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1. 发明授权

US06607799B1 Surgical dressing with delivery system and method of manufacture 有权
标题翻译：输送系统的手术敷料和制造方法
公开(公告)号：US06607799B1
公开(公告)日：2003-08-19
申请号：US09172815
申请日：1998-10-15
申请人： Steven B. Heinecke , Donald G. Peterson , Karen M. Bisbee , Richard L. Jacobson
发明人： Steven B. Heinecke , Donald G. Peterson , Karen M. Bisbee , Richard L. Jacobson
IPC分类号： A61L1516
CPC分类号： G09F3/0292 , Y10T428/14 , Y10T428/1471 , Y10T428/1476 , Y10T428/149 , Y10T428/1495 , Y10T428/15
摘要： Adhesive composite dressings with simple and inexpensive delivery systems and methods of manufacturing the dressings are disclosed. The dressings include liners having a release surface and a retention surface. The bond strength between the liner and the pressure sensitive adhesive in the area of the retention surface is greater than the bond strength between the liner and the pressure sensitive adhesive in release surface. The increased bond strength in the area of the retention surface allows the backing to be held taut during delivery to assist in smooth aseptic delivery of the dressing. The retention surfaces can be provided by abrasion, embossing, perforating the liner, or combinations thereof. In addition, the methods of manufacturing the dressings can be practiced in-line with other converting operations using standard release liners.
摘要翻译：公开了具有简单且廉价的输送系统的粘合剂复合敷料和制造敷料的方法。敷料包括具有释放表面和保持表面的衬垫。衬垫与压敏粘合剂在保持表面区域的结合强度大于衬垫与释放表面的压敏粘合剂之间的结合强度。在保持表面区域中增加的粘合强度允许背衬在输送期间保持拉紧，以有助于平滑无菌递送敷料。保持表面可以通过磨损，压花，穿孔衬垫或其组合来提供。此外，制造敷料的方法可以与使用标准剥离衬垫的其它转化操作一起实施。

2. 发明授权

US06375977B1 Hydrocolloid adhesive mass useful for medical purposes 有权
标题翻译：水胶体粘合剂用于医疗用途
公开(公告)号：US06375977B1
公开(公告)日：2002-04-23
申请号：US09655429
申请日：2000-09-05
申请人： Stephane Auguste , Laurent Apert , Luc Garima
发明人： Stephane Auguste , Laurent Apert , Luc Garima
IPC分类号： A61L1516
CPC分类号： A61L15/585
摘要： The present invention relates to a novel hydrocolloid adhesive mass useful for medical purposes, characterized in that said hydrocolloid adhesive mass comprises: a) 0.2 to 5 parts by weight of an ethoxylated sorbitan fatty acid ester; b) 20 to 50 parts by weight of a hydrocolloid; c) 32 to 120 to parts by weight of an adhesive matrix made up of one or more polymers selected from poly(styrene/olefin/styrene) block copolymers, low-molecular polyisobutylenes and high-molecular polyisobutylenes, and one or more compounds selected from sticky resins, or tackifying resins, plasticizers, polybutenes, antioxidants, ethylene/vinyl acetate copolymers, butyl rubbers and ethylene/propylene block copolymers; and d) 0 to 15 parts by weight of an acrylate copolymer with a glass transition temperature below −20° C. It further relates to the use of this hydrocolloid adhesive mass for the production of dressings, especially for the treatment of superficial, deep, chronic or acute dermo-epidermal lesions, exudative wounds and bums.
摘要翻译：本发明涉及一种用于医疗目的的新型水胶体粘合剂组合物，其特征在于所述水胶体粘合剂组合物包括：a）0.2至5重量份的乙氧基化山梨糖醇酐脂肪酸酯; b）20至50重量份的水解胶体; c）32至120重量份的由选自聚（苯乙烯/烯烃/苯乙烯）嵌段共聚物，低分子量聚异丁烯和高分子量聚异丁烯的一种或多种聚合物组成的粘合剂基质和一种或多种化合物选自粘性树脂或增粘树脂，增塑剂，聚丁烯，抗氧化剂，乙烯/乙酸乙烯酯共聚物，丁基橡胶和乙烯/丙烯嵌段共聚物; andd）0至15重量份的玻璃化转变温度低于-20℃的丙烯酸酯共聚物。此外还涉及该水胶体粘合剂用于生产敷料的用途，特别是用于治疗浅层，深层，慢性或急性皮肤 - 表皮损伤，渗出性伤口和烧伤。

3. 发明授权

US06210703B1 Glass fiber chemical delivery system 失效
标题翻译：玻璃纤维化学品输送系统
公开(公告)号：US06210703B1
公开(公告)日：2001-04-03
申请号：US08994616
申请日：1997-12-19
申请人： Bruce E. Novich
发明人： Bruce E. Novich
IPC分类号： A61L1516
CPC分类号： A61L29/106 , A61K47/6953 , A61K51/1275 , A61L29/146 , A61L29/16 , A61L31/088 , A61L31/146 , A61L31/16 , A61L2300/258 , A61L2300/416 , A61L2300/602 , A61L2300/606
摘要： A glass fiber chemical delivery system including water soluble fiberglass particles containing a chemical composition. The water soluble fiberglass particles may define pores in which the chemical composition is contained or the water soluble fiberglass particles may each define a hollow core containing the chemical composition. As the fiberglass particles dissolve in an aqueous environment, such as within cells of a blood vessel wall or in a reaction vessel, the chemical composition is released.
摘要翻译：玻璃纤维化学输送系统，包括含有化学成分的水溶性玻璃纤维颗粒。水溶性玻璃纤维颗粒可以限定其中含有化学组成的孔，或者水溶性玻璃纤维颗粒可以各自限定含有化学组成的中空芯。当玻璃纤维颗粒溶解在诸如血管壁的细胞内或在反应容器中的水性环境中时，化学组成被释放。

4. 发明授权

US06737079B2 Bandage composition containing a phage associated lytic enzyme 失效
标题翻译：含有噬菌体相关裂解酶的绷带组合物
公开(公告)号：US06737079B2
公开(公告)日：2004-05-18
申请号：US09932460
申请日：2001-08-20
申请人： Vincent Fischetti , Lawrence Loomis
发明人： Vincent Fischetti , Lawrence Loomis
IPC分类号： A61L1516
CPC分类号： C12Y302/01017 , A61K38/47 , C12N9/503 , Y10S514/937
摘要： A composition for treatment of bacterial infections of burns and wounds of the skin, comprising an effective amount of at least one lytic enzyme produced by a bacteria infected with a bacteriophage specific for said bacteria, and a carrier for delivering said at least one lytic enzyme to the skin. The carrier may be, but is not limited to, a liquid solution applied to a bandage.
摘要翻译：一种用于治疗皮肤烧伤和创伤的细菌感染的组合物，其包含有效量的由感染了所述细菌特异性噬菌体的细菌产生的至少一种裂解酶，以及用于将所述至少一种裂解酶递送至皮。载体可以是但不限于施加到绷带上的液体溶液。

5. 发明授权

US06592890B1 Conveyance of anti-infective activity to wound dressings 失效
标题翻译：传染性感染活动对伤口敷料
公开(公告)号：US06592890B1
公开(公告)日：2003-07-15
申请号：US09694104
申请日：2000-10-19
申请人： Terrence R. Green
发明人： Terrence R. Green
IPC分类号： A61L1516
CPC分类号： A61L15/46 , A61L15/24 , A61L15/26 , A61L15/38 , A61L2300/106 , A61L2300/254 , A61L2300/404 , C08L33/26
摘要： A wound dressing having anti-infective activity. The wound dressing provides stable and improved formulations of precursors required in generating anti-infective iodine specifically within a wound site where the oxygen tension may be very low. Furthermore, the design of the invention precludes interference by catalase (and other heme proteins.) in competing for hydrogen peroxide where hydrogen peroxide is used as a component of the iodine generating formulation, ensuring more efficient and sustained production of free iodine as a potent anti-infective agent. The invention takes advantage of the physical design of the wound dressing, and the permeation of body fluid into the dressing, which together serve to initiate formation of nascent iodine concomitant with placement of the dressing into, or over, a wound site. The invention circumvents the problem of trapping elemental iodine in the form of tri-iodide, which lacks microbicidal activity, by the chemical method of generating iodine de novo, and in the presence of excess oxidant. Newly formed iodine is thus able to egress and disperse throughout the wound site before there is an opportunity for it to become fully bound as tri-iodide, conferring to the wound site anti-infective activity. Two embodiments of the wound dressing invention are described comprising a mono- and bilayer configuration which, when placed in a wound site, confer to the site anti-infective properties.
摘要翻译：伤口敷料具有抗感染活性。创伤敷料提供稳定和改进的前体制剂，其特别是在氧压力可能非常低的伤口部位产生抗感染性碘所需的前体制剂。此外，本发明的设计排除了过氧化氢酶（和其他血红素蛋白质）在竞争过氧化氢中的干扰，其中过氧化氢被用作碘产生制剂的组分，确保更有效和持续地生产游离碘作为有效的抗有效代理。本发明利用伤口敷料的物理设计，以及体液渗透到敷料中，这些一起用于起始形成新生碘，同时将敷料放置在伤口部位中或上方。本发明通过从过去产生碘的化学方法，在过量的氧化剂存在下，克服了以三碘化物形式捕获元素碘，缺乏杀菌活性的问题。因此，新形成的碘能够在整个伤口部位出口并分散，在其有机会完全结合为三碘化物，赋予伤口部位抗感染活性。描述了伤口敷料发明的两个实施方案，其包括单层和双层构型，其在置于伤口部位时赋予该部位抗感染性质。

6. 发明授权

US06555129B1 Transdermal therapeutic system (TTS) containing oxybutynin 失效
标题翻译：透皮治疗系统（TTS）含有奥昔布宁
公开(公告)号：US06555129B1
公开(公告)日：2003-04-29
申请号：US09622848
申请日：2000-10-26
申请人： Christoph Arth , Andreas Kollmeyer-Seeger , Stephan Rimpler , Hans-Michael Wolff
发明人： Christoph Arth , Andreas Kollmeyer-Seeger , Stephan Rimpler , Hans-Michael Wolff
IPC分类号： A61L1516
CPC分类号： A61L15/16 , A61K9/7061 , A61K31/216
摘要： A transdermal therapeutic system (TTS) for transcutaneous administration of oxybutynin over a period of several days, in addition to a method for the production of the TTS without the use of solvents, are disclosed. The TTS contains a matrix mass containing oxybutynin in the form of a self-adhesive layer. The matrix mass includes ammonium-group-containing (meth)acrylic polymers, at least one citric acid ester, and 5-25 wt. % oxybutynin.
摘要翻译：公开了一种用于在几天内经皮给药奥昔布宁的透皮治疗系统（TTS），以及不使用溶剂生产TTS的方法。 TTS含有含有自粘层形式的奥昔布宁的基体质量。基质团包括含铵基的（甲基）丙烯酸聚合物，至少一种柠檬酸酯和5-25wt。奥昔布宁。

7. 发明授权

US06613350B1 Electrical apparatus for heating to a desired temperature for improved administration of pharmaceutically active compounds 失效
标题翻译：用于加热至所需温度的电气设备，用于改善药物活性化合物的给药
公开(公告)号：US06613350B1
公开(公告)日：2003-09-02
申请号：US09544897
申请日：2000-04-07
申请人： Jie Zhang , Hao Zhang
发明人： Jie Zhang , Hao Zhang
IPC分类号： A61L1516
CPC分类号： A61K9/0009 , A61F7/032 , A61F7/034 , A61F2013/00187 , A61F2013/00204 , A61F2013/00906 , A61F2013/0091 , A61K9/0024 , A61K9/7023 , A61K31/4468 , A61K31/4535 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61N1/30 , Y10S514/817 , Y10S514/937 , Y10S514/944
摘要： Methods and apparatus for improving administration of drugs through the use of heat and other physical means. The present invention relates to the use of heat and other physical means in conjunction with specially designed dermal drug delivery systems, conventional commercial dermal drug delivery systems, or drugs delivered into a sub-skin depot site via injection and other methods to alter, mainly increase, the drug release rate from the dermal drug delivery systems or the depot sites to accommodate certain clinical needs.
摘要翻译：通过使用热等物理手段改善药物的给药方法和装置。本发明涉及热和其他物理手段与特殊设计的真皮药物递送系统，常规商业皮肤药物递送系统或通过注射递送至次皮肤贮存部位的药物的使用以及其它改变方法，主要增加，药物释放速率从皮肤药物输送系统或仓库站点，以适应某些临床需要。

8. 发明授权

US06596304B1 Method for preparing two-layer bicomposite collagen material for preventing post-operative adhesions 有权
标题翻译：制备双层双层复合胶原材料以防止手术后粘连的方法
公开(公告)号：US06596304B1
公开(公告)日：2003-07-22
申请号：US09554509
申请日：2000-07-11
申请人： Yves Bayon , Philippe Gravagna , Jean-Lois Tayot
发明人： Yves Bayon , Philippe Gravagna , Jean-Lois Tayot
IPC分类号： A61L1516
CPC分类号： A61L15/325 , A61L31/044
摘要： A bicomposite material based on collagen is prepared which has two closely bound layers and is biocompatible, non-toxic, hemostatic and biodegradable in less than a month, and can be used in surgery to achieve hemostasis and prevent post-surgical adhesion. To prepare the material, a solution of collagen or gelatin, which may contain glycerine and a hydrophilic additive such as polyethylene glycol or a polysaccharide, is poured onto an inert support to form a layer 30 &mgr;m to less than 100 &mgr;m thick. Then a polymeric porous fibrous layer is applied during gelling of the collagen or gelatin, and the resultant material is dried. The polymeric porous fibrous layer may be made of collagen or a polysaccharide, and have a density of not more than 75 mg/cm2, a pore size from 30 &mgr;m to 300 &mgr;m and a thickness of 0.2 cm to 1.5 cm.
摘要翻译：制备基于胶原的双组分材料，其具有两个紧密结合的层，并且在不到一个月的时间内具有生物相容性，无毒性，止血性和生物降解性，并且可用于手术以实现止血并防止手术后粘连。为了制备材料，将可能含有甘油和亲水性添加剂如聚乙二醇或多糖的胶原蛋白或明胶溶液倒入惰性支持体中以形成30μm至小于100μm厚的层。然后在胶原或明胶的胶凝过程中施加聚合物多孔纤维层，并将所得材料干燥。聚合物多孔纤维层可以由胶原或多糖制成，密度不超过75mg / cm 2，孔径从30μm至300μm，厚度为0.2cm至1.5cm。

9. 发明授权

US06399093B1 Method and composition to treat musculoskeletal disorders 失效
标题翻译：治疗肌肉骨骼疾病的方法和组成
公开(公告)号：US06399093B1
公开(公告)日：2002-06-04
申请号：US09314829
申请日：1999-05-19
申请人： Edward J. Petrus
发明人： Edward J. Petrus
IPC分类号： A61L1516
CPC分类号： A61K9/0014 , A61K31/165 , A61K31/192 , A61K31/196 , A61K45/06 , A61K47/10 , A61K47/20 , A61K47/32
摘要： A method and composition for the treatment of musculoskeletal disorders in mammals by the application of a topical composition comprising a permeation enhancing amount of one or more penetration enhancers, and one or more bio-affecting agents to provide anti-inflammatory relief and analgesia to the applied body part.
摘要翻译：一种用于治疗哺乳动物肌肉骨骼疾病的方法和组合物，其通过使用包含渗透促进量的一种或多种渗透促进剂的局部组合物和一种或多种生物影响剂来提供抗炎减轻和镇痛身体的一部分。

10. 发明授权

US06231872B1 Structured occlusive dressings 有权
标题翻译：结构闭塞敷料
公开(公告)号：US06231872B1
公开(公告)日：2001-05-15
申请号：US09153408
申请日：1998-09-15
申请人： Mark Mooney , Anthony Gallo , John Perucki
发明人： Mark Mooney , Anthony Gallo , John Perucki
IPC分类号： A61L1516
CPC分类号： A61L15/20 , A61F13/0203 , A61F2013/00885 , A61F2013/0091 , A61L15/22 , A61L15/42 , A61L15/44 , A61L2300/402 , A61L2300/404 , A61L2300/406 , A61L2300/41 , A61L2300/412
摘要： This invention relates to a composition containing a hydrophobic solvent, a network polymer and a flow control agent which is useful in healing wounds. The composition of this invention may be applied directly to a wound to create a structured occlusive dressing. The dressings of this invention do not migrate, but maintain their integrity at skin temperature, and encourage the creation of a moist wound environment while protecting the wound in order to accelerate healing.
摘要翻译：本发明涉及含有疏水性溶剂，网状聚合物和流动控制剂的组合物，其可用于治疗伤口。本发明的组合物可以直接应用于伤口以产生结构化闭塞敷料。本发明的敷料不会迁移，而是保持其在皮肤温度下的完整性，并且鼓励创造潮湿的伤口环境，同时保护伤口以加速愈合。

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