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1. 发明授权

US06580868B2 High-resolution variable optical attenuator with mechanical adjustment 失效
公开(公告)号：US06580868B2
公开(公告)日：2003-06-17
申请号：US09812358
申请日：2001-03-19
申请人： Jian J. Chen , Jianhua Wang
发明人： Jian J. Chen , Jianhua Wang
IPC分类号： G02B600
CPC分类号： G02B26/02 , G02B6/266
摘要： A mechanically-adjustable variable optical attenuator includes a beam attenuator shaped as a concave quasi-cone. The beam attenuator has a sharp tip and a base, and can be rotationally symmetric with respect to a central axis extending between the tip and the base. The beam attenuator is positioned with its central axis perpendicular to the direction of the light beam to be attenuated. The extent of the beam attenuator obstructing the light beam is varied by moving the beam attenuator into and out of the light beam. The inwardly-curving, quasi-cone shape of the beam attenuator allows achieving a high resolution while limiting the beam attenuator size.

2. 发明授权

US06904223B1 Tilted-translation variable optical attenuator 失效
标题翻译：倾斜变换光衰减器
公开(公告)号：US06904223B1
公开(公告)日：2005-06-07
申请号：US10408073
申请日：2003-04-04
申请人： Zuyun Fang , Jianhua Wang , Jian J. Chen
发明人： Zuyun Fang , Jianhua Wang , Jian J. Chen
IPC分类号： G02B6/00 , G02B6/26
CPC分类号： G02B6/266
摘要： In a preferred embodiment, a motorized variable optical attenuator comprises an input fiber collimator; an output fiber collimator disposed substantially along the first collimator; and a right-angle reflector movable relative to the input collimator and the output collimator along a translation direction forming a non-zero angle with a direction of a light beam emitted by the input collimator. The reflector comprises two mutually-perpendicular reflective surfaces for sequentially reflecting the light beam emitted by the input collimator to the output collimator. A variable attenuation imparted by the attenuator on the light beam is determined by a position of the reflector relative to the input collimator and the output collimator, along the translation direction. The reflector preferably comprises a right-angle prism adhered to a nut mounted on a threaded axle driven by a stepper motor. The attenuator can achieve stable, ripple-free attenuation characteristics at insertion losses beyond −40 dB.
摘要翻译：在优选实施例中，电动可变光衰减器包括输入光纤准直器; 基本上沿着所述第一准直仪设置的输出光纤准直器; 以及直角反射体，其相对于输入准直器和输出准直器沿着与由输入准直仪发射的光束的方向成非零角度的平移方向移动。反射器包括两个相互垂直的反射表面，用于将由输入准直仪发射的光束顺序反射到输出准直器。由衰减器在光束上赋予的可变衰减由反射器相对于输入准直仪和输出准直器沿平移方向的位置确定。反射器优选地包括附接到安装在由步进马达驱动的螺纹轴上的螺母的直角棱镜。衰减器可以在插入损耗超过-40 dB时实现稳定的无纹波衰减特性。

3. 发明授权

US06721474B2 Fiber optic switch using galvanometer-driven x-y scanning 失效
标题翻译：光电开关采用电流计驱动的x-y扫描
公开(公告)号：US06721474B2
公开(公告)日：2004-04-13
申请号：US09812617
申请日：2001-03-19
申请人： Jianhua Wang , Zuyun Fang , Jian J. Chen
发明人： Jianhua Wang , Zuyun Fang , Jian J. Chen
IPC分类号： G02B635
CPC分类号： G02B6/352 , G02B6/32 , G02B6/3558 , G02B6/3572
摘要： A 1×N optical switch includes an input fiber collimator, an x-y scanning device including two perpendicular galvanometer-driven rotatable mirrors, and a 2-D array of output fiber collimators arranged over an output surface so as to be aligned with a corresponding ray extending from the x-y scanning device. Each of the output fiber collimators corresponds to a unique pair of rotation angles of the two mirrors. The output surface can have a spherical curvature, or a curvature which accounts for the dependency of optical path on the angles of the two mirrors. The switch allows improved switching speeds, accuracy, and reduced and uniform insertion losses. The architecture can be used for N×M switches and N×M cross-connects.
摘要翻译： 1xN光开关包括输入光纤准直器，包括两个垂直的检流计驱动的可旋转反射镜的xy扫描装置和布置在输出表面上的输出光纤准直器的2-D阵列，以便与从该 xy扫描装置。每个输出光纤准直仪对应于两个反射镜的独特的一对旋转角度。输出表面可以具有球形曲率或者考虑光路对两个反射镜的角度的依赖性的曲率。该开关允许改进的开关速度，精度和减少的和均匀的插入损耗。该架构可用于NxM交换机和NxM交叉连接。

4. 发明授权

US08497264B2 Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use 有权
公开(公告)号：US08497264B2
公开(公告)日：2013-07-30
申请号：US13047693
申请日：2011-03-14
申请人： Jian J. Chen , Wenge Zhong , Bryant Yang , Ryan White , Matthew Weiss , Timothy Powers , Yuan Cheng
发明人： Jian J. Chen , Wenge Zhong , Bryant Yang , Ryan White , Matthew Weiss , Timothy Powers , Yuan Cheng
IPC分类号： C07D513/10 , C07D498/20 , A61K31/547 , A61K31/5386
CPC分类号： C07D513/10 , C07D498/10 , C07D498/20 , C07D513/20
摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, R2, R7, X, Y and Z of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.

5. 发明申请

US20090054460A1 Piperazine derivatives and methods of use 审中-公开
标题翻译：哌嗪衍生物和使用方法
公开(公告)号：US20090054460A1
公开(公告)日：2009-02-26
申请号：US12008696
申请日：2008-01-11
申请人： Jian J. Chen , Ben C. Askew , Kaustav Biswas , Jennifer N. Chau , Derin C. D'Amico , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jiawang Zhu , Christopher H. Fotsch , Aiwen Li , Qingyian Liu , Nobuku Nishimura , Tanya Peterkin , Babak Riahi , Chester Chenguang Yuan , Nianhe Han , Rana Nomak , Kevin Yang
发明人： Jian J. Chen , Ben C. Askew , Kaustav Biswas , Jennifer N. Chau , Derin C. D'Amico , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jiawang Zhu , Christopher H. Fotsch , Aiwen Li , Qingyian Liu , Nobuku Nishimura , Tanya Peterkin , Babak Riahi , Chester Chenguang Yuan , Nianhe Han , Rana Nomak , Kevin Yang
IPC分类号： A61K31/495 , C07D241/04
CPC分类号： C07D241/08 , C07D243/08 , C07D245/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14
摘要： Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。本发明包括新的化合物，类似物，前药和其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及疼痛，炎症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

6. 发明授权

US07414134B2 B1 bradykinin receptor antagonists 有权
标题翻译： B1缓激肽受体拮抗剂
公开(公告)号：US07414134B2
公开(公告)日：2008-08-19
申请号：US11247050
申请日：2005-10-11
申请人： Benny C. Askew, Jr. , Jian J. Chen , Derin C. D'Amico , Thomas Nguyen , Kevin Yang
发明人： Benny C. Askew, Jr. , Jian J. Chen , Derin C. D'Amico , Thomas Nguyen , Kevin Yang
IPC分类号： C07D211/04 , C07D261/08 , C07D249/04 , C07D249/06
CPC分类号： C07C271/22 , C07C2603/18 , C07D249/04 , C07D295/135 , C07D311/68 , C07D405/04 , C07D405/06 , C07D405/14
摘要： The invention encompasses novel compounds and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for treatment of diseases mediated by B1 bradykinin receptor.
摘要翻译：本发明包括新颖的化合物及其药学上可接受的衍生物，用于治疗由B1缓激肽受体介导的疾病的药物组合物和方法。

7. 发明申请

US20130157996A1 TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS 有权
标题翻译： TRPM8拮抗剂及其在治疗中的应用
公开(公告)号：US20130157996A1
公开(公告)日：2013-06-20
申请号：US13529860
申请日：2012-06-21
申请人： Kaustav Biswas , James Brown , Jian J. Chen , Vijay Keshav Gore , Scott Harried , Daniel B. Horne , Matthew R. Kaller , Qingyian Liu , Vu Van Ma , Holger Monenschein , Thomas T. Nguyen , David J. St. Jean, JR. , Chester Chenguang Yuan , Wenge Zhong
发明人： Kaustav Biswas , James Brown , Jian J. Chen , Vijay Keshav Gore , Scott Harried , Daniel B. Horne , Matthew R. Kaller , Qingyian Liu , Vu Van Ma , Holger Monenschein , Thomas T. Nguyen , David J. St. Jean, JR. , Chester Chenguang Yuan , Wenge Zhong
IPC分类号： C07D498/04 , C07D401/14 , C07D213/81 , C07D487/04 , C07D413/12 , C07D401/12 , C07D471/04
CPC分类号： C07D213/82 , C07D213/40 , C07D213/61 , C07D213/81 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D498/04
摘要： Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
摘要翻译：式I的化合物可用作TRPM8的拮抗剂。这些化合物可用于治疗多种TRPM8介导的病症和病症，并且可用于制备用于治疗这种病症和病症的药物和药物组合物。这些疾病的实例包括但不限于偏头痛和神经性疼痛。式I的化合物具有以下结构：其中本文提供变量的定义。

8. 发明授权

US07662811B2 1,2,3,4-tetrahydropyrazin-2-yl acetamides and methods of use 有权
标题翻译： 1,2,3,4-四氢吡嗪-2-基乙酰胺及其使用方法
公开(公告)号：US07662811B2
公开(公告)日：2010-02-16
申请号：US11182216
申请日：2005-07-15
申请人： Benny C. Askew, Jr. , Toshihiro Aya , Kaustav Biswas , Guolin Cai , Jian J. Chen , Nianhe Han , Qingyian Liu , Thomas Nguyen , Nobuko Nishimura , Rana Nomak , Tanya Peterkin , Wenyuan Qian , Kevin Yang , Chester Chenguang Yuan , Jiawang Zhu , Derin C. D'Amico , Jason B. Human , Qi Huang
发明人： Benny C. Askew, Jr. , Toshihiro Aya , Kaustav Biswas , Guolin Cai , Jian J. Chen , Nianhe Han , Qingyian Liu , Thomas Nguyen , Nobuko Nishimura , Rana Nomak , Tanya Peterkin , Wenyuan Qian , Kevin Yang , Chester Chenguang Yuan , Jiawang Zhu , Derin C. D'Amico , Jason B. Human , Qi Huang
IPC分类号： A01N43/00 , A61K31/00 , A61K31/55 , A61K31/4965 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C07D221/10 , C07D221/08 , C07D239/74 , C07D241/08 , C07D243/08 , C07D249/08 , C07D295/135 , C07D311/96 , C07D335/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D417/12 , C07D491/04
摘要： Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。本发明包括新的化合物，类似物，前药和其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及疼痛，炎症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

9. 发明授权

US07612060B2 Triazoles and methods of use 有权
标题翻译：三唑和使用方法
公开(公告)号：US07612060B2
公开(公告)日：2009-11-03
申请号：US11247046
申请日：2005-10-11
申请人： Toshihiro Aya , Guolin Cai , Jian J. Chen , Derin D'Amico , Thomas Nguyen , Wenyuan Qian
发明人： Toshihiro Aya , Guolin Cai , Jian J. Chen , Derin D'Amico , Thomas Nguyen , Wenyuan Qian
IPC分类号： C07D403/00 , C07D401/00 , C07D413/00 , A01N43/46 , A61K31/535 , A61K31/497
CPC分类号： C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D471/04
摘要： Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。本发明包括新的化合物，类似物，前药和其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及疼痛，炎症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

10. 发明授权

US07393852B2 Piperazine derivatives and methods of use 失效
标题翻译：哌嗪衍生物和使用方法
公开(公告)号：US07393852B2
公开(公告)日：2008-07-01
申请号：US10874086
申请日：2004-06-21
申请人： Jian J. Chen , Ben C. Askew , Kaustav Biswas , Jennifer N. Chau , Derin C. D'Amico , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jiawang Zhu , Christopher H. Fotsch , Aiwen Li , Qingyian Liu , Nobuku Nishimura , Tanya Peterkin , Babak Riahi , Chester Chenguang Yuan , Nianhe Han , Rana Nomak , Kevin Yang
发明人： Jian J. Chen , Ben C. Askew , Kaustav Biswas , Jennifer N. Chau , Derin C. D'Amico , Scott Harried , Thomas Nguyen , Wenyuan Qian , Jiawang Zhu , Christopher H. Fotsch , Aiwen Li , Qingyian Liu , Nobuku Nishimura , Tanya Peterkin , Babak Riahi , Chester Chenguang Yuan , Nianhe Han , Rana Nomak , Kevin Yang
IPC分类号： A61K31/54 , A61K31/4965 , C07D241/04 , C07D265/30 , C07D279/12
CPC分类号： C07D241/08 , C07D243/08 , C07D245/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14
摘要： Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于治疗疼痛和疾病如炎症介导的疾病是有效的。本发明包括新的化合物，类似物，前药和其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及疼痛，炎症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

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