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    • 2. 发明申请
    • Water soluble extract of spinach for prevention and repair of DNA damage
    • 菠菜水溶性提取物,用于预防和修复DNA损伤
    • US20080138393A1
    • 2008-06-12
    • US11698016
    • 2007-01-25
    • Jesse C. LeverettRodney M. JohnsonStephen R. MisslerDavid J. FastTom LaJohn V. Scimeca
    • Jesse C. LeverettRodney M. JohnsonStephen R. MisslerDavid J. FastTom LaJohn V. Scimeca
    • A61K36/00A61K9/127A61K36/31A61K38/47A61P43/00
    • A61K38/05A61K9/127A61K31/683
    • Compositions comprising a water soluble spinach extract, compositions comprising a water soluble spinach extract, a liposome, a cardiolipin, and at least one antioxidant, compositions comprising a water soluble spinach extract, an extract of Arabidopsis thaliana or of the mustard (Brassica) plant, a liposome, a cardiolipin, and at least one antioxidant, processes for obtaining such compositions, and methods of using such compositions to repair damage to nuclear DNA, mitochondrial DNA, or both, prevent or decrease damage to such DNA from, for example, reactive oxygen species or 8-hydroxydeoxyguanosine and/or to repair or prevent mitochondrial damage and loss of membrane fluidity are disclosed. Compositions of the present invention may be topically administered, orally administered or parenterally, such as administration by injection. When topically administered, additives such as penetration enhancers, fragrances, preservatives, moisturizers and cosmetic adjuvants may be included in compositions of the present invention.
    • 包含水溶性菠菜提取物的组合物,包含水溶性菠菜提取物,脂质体,心磷脂和至少一种抗氧化剂的组合物,包含水溶性菠菜提取物,拟南芥提取物或芥菜(芸苔属)植物的组合物, 脂质体,心磷脂和至少一种抗氧化剂,获得这样的组合物的方法,以及使用这些组合物来修复对核DNA,线粒体DNA或两者的损伤的方法,从例如反应性的 公开了氧类或8-羟基脱氧鸟苷和/或修复或预防线粒体损伤和膜流动性的丧失。 本发明的组合物可以局部施用,口服给药或肠胃外给药,例如通过注射给药。 当局部施用时,可以在本发明的组合物中包括添加剂,例如渗透促进剂,香料,防腐剂,保湿剂和化妆品佐剂。
    • 9. 发明授权
    • Liposome containing cardiolipin for improvement of mitochondrial function
    • 含有心磷脂的脂质体用于改善线粒体功能
    • US07824708B2
    • 2010-11-02
    • US11636889
    • 2006-12-11
    • Jesse C. LeverettStephen R. MisslerDavid J. Fast
    • Jesse C. LeverettStephen R. MisslerDavid J. Fast
    • A61K9/127
    • A61K9/127A61K45/06
    • Disclosed herein is a composition comprising a liposome, a cardiolipin, and at least one antioxidant, wherein the composition is useful for improving, maintaining, or restoring a mitochondrial membrane and/or mitochondrial function. In one example, the liposome is primarily composed of phosphatidylcholine, the cardiolipin is tetraoleoyl-cardiolipin, and the at least one antioxidant is methylgentisate, l-carnosine, or both. The composition may be topically administered, orally administered, or parenterally administered, for example administered by injection. If topically administered, the composition may be administered for example, as a cream, lotion, gel, paste, spray, tonic, or other suitable form and may contain various additives, for example, one or more of an emollient, a humectant, a penetration enhancer, a vitamin, a fragrance, a pigment, and a moisturizer.
    • 本文公开了包含脂质体,心磷脂和至少一种抗氧化剂的组合物,其中所述组合物可用于改善,维持或恢复线粒体膜和/或线粒体功能。 在一个实例中,脂质体主要由磷脂酰胆碱组成,心磷脂是四油酰 - 心磷脂,至少一种抗氧化剂是甲基化,1-肌肽或二者。 组合物可以局部给药,口服给药或胃肠外给药,例如通过注射给药。 如果局部施用,组合物可以例如作为乳膏,洗剂,凝胶,糊剂,喷雾剂,补品或其它合适的形式施用,并且可以含有各种添加剂,例如润肤剂,保湿剂, 渗透促进剂,维生素,香料,颜料和保湿剂。
    • 10. 发明申请
    • INDUCTIVELY-HEATED APPLICATOR SYSTEM
    • 电感加热器系统
    • US20090289055A1
    • 2009-11-26
    • US12126190
    • 2008-05-23
    • David W. BaarmanRichard BylsmaThomas Jay LeppienJesse C. LeverettSteve O. Mork
    • David W. BaarmanRichard BylsmaThomas Jay LeppienJesse C. LeverettSteve O. Mork
    • H05B6/04
    • B05C17/001A45D34/041A45D40/261A45D2200/055A45D2200/056A45D2200/155B05C1/00B05C1/003H05B6/105
    • An inductively-heated applicator system including a heating module and an applicator, such as an applicator pen. The heating module include a dock for seating the applicator. The heating module includes circuitry to selectively generate an electromagnetic field to wirelessly provide energy to the applicator when it is positioned in the dock. The heating module may also include temperature control circuitry to monitor and/or control the temperature of the applicator. The applicator pen includes a heating element that it heated through energy provided by the electromagnetic field. The heating element may be directly inductively heated by the electromagnetic field. The heating element may be a roller element that heats and applies the product. Alternatively, the applicator may include a secondary in which electrical power is induced when the electromagnetic field is present. In this alternative, the power may be applied to the heating element to produce resistive heat.
    • 一种感应加热的施加器系统,其包括加热模块和施加器,例如施加器笔。 加热模块包括用于安放敷贴器的底座。 加热模块包括用于选择性地产生电磁场的电路,以便当定位在基座中时向施加器无线地提供能量。 加热模块还可以包括温度控制电路以监测和/或控制施加器的温度。 涂抹笔包括通过由电磁场提供的能量加热的加热元件。 加热元件可以被电磁场直接感应加热。 加热元件可以是加热和施加产品的辊元件。 或者,施加器可以包括次级,其中当存在电磁场时,其中引入电功率。 在这种替代方案中,可以将功率施加到加热元件以产生电阻热。