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1. 发明申请

US20050233958A1 Death domain containing receptor 5 审中-公开
标题翻译：含有受体5的死亡域
公开(公告)号：US20050233958A1
公开(公告)日：2005-10-20
申请号：US10979831
申请日：2004-11-03
申请人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig Rosen
发明人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig Rosen
IPC分类号： A61K38/00 , A61K38/17 , C07K14/705 , C07K16/28
CPC分类号： C07K16/2878 , A61K38/00 , C07K14/70578 , C07K2317/622 , C07K2319/30
摘要： The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR5, which may be agonists and/or antagonists of DR5 activity.
摘要翻译：本发明涉及作为肿瘤坏死因子（TNF）受体家族的成员的新的含有死亡域的受体-5（DR5）蛋白，现在已经显示结合TRAIL。特别地，提供编码人DR5蛋白的分离的核酸分子。还提供了DR5多肽，载体，宿主细胞以及用于制备它们的重组方法。本发明还涉及用于鉴定DR5活性的拮抗剂和拮抗剂的筛选方法。本发明还涉及使用DR5特异性抗体（其可以是DR5活性的激动剂和/或拮抗剂）的减少或增加的细胞凋亡相关疾病的治疗。

2. 发明授权

US07393943B1 Polynucleotides encoding a human chemotactic cytokine I 失效
标题翻译：编码人趋化因子I的多核苷酸
公开(公告)号：US07393943B1
公开(公告)日：2008-07-01
申请号：US08761289
申请日：1996-12-06
申请人： Jian Ni , Guo-Liang Yu , Pedro Alfonso , Reiner Gentz , Jeffrey Y. Su
发明人： Jian Ni , Guo-Liang Yu , Pedro Alfonso , Reiner Gentz , Jeffrey Y. Su
IPC分类号： C07H21/04 , C12P21/06 , C12N1/20 , C12N15/00 , C12N5/00 , C12N5/02 , C12N15/74
CPC分类号： C07K14/52 , C07H21/04
摘要： Human chemotactic cytokine I polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.
摘要翻译：公开了人类趋化性细胞因子I多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫，慢性和急性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

3. 发明申请

US20050239123A1 Human tumor necrosis receptor TR9 审中-公开
标题翻译：人肿瘤坏死受体TR9
公开(公告)号：US20050239123A1
公开(公告)日：2005-10-27
申请号：US11148333
申请日：2005-06-09
申请人： Jian Ni , Guo-Liang Yu , Ping Fan , Reiner Gentz
发明人： Jian Ni , Guo-Liang Yu , Ping Fan , Reiner Gentz
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C07K14/715 , C12Q1/68 , C07H21/04 , C12N15/09
CPC分类号： C07K14/70578 , A61K38/00 , C07K14/4747 , C07K14/7151 , C12N2799/026
摘要： The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR9 receptor activity.
摘要翻译：本发明涉及肿瘤坏死因子受体家族的新成员。特别地，提供编码人TR9受体的分离的核酸分子。还提供TR9多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定TR9受体活性的激动剂和拮抗剂的筛选方法。

4. 发明申请

US20050186616A1 Human cystatin F 审中-公开
标题翻译：人类半胱氨酸蛋白酶抑制剂F
公开(公告)号：US20050186616A1
公开(公告)日：2005-08-25
申请号：US11088093
申请日：2005-03-24
申请人： Haodong Li , Guo-Liang Yu , Reiner Gentz , Jian Ni
发明人： Haodong Li , Guo-Liang Yu , Reiner Gentz , Jian Ni
IPC分类号： G01N33/53 , A61K38/00 , A61P27/02 , A61P29/00 , A61P31/00 , A61P43/00 , C07K14/81 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12Q1/68 , C07H21/04 , C12N9/99
CPC分类号： C07K14/8139 , A61K38/00 , C07K2319/00
摘要： The invention relates to Cystatin F polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及半胱氨酸蛋白酶抑制剂F多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

5. 发明授权

US06338948B1 Human endometrial specific steroid-binding factor I, II and III 失效
公开(公告)号：US06338948B1
公开(公告)日：2002-01-15
申请号：US09583169
申请日：2000-05-30
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz
IPC分类号： C07K1618
CPC分类号： C07K14/4702
摘要： The invention relates to hESF I, II and III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

6. 发明申请

US20060234285A1 Tumor Necrosis Factor Receptors 6 Alpha & 6 Beta 审中-公开
标题翻译：肿瘤坏死因子受体6 Alpha＆6 Beta
公开(公告)号：US20060234285A1
公开(公告)日：2006-10-19
申请号：US11419656
申请日：2006-05-22
申请人： Reiner Gentz , Guo-Liang Yu , Jian Ni , Reinhard Ebner , Ping Feng , Steven Ruben
发明人： Reiner Gentz , Guo-Liang Yu , Jian Ni , Reinhard Ebner , Ping Feng , Steven Ruben
IPC分类号： C12Q1/68 , G01N33/574 , A61K38/17 , C07H21/04 , C12P21/06 , C07K14/715
CPC分类号： G01N33/57488 , A61K38/00 , C07K14/70578 , C07K14/7151
摘要： The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α & -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α & -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及新型肿瘤坏死因子受体蛋白。特别地，提供编码人TNFR-6α和-6β蛋白的分离的核酸分子。还提供了TNFR-6α和-6β多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及鉴定TNFR-6α和-6β活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

7. 发明申请

US20060073573A1 Chemotactic cytokine III 审中-公开
标题翻译：趋化性细胞因子III
公开(公告)号：US20060073573A1
公开(公告)日：2006-04-06
申请号：US11244394
申请日：2005-10-06
申请人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Jeffrey Su , Patrick Dillon
发明人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Jeffrey Su , Patrick Dillon
IPC分类号： C12P21/02 , C07H21/04 , C07K14/52
CPC分类号： C07K14/52 , A61K38/00 , C07K14/521 , Y02A50/423
摘要： Human chemotactic cytokine III polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever, cerebral ischemia, glomerulonephritis, HTLV-1 related diseases and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding chemotactic cytokine III and for detecting altered levels of the polypeptide in a host.
摘要翻译：公开了人类趋化性细胞因子III多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。针对这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫和慢性和急性炎症和感染性疾病，过敏反应，前列腺素不依赖性发烧，脑缺血，肾小球肾炎，HTLV-1相关疾病和骨髓衰竭的治疗用途也被披露。还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。还公开了用于检测编码趋化性细胞因子III的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

8. 发明授权

US6130061A Human stem cell antigen 2 失效
公开(公告)号：US6130061A
公开(公告)日：2000-10-10
申请号：US746397
申请日：1996-11-08
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Jeannine D. Gocayne
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Jeannine D. Gocayne
IPC分类号： A61K38/00 , C07K14/705 , C12N1/15 , C12N1/21 , C12N15/12 , C07H21/00 , C12N5/10 , C12N15/63
CPC分类号： C07K14/705 , A61K38/00
摘要： A human stem cell antigen 2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating thymocyte maturation and differentiation, protecting neuronal cells, preventing rejection during organ transplantation, treating PNH, Alzheimer's Disease and inflammation is disclosed. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

9. 发明授权

US5952197A DNA encoding the chemotactic cytokine III 失效
标题翻译：编码趋化性细胞因子III的DNA
公开(公告)号：US5952197A
公开(公告)日：1999-09-14
申请号：US812003
申请日：1997-03-05
申请人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Jeffrey Su , Patrick J. Dillon
发明人： Jian Ni , Reiner Gentz , Guo-Liang Yu , Jeffrey Su , Patrick J. Dillon
IPC分类号： A61K38/00 , C07K14/52 , C12N15/19 , C12N15/00 , C12N15/63
CPC分类号： C07K14/52 , C07K14/521 , A61K38/00
摘要： Human chemotactic cytokine III polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever, cerebral ischemia, glomerulonephritis, HTLV-1 related diseases and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding chemotactic cytokine III and for detecting altered levels of the polypeptide in a host.
摘要翻译：公开了人类趋化性细胞因子III多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。针对这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫和慢性和急性炎症和感染性疾病，过敏反应，前列腺素不依赖性发烧，脑缺血，肾小球肾炎，HTLV-1相关疾病和骨髓衰竭的治疗用途也被披露。还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。还公开了用于检测编码趋化性细胞因子III的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

10. 发明授权

US5874240A Human 4-1BB receptor splicing variant 失效
公开(公告)号：US5874240A
公开(公告)日：1999-02-23
申请号：US816605
申请日：1997-03-13
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Patrick J. Dillon
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Patrick J. Dillon
IPC分类号： A61K38/00 , C07K14/715 , C12N15/12 , C12N5/10 , C07K14/705
CPC分类号： C07K14/715 , A61K38/00
摘要： The invention relates to h4-1BBSV receptor polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

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