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1. 发明授权

US07428848B2 Electrostatic sampler and method 有权
标题翻译：静电采样器和方法
公开(公告)号：US07428848B2
公开(公告)日：2008-09-30
申请号：US11199754
申请日：2005-08-09
申请人： Kapil Pant , Guiren Wang , Jianjun Feng , Shankar Sundaram
发明人： Kapil Pant , Guiren Wang , Jianjun Feng , Shankar Sundaram
IPC分类号： G01N1/24
CPC分类号： G01N1/2202
摘要： The present invention is an electrostatic collector for low cost, high throughput, high efficiency sampling and concentration of bioaerosols. The device is small enough to be portable and can be contained within or placed on the wall of a typical office or hospital building. The collector comprises one or more collector modules, each having an ionizing electrode, a conical outer electrode, a wet collection electrode, and a liquid collection system. Airflow through a collector module may be partially blocked to enhance the collection of smaller particles and the collection electrode may comprise multiple, programmable electrodes to focus particle deposition onto a smaller area. Particles are collected into a small volume of liquid to facilitate subsequent analysis by an attached analyzer or at a remote site.
摘要翻译：本发明是用于低成本，高产量，高效率采样和浓缩生物气溶胶的静电收集器。该装置足够小以便于携带并且可以被包含在典型的办公室或医院建筑物的墙壁内或放置在典型的办公室或医院建筑物的墙壁上。收集器包括一个或多个收集器模块，每个收集器模块具有电离电极，圆锥形外部电极，湿式收集电极和液体收集系统。通过收集器模块的气流可能被部分阻塞以增强较小颗粒的收集，并且收集电极可以包括多个可编程电极，以将颗粒沉积物聚焦到更小的区域上。将颗粒收集到少量液体中，以便随后通过附着的分析仪或远程位置进行分析。

2. 发明申请

US20070034025A1 Electrostatic sampler and method 有权
标题翻译：静电采样器和方法
公开(公告)号：US20070034025A1
公开(公告)日：2007-02-15
申请号：US11199754
申请日：2005-08-09
申请人： Kapil Pant , Guiren Wang , Jianjun Feng , Shankar Sundaram
发明人： Kapil Pant , Guiren Wang , Jianjun Feng , Shankar Sundaram
IPC分类号： G01N1/24
CPC分类号： G01N1/2202
摘要： The present invention is an electrostatic collector for low cost, high throughput, high efficiency sampling and concentration of bioaerosols. The device is small enough to be portable and can be contained within or placed on the wall of a typical office or hospital building. The collector comprises one or more collector modules, each having an ionizing electrode, a conical outer electrode, a wet collection electrode, and a liquid collection system. Airflow through a collector module may be partially blocked to enhance the collection of smaller particles and the collection electrode may comprise multiple, programmable electrodes to focus particle deposition onto a smaller area. Particles are collected into a small volume of liquid to facilitate subsequent analysis by an attached analyzer or at a remote site.
摘要翻译：本发明是用于低成本，高产量，高效率采样和浓缩生物气溶胶的静电收集器。该装置足够小以便于携带并且可以被包含在典型的办公室或医院建筑物的墙壁内或放置在典型的办公室或医院建筑物的墙壁上。收集器包括一个或多个收集器模块，每个收集器模块具有电离电极，圆锥形外部电极，湿式收集电极和液体收集系统。通过收集器模块的气流可能被部分阻塞以增强较小颗粒的收集，并且收集电极可以包括多个可编程电极，以将颗粒沉积物聚焦到更小的区域上。将颗粒收集到少量液体中，以便随后通过附着的分析仪或远程位置进行分析。

3. 发明授权

US07842006B2 Thrombectomy microcatheter 有权
标题翻译：血栓切除微导管
公开(公告)号：US07842006B2
公开(公告)日：2010-11-30
申请号：US11561303
申请日：2006-11-17
申请人： Guiren Wang , Shivshankar Sundaram , Kapil Pant , Jianjun Feng , Peter Storm
发明人： Guiren Wang , Shivshankar Sundaram , Kapil Pant , Jianjun Feng , Peter Storm
IPC分类号： A61B17/22
CPC分类号： A61B17/2202 , A61B2017/00778 , A61B2017/22001 , A61B2017/22021
摘要： The present invention is an ultrasonic thrombectomy catheter that produces physical forces (shear rates) strong enough to emulsify obstructions such as thrombi and emboli without causing damage to arterial walls. This is accomplished by properly arranging piezoelectric transducers within a catheter and a tubular catheter head separated by a gap to generate acoustic streaming that simultaneously emulsifies the obstruction and sweeps resulting debris into a catheter lumen for removal. The open gap may be formed by supporting struts that connect the catheter to the catheter head. The design of the catheter tip allows the fabrication of catheters capable of removing partial or complete blockages from arteries and other vessels having diameters as small as 2 mm.
摘要翻译：本发明是一种超声波血栓切除术导管，其产生足够强的物理力（剪切速率）以乳化阻塞物如血栓和栓塞，而不会对动脉壁造成损伤。这是通过将压电换能器适当地布置在导管内的管状导管头和由间隙分开的管状导管头来实现的，以产生声流，其同时乳化阻塞物并将所得碎片扫入导管腔以便移除。开放间隙可以通过将导管连接到导管头上的支柱支撑而形成。导管尖端的设计允许制造能够从直径小至2mm的动脉和其他容器中去除部分或完全阻塞的导管。

4. 发明申请

US20060290745A1 Method and apparatus for separating particles by dielectrophoresis 有权
标题翻译：通过介电电泳分离颗粒的方法和装置
公开(公告)号：US20060290745A1
公开(公告)日：2006-12-28
申请号：US11167428
申请日：2005-06-27
申请人： Jianjun Feng , Guiren Wang , Sivaramakrishnan Krishnamoorthy , Kapil Pant , Shivshankar Sundaram
发明人： Jianjun Feng , Guiren Wang , Sivaramakrishnan Krishnamoorthy , Kapil Pant , Shivshankar Sundaram
IPC分类号： B41J2/05
CPC分类号： B03C5/005 , B03C5/026
摘要： Methods and apparatus for the micro-scale, dielectrophoretic separation of particles are provided. Fluid suspensions of particles are sorted and separated by dielectrophoretic separation chambers that have at least two consecutive, electrically coupled planar electrodes separated by a gap in a fluid flow channel. The gap distance as well as applied potential can be used to control the dielectrophoretic forces generated. Using consecutive, electrically coupled electrodes rather than electrically coupled opposing electrodes facilitates higher flow volumes and rates. The methods and apparatus can be used, for example, to sort living, damaged, diseased, and/or dead cells and functionalized or ligand-bound polymer beads for subsequent identification and/or analysis.
摘要翻译：提供微尺度，介电泳分离颗粒的方法和装置。颗粒的流体悬浮液通过介电泳分离室进行分选和分离，所述介电泳分离室具有至少两个由流体流动通道中的间隙隔开的电耦合平面电极。间隙距离和施加电位可用于控制所产生的介电电泳力。使用连续的电耦合电极而不是电耦合的相对电极有助于更高的流量和速率。方法和装置可以用于例如分类活体，损伤的，患病的和/或死细胞和官能化或配体结合的聚合物珠粒，用于随后的鉴定和/或分析。

5. 发明授权

US07998328B2 Method and apparatus for separating particles by dielectrophoresis 有权
标题翻译：通过介电电泳分离颗粒的方法和装置
公开(公告)号：US07998328B2
公开(公告)日：2011-08-16
申请号：US11167428
申请日：2005-06-27
申请人： Jianjun Feng , Guiren Wang , Sivaramakrishnan Krishnamoorthy , Kapil Pant , Shivshankar Sundaram
发明人： Jianjun Feng , Guiren Wang , Sivaramakrishnan Krishnamoorthy , Kapil Pant , Shivshankar Sundaram
IPC分类号： B03C5/02
CPC分类号： B03C5/005 , B03C5/026
摘要： Methods and apparatus for the micro-scale, dielectrophoretic separation of particles are provided. Fluid suspensions of particles are sorted and separated by dielectrophoretic separation chambers that have at least two consecutive, electrically coupled planar electrodes separated by a gap in a fluid flow channel. The gap distance as well as applied potential can be used to control the dielectrophoretic forces generated. Using consecutive, electrically coupled electrodes rather than electrically coupled opposing electrodes facilitates higher flow volumes and rates. The methods and apparatus can be used, for example, to sort living, damaged, diseased, and/or dead cells and functionalized or ligand-bound polymer beads for subsequent identification and/or analysis.
摘要翻译：提供微尺度，介电泳分离颗粒的方法和装置。颗粒的流体悬浮液通过介电泳分离室进行分选和分离，所述介电泳分离室具有至少两个由流体流动通道中的间隙隔开的电耦合平面电极。间隙距离和施加电位可用于控制所产生的介电电泳力。使用连续的电耦合电极而不是电耦合的相对电极有助于更高的流量和速率。方法和装置可以用于例如分类活体，损伤的，患病的和/或死细胞和官能化或配体结合的聚合物珠粒，用于随后的鉴定和/或分析。

6. 发明申请

US20080119780A1 Thrombectomy Microcatheter 有权
标题翻译：血栓切除术
公开(公告)号：US20080119780A1
公开(公告)日：2008-05-22
申请号：US11561303
申请日：2006-11-17
申请人： Guiren Wang , Shivshankar Sundaram , Kapil Pant , Jianjun Feng , Peter Storm
发明人： Guiren Wang , Shivshankar Sundaram , Kapil Pant , Jianjun Feng , Peter Storm
IPC分类号： A61B17/22
CPC分类号： A61B17/2202 , A61B2017/00778 , A61B2017/22001 , A61B2017/22021
摘要： The present invention is an ultrasonic thrombectomy catheter that produces physical forces (shear rates) strong enough to emulsify obstructions such as thrombi and emboli without causing damage to arterial walls. This is accomplished by properly arranging piezoelectric transducers within a catheter and a tubular catheter head separated by a gap to generate acoustic streaming that simultaneously emulsifies the obstruction and sweeps resulting debris into a catheter lumen for removal. The open gap may be formed by supporting struts that connect the catheter to the catheter head. The design of the catheter tip allows the fabrication of catheters capable of removing partial or complete blockages from arteries and other vessels having diameters as small as 2 mm.
摘要翻译：本发明是一种超声波血栓切除术导管，其产生足够强的物理力（剪切速率）以乳化阻塞物如血栓和栓塞，而不会对动脉壁造成损伤。这是通过将压电换能器适当地布置在导管内的管状导管头和由间隙分开的管状导管头来实现的，以产生声流，其同时乳化阻塞物并将所得碎片扫入导管腔以便移除。开放间隙可以通过将导管连接到导管头上的支柱支撑而形成。导管尖端的设计允许制造能够从直径小至2mm的动脉和其他容器中去除部分或完全阻塞的导管。

7. 发明授权

US08417465B2 Synthetic microfluidic blood-brain barrier 有权
标题翻译：合成微流体血脑屏障
公开(公告)号：US08417465B2
公开(公告)日：2013-04-09
申请号：US12726140
申请日：2010-03-17
申请人： Balabhaskar Prabhakarpandian , Kapil Pant , Shivshankar Sundaram , Ketan Harendrakumar Bhatt
发明人： Balabhaskar Prabhakarpandian , Kapil Pant , Shivshankar Sundaram , Ketan Harendrakumar Bhatt
IPC分类号： G01N33/48
CPC分类号： G01N33/5082 , G01N33/5029 , G01N33/5032 , G01N33/54366 , G01N33/56972
摘要： An apparatus and method for assaying blood-brain barrier properties for drug and drug delivery vehicle screening comprising of a microfluidic apparatus with gaps separating lumen and tissue space enabling formation of tight junctions similar to in vivo conditions using endothelial cells and brain cells.
摘要翻译：用于测定用于药物和药物递送载体筛选的血脑屏障性质的装置和方法，包括具有分隔内腔和组织空间的间隙的微流体装置，从而能够形成类似于使用内皮细胞和脑细胞的体内条件的紧密连接。

8. 发明申请

US20120312690A1 Method and Apparatus for Separating Particles by Dielectrophoresis 有权
标题翻译：通过电泳分离颗粒的方法和装置
公开(公告)号：US20120312690A1
公开(公告)日：2012-12-13
申请号：US13190882
申请日：2011-07-26
申请人： Kapil Pant , Yi Wang , Ketan Bhatt , Balabhaskar Prabhakarpandian
发明人： Kapil Pant , Yi Wang , Ketan Bhatt , Balabhaskar Prabhakarpandian
IPC分类号： B01D57/02
CPC分类号： B03C5/02 , B01L2400/0424 , B03C5/005 , B03C5/022 , B03C5/026
摘要： Particle separation apparatus separate particles and particle populations using dielectrophoretic (DEP) forces generated by one or more pairs of electrically coupled electrodes separated by a gap. Particles suspended in a fluid are separated by DEP forces generated by the at least one electrode pair at the gap as they travel over a separation zone comprising the electrode pair. Selected particles are deflected relative to the flow of incoming particles by DEP forces that are affected by controlling applied potential, gap width, and the angle linear gaps with respect to fluid flow. The gap between an electrode pair may be a single, linear gap of constant gap, a single linear gap having variable width, or a be in the form of two or more linear gaps having constant or variable gap width having different angles with respect to one another and to the flow.
摘要翻译：颗粒分离装置使用由间隙分开的一对或多对电耦合电极产生的介电泳（DEP）力分离颗粒和颗粒群。悬浮在流体中的颗粒在由间隙中由至少一个电极对产生的DEP力分离，因为它们在包括电极对的分离区域上移动。所选择的颗粒相对于进入的颗粒的流动通过受到施加的电势，间隙宽度和相对于流体流动的角度线性间隙的影响的DEP力而偏转。电极对之间的间隙可以是恒定间隙的单个线性间隙，具有可变宽度的单个线性间隙，或者具有两个或更多个线性间隙的形式，具有相对于一个具有不同角度的不同角度的恒定或可变间隙宽度另一个和流。

9. 发明申请

US20110277632A1 Electrostatic Aerosol Concentrator 有权
标题翻译：静电气雾浓缩器
公开(公告)号：US20110277632A1
公开(公告)日：2011-11-17
申请号：US11831613
申请日：2007-07-31
申请人： Kapil Pant , Shivshakar Sundaram , Yi Wang
发明人： Kapil Pant , Shivshakar Sundaram , Yi Wang
IPC分类号： B03C3/45 , B03C3/00
CPC分类号： B03C3/68 , B03C3/025 , B03C3/06 , B03C3/41 , B03C3/49
摘要： Disclosed is an electrostatic aerosol concentrator for the concentration of aerosol particles and their collection for subsequent analysis. The concentrator comprises an airflow chamber that includes alternately energized and grounded electrode elements that work in concert to impart radial inward motion to charged aerosol particles and focusing them toward an enriched aerosol outlet. If desired, filtered air inlets may be used to provide a sheath of aerosol-free air along the chamber periphery and prevent deposition of particles onto electrode surfaces. Aerosol particles entering the airflow chamber may carry a positive or negative charge naturally, or a charge may be induced on the particles using a charging section located upstream of the aerosol inlet. Natural or induced charges on the aerosol particles may be used to selectively concentrate subpopulations of aerosol particles from a mixture of particles. For example, bacterial spores or aerosolized viruses may be selectively enriched without concentrating other aerosol particles. The particles of interest are focused and collected at an aerosol rich outlet in a small air volume, while the majority of the airflow, stripped of particles of interest, is purged to the atmosphere through an aerosol lean outlet.
摘要翻译：公开了一种用于浓缩气溶胶颗粒的静电气溶胶浓缩器及其收集用于随后的分析。集中器包括气流室，其包括交替地供电和接地的电极元件，其一致地工作以向带电气溶胶颗粒进行径向向内运动并将它们聚焦到富集的气溶胶出口。如果需要，可以使用过滤的空气入口来沿着室周边提供无气溶胶空气的护套，并防止颗粒沉积到电极表面上。进入气流室的气溶胶颗粒可以自然携带正电荷或负电荷，或者可以使用位于气溶胶入口上游的充电部分在颗粒上诱导电荷。气雾剂颗粒上的天然或诱导电荷可用于从颗粒混合物中选择性地浓缩气溶胶颗粒的亚群。例如，细菌孢子或气雾化病毒可以选择性富集而不浓缩其它气溶胶颗粒。将感兴趣的颗粒聚焦并收集在小气泡体积的气溶胶浓缩出口处，而大部分气流被汽提的感兴趣的颗粒通过气溶胶倾倒出口被吹扫到大气中。

10. 发明申请

US20130192462A1 ELECTROSTATIC AEROSOL CONCENTRATOR 有权
标题翻译：静电空气浓缩器
公开(公告)号：US20130192462A1
公开(公告)日：2013-08-01
申请号：US13566297
申请日：2012-08-03
申请人： Kapil Pant , Shivshankar Sundaram , Yi Wang
发明人： Kapil Pant , Shivshankar Sundaram , Yi Wang
IPC分类号： B03C3/68
CPC分类号： B03C3/68 , B03C3/025 , B03C3/06 , B03C3/41 , B03C3/49
摘要： Disclosed is an electrostatic aerosol concentrator for the concentration of aerosol particles and their collection for subsequent analysis. The concentrator comprises an airflow chamber that includes alternately energized and grounded electrode elements that work in concert to impart radial inward motion to charged aerosol particles and focusing them toward an enriched aerosol outlet. If desired, filtered air inlets may be used to provide a sheath of aerosol-free air along the chamber periphery and prevent deposition of particles onto electrode surfaces. Aerosol particles entering the airflow chamber may carry a positive or negative charge naturally, or a charge may be induced on the particles using a charging section located upstream of the aerosol inlet. Natural or induced charges on the aerosol particles may be used to selectively concentrate subpopulations of aerosol particles from a mixture of particles. For example, bacterial spores or aerosolized viruses may be selectively enriched without concentrating other aerosol particles. The particles of interest are focused and collected at an aerosol rich outlet in a small air volume, while the majority of the airflow, stripped of particles of interest, is purged to the atmosphere through an aerosol lean outlet.
摘要翻译：公开了一种用于浓缩气溶胶颗粒的静电气溶胶浓缩器及其收集用于随后的分析。集中器包括气流室，其包括交替地供电和接地的电极元件，其一起工作以向带电的气溶胶颗粒进行径向向内运动并将它们聚焦到富集的气溶胶出口。如果需要，可以使用过滤的空气入口来沿着室周边提供无气溶胶空气的护套，并防止颗粒沉积到电极表面上。进入气流室的气溶胶颗粒可以自然携带正电荷或负电荷，或者可以使用位于气溶胶入口上游的充电部分在颗粒上诱导电荷。气雾剂颗粒上的天然或诱导电荷可用于从颗粒混合物中选择性地浓缩气溶胶颗粒的亚群。例如，细菌孢子或气雾化病毒可以选择性富集而不浓缩其它气溶胶颗粒。将感兴趣的颗粒聚焦并收集在小气泡体积的气溶胶浓缩出口处，而大部分气流被汽提的感兴趣的颗粒通过气溶胶倾倒出口被吹扫到大气中。

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