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1. 发明授权

US06642041B2 Polynucleotides encoding a novel metalloprotease, MP-1 有权
标题翻译：编码新型金属蛋白酶MP-1的多核苷酸
公开(公告)号：US06642041B2
公开(公告)日：2003-11-04
申请号：US10067443
申请日：2002-02-05
申请人： Jian Chen , John N. Feder , Thomas C. Nelson , Stanley R. Krystek , Franck Duclos
发明人： Jian Chen , John N. Feder , Thomas C. Nelson , Stanley R. Krystek , Franck Duclos
IPC分类号： C12N948
CPC分类号： C12N9/6489 , C07K2299/00
摘要： The present invention provides novel polynucleotides encoding MP-1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MP-1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码MP-1多肽，其片段和同系物的新型多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型MP-1多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

2. 发明授权

US07186564B2 Polynucleotides encoding novel cysteine proteases of the calpain superfamily, CAN-12v1 and CAN-12v2. 有权
标题翻译：编码钙蛋白酶超家族，CAN-12v1和CAN-12v2的新型半胱氨酸蛋白酶的多核苷酸。
公开(公告)号：US07186564B2
公开(公告)日：2007-03-06
申请号：US10116519
申请日：2002-04-03
申请人： Jian Chen , Thomas C. Nelson , Roy J. Vaz , Franck Duclos
发明人： Jian Chen , Thomas C. Nelson , Roy J. Vaz , Franck Duclos
IPC分类号： C12N15/57 , C12N9/64 , C12N15/74 , C12N15/79
CPC分类号： C12N9/6472 , A61K38/00 , C07K2299/00 , Y02A90/26
摘要： The present invention provides novel polynucleotides encoding CAN-12 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants of CAN-12 polypeptides, CAN-12v1 and CAN-12v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel CAN-12, CAN-12v1, and CAN-12v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly neuro- and musculo-degenerative conditions. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码CAN-12多肽的新型多核苷酸，其片段和同系物。本发明还提供编码CAN-12多肽，CAN-12v1和CAN-12v2变体的多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型CAN-12，CAN-12v1和CAN-12v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法，特别是神经 - 和肌肉退行性疾病。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

3. 发明申请

US20060183196A1 Polynucleotide encoding a novel cysteine protease of the calpain superfamily, CAN-12, and variants thereof 审中-公开
公开(公告)号：US20060183196A1
公开(公告)日：2006-08-17
申请号：US11407134
申请日：2006-04-19
申请人： Jian Chen , John Feder , Thomas Nelson , Steven Seiler , Roy Vaz , Franck Duclos
发明人： Jian Chen , John Feder , Thomas Nelson , Steven Seiler , Roy Vaz , Franck Duclos
IPC分类号： C07H21/04 , C12P21/06 , C12N9/64
CPC分类号： C12N9/6472 , A61K38/00 , C07K2299/00 , Y02A90/26
摘要： The present invention provides novel polynucleotides encoding CAN-12 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants of CAN-12 polypeptides, CAN-12v1 and CAN-12v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel CAN-12, CAN-12v1, and CAN-12v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly neuro- and musculo-degenerative conditions. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

4. 发明申请

US20060147973A1 Polynucleotide encoding a novel human serpin secreted from lymphoid cells, LSI-01 有权
公开(公告)号：US20060147973A1
公开(公告)日：2006-07-06
申请号：US11329900
申请日：2006-01-11
申请人： Jian Chen , John Feder , Thomas Nelson , Steven Seiler , Donna Bassolino , Daniel Cheney , Franck Duclos
发明人： Jian Chen , John Feder , Thomas Nelson , Steven Seiler , Donna Bassolino , Daniel Cheney , Franck Duclos
IPC分类号： C12Q1/68 , C07H21/04 , C12N9/99
CPC分类号： C07K14/8121 , A61K38/00 , C07K2299/00
摘要： The present invention provides novel polynucleotides encoding LSI-01 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LSI-01 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

5. 发明授权

US5994760A Device having a low threshold voltage for protection against electrostatic discharges 有权
标题翻译：具有低阈值电压的器件，用于防止静电放电
公开(公告)号：US5994760A
公开(公告)日：1999-11-30
申请号：US176418
申请日：1998-10-21
申请人： Franck Duclos
发明人： Franck Duclos
IPC分类号： G11B5/40 , H01L21/822 , H01L23/60 , H01L27/02 , H01L27/04 , H01L27/08 , H01L29/861 , H05F3/02 , H01L29/00 , H01L29/74 , H01L31/111
CPC分类号： H01L27/0248 , H01L27/0814 , H01L2924/0002
摘要： The present invention relates to an assembly of two pairs of diodes in a single semiconductor substrate of a first type of conductivity, the first pair including a first diode in series with a second diode, the second pair including a third diode in series with a fourth diode, the two pairs of diodes being arranged in parallel. Each of the first and third diodes includes neighboring regions of distinct types of conductivity formed in a lightly-doped well of the second type of conductivity, these wells being separated; each of the second and fourth diodes includes separated regions of distinct types of conductivity; and metallizations connect the electrodes of the diodes to form the desired series-to-parallel assembly.
摘要翻译：本发明涉及在第一种导电类型的单个半导体衬底中的两对二极管的组件，第一对包括与第二二极管串联的第一二极管，第二对包括与第四导体串联的第三二极管二极管，两对二极管并联布置。第一和第三二极管中的每一个包括在第二导电类型的轻掺杂阱中形成的不同类型导电体的相邻区域，这些阱被分离; 第二和第四二极管中的每一个包括不同类型导电性的分离区域; 并且金属化连接二极管的电极以形成所需的串联到并联组件。

6. 发明授权

US06882180B2 Switching aid circuit for a logic circuit 有权
标题翻译：用于逻辑电路的开关辅助电路
公开(公告)号：US06882180B2
公开(公告)日：2005-04-19
申请号：US10415461
申请日：2001-10-30
申请人： Franck Duclos , Olivier Ladiray , Jérôme Heurtier
发明人： Franck Duclos , Olivier Ladiray , Jérôme Heurtier
IPC分类号： H03K5/1534 , H03K19/013
CPC分类号： H03K19/0136 , H03K5/1534
摘要： The invention concerns a switching circuit (20) adapted to generate a pulse when there occurs a rising edge of a signal applied on an input terminal (CTRL), comprising: a first NPN type bipolar transistor (TN2) whereof the transmitter is connected to the input terminal; a second transistor (TP2) whereof a control electrode is connected, through a first resistor (Re2), to the input terminal, the base of the first transistor being connected to a supply potential (VDD) by the second transistor in series with a second resistor (Rp2); and a third transistor (TN3) connecting an output terminal (22) of the switching circuit to a reference potential (GND) and whereof a control electrode is connected to the collector of the first transistor (TN2).
摘要翻译：本发明涉及一种适于在发生施加在输入端（CTRL）上的信号的上升沿产生脉冲的开关电路（20），包括：第一NPN型双极晶体管（TN2），其中发射器连接到输入端; 控制电极通过第一电阻器（Re 2）连接到输入端子的第二晶体管（TP2），第一晶体管的基极与第二晶体管的电源电位（VDD）串联连接第二电阻器（Rp 2）; 以及将开关电路的输出端子（22）连接到基准电位（GND）的第三晶体管（TN 3），并且其控制电极连接到第一晶体管（TN2）的集电极。

7. 发明授权

US06211340B1 &dgr;-sarcoglycan antibodies 失效
标题翻译： δ-糖聚糖抗体
公开(公告)号：US06211340B1
公开(公告)日：2001-04-03
申请号：US09119827
申请日：1998-07-21
申请人： Kevin P. Campbell , Daniel Jung , Franck Duclos , Volker Straub , John McPherson
发明人： Kevin P. Campbell , Daniel Jung , Franck Duclos , Volker Straub , John McPherson
IPC分类号： C07K1618
CPC分类号： C07K14/4707
摘要： Disclosed herein is a substantially pure nucleic acid sequence encoding a mammalian 35 kDa non-dystrophin component (&dgr;-sarcoglycan) of the dystrophin-glycoprotein complex. Also disclosed are the amino acid sequence and an immunogenic peptide of &dgr;-sarcoglycan. The peptide when used to immunize a mammal, stimulates the production of antibodies which bind specifically to the &dgr;-sarcoglycan. Methods to identify mutations in the &dgr;-sarcoglycan gene associated with autosomal recessive limb-girdle muscular dystrophy are also disclosed. The identification of such mutations enables the design of nucleic acid probes which hybridize specifically to a mutant form of &dgr;-sarcoglycan, or the complement thereof, but not to the DNA of the wild-type form of the gene (or the complement thereof), under stringent hybridization conditions. Such probes are useful, for example, in connection with the diagnosis of autosomal recessive limb-girdle muscular dystrophy. In addition, the identification of such mutations enables the diagnosis of autosomal recessive limb-girdle muscular dystrophy through the use of direct DNA sequencing techniques.
摘要翻译：本文公开了编码肌营养不良蛋白 - 糖蛋白复合物的哺乳动物35kDa非肌营养不良蛋白成分（δ-莽草酸）的基本上纯的核酸序列。还公开了δ-色氨酸的氨基酸序列和免疫原性肽。当肽用于免疫哺乳动物时，刺激产生与δ-糖聚糖特异性结合的抗体。还公开了鉴定与常染色体隐性遗传性肢体肌营养不良症相关的δ-色氨酸聚糖基因突变的方法。这种突变的鉴定使得能够设计特异性地与δ-色氨酸聚糖或其互补体的突变形式杂交的核酸探针，而不与野生型形式的基因（或其互补物）的DNA杂交，在严格的杂交条件下。这样的探针可用于例如与常染色体隐性性腰带肌营养不良症的诊断有关。此外，通过使用直接DNA测序技术，鉴定这种突变能够诊断常染色体隐性的腰带肌营养不良症。

8. 发明授权

US06262035B1 Gene replacement therapy for muscular dystrophy 有权
标题翻译：肌营养不良症的基因替代疗法
公开(公告)号：US06262035B1
公开(公告)日：2001-07-17
申请号：US09164664
申请日：1998-10-01
申请人： Kevin P. Campbell , Kathleen H. Holt , Franck Duclos , Leland E. Lim , Volker Straub , Beverly Davidson , Roger Williamson
发明人： Kevin P. Campbell , Kathleen H. Holt , Franck Duclos , Leland E. Lim , Volker Straub , Beverly Davidson , Roger Williamson
IPC分类号： A01N4304
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2207/15 , A01K2217/00 , A01K2217/075 , A01K2227/105 , A01K2267/0306 , A61K38/1709 , A61K48/00
摘要： Disclosed is a method for treating a patient suffering from the disease sarcoglycan-deficient limb-girdle muscular dystrophy by gene replacement therapy. Sarcoglycan gene replacement therapy produces extensive long-term expression of the sarcoglycan species which restores the entire sarcoglycan complex, results in the stable association of alph&agr;-dystroglycan with the sarcolemma, and eliminates the morphological markers of limb-girdle muscular dystrophy. In another aspect, the invention relates to a method for determining a specific defective sarcoglycan species in the tissue of a patient. The method involves culture of muscle cells obtained from the patient, and the independent introduction of expression vectors encoding each of the sarcoglycan species, &agr;, &bgr;, &ggr;, and &dgr;, into the cultured cells with subsequent assaying for restoration of the dystrophin-glycoprotein complex. In another aspect, the invention relates to a mouse, and cells derived therefrom, homozygous for a disrupted &agr;-sarcoglycan gene. The disruption prevents the synthesis of functional &agr;-sarcoglycan in cells of the mouse and results in the mutant mouse having no detectable sarcospan, &bgr;-, &ggr;-, &dgr;-sarcoglycan, and reduced &agr;-dystroglycan in the sarcolemma of skeletal and cardiac muscles, and a reduction of dystrophin in skeletal muscle, when compared to tissue of a mouse lacking a disrupted &agr;-sarcoglycan gene. In another aspect, the invention relates to methods for screening for therapeutic agents useful in the treatment of sarcoglycan-deficient limb-girdle muscular dystrophy. The methods involve administering a candidate therapeutic agent to a mouse, or cells derived therefrom, and assaying for therapeutic effects on the mouse or cells, with the determination of therapeutic effects being a reduction or reversal in disease progression, or a restoration of the dystroglycan complex.
摘要翻译：本发明公开了一种通过基因替代疗法治疗患有疾病肌糖肌苷缺乏症的肢体肌营养不良症的患者的方法。 Sarcoglycan基因替代疗法产生广泛的长期表达的sarcoglycan物种，其恢复整个slegoglycan复合物，导致αphorpha-dystroglycan与肌膜的稳定关联，并消除肢体肌营养不良的形态学标志物。另一方面，本发明涉及一种用于确定患者组织中的特定缺陷型糖团聚物物种的方法。该方法包括从患者获得的肌肉细胞的培养，以及将编码每种肌糖原聚糖物质，α，β，γ和δ的表达载体独立引入培养的细胞中，随后测定肌营养不良蛋白 - 糖蛋白复合物的恢复。另一方面，本发明涉及一种小鼠及其衍生的细胞，用于破坏的α-丝裂霉素基因是纯合的。该破坏阻止了小鼠细胞中功能性α-sarcoglycan的合成，并导致突变小鼠在骨骼肌和心脏肌肉的肌膜中不具有可检测的sarcospan，β - ，γ-，δ-色氨酸聚糖和还原的α-二糖聚糖，和与缺乏α-sarcoglycan基因的小鼠的组织相比，骨骼肌中营养不良蛋白的减少。另一方面，本发明涉及筛选用于治疗肌糖原缺乏型肢体肌营养不良症的治疗剂的方法。所述方法包括将候选治疗剂施用于小鼠或由其衍生的细胞，以及测定对小鼠或细胞的治疗效果，其中治疗效果的确定是疾病进展中的减少或逆转，或者肌萎缩糖复合物的恢复。

9. 发明授权

US5837537A .delta.-sarcoglycan nucleic acid sequences 失效
标题翻译： δ-聚糖核酸序列
公开(公告)号：US5837537A
公开(公告)日：1998-11-17
申请号：US719758
申请日：1996-09-25
申请人： Kevin P. Campbell , Daniel Jung , Franck Duclos , Volker Straub , John McPherson
发明人： Kevin P. Campbell , Daniel Jung , Franck Duclos , Volker Straub , John McPherson
IPC分类号： C07K14/47 , C12N15/12 , C12N15/63 , C12N15/85
CPC分类号： C07K14/4707
摘要： Disclosed herein is a substantially pure nucleic acid sequence encoding a mammalian 35 kDa non-dystrophin component (.delta.-sarcoglycan) of the dystrophin-glycoprotein complex. Also disclosed are the amino acid sequence and an immunogenic peptide of .delta.-sarcoglycan. The peptide when used to immunize a mammal, stimulates the production of antibodies which bind specifically to the .delta.-sarcoglycan. Methods to identify mutations in the .delta.-sarcoglycan gene associated with autosomal recessive limb-girdle muscular dystrophy are also disclosed. The identification of such mutations enables the design of nucleic acid probes which hybridize specifically to a mutant form of .delta.-sarcoglycan, or the complement thereof, but not to the DNA of the wild-type form of the gene (or the complement thereof), under stringent hybridization conditions. Such probes are useful, for example, in connection with the diagnosis of autosomal recessive limb-girdle muscular dystrophy. In addition, the identification of such mutations enables the diagnosis of autosomal recessive limb-girdle muscular dystrophy through the use of direct DNA sequencing techniques.
摘要翻译：本文公开了编码肌营养不良蛋白 - 糖蛋白复合物的哺乳动物35kDa非肌营养不良蛋白成分（δ-聚糖）的基本上纯的核酸序列。还公开了δ-聚糖的氨基酸序列和免疫原性肽。当肽用于免疫哺乳动物时，刺激产生与δ-聚糖结合特异性的抗体。还公开了鉴定与常染色体隐性遗传性肢体肌营养不良症相关的δ-聚糖基因突变的方法。这种突变的鉴定使得能够设计与δ-聚糖或其互补体的突变形式特异性杂交的核酸探针，而不与野生型形式的基因（或其补体）的DNA杂交，在严格的杂交条件下。这样的探针可用于例如与常染色体隐性性腰带肌营养不良症的诊断有关。此外，通过使用直接DNA测序技术，鉴定这种突变能够诊断常染色体隐性的腰带肌营养不良症。

10. 发明授权

US06593600B1 Responsive bidirectional static switch 有权
标题翻译：响应式双向静态开关
公开(公告)号：US06593600B1
公开(公告)日：2003-07-15
申请号：US09634076
申请日：2000-08-08
申请人： Franck Duclos , Jean-Michel Simonnet , Olivier Ladiray
发明人： Franck Duclos , Jean-Michel Simonnet , Olivier Ladiray
IPC分类号： H01L2974
CPC分类号： H01L29/747
摘要： A monolithic bidirectional switch formed in a semiconductor substrate of type N, including a first main vertical thyristor, the rear surface layer of which is of type P, a second main vertical thyristor, the rear surface layer of which is of type N, an auxiliary vertical thyristor, the rear surface layer of which is of type P and is common with that of the first main thyristor, a peripheral region of type P especially connecting the rear surface layer of the auxiliary thyristor to the layer of this thyristor located on the other side of the substrate, a first metallization on the rear surface side, a second metallization on the front surface side connecting the front surface layers of the first and second thyristors. An additional region has a function of isolating the rear surface of the auxiliary thyristor and the first metallization.
摘要翻译：形成在N型半导体衬底中的单片双向开关，包括其表面层为P型的第一主垂直晶闸管，后表面为N型的第二主垂直晶闸管，辅助垂直晶闸管的后表面层为P型，与第一主晶闸管相同，P型周边区域特别将辅助晶闸管的背面层与位于另一侧的该晶闸管的层连接在第一和第二晶闸管的前表面层连接前表面侧上的第二金属化层。附加区域具有隔离辅助晶闸管的后表面和第一金属化的功能。

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