专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4250304A 2-Deoxy-2-substituted fortimicin A and B and derivatives 失效
标题翻译： 2-脱氧-2-取代的fortimicin A和B及其衍生物
公开(公告)号：US4250304A
公开(公告)日：1981-02-10
申请号：US79145
申请日：1979-09-26
申请人： Jerry R. Martin , John S. Tadanier , Paulette Johnson , Alex M. Nadzan
发明人： Jerry R. Martin , John S. Tadanier , Paulette Johnson , Alex M. Nadzan
IPC分类号： C07H15/224 , C07H15/22
CPC分类号： C07H15/224
摘要： Disclosed are 2-deoxy-2-substituted fortimicin A and B derivatives represented by the formula ##STR1## wherein R is hydrogen glycyl, .beta.-alanyl, acetyl, or .beta.-amino lower alkyl, R.sub.1 is hydrogen, amino, azido, halo, glycylamido, .beta.-alanyl amido or 2-O-methanesulfonyl and R.sub.2 is hydrogen or halo and their pharmaceutically acceptable salts. The compounds are active antibacterial agents.
摘要翻译：公开了由式“IMAGE”表示的2-脱氧-2-取代的fortimicin A和B衍生物，其中R是氢甘氨酰，β-丙氨酰基，乙酰基或β-氨基低级烷基，R 1是氢，氨基，叠氮基，卤素，甘氨酰胺基，β-丙氨酰氨基或2-O-甲磺酰基，R2是氢或卤素及其药学上可接受的盐。这些化合物是活性抗菌剂。

2. 发明授权

US4340727A 1,2-Modified fortimicins A and B, intermediates therefor and method for their manufacture 失效
标题翻译： 1,2-改性的fortimicins A和B，其中间体及其制备方法
公开(公告)号：US4340727A
公开(公告)日：1982-07-20
申请号：US201651
申请日：1980-10-28
申请人： Jerry R. Martin , John S. Tadanier , Paulette Johnson
发明人： Jerry R. Martin , John S. Tadanier , Paulette Johnson
IPC分类号： C07H15/224 , C07H15/22
CPC分类号： C07H15/224
摘要： A 1,2-modified fortimicin A or B represented by the formulae I, II and III: ##STR1## wherein R is hydrogen or loweralkyl; and R.sub.1 is selected from the group consisting of hydrogen, loweralkyl, aminoloweralkyl, diaminoloweralkyl, N-lower-alkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, hydroxyloweralkyl, amino hydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N-N-diloweralkylaminohydroxyloweralkyl, acyl, aminoacyl, hydroxy-substituted aminoacyl, diaminoacyl, hydroxyacyl, hydroxy-substituted diaminoacyl, N-loweralkylaminoacyl, N, N-diloweralkylaminoacyl, hydroxysubstituted-N-loweralkylaminoacyl and hydroxy-substituted-N, N-diloweralkylaminoacyl, and the pharmaceutically acceptable salts thereof. The compounds are broad spectrum antibiotics.
摘要翻译：由式I，II和III表示的1,2-改性的fortimicin A或B：其中R是氢或低级烷基; 其中R 1选自氢，低级烷基，氨基低级烷基，二氨基低级烷基，N-低级烷基氨基低级烷基，N，N-二低级烷基氨基低级烷基，羟基低级烷基，氨基羟基低级烷基，N-低级烷基氨基羟基低级烷基，，二氨基酰基，羟基酰基，羟基取代的二氨基酰基，N-低级烷基氨基酰基，N，N-二低级烷基氨基酰基，羟基取代的N-低级烷基氨基酰基和羟基取代的N，N-二低级烷基氨基酰基及其药学上可接受的盐。这些化合物是广谱抗生素。

3. 发明授权

US4251516A 2-Deoxy-3-O-Demethylfortimicins 失效
公开(公告)号：US4251516A
公开(公告)日：1981-02-17
申请号：US79132
申请日：1979-09-26
申请人： Jerry R. Martin , John S. Tadanier , Paulette Johnson
发明人： Jerry R. Martin , John S. Tadanier , Paulette Johnson
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/224 , A61K31/71 , C07H15/22
CPC分类号： C07H15/224
摘要： The present invention provides 2-deoxy-3-O-demethyl-fortimcins A and B and the 4-N-acyl and alkyl derivatives thereof, represented by the formula: ##STR1## wherein R is selected from the group consisting of hydrogen, acyl, aminoacyl,diaminoacyl,N-monoloweralkylaminoalkyl,N,N-diloweralkylaminoalkyl, hydroxy-substituted aminoacyl,loweralkyl, aminoloweralkyl, N-monoloweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl and hydroxy-substituted aminoloweralkyl and the pharmaceutically acceptable salts thereof.

4. 发明授权

US4273925A 1,2-Modified fortimicins A and B, intermediates therefor and method for their manufacture 失效
标题翻译： 1,2-改性的fortimicins A和B，其中间体及其制备方法
公开(公告)号：US4273925A
公开(公告)日：1981-06-16
申请号：US79135
申请日：1979-09-26
申请人： Jerry R. Martin , John S. Tadanier , Paulette Johnson
发明人： Jerry R. Martin , John S. Tadanier , Paulette Johnson
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/224 , C07H15/22
CPC分类号： C07H15/224
摘要： A 1,2-modified fortimicin A or B represented by the formulae I, II and III: ##STR1## wherein R is hydrogen or loweralkyl.
摘要翻译：由式I，II和III表示的1,2-改性的fortimicin A或B：其中R是氢或低级烷基。

5. 发明授权

US4360666A 2-Deoxyfortimicin A, 4-N-alkyl and 4-N-acyl-2-deoxyfortimicin B derivatives and intermediates therefor 失效
标题翻译： 2-脱氧有益霉素A，4-N-烷基和4-N-酰基-2-脱氧有机霉素B衍生物及其中间体
公开(公告)号：US4360666A
公开(公告)日：1982-11-23
申请号：US266030
申请日：1981-05-22
申请人： John S. Tadanier , Jerry R. Martin , Paulette Collum
发明人： John S. Tadanier , Jerry R. Martin , Paulette Collum
IPC分类号： C07H15/224
CPC分类号： C07H15/224
摘要： 2-Deoxyfortimicin A, 2-deoxy-4-N-alkyl fortimicins and 2-deoxy-4-N-acyl fortimicins represented by the formula ##STR1## wherein R is selected from the group consisting of acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, an amino acid residue, hydroxyacyl, loweralkyl, aminoloweralkyl, N-monoloweralkylaminoloweralkyl, hydroxyloweralkyl, N-N-diloweralkylaminoloweralkyl or hydroxy-substituted aminoloweralkyl, and the pharmaceutically acceptable salts thereof; intermediates therefor; and pharmaceutical compositions containing the compounds of this invention.
摘要翻译： 2-脱氧有益霉素A，2-脱氧-4-N-烷基苦味蛋白和由式“IMAGE”表示的2-脱氧-4-N-酰基酪氨酸，其中R选自酰基，氨基酰基，N-单低级烷基氨基酰基， N，N-二烷基氨基酰基，羟基取代的酰基酰基，氨基酸残基，羟基酰基，低级烷基，氨基低级烷基，N-单低级烷基氨基低级烷基，羟基低级烷基，N，N-二烷基氨基低级烷基或羟基取代的氨基低级烷基。中间体和含有本发明化合物的药物组合物。

6. 发明授权

US4187298A 2'N-acyl and alkyl fortimicin B and derivatives, 4,2'-N,N'diacyl and dialkyl fortimicin B derivatives 4-N-acyl-2'-N-alkyl and 4-N-alkyl-2'-N-acyl fortimicin B derivatives 失效
标题翻译： 2'N-酰基和烷基苦味蛋白B及其衍生物，4,2'-N，N'-二酰基和二烷基苦味蛋白B衍生物4-N-酰基-2'-N-烷基和4-N-烷基-2'- -acyl fortimicin B衍生物
公开(公告)号：US4187298A
公开(公告)日：1980-02-05
申请号：US863012
申请日：1977-12-21
申请人： Jerry R. Martin , John S. Tadanier , Paulette Collum
发明人： Jerry R. Martin , John S. Tadanier , Paulette Collum
IPC分类号： C07H15/224 , A61K31/71 , C07H15/22
CPC分类号： C07H15/224
摘要： 2'-N-Acyl and alkyl fortimicin B and fortimicin B derivatives, 4,2'-N,N'-diacyl and dialkyl derivatives, 4-N-acyl-2'-N-alkyl and 4-N-alkyl-2'-N-acyl fortimicin B derivatives represented by the formula ##STR1## wherein: R is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl or N,N-diloweralkylaminohydroxyloweralkyl; and R.sub.1 is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, an amino acid residue, hydroxyacyl, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkylaminohydroxyloweralkyl or hydrogen and the pharmaceutically acceptable salts thereof; pharmaceutical compositions containing the compounds; and methods of making and using the compounds. The compounds are useful as antibiotics, intermediates, and are further useful in making moth proofing agents and pickling inhibitors.
摘要翻译： 2-N-酰基和烷基维生素B和fortimicin B衍生物，4,2'-N，N'-二酰基和二烷基衍生物，4-N-酰基-2'-N-烷基和4-N-烷基-2 其中：R是酰基，氨基酰基，N-单低级烷基氨基酰基，N，N-二低级烷基氨基酰基，羟基取代的酰基酰基，羟基酰基，氨基酸残基，低级烷基，氨基低级烷基，羟基低级烷基 N，N-二烷基氨基低级烷基，N，N-二烷基氨基低级烷基，氨基羟基低级烷基，N-低级烷基氨基羟基低级烷基或N，氨基酸残基，羟基酰基，低级烷基，氨基低级烷基，羟基低级烷基，N-低级烷基氨基低级烷基，N，N-二低级烷基氨基低级烷基，氨基羟基低级烷基，N-低级烷基氨基羟基低级烷基，N-低级烷基氨基低级烷基氨基甲酰基，，N，N-二低级烷基氨基羟基低级烷基或氢及其药学上可接受的盐; 含有这些化合物的药物组合物; 以及制备和使用该化合物的方法。这些化合物可用作抗生素，中间体，并且还可用于制备防蛀剂和酸洗抑制剂。

7. 发明授权

US4155902A 4-N-acylfortimicin B derivatives and the chemical conversion of fortimicin B to fortimicin A 失效
公开(公告)号：US4155902A
公开(公告)日：1979-05-22
申请号：US888085
申请日：1978-03-20
申请人： John S. Tadanier , Jerry R. Martin , Paul Kurath
发明人： John S. Tadanier , Jerry R. Martin , Paul Kurath
IPC分类号： C07D309/14 , A61K31/35 , A61K31/351 , A61K31/415 , A61P31/04 , C07D405/12 , C07H15/224 , C07C103/52
CPC分类号： C07H15/224
摘要： This invention provides 4-N-acylfortimicin B derivatives of the structure ##STR1## wherein R is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, or substituted aminoacyl of the formula ##STR2## where R.sup.1 is an acyl radical derived from an amino acid or a short peptide, and the pharmaceutically acceptable salts thereof.The compounds are useful as intermediates for preparing 4-N-alkyl or substituted alkylfortimicin B derivatives. In addition to their utility as intermediates, some of the compounds of this invention are also useful as antimicrobial agents.

8. 发明授权

US4431799A 6'-Modified fortimicin compounds 失效
标题翻译： 6'-改性的fortimicin化合物
公开(公告)号：US4431799A
公开(公告)日：1984-02-14
申请号：US79129
申请日：1979-09-26
申请人： John S. Tadanier , Robert Hallas , Jerry R. Martin
发明人： John S. Tadanier , Robert Hallas , Jerry R. Martin
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61K31/7042 , A61P31/04 , C07H15/224 , C07H17/00 , A61K31/71 , C07H17/04
CPC分类号： C07H15/224
摘要： Described is a method for the preparation of 6'-modified fortimicin compounds including 6'-epi fortimicin by converting 1,2-di-N-protected fortimicin B into 4,6'-di-N-substituted alkoxycarbonyl-1,2'-di-N-protected fortimicin B which is further converted to 1,2'-di-substituted fortimicin B-4,5-carbamate, a compound whose substitution pattern is particularly suited to modification at the 6'-amino group and novel compounds thereof.
摘要翻译：描述了通过将1,2-二-N-保护的fortimicin B转化成4,6'-二-N-取代的烷氧基羰基-1,2'的6'-改性的fortimicin化合物，包括6'-epi fortimicin的方法， -di-N-保护的fortimicin B，其进一步转化为1,2'-二取代的fortimicin B-4,5-氨基甲酸酯，其取代模式特别适于在6'-氨基改性的化合物和新化合物其中。

9. 发明授权

US4360668A 2-O-Methanesulfonylfortimicin B 失效
标题翻译： 2-O-甲磺酰基有益霉素B
公开(公告)号：US4360668A
公开(公告)日：1982-11-23
申请号：US266266
申请日：1981-05-22
申请人： Jerry R. Martin , John S. Tadanier , Paulette Collum
发明人： Jerry R. Martin , John S. Tadanier , Paulette Collum
IPC分类号： C07H15/224 , C07H15/22
CPC分类号： C07H15/224
摘要： 2-Deoxyfortimicin, A, 2-deoxy-4-N-alkyl fortimicins and 2-deoxy-4-N-acyl fortimicins represented by the formula ##STR1## wherein R is selected from the group consisting of acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, an amino acid residue, hydroxyacyl, loweralkyl, aminoloweralkyl, N-monoloweralkylaminoloweralkyl, hydroxyloweralkyl, N-N-diloweralkylaminoloweralkyl or hydroxy-substituted aminoloweralkyl, and the pharmaceutically acceptable salts thereof; intermediates therefor; and pharmaceutical compositions containing the compounds of this invention.
摘要翻译：由式“IMAGE”表示的2-脱氧有机霉素，A，2-脱氧-4-N-烷基苦味蛋白和2-脱氧-4-N-酰基苦味霉素，其中R选自酰基，氨基酰基，N-单低级烷基氨基酰基 N，N-二烷基氨基酰基，羟基取代的酰基酰基，氨基酸残基，羟基酰基，低级烷基，氨基低级烷基，N-单低级烷基氨基低级烷基，羟基低级烷基，N，N-二烷基氨基低级烷基或羟基取代的氨基低级烷基。中间体和含有本发明化合物的药物组合物。

10. 发明授权

US4276413A Fortimicin intermediates for producing 2-deoxyfortimicins 失效
标题翻译：用于生产2-脱氧舒缓素的富咪咪嗪中间体
公开(公告)号：US4276413A
公开(公告)日：1981-06-30
申请号：US91864
申请日：1979-11-06
申请人： Jerry R. Martin , John S. Tadanier , Paulette Collum
发明人： Jerry R. Martin , John S. Tadanier , Paulette Collum
IPC分类号： C07H15/224 , C07H15/20
CPC分类号： C07H15/224
摘要： 2-Deoxyfortimicin A, 2-deoxy-4-N-alkyl fortimicins and 2-deoxy-4-N-acyl fortimicins represented by the formula ##STR1## wherein R is selected from the group consisting of acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, an amino acid residue, hydroxyacyl, loweralkyl, aminoloweralkyl, N-monoloweralkylaminoloweralkyl, hydroxyloweralkyl, N-N-diloweralkylaminoloweralkyl or hydroxysubstituted aminoloweralkyl, and the pharmaceutically acceptable salts thereof; intermediates therefor; and pharmaceutical compositions containing the compounds of this invention.
摘要翻译： 2-脱氧有益霉素A，2-脱氧-4-N-烷基苦味蛋白和由式“IMAGE”表示的2-脱氧-4-N-酰基酪氨酸，其中R选自酰基，氨基酰基，N-单低级烷基氨基酰基， N，N-二烷基氨基酰基，羟基取代的酰基酰基，氨基酸残基，羟基酰基，低级烷基，氨基低级烷基，N-单低级烷基氨基低级烷基，羟基低级烷基，N，N'-二低级烷基氨基低级烷基或羟基取代的氨基低级烷基。中间体和含有本发明化合物的药物组合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式