装置。来自温度改变装置的加热提高了雄激素透皮治疗系统的温度，并且提高了患者皮肤的温度，以达到通过皮肤递送雄激素的增加的速率。受控热也可用于调节雄激素透皮治疗系统的剂量率，并模拟自然昼夜节律模式。受控加热也可用于改善或调节注射/植入的扩增/控制释放系统中雄激素的释放。

2. 发明授权

US06546281B1 Integrated apparatus for controlled heat aided dermal drug delivery 有权
标题翻译：用于受控热辅助皮肤药物递送的综合装置
公开(公告)号：US06546281B1
公开(公告)日：2003-04-08
申请号：US09317372
申请日：1999-05-24
申请人： Jie Zhang , Hao Zhang , Wade A. Hull , Larry Rigby
发明人： Jie Zhang , Hao Zhang , Wade A. Hull , Larry Rigby
IPC分类号： A61N130
CPC分类号： A61K9/0009 , A61F7/032 , A61F7/034 , A61F2013/00187 , A61F2013/00204 , A61F2013/00906 , A61F2013/0091 , A61K9/0024 , A61K9/7023 , A61K31/4468 , A61K31/4535 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61N1/30 , Y10S514/817 , Y10S514/937 , Y10S514/944
摘要： An integrated apparatus for controlled heat aided dermal drug delivery is disclosed. The apparatus has a temperature control component and a drug delivery component. The temperature control component may and dermal drug delivery component are an integrated unit. The apparatus also comprises means to prevent exchange of substance(s) among the heat generating component, the drug delivery component and the outside environment. The apparatus is designed to be easy to use.
摘要翻译：公开了一种用于受控加热皮肤药物递送的综合装置。该装置具有温度控制部件和药物输送部件。温度控制组分可以和皮肤药物递送组分是一体化单元。该装置还包括防止发热部件，药物输送部件和外部环境之间的物质交换的装置。该设备被设计为易于使用。

3. 发明授权

US06453648B1 Method for manufacturing a heat generating apparatus 有权
标题翻译：制造发热装置的方法
公开(公告)号：US06453648B1
公开(公告)日：2002-09-24
申请号：US09347963
申请日：1999-07-06
申请人： Jie Zhang , Hao Zhang , Larry Rigby , Wade A. Hull
发明人： Jie Zhang , Hao Zhang , Larry Rigby , Wade A. Hull
IPC分类号： A61F700
CPC分类号： A61F7/034 , A61F2007/0226 , A61F2007/0249
摘要： The present invention relates to a method for manufacturing a heating device which is capable of generating heat when exposed to oxygen. The heat generating element comprises activated carbon and iron is used to generate an exothermic oxidation reaction within the heating device. Introducing an oxidation inhibitor during the manufacturing process allows the manufacturing of the device to take place in ambient atmospheric conditions. The present invention also includes a loading facilitator which allows the heat generating medium to be more easily and efficiently loaded into the heat generating device. When appropriate, the oxidation inhibitor and loading facilitator can be removed.
摘要翻译：本发明涉及一种能够在暴露于氧气时产生热量的加热装置的制造方法。发热元件包括活性炭和铁，用于在加热装置内产生放热氧化反应。在制造过程中引入氧化抑制剂可使装置的制造在环境大气条件下进行。本发明还包括能够使发热介质更容易且有效地装载到发热装置中的负载辅助装置。适当时，可以除去氧化抑制剂和负载促进剂。

4. 发明授权

US06245347B1 Methods and apparatus for improved administration of pharmaceutically active compounds 有权
公开(公告)号：US06245347B1
公开(公告)日：2001-06-12
申请号：US09162890
申请日：1998-09-29
申请人： Jie Zhang , Hao Zhang
发明人： Jie Zhang , Hao Zhang
IPC分类号： A61F1302
CPC分类号： A61K9/0009 , A61F7/032 , A61F7/034 , A61F2013/00187 , A61F2013/00204 , A61F2013/00906 , A61F2013/0091 , A61K9/0024 , A61K9/7023 , A61K31/4468 , A61K31/4535 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61N1/30 , Y10S514/817 , Y10S514/937 , Y10S514/944
摘要： Methods and apparatus for improving administration of drugs through the use of heat and other physical means. The present invention relates to the use of heat and other physical means in conjunction with specially designed dermal drug delivery systems, conventional commercial dermal drug delivery systems, or drugs delivered into a sub-skin depot site via injection and other methods to alter, mainly increase, the drug release rate from the dermal drug delivery systems or the depot sites to accommodate certain clinical needs.

5. 发明授权

US06284266B1 Methods and apparatus for improved administration of fentanyl and sufentanil 失效
标题翻译：改善氟芬太尼和舒芬太尼治疗的方法和装置
公开(公告)号：US06284266B1
公开(公告)日：2001-09-04
申请号：US09162587
申请日：1998-09-29
申请人： Jie Zhang , Hao Zhang
发明人： Jie Zhang , Hao Zhang
IPC分类号： A61K970
CPC分类号： A61F7/02 , A61B2017/00765 , A61F7/032 , A61F7/034 , A61F2013/00187 , A61F2013/00204 , A61F2013/00906 , A61F2013/0091 , A61K9/0009 , A61K9/0024 , A61K9/7023 , A61K31/4468 , A61K31/4535 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61N1/30
摘要： Methods and apparatus for improving administration of analgesics through the use of heat. The present invention relates to the use of heat in conjunction with specially designed transdermal analgesic delivery systems and conventional commercial transdermal analgesic delivery systems to alter, mainly increase, the analgesic release rate from the transdermal analgesic delivery systems or the depot sites to accommodate certain clinical needs.
摘要翻译：通过使用热量来改善镇痛药的施用方法和装置。本发明涉及加热与特别设计的透皮止痛递送系统和常规商业经皮止痛递送系统的用途，以改变，主要增加经皮止痛剂递送系统或贮库部位的镇痛释放速率以适应某些临床需要。

6. 发明授权

US06613350B1 Electrical apparatus for heating to a desired temperature for improved administration of pharmaceutically active compounds 失效
标题翻译：用于加热至所需温度的电气设备，用于改善药物活性化合物的给药
公开(公告)号：US06613350B1
公开(公告)日：2003-09-02
申请号：US09544897
申请日：2000-04-07
申请人： Jie Zhang , Hao Zhang
发明人： Jie Zhang , Hao Zhang
IPC分类号： A61L1516
CPC分类号： A61K9/0009 , A61F7/032 , A61F7/034 , A61F2013/00187 , A61F2013/00204 , A61F2013/00906 , A61F2013/0091 , A61K9/0024 , A61K9/7023 , A61K31/4468 , A61K31/4535 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61N1/30 , Y10S514/817 , Y10S514/937 , Y10S514/944
摘要： Methods and apparatus for improving administration of drugs through the use of heat and other physical means. The present invention relates to the use of heat and other physical means in conjunction with specially designed dermal drug delivery systems, conventional commercial dermal drug delivery systems, or drugs delivered into a sub-skin depot site via injection and other methods to alter, mainly increase, the drug release rate from the dermal drug delivery systems or the depot sites to accommodate certain clinical needs.
摘要翻译：通过使用热等物理手段改善药物的给药方法和装置。本发明涉及热和其他物理手段与特殊设计的真皮药物递送系统，常规商业皮肤药物递送系统或通过注射递送至次皮肤贮存部位的药物的使用以及其它改变方法，主要增加，药物释放速率从皮肤药物输送系统或仓库站点，以适应某些临床需要。

7. 发明授权

US06303142B1 Methods and apparatus for improved administration of pharmaceutically active compounds 失效
标题翻译：用于改善药物活性化合物的给药的方法和装置
公开(公告)号：US06303142B1
公开(公告)日：2001-10-16
申请号：US09545591
申请日：2000-04-07
申请人： Jie Zhang , Hao Zhang
发明人： Jie Zhang , Hao Zhang
IPC分类号： A61F1302
CPC分类号： A61K9/0009 , A61F7/032 , A61F7/034 , A61F2013/00187 , A61F2013/00204 , A61F2013/00906 , A61F2013/0091 , A61K9/0024 , A61K9/7023 , A61K31/4468 , A61K31/4535 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61N1/30 , Y10S514/817 , Y10S514/937 , Y10S514/944
摘要： Methods and apparatus for improving administration of drugs through the use of heat and other physical means. The present invention relates to the use of heat and other physical means in conjunction with specially designed dermal drug delivery systems, conventional commercial dermal drug delivery systems, or drugs delivered into a sub-skin depot site via injection and other methods to alter, mainly increase, the drug release rate from the dermal drug delivery systems or the depot sites to accommodate certain clinical needs.
摘要翻译：通过使用热等物理手段改善药物的给药方法和装置。本发明涉及热和其他物理手段与特殊设计的真皮药物递送系统，常规商业皮肤药物递送系统或通过注射递送至次皮肤贮存部位的药物的使用以及其它改变方法，主要增加，药物释放速率从皮肤药物输送系统或仓库站点，以适应某些临床需要。

8. 发明授权

US5919479A Noninvasive dermal anesthetics 失效
标题翻译：无创皮肤麻醉药
公开(公告)号：US5919479A
公开(公告)日：1999-07-06
申请号：US819880
申请日：1997-03-18
申请人： Jie Zhang , Hao Zhang
发明人： Jie Zhang , Hao Zhang
IPC分类号： A61M37/00 , A61F7/02 , A61F7/03 , A61F13/00 , A61K9/70 , A61K31/167 , A61K31/245 , A61L15/42 , A61L15/44 , A61P23/00
CPC分类号： A61F7/034 , A61K31/167 , A61K31/216 , A61K31/245 , A61K9/7023 , A61F2007/0261 , A61F2013/00187 , A61F2013/00204 , A61F2013/00906 , A61F2013/0091 , A61M37/00 , Y10S514/817 , Y10S514/937 , Y10S514/938 , Y10S514/944
摘要： An apparatus, product formulation, and method for improved dermal permeation of pharmaceuticals wherein the apparatus includes a thin drug formulation reservoir and a heat-generating chamber separated by a first non-permeable wall, wherein the reservoir and chamber are formed in or supported by a housing. The drug formulation reservoir houses or is capable of housing a predetermined amount of a formulation containing pharmaceutically-active agent(s). The heat-generating/temperature-regulating chamber includes a medium for generating controlled heat, preferably a chemical composition made of carbon, iron, water and/or salt which is activated upon contact with air (oxygen). The function of the heat-generating/temperature-regulating element is to heat the user's skin, rapidly bring the skin temperature to a desired and elevated narrow range and keep it in this range for sufficient time to obtain more rapid, enhanced and less variable dermal absorption of selected pharmaceutically-active agents and to obtain improved clinical effects. Structure for controlling the generation of heat is also disclosed. The apparatus may optionally include a spacing or standoff structure which spans the drug formulation reservoir between the non-permeable wall and the user's skin surface for maintaining a predetermined thickness of the drug formulation on the user's skin surface. Also, a novel product formulation which can be used with the apparatus which uses high percentage of eutectic mixture of local anesthetics to reduce the overall degradation rate of the local anesthetic compound(s) in formulations which are subject to hydrolysis.
摘要翻译：一种用于改善药物皮肤渗透的装置，产品制剂和方法，其中所述装置包括薄的药物制剂储存器和由第一不可渗透壁分隔开的发热室，其中所述储存器和室由住房。药物制剂储存器容纳或能够容纳预定量的含有药物活性剂的制剂。发热/温度调节室包括用于产生受控热的介质，优选由碳，铁，水和/或盐制成的化学组成，其在与空气（氧气）接触时被活化。发热/温度调节元件的功能是加热使用者的皮肤，迅速使皮肤温度达到所需和升高的窄范围，并将其保持在该范围内足够的时间以获得更快速，增强和更少变化的皮肤吸收所选的药物活性剂并获得改善的临床效果。还公开了用于控制发热的结构。该装置可以可选地包括跨越药物制剂储存器在不可渗透的壁和使用者的皮肤表面之间的间隔或间隔结构，用于维持用户皮肤表面上的药物制剂的预定厚度。另外，可以与使用高百分比的局部麻醉剂共晶混合物的装置一起使用的新产品制剂来降低在待水解的制剂中的局部麻醉剂的总体降解速率。

9. 发明授权

US5658583A Apparatus and methods for improved noninvasive dermal administration of pharmaceuticals 失效
标题翻译：用于改善药物非侵入性皮肤给药的装置和方法
公开(公告)号：US5658583A
公开(公告)日：1997-08-19
申请号：US508463
申请日：1995-07-28
申请人： Jie Zhang , Hao Zhang
发明人： Jie Zhang , Hao Zhang
IPC分类号： A61M37/00 , A61F7/02 , A61F7/03 , A61F13/00 , A61K9/70 , A61K31/167 , A61K31/245 , A61L15/42 , A61L15/44 , A61P23/00 , A01N25/34
CPC分类号： A61F7/034 , A61K31/167 , A61K31/216 , A61K31/245 , A61K9/7023 , A61F2007/0261 , A61F2013/00187 , A61F2013/00204 , A61F2013/00906 , A61F2013/0091 , A61M37/00 , Y10S514/817 , Y10S514/937 , Y10S514/938 , Y10S514/944
摘要： An apparatus, product formulation, and method for improved dermal permeation of pharmaceuticals wherein the apparatus includes a thin drug formulation reservoir and a heat-generating chamber separated by a first non-permeable wall, wherein the reservoir and chamber are formed in or supported by a housing. The drug formulation reservoir houses or is capable of housing a predetermined amount of a formulation containing pharmaceutically-active agent(s). The heat-generating/temperature-regulating chamber includes a medium for generating controlled heat, preferably a chemical composition made of carbon, iron, water and/or salt which is activated upon contact with air (oxygen). The function of the heat-generating/temperature-regulating element is to heat the user's skin, rapidly bring the skin temperature to a desired and elevated narrow range and keep it in this range for sufficient time to obtain more rapid, enhanced and less variable dermal absorption of selected pharmaceutically-active agents and to obtain improved clinical effects. Structure for controlling the generation of heat is also disclosed. The apparatus may optionally include a spacing or standoff structure which spans the drug formulation reservoir between the non-permeable wall and the user's skin surface for maintaining a predetermined thickness of the drug formulation on the user's skin surface. Also, a novel product formulation which can be used with the apparatus which uses high percentage of eutectic mixture of local anesthetics to reduce the overall degradation rate of the local anesthetic compound(s) in formulations which are subject to hydrolysis.
摘要翻译：一种用于改善药物皮肤渗透的装置，产品制剂和方法，其中所述装置包括薄的药物制剂储存器和由第一不可渗透壁分隔开的发热室，其中所述储存器和室由住房。药物制剂储存器容纳或能够容纳预定量的含有药物活性剂的制剂。发热/温度调节室包括用于产生受控热的介质，优选由碳，铁，水和/或盐制成的化学组成，其在与空气（氧气）接触时被活化。发热/温度调节元件的功能是加热使用者的皮肤，迅速使皮肤温度达到所需和升高的窄范围，并将其保持在该范围内足够的时间以获得更快速，增强和更少变化的皮肤吸收所选的药物活性剂并获得改善的临床效果。还公开了用于控制发热的结构。该装置可以可选地包括跨越药物制剂储存器在不可渗透的壁和使用者的皮肤表面之间的间隔或间隔结构，用于维持用户皮肤表面上的药物制剂的预定厚度。另外，可以与使用高百分比的局部麻醉剂共晶混合物的装置一起使用的新产品制剂来降低在待水解的制剂中的局部麻醉剂的总体降解速率。

10. 发明授权

US06465006B1 Method for facilitating absorption of pharmaceutically active compounds 有权
标题翻译：促进药物活性化合物吸收的方法
公开(公告)号：US06465006B1
公开(公告)日：2002-10-15
申请号：US09545496
申请日：2000-04-07
申请人： Jie Zhang , Hao Zhang
发明人： Jie Zhang , Hao Zhang
IPC分类号： A61F1302
CPC分类号： A61K9/0009 , A61F7/032 , A61F7/034 , A61F2013/00187 , A61F2013/00204 , A61F2013/00906 , A61F2013/0091 , A61K9/0024 , A61K9/7023 , A61K31/4468 , A61K31/4535 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61N1/30 , Y10S514/817 , Y10S514/937 , Y10S514/944
摘要： Methods and apparatus for improving administration of drugs through the use of heat and other physical means. The present invention relates to the use of heat and other physical means in conjunction with specially designed dermal drug delivery systems, conventional commercial dermal drug delivery systems, or drugs delivered into a sub-skin depot site via injection and other methods to alter, mainly increase, the drug release rate from the dermal drug delivery systems or the depot sites to accommodate certain clinical needs.
摘要翻译：通过使用热等物理手段改善药物的给药方法和装置。本发明涉及热和其他物理手段与特殊设计的真皮药物递送系统，常规商业皮肤药物递送系统或通过注射递送至次皮肤贮存部位的药物的使用以及其它改变方法，主要增加，药物释放速率从皮肤药物输送系统或仓库站点，以适应某些临床需要。

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