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    • 1. 发明授权
    • Vanilloid receptor ligands and their use in treatments
    • 香草素受体配体及其在治疗中的应用
    • US07544803B2
    • 2009-06-09
    • US11041173
    • 2005-01-21
    • Christopher HulmeMghele Vellah NcubeMark H. NormanVassil I. OgnyanovLiping H. PettusXianghong WangJiawang Zhu
    • Christopher HulmeMghele Vellah NcubeMark H. NormanVassil I. OgnyanovLiping H. PettusXianghong WangJiawang Zhu
    • C07D215/38
    • C07D471/04C07D215/38C07D215/48C07D401/12C07D401/14C07D405/12C07D409/12C07D495/04
    • Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
    • 具有一般结构和含有它们的组合物的化合物,用于治疗急性,炎性和神经性疼痛,牙痛,一般头痛,偏头痛,丛集性头痛,混合血管和非血管综合征,紧张性头痛,一般炎症,关节炎,风湿性 疾病,骨关节炎,炎症性肠病,炎症性眼病,炎症性或不稳定性膀胱病,银屑病,皮肤炎症成分炎症,慢性炎性病症,炎性疼痛及相关的痛觉过敏和异常性疼痛,神经性疼痛及相关的痛觉过敏和异常性疼痛,糖尿病性神经病疼痛, 咳嗽痛,交感神经痛,交感综合征,哮喘,上皮组织损伤或功能障碍,单纯疱疹,呼吸系统内脏运动紊乱,泌尿生殖道,胃肠道或血管区,伤口,烧伤,过敏性皮肤反应,瘙痒,白癜风,一般胃肠道疾病, G 腹部溃疡,十二指肠溃疡,腹泻,坏死因子诱发的胃损伤,毛发生长,血管舒缩或过敏性鼻炎,支气管疾病或膀胱疾病。
    • 3. 发明授权
    • Vanilloid receptor ligands and their use in treatments
    • 香草素受体配体及其在治疗中的应用
    • US07335672B2
    • 2008-02-26
    • US11226844
    • 2005-09-13
    • Mark H. NormanLiping H. PettusXianghong WangJiawang Zhu
    • Mark H. NormanLiping H. PettusXianghong WangJiawang Zhu
    • C07D239/34C07D239/38C07D239/48C07D213/30C07D213/32C07D213/36C07D401/12C07D401/14C07D403/12C07D403/14A61K31/4422A61K31/505A61K31/506A61P19/02
    • C07D239/48C07D401/12C07D401/14C07D403/12C07D405/12C07D405/14C07D417/12C07D417/14
    • Substituted pyridines and pyrimidines and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
    • 取代的吡啶类和嘧啶类和含有它们的组合物,用于治疗急性,炎性和神经性疼痛,牙痛,一般头痛,偏头痛,丛集性头痛,混合血管和非血管性综合征,紧张性头痛,一般炎症,关节炎,风湿性疾病 ,骨关节炎,炎症性肠病,炎症性眼病,炎症性或不稳定性膀胱病,牛皮癣,皮肤炎症成分炎症,慢性炎性病症,炎性疼痛及相关的痛觉过敏和异常性疼痛,神经性疼痛及相关的痛觉过敏和异常性疼痛,糖尿病性神经病疼痛,灼痛 ,同情维持疼痛,传入综合征,哮喘,上皮组织损伤或功能障碍,单纯疱疹,呼吸道内脏运动性紊乱,泌尿生殖道,胃肠道或血管区域,伤口,烧伤,过敏性皮肤反应,瘙痒,白癜风,一般胃肠道疾病 严重溃疡,十二指肠溃疡,腹泻,坏死因子诱导的胃损伤,毛发生长,血管舒缩或过敏性鼻炎,支气管疾病或膀胱疾病。