专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070298459A1 Human Tumor Necrosis Factor Receptor TR9 有权
标题翻译：人类肿瘤坏死因子受体TR9
公开(公告)号：US20070298459A1
公开(公告)日：2007-12-27
申请号：US11780643
申请日：2007-07-20
申请人： Jian Ni , Guo-Liang Yu , Ping Fan , Reiner Gentz
发明人： Jian Ni , Guo-Liang Yu , Ping Fan , Reiner Gentz
IPC分类号： C12P21/00 , C07H21/00 , C07K14/00 , C07K16/00 , C12N1/00 , C12N15/63
CPC分类号： C07K16/1271 , A61K38/00 , C07K14/4747 , C07K14/70578 , C07K14/7151 , C07K2319/00 , C07K2319/30 , C12N2799/026
摘要： The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR9 receptor activity.
摘要翻译：本发明涉及肿瘤坏死因子受体家族的新成员。特别地，提供编码人TR9受体的分离的核酸分子。还提供TR9多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定TR9受体活性的激动剂和拮抗剂的筛选方法。

2. 发明申请

US20050239123A1 Human tumor necrosis receptor TR9 审中-公开
标题翻译：人肿瘤坏死受体TR9
公开(公告)号：US20050239123A1
公开(公告)日：2005-10-27
申请号：US11148333
申请日：2005-06-09
申请人： Jian Ni , Guo-Liang Yu , Ping Fan , Reiner Gentz
发明人： Jian Ni , Guo-Liang Yu , Ping Fan , Reiner Gentz
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C07K14/715 , C12Q1/68 , C07H21/04 , C12N15/09
CPC分类号： C07K14/70578 , A61K38/00 , C07K14/4747 , C07K14/7151 , C12N2799/026
摘要： The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR9 receptor activity.
摘要翻译：本发明涉及肿瘤坏死因子受体家族的新成员。特别地，提供编码人TR9受体的分离的核酸分子。还提供TR9多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定TR9受体活性的激动剂和拮抗剂的筛选方法。

3. 发明申请

US20060193861A1 Tumor necrosis factor receptors 6 alpha & 6 beta 有权
标题翻译：肿瘤坏死因子受体6α和6β
公开(公告)号：US20060193861A1
公开(公告)日：2006-08-31
申请号：US11416310
申请日：2006-05-03
申请人： Reiner Gentz , Reinhard Ebner , Guo-Liang Yu , Steven Ruben , Jian Ni , Ping Feng
发明人： Reiner Gentz , Reinhard Ebner , Guo-Liang Yu , Steven Ruben , Jian Ni , Ping Feng
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K16/24 , C12N1/18 , C12N5/06
CPC分类号： A61K48/005 , A61K38/00 , A61K48/0058 , C07K14/4703 , C07K14/70578 , C07K14/7151 , C07K2319/00 , C07K2319/30 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α & -6β polypeptides and antibodies that bind TNFR-6α & -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α & -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及新型肿瘤坏死因子受体蛋白。特别地，提供编码人TNFR-6α和-6β蛋白的分离的核酸分子。还提供TNFR-6α和-6β多肽和结合TNFR-6α和-6β多肽的抗体，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及鉴定TNFR-6α和-6β活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

4. 发明申请

US20060159686A1 Natural killer cell activating factor II 失效
公开(公告)号：US20060159686A1
公开(公告)日：2006-07-20
申请号：US11378243
申请日：2006-03-20
申请人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner Gentz
发明人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner Gentz
IPC分类号： A61K39/395 , G01N33/567 , G01N33/53 , C07K16/28
CPC分类号： C07K16/28 , A61K38/00 , C07K14/52
摘要： The invention relates to NKAF II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

5. 发明申请

US20060068463A1 NATURAL KILLER CELL ACTIVATING FACTOR II 失效
标题翻译：自然杀伤细胞活化因子II
公开(公告)号：US20060068463A1
公开(公告)日：2006-03-30
申请号：US10192611
申请日：2002-07-11
申请人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner Gentz
发明人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner Gentz
IPC分类号： C12N9/12 , C07H21/04 , C12P21/02 , C12N5/06
CPC分类号： C07K16/28 , A61K38/00 , C07K14/52
摘要： The invention relates to NKAF II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及NKAF II多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

6. 发明申请

US20050069945A1 Human chemotactic cytokine I polypeptides 审中-公开
标题翻译：人类趋化性细胞因子I多肽
公开(公告)号：US20050069945A1
公开(公告)日：2005-03-31
申请号：US10994821
申请日：2004-11-23
申请人： Jian Ni , Guo-Liang Yu , Pedro Alfonso , Reiner Gentz , Jeffrey Su
发明人： Jian Ni , Guo-Liang Yu , Pedro Alfonso , Reiner Gentz , Jeffrey Su
IPC分类号： C07H21/04 , C07K14/52 , C12P21/02 , C12Q1/68
CPC分类号： C07K14/52 , C07H21/04
摘要： Human chemotactic cytokine I polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.
摘要翻译：公开了人类趋化性细胞因子I多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫，慢性和急性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

7. 发明授权

US06232291B1 Cytostatin III 有权
标题翻译：细胞抑素III
公开(公告)号：US06232291B1
公开(公告)日：2001-05-15
申请号：US09307817
申请日：1999-05-10
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Patrick J. Dillon
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Patrick J. Dillon
IPC分类号： C07K14435
CPC分类号： C07K14/475 , C07K2319/00
摘要： The invention relates to Cytostatin III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及细胞抑制素III多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

8. 发明授权

US06174992B1 Human endometrial specific steroid-binding factor I, II and III 失效
标题翻译：人子宫内膜特异性类固醇结合因子I，II和III
公开(公告)号：US06174992B1
公开(公告)日：2001-01-16
申请号：US09263810
申请日：1999-03-08
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz
IPC分类号： C07K1446
CPC分类号： C07K14/4702
摘要： The invention relates to hESF I, II and III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及hESF I，II和III多肽，编码多肽的多核苷酸，特别是通过表达多核苷酸产生多肽的方法，以及多肽的激动剂和拮抗剂。本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

9. 发明授权

US5985612A Polynucleotides encoding natural killer cell enhancing factor C 失效
公开(公告)号：US5985612A
公开(公告)日：1999-11-16
申请号：US467265
申请日：1995-06-06
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
摘要： A human natural killer cell enhancing factor C and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating viral infections, inflammation, neoplasia and damage from superoxide radicals. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

10. 发明申请

US20060234285A1 Tumor Necrosis Factor Receptors 6 Alpha & 6 Beta 审中-公开
标题翻译：肿瘤坏死因子受体6 Alpha＆6 Beta
公开(公告)号：US20060234285A1
公开(公告)日：2006-10-19
申请号：US11419656
申请日：2006-05-22
申请人： Reiner Gentz , Guo-Liang Yu , Jian Ni , Reinhard Ebner , Ping Feng , Steven Ruben
发明人： Reiner Gentz , Guo-Liang Yu , Jian Ni , Reinhard Ebner , Ping Feng , Steven Ruben
IPC分类号： C12Q1/68 , G01N33/574 , A61K38/17 , C07H21/04 , C12P21/06 , C07K14/715
CPC分类号： G01N33/57488 , A61K38/00 , C07K14/70578 , C07K14/7151
摘要： The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α & -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α & -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及新型肿瘤坏死因子受体蛋白。特别地，提供编码人TNFR-6α和-6β蛋白的分离的核酸分子。还提供了TNFR-6α和-6β多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及鉴定TNFR-6α和-6β活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式