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1. 发明授权

US08682620B2 Method for designing extrusion dies 有权
标题翻译：挤出模具设计方法
公开(公告)号：US08682620B2
公开(公告)日：2014-03-25
申请号：US12949851
申请日：2010-11-19
申请人： Jianjun Feng , Eric Paul Granberg , Maxwell Joseph Wingert
发明人： Jianjun Feng , Eric Paul Granberg , Maxwell Joseph Wingert
IPC分类号： G06F17/50 , G06F7/66
CPC分类号： B29C47/0859 , B29C33/3835 , B29C47/0002 , B29C47/0009 , B29C47/0854 , B29C47/14 , B29C47/92 , B29C2947/92514 , B29C2947/926 , B29C2947/92666 , B29C2947/92904
摘要： A method of designing a die cavity that may include performing a flow analysis using characteristics of a predetermined die cavity, density and rheological properties of a material, and a flow rate of the material to calculate the pressure distribution exerted on the die cavity and cross-sectional flow profile. The method further includes a structural analysis using the calculated pressure distribution and structural characteristics of the die cavity to calculate a deformed die cavity. The flow analysis is repeated using the characteristics of the deformed die cavity to calculate a pressure distribution exerted on the die cavity and cross-sectional flow profile. The outcome is compared to determine if the pressure distributions and/or cross-sectional flow profiles converge. These steps are iteratively repeated until convergence of the pressure and/or cross-sectional flow profile is observed. The variation of the cross-sectional flow profile is analyzed to determine if it is below a predetermined tolerance.
摘要翻译：设计模腔的方法，其可以包括使用预定模腔的特性，材料的密度和流变特性以及材料的流速来执行流动分析，以计算施加在模腔上的压力分布，截面流动剖面图。该方法还包括使用计算的压模分布和模腔的结构特征来计算变形模腔的结构分析。使用变形模腔的特征重复流动分析，以计算施加在模腔上的压力分布和横截面流动分布。比较结果以确定压力分布和/或横截面流动剖面是否收敛。迭代地重复这些步骤，直到观察到压力和/或横截面流动分布的收敛。分析横截面流动剖面的变化以确定其是否低于预定的公差。

2. 发明申请

US20120130684A1 METHOD FOR DESIGNING EXTRUSION DIES 有权
标题翻译：设计挤出机的方法
公开(公告)号：US20120130684A1
公开(公告)日：2012-05-24
申请号：US12949851
申请日：2010-11-19
申请人： Jianjun Feng , Eric Paul Granberg , Maxwell Joseph Wingert
发明人： Jianjun Feng , Eric Paul Granberg , Maxwell Joseph Wingert
IPC分类号： G06F17/50
CPC分类号： B29C47/0859 , B29C33/3835 , B29C47/0002 , B29C47/0009 , B29C47/0854 , B29C47/14 , B29C47/92 , B29C2947/92514 , B29C2947/926 , B29C2947/92666 , B29C2947/92904
摘要： A method of designing a die cavity can include performing a flow analysis using characteristics of a predetermined die cavity design, density and rheological properties of a material to be extruded, and a flow rate of the material to calculate the pressure distribution exerted on the die cavity and cross-sectional flow profile. The method further includes performing a structural analysis using the calculated pressure distribution and structural characteristics of the die cavity to calculate a deformed die cavity. The flow analysis is then repeated using the characteristics of the deformed die cavity to calculate a pressure distribution exerted on the die cavity and cross-sectional flow profile. The calculated pressure distributions and/or cross-sectional flow profiles are compared to determine if the pressure distributions and/or cross-sectional flow profiles converge. These steps are iteratively repeated until convergence of the pressure and/or cross-sectional flow profile is observed. Once convergence is observed, the variation of the cross-sectional flow profile is analyzed to determine if it is less than a predetermined tolerance.
摘要翻译：设计模具腔的方法可以包括使用预定模腔设计特性，要挤出的材料的密度和流变特性以及材料的流速来计算施加在模腔上的压力分布的流动分析和截面流动剖面。该方法还包括使用计算出的模腔的压力分布和结构特征进行结构分析以计算变形的模腔。然后使用变形模腔的特征重复流动分析，以计算施加在模腔上的压力分布和横截面流动分布。比较计算出的压力分布和/或横截面流动分布，以确定压力分布和/或横截面流动分布是否收敛。迭代地重复这些步骤，直到观察到压力和/或横截面流动分布的收敛。一旦观察到收敛，则分析横截面流动分布的变化以确定其是否小于预定的公差。

3. 发明授权

US07189578B1 Methods and systems employing electrothermally induced flow for mixing and cleaning in microsystems 有权
标题翻译：在微系统中采用电热诱导流混合和清洗的方法和系统
公开(公告)号：US07189578B1
公开(公告)日：2007-03-13
申请号：US10307907
申请日：2002-12-02
申请人： Jianjun Feng , Sivaramakrishnan Krishnamoorthy , Vinod Bhagwan Makhijani
发明人： Jianjun Feng , Sivaramakrishnan Krishnamoorthy , Vinod Bhagwan Makhijani
IPC分类号： G01N1/00 , G01N1/10 , G01N35/00 , H05F3/00 , B01D57/02
CPC分类号： B08B9/00 , B01F13/0079 , B01F13/0081 , B01L3/5027 , B01L99/00 , B01L2300/1833 , B01L2400/0415 , B01L2400/0442 , B01L2400/0493 , B08B7/0064 , F04B19/006 , F04B19/24 , Y10T29/49 , Y10T29/49002 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A method and system for controlling flow motion in a channel/cavity in a microfluidic system includes positioning at least one pair of electrodes in and/or proximate to the channel/cavity. A buffer solution is placed in the channel/cavity, the buffer solution having at least one dielectric property that varies in response to changes in temperature of the solution. An AC/DC voltage is applied to the electrodes to generate an electric field in the channel/cavity; the AC voltage having a known magnitude and frequency and the DC voltage having a known magnitude. The magnitude of the AC/DC voltage is adjusted to cause Joule heating of the buffer solution in the channel/cavity. The geometry and position of the electrodes is adjusted to generate a temperature gradient in the buffer solution, thereby causing a non-uniform distribution of the dielectric property within the solution in the channel/cavity. The dielectric non-uniformity produces a body force and flow in the solution. Also, the frequency of the AC voltage is adjusted to generate flow of the buffer solution in the channel/cavity in response to the non-uniform distribution of the dielectric property.
摘要翻译：用于控制微流体系统中的通道/空腔中的流动的方法和系统包括将至少一对电极定位在通道/空腔中和/或接近通道/空腔。将缓冲溶液放置在通道/空腔中，缓冲溶液具有响应于溶液温度变化而变化的至少一种介电特性。 AC / DC电压施加到电极以在通道/空腔中产生电场; AC电压具有已知的幅度和频率，并且DC电压具有已知的幅度。调整AC / DC电压的大小，使通道/腔中的缓冲溶液焦耳加热。调节电极的几何形状和位置以在缓冲溶液中产生温度梯度，从而导致溶液中的介电性质在通道/空腔中的不均匀分布。电介质非均匀性会在溶液中产生体力和流动。此外，响应于介电性质的不均匀分布，调节AC电压的频率以产生通道/空腔中的缓冲溶液的流动。

4. 发明申请

US20060290745A1 Method and apparatus for separating particles by dielectrophoresis 有权
标题翻译：通过介电电泳分离颗粒的方法和装置
公开(公告)号：US20060290745A1
公开(公告)日：2006-12-28
申请号：US11167428
申请日：2005-06-27
申请人： Jianjun Feng , Guiren Wang , Sivaramakrishnan Krishnamoorthy , Kapil Pant , Shivshankar Sundaram
发明人： Jianjun Feng , Guiren Wang , Sivaramakrishnan Krishnamoorthy , Kapil Pant , Shivshankar Sundaram
IPC分类号： B41J2/05
CPC分类号： B03C5/005 , B03C5/026
摘要： Methods and apparatus for the micro-scale, dielectrophoretic separation of particles are provided. Fluid suspensions of particles are sorted and separated by dielectrophoretic separation chambers that have at least two consecutive, electrically coupled planar electrodes separated by a gap in a fluid flow channel. The gap distance as well as applied potential can be used to control the dielectrophoretic forces generated. Using consecutive, electrically coupled electrodes rather than electrically coupled opposing electrodes facilitates higher flow volumes and rates. The methods and apparatus can be used, for example, to sort living, damaged, diseased, and/or dead cells and functionalized or ligand-bound polymer beads for subsequent identification and/or analysis.
摘要翻译：提供微尺度，介电泳分离颗粒的方法和装置。颗粒的流体悬浮液通过介电泳分离室进行分选和分离，所述介电泳分离室具有至少两个由流体流动通道中的间隙隔开的电耦合平面电极。间隙距离和施加电位可用于控制所产生的介电电泳力。使用连续的电耦合电极而不是电耦合的相对电极有助于更高的流量和速率。方法和装置可以用于例如分类活体，损伤的，患病的和/或死细胞和官能化或配体结合的聚合物珠粒，用于随后的鉴定和/或分析。

5. 发明授权

US07842006B2 Thrombectomy microcatheter 有权
标题翻译：血栓切除微导管
公开(公告)号：US07842006B2
公开(公告)日：2010-11-30
申请号：US11561303
申请日：2006-11-17
申请人： Guiren Wang , Shivshankar Sundaram , Kapil Pant , Jianjun Feng , Peter Storm
发明人： Guiren Wang , Shivshankar Sundaram , Kapil Pant , Jianjun Feng , Peter Storm
IPC分类号： A61B17/22
CPC分类号： A61B17/2202 , A61B2017/00778 , A61B2017/22001 , A61B2017/22021
摘要： The present invention is an ultrasonic thrombectomy catheter that produces physical forces (shear rates) strong enough to emulsify obstructions such as thrombi and emboli without causing damage to arterial walls. This is accomplished by properly arranging piezoelectric transducers within a catheter and a tubular catheter head separated by a gap to generate acoustic streaming that simultaneously emulsifies the obstruction and sweeps resulting debris into a catheter lumen for removal. The open gap may be formed by supporting struts that connect the catheter to the catheter head. The design of the catheter tip allows the fabrication of catheters capable of removing partial or complete blockages from arteries and other vessels having diameters as small as 2 mm.
摘要翻译：本发明是一种超声波血栓切除术导管，其产生足够强的物理力（剪切速率）以乳化阻塞物如血栓和栓塞，而不会对动脉壁造成损伤。这是通过将压电换能器适当地布置在导管内的管状导管头和由间隙分开的管状导管头来实现的，以产生声流，其同时乳化阻塞物并将所得碎片扫入导管腔以便移除。开放间隙可以通过将导管连接到导管头上的支柱支撑而形成。导管尖端的设计允许制造能够从直径小至2mm的动脉和其他容器中去除部分或完全阻塞的导管。

6. 发明申请

US20070209940A1 Self-cleaning and mixing microfluidic elements 有权
标题翻译：自清洁和混合微流体元件
公开(公告)号：US20070209940A1
公开(公告)日：2007-09-13
申请号：US11516358
申请日：2006-09-06
申请人： Sivaramakrishnan Krishnamoorthy , Jianjun Feng
发明人： Sivaramakrishnan Krishnamoorthy , Jianjun Feng
IPC分类号： B01D57/02 , B03C5/00
CPC分类号： B08B7/0064 , B01F13/0079 , B01F13/0081 , B01L3/5027 , B01L99/00 , B01L2300/1833 , B01L2400/0415 , B01L2400/0442 , B01L2400/0493 , B08B9/00 , F04B19/006 , F04B19/24 , Y10S366/04 , Y10T137/0329 , Y10T137/034 , Y10T137/0391
摘要： Apparatus and methods are disclosed for mixing and self-cleaning elements in microfluidic systems based on electrothermally induced fluid flow. The apparatus and methods provide for the control of fluid flow in and between components in a microfluidic system to cause the removal of unwanted liquids and particulates or mixing of liquids. The geometry and position of electrodes is adjusted to generate a temperature gradient in the liquid, thereby causing a non-uniform distribution of dielectric properties within the liquid. The dielectric non-uniformity produces a body force and flow in the solution, which is controlled by element and electrode geometries, electrode placement, and the frequency and waveform of the applied voltage.
摘要翻译：公开了用于基于电热诱导流体流动的微流体系统中的混合和自清洁元件的装置和方法。该装置和方法提供了在微流体系统中的组件之间和之间的流体流动的控制，以便除去不期望的液体和微粒或混合液体。调节电极的几何形状和位置，以在液体中产生温度梯度，从而导致液体内介电性质的不均匀分布。电介质非均匀性在溶液中产生体力和流动，其由元件和电极几何形状，电极布置以及施加电压的频率和波形控制。

7. 发明授权

US09283597B2 Miniaturized electrothermal flow induced infusion pump 有权
标题翻译：小型电热流感诱导输液泵
公开(公告)号：US09283597B2
公开(公告)日：2016-03-15
申请号：US11516269
申请日：2006-09-06
申请人： Sivaramakrishnan Krishnamoorthy , Guiren Wang , Jianjun Feng , Yi Wang
发明人： Sivaramakrishnan Krishnamoorthy , Guiren Wang , Jianjun Feng , Yi Wang
IPC分类号： G01N30/00 , B08B7/00 , B01F13/00 , B08B9/00 , F04B19/00 , F04B19/24 , B01L99/00 , B01L3/00
CPC分类号： A61M5/14244 , A61M2205/0244 , B01F13/0079 , B01F13/0081 , B01L3/5027 , B01L99/00 , B01L2300/1833 , B01L2400/0415 , B01L2400/0442 , B01L2400/0493 , B01L2400/0496 , B08B7/0064 , B08B9/00 , F04B19/006 , F04B19/24 , G01N2030/0035 , G01N2030/0065
摘要： A micropump that pumps liquid using electrothermally-induced flow is described, along with a corresponding self-regulating pump and infusion pump. The micropump has applications in microfluidic systems such as biochips. The self-regulating infusion pump is useful for the administration of large and small volumes of liquids such as drugs to patients and can be designed for a wide range of flow rates by combining multiple micropumps in one infusion pump system.
摘要翻译：描述了使用电热诱导流体泵送液体的微型泵，以及相应的自调节泵和输液泵。微型泵应用于微流体系统，如生物芯片。自调节输液泵可用于向患者施用大量和小体积的液体如药物，并且可以通过在一个输液泵系统中组合多个微泵来设计用于各种流量的流量。

8. 发明申请

US20120253769A1 Systems and Methods for Airborne Particle Contamination Control 有权
标题翻译：空载粒子污染控制系统与方法
公开(公告)号：US20120253769A1
公开(公告)日：2012-10-04
申请号：US13077560
申请日：2011-03-31
申请人： Shirdish Poondru , Mel Allende-Blanco , Joseph Francis Kitching , Savas Aydore , Hasan Eroglu , Krista Beth Comstock , Jianjun Feng , Yunpeng Yang , John Ferney McKibben , James Kenneth Comer, JR.
发明人： Shirdish Poondru , Mel Allende-Blanco , Joseph Francis Kitching , Savas Aydore , Hasan Eroglu , Krista Beth Comstock , Jianjun Feng , Yunpeng Yang , John Ferney McKibben , James Kenneth Comer, JR.
IPC分类号： G06G7/57
CPC分类号： G06F17/5009 , F24F11/30 , F24F11/62 , F24F2110/64 , G06F2217/16 , Y02A50/25
摘要： The present invention relates to a method for airborne particle contamination control, comprising: creating a simulation by modeling a turbulent airflow in an environment that includes an equipment of interest; plotting a flow parameter on the simulation to visualize a flow field of air according to a current design; creating an injection point on the simulation for particles in the environment; determining a particle concentration of the particles; determining, by a computing device and from the particle concentration, whether the current design provides contamination control; in response to determining that the current design does not provide contamination control, creating a modified design; and providing the modified design for implementation. The present invention further relates to a computing device for airborne particle contamination control. The present invention still further relates to a non-transitory computer-readable medium for airborne particle contamination control.
摘要翻译：本发明涉及一种空气中颗粒物污染控制的方法，包括：通过在包括感兴趣的设备的环境中模拟湍流气流来创建模拟; 在模拟中绘制流量参数，以根据当前设计可视化空气流场; 在环境中的颗粒模拟中创建注射点; 确定颗粒的颗粒浓度; 通过计算设备和从粒子浓度确定当前设计是否提供污染控制; 响应于确定当前设计不提供污染控制，创建修改后的设计; 并提供修改后的设计实现。本发明还涉及一种用于空中传播粒子污染控制的计算装置。本发明还涉及一种用于空中传播颗粒污染控制的非瞬时计算机可读介质。

9. 发明授权

US07428848B2 Electrostatic sampler and method 有权
标题翻译：静电采样器和方法
公开(公告)号：US07428848B2
公开(公告)日：2008-09-30
申请号：US11199754
申请日：2005-08-09
申请人： Kapil Pant , Guiren Wang , Jianjun Feng , Shankar Sundaram
发明人： Kapil Pant , Guiren Wang , Jianjun Feng , Shankar Sundaram
IPC分类号： G01N1/24
CPC分类号： G01N1/2202
摘要： The present invention is an electrostatic collector for low cost, high throughput, high efficiency sampling and concentration of bioaerosols. The device is small enough to be portable and can be contained within or placed on the wall of a typical office or hospital building. The collector comprises one or more collector modules, each having an ionizing electrode, a conical outer electrode, a wet collection electrode, and a liquid collection system. Airflow through a collector module may be partially blocked to enhance the collection of smaller particles and the collection electrode may comprise multiple, programmable electrodes to focus particle deposition onto a smaller area. Particles are collected into a small volume of liquid to facilitate subsequent analysis by an attached analyzer or at a remote site.
摘要翻译：本发明是用于低成本，高产量，高效率采样和浓缩生物气溶胶的静电收集器。该装置足够小以便于携带并且可以被包含在典型的办公室或医院建筑物的墙壁内或放置在典型的办公室或医院建筑物的墙壁上。收集器包括一个或多个收集器模块，每个收集器模块具有电离电极，圆锥形外部电极，湿式收集电极和液体收集系统。通过收集器模块的气流可能被部分阻塞以增强较小颗粒的收集，并且收集电极可以包括多个可编程电极，以将颗粒沉积物聚焦到更小的区域上。将颗粒收集到少量液体中，以便随后通过附着的分析仪或远程位置进行分析。

10. 发明申请

US20070110625A1 Miniaturized electrothermal flow induced infusion pump 有权
标题翻译：小型电热流感诱导输液泵
公开(公告)号：US20070110625A1
公开(公告)日：2007-05-17
申请号：US11516269
申请日：2006-09-06
申请人： Sivaramakrishnan Krishnamoorthy , Guiren Wang , Jianjun Feng , Yi Wang
发明人： Sivaramakrishnan Krishnamoorthy , Guiren Wang , Jianjun Feng , Yi Wang
IPC分类号： B01L3/00
CPC分类号： A61M5/14244 , A61M2205/0244 , B01F13/0079 , B01F13/0081 , B01L3/5027 , B01L99/00 , B01L2300/1833 , B01L2400/0415 , B01L2400/0442 , B01L2400/0493 , B01L2400/0496 , B08B7/0064 , B08B9/00 , F04B19/006 , F04B19/24 , G01N2030/0035 , G01N2030/0065
摘要： A micropump that pumps liquid using electrothermally-induced flow is described, along with a corresponding self-regulating pump and infusion pump. The micropump has applications in microfluidic systems such as biochips. The self-regulating infusion pump is useful for the administration of large and small volumes of liquids such as drugs to patients and can be designed for a wide range of flow rates by combining multiple micropumps in one infusion pump system.
摘要翻译：描述了使用电热诱导流体泵送液体的微型泵，以及相应的自调节泵和输液泵。微型泵应用于微流体系统，如生物芯片。自调节输液泵可用于向患者施用大量和小体积的液体如药物，并且可以通过在一个输液泵系统中组合多个微泵来设计用于各种流量的流量。

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