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1. 发明授权

US4360666A 2-Deoxyfortimicin A, 4-N-alkyl and 4-N-acyl-2-deoxyfortimicin B derivatives and intermediates therefor 失效
标题翻译： 2-脱氧有益霉素A，4-N-烷基和4-N-酰基-2-脱氧有机霉素B衍生物及其中间体
公开(公告)号：US4360666A
公开(公告)日：1982-11-23
申请号：US266030
申请日：1981-05-22
申请人： John S. Tadanier , Jerry R. Martin , Paulette Collum
发明人： John S. Tadanier , Jerry R. Martin , Paulette Collum
IPC分类号： C07H15/224
CPC分类号： C07H15/224
摘要： 2-Deoxyfortimicin A, 2-deoxy-4-N-alkyl fortimicins and 2-deoxy-4-N-acyl fortimicins represented by the formula ##STR1## wherein R is selected from the group consisting of acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, an amino acid residue, hydroxyacyl, loweralkyl, aminoloweralkyl, N-monoloweralkylaminoloweralkyl, hydroxyloweralkyl, N-N-diloweralkylaminoloweralkyl or hydroxy-substituted aminoloweralkyl, and the pharmaceutically acceptable salts thereof; intermediates therefor; and pharmaceutical compositions containing the compounds of this invention.
摘要翻译： 2-脱氧有益霉素A，2-脱氧-4-N-烷基苦味蛋白和由式“IMAGE”表示的2-脱氧-4-N-酰基酪氨酸，其中R选自酰基，氨基酰基，N-单低级烷基氨基酰基， N，N-二烷基氨基酰基，羟基取代的酰基酰基，氨基酸残基，羟基酰基，低级烷基，氨基低级烷基，N-单低级烷基氨基低级烷基，羟基低级烷基，N，N-二烷基氨基低级烷基或羟基取代的氨基低级烷基。中间体和含有本发明化合物的药物组合物。

2. 发明授权

US4187298A 2'N-acyl and alkyl fortimicin B and derivatives, 4,2'-N,N'diacyl and dialkyl fortimicin B derivatives 4-N-acyl-2'-N-alkyl and 4-N-alkyl-2'-N-acyl fortimicin B derivatives 失效
标题翻译： 2'N-酰基和烷基苦味蛋白B及其衍生物，4,2'-N，N'-二酰基和二烷基苦味蛋白B衍生物4-N-酰基-2'-N-烷基和4-N-烷基-2'- -acyl fortimicin B衍生物
公开(公告)号：US4187298A
公开(公告)日：1980-02-05
申请号：US863012
申请日：1977-12-21
申请人： Jerry R. Martin , John S. Tadanier , Paulette Collum
发明人： Jerry R. Martin , John S. Tadanier , Paulette Collum
IPC分类号： C07H15/224 , A61K31/71 , C07H15/22
CPC分类号： C07H15/224
摘要： 2'-N-Acyl and alkyl fortimicin B and fortimicin B derivatives, 4,2'-N,N'-diacyl and dialkyl derivatives, 4-N-acyl-2'-N-alkyl and 4-N-alkyl-2'-N-acyl fortimicin B derivatives represented by the formula ##STR1## wherein: R is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl or N,N-diloweralkylaminohydroxyloweralkyl; and R.sub.1 is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, an amino acid residue, hydroxyacyl, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkylaminohydroxyloweralkyl or hydrogen and the pharmaceutically acceptable salts thereof; pharmaceutical compositions containing the compounds; and methods of making and using the compounds. The compounds are useful as antibiotics, intermediates, and are further useful in making moth proofing agents and pickling inhibitors.
摘要翻译： 2-N-酰基和烷基维生素B和fortimicin B衍生物，4,2'-N，N'-二酰基和二烷基衍生物，4-N-酰基-2'-N-烷基和4-N-烷基-2 其中：R是酰基，氨基酰基，N-单低级烷基氨基酰基，N，N-二低级烷基氨基酰基，羟基取代的酰基酰基，羟基酰基，氨基酸残基，低级烷基，氨基低级烷基，羟基低级烷基 N，N-二烷基氨基低级烷基，N，N-二烷基氨基低级烷基，氨基羟基低级烷基，N-低级烷基氨基羟基低级烷基或N，氨基酸残基，羟基酰基，低级烷基，氨基低级烷基，羟基低级烷基，N-低级烷基氨基低级烷基，N，N-二低级烷基氨基低级烷基，氨基羟基低级烷基，N-低级烷基氨基羟基低级烷基，N-低级烷基氨基低级烷基氨基甲酰基，，N，N-二低级烷基氨基羟基低级烷基或氢及其药学上可接受的盐; 含有这些化合物的药物组合物; 以及制备和使用该化合物的方法。这些化合物可用作抗生素，中间体，并且还可用于制备防蛀剂和酸洗抑制剂。

3. 发明授权

US4360668A 2-O-Methanesulfonylfortimicin B 失效
标题翻译： 2-O-甲磺酰基有益霉素B
公开(公告)号：US4360668A
公开(公告)日：1982-11-23
申请号：US266266
申请日：1981-05-22
申请人： Jerry R. Martin , John S. Tadanier , Paulette Collum
发明人： Jerry R. Martin , John S. Tadanier , Paulette Collum
IPC分类号： C07H15/224 , C07H15/22
CPC分类号： C07H15/224
摘要： 2-Deoxyfortimicin, A, 2-deoxy-4-N-alkyl fortimicins and 2-deoxy-4-N-acyl fortimicins represented by the formula ##STR1## wherein R is selected from the group consisting of acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, an amino acid residue, hydroxyacyl, loweralkyl, aminoloweralkyl, N-monoloweralkylaminoloweralkyl, hydroxyloweralkyl, N-N-diloweralkylaminoloweralkyl or hydroxy-substituted aminoloweralkyl, and the pharmaceutically acceptable salts thereof; intermediates therefor; and pharmaceutical compositions containing the compounds of this invention.
摘要翻译：由式“IMAGE”表示的2-脱氧有机霉素，A，2-脱氧-4-N-烷基苦味蛋白和2-脱氧-4-N-酰基苦味霉素，其中R选自酰基，氨基酰基，N-单低级烷基氨基酰基 N，N-二烷基氨基酰基，羟基取代的酰基酰基，氨基酸残基，羟基酰基，低级烷基，氨基低级烷基，N-单低级烷基氨基低级烷基，羟基低级烷基，N，N-二烷基氨基低级烷基或羟基取代的氨基低级烷基。中间体和含有本发明化合物的药物组合物。

4. 发明授权

US4276413A Fortimicin intermediates for producing 2-deoxyfortimicins 失效
标题翻译：用于生产2-脱氧舒缓素的富咪咪嗪中间体
公开(公告)号：US4276413A
公开(公告)日：1981-06-30
申请号：US91864
申请日：1979-11-06
申请人： Jerry R. Martin , John S. Tadanier , Paulette Collum
发明人： Jerry R. Martin , John S. Tadanier , Paulette Collum
IPC分类号： C07H15/224 , C07H15/20
CPC分类号： C07H15/224
摘要： 2-Deoxyfortimicin A, 2-deoxy-4-N-alkyl fortimicins and 2-deoxy-4-N-acyl fortimicins represented by the formula ##STR1## wherein R is selected from the group consisting of acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, an amino acid residue, hydroxyacyl, loweralkyl, aminoloweralkyl, N-monoloweralkylaminoloweralkyl, hydroxyloweralkyl, N-N-diloweralkylaminoloweralkyl or hydroxysubstituted aminoloweralkyl, and the pharmaceutically acceptable salts thereof; intermediates therefor; and pharmaceutical compositions containing the compounds of this invention.
摘要翻译： 2-脱氧有益霉素A，2-脱氧-4-N-烷基苦味蛋白和由式“IMAGE”表示的2-脱氧-4-N-酰基酪氨酸，其中R选自酰基，氨基酰基，N-单低级烷基氨基酰基， N，N-二烷基氨基酰基，羟基取代的酰基酰基，氨基酸残基，羟基酰基，低级烷基，氨基低级烷基，N-单低级烷基氨基低级烷基，羟基低级烷基，N，N'-二低级烷基氨基低级烷基或羟基取代的氨基低级烷基。中间体和含有本发明化合物的药物组合物。

5. 发明授权

US4187297A 3-De-O-methyl-2-N-acyl and alkyl fortimicins A and B 失效
标题翻译： 3-脱-O-甲基-2-N-酰基和烷基fortimicins A和B
公开(公告)号：US4187297A
公开(公告)日：1980-02-05
申请号：US863014
申请日：1977-12-21
申请人： Jerry R. Martin , John S. Tadanier , Paulette Collum
发明人： Jerry R. Martin , John S. Tadanier , Paulette Collum
IPC分类号： A01N43/14 , C07H15/224 , A61K31/71 , C07H15/22
CPC分类号： C07H15/224
摘要： 3-De-O-methyl-2'-N-acyl and alkyl fortimicin B derivatives represented by the formula ##STR1## wherein R is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl N,N-diloweralkylaminohydroxyloweralkyl; and R.sub.1 is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, an amino acid residue, hydroxyacyl, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkylaminohydroxyloweralkyl, hydrogen; the pharmaceutically acceptable salts thereof; pharmaceutical compositions containing the compounds; and methods of making and using the compounds. The compounds are antibiotics.
摘要翻译：其中R是酰基，氨基酰基，N-单低级烷基氨基酰基，N，N-二低级烷基氨基酰基，羟基取代的氨基酰基，羟基酰基，羟基酰基，氨基酸残基，低级烷基，氨基低级烷基，羟基低级烷基，N-低级烷基氨基低级烷基，N，N-二低级烷基氨基低级烷基，氨基羟基低级烷基，N-低级烷基氨基羟基低级烷基，N，N-二烷基氨基羟基低级烷基。氨基酸残基，羟基酰基，低级烷基，氨基低级烷基，羟基低级烷基，N-低级烷基氨基低级烷基，N，N-二低级烷基氨基低级烷基，氨基羟基低级烷基，N-低级烷基氨基羟基低级烷基，N-低级烷基氨基低级烷基氨基甲酰基，，N，N-二低级烷基氨基羟基低级烷基，氢; 其药学上可接受的盐; 含有这些化合物的药物组合物; 以及制备和使用该化合物的方法。这些化合物是抗生素。

6. 发明授权

US4319022A 2-O-Substituted sulfonyl derivatives of fortimicin B 失效
标题翻译： fortimicin B的2-O-取代磺酰基衍生物
公开(公告)号：US4319022A
公开(公告)日：1982-03-09
申请号：US131468
申请日：1980-04-27
申请人： Jerry R. Martin , John S. Tadanier , Paulette Collum
发明人： Jerry R. Martin , John S. Tadanier , Paulette Collum
IPC分类号： C07H15/224 , A61K31/71 , C07H15/22
CPC分类号： C07H15/224
摘要： A new fortimicin antibiotic, 2-deoxyfortimicin B, intermediates useful in the preparation of the compound, methods of making and using the compound and compositions containing 2-deoxyfortimicin B.
摘要翻译：一种新的fortimicin抗生素，2-脱氧好坏疽蛋白B，可用于制备化合物的中间体，制备和使用该化合物的方法和含有2-脱氧好坏疽蛋白B的组合物。

7. 发明授权

US4317904A 1,2-Epiminofortimicin B 失效
标题翻译： 1,2-二亚麻黄素B
公开(公告)号：US4317904A
公开(公告)日：1982-03-02
申请号：US131147
申请日：1979-04-27
申请人： Jerry R. Martin , John S. Tadanier , Paulette Collum
发明人： Jerry R. Martin , John S. Tadanier , Paulette Collum
IPC分类号： C07H15/224 , C07H15/22
CPC分类号： C07H15/224
摘要： A new fortimicin antibiotic, 2-deoxyfortimicin B, intermediates useful in the preparation of the compound, methods of making and using the compound and compositions containing 2-deoxyfortimicin B.
摘要翻译：一种新的fortimicin抗生素，2-脱氧好坏疽蛋白B，可用于制备化合物的中间体，制备和使用该化合物的方法和含有2-脱氧好坏疽蛋白B的组合物。

8. 发明授权

US4176178A 2-Deoxy-2'-N-acyl and alkyl fortimicins A and B 失效
标题翻译： 2-脱氧-2'-N-酰基和烷基苦味素A和B
公开(公告)号：US4176178A
公开(公告)日：1979-11-27
申请号：US863011
申请日：1977-12-21
申请人： Jerry R. Martin , John S. Tadanier , Paulette Collum
发明人： Jerry R. Martin , John S. Tadanier , Paulette Collum
IPC分类号： C07H15/224 , A61K31/71 , C07H15/22
CPC分类号： C07H15/224
摘要： 2-Deoxy-2'-N-acyl and alkyl fortimicin B and derivatives, 4,2'-N,N'-diacyl and dialkyl fortimicin B derivatives, 4-N-acyl-2'-N-alkyl- and 4-N-alkyl-2'-N-acyl fortimicin B derivatives represented by the formula ##STR1## wherein R is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl or N,N-diloweralkylaminohydroxyloweralkyl; and R.sub.1 is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkylaminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkylaminohydroxyloweralkyl, hydrogen; and the pharmaceutically acceptable salts therefor, pharmaceutical compositions containing the compounds and methods of making and using the compounds. The compounds of this invention are useful as antibiotics.
摘要翻译： 2-脱氧-2'-N-酰基和烷基苦味蛋白B及其衍生物，4,2'-N，N'-二酰基和二烷基苦味蛋白B衍生物，4-N-酰基-2'-N-烷基 - 和4- 其中R是酰基，氨基酰基，N-单低级烷基氨基酰基，N，N-二低级烷基氨基酰基，羟基取代的酰基酰基，羟基酰基，氨基酸残基，低级烷基，氨基低级烷基，羟基低级烷基，N-低级烷基氨基低级烷基，N，N-二低级烷基氨基低级烷基，氨基羟基低级烷基，N-低级烷基氨基羟基低级烷基或N，并且R 1是酰基，氨基酰基，N-单低级烷基氨基酰基，N，N-二低级烷基氨基酰基，羟基取代的酰基酰基，羟基酰基，氨基酸残基，低级烷基氨基低级烷基，羟基低级烷基，N-低级烷基氨基低级烷基，N，N-二烷基氨基低级烷基，氨基羟基低级烷基，N-低级烷基氨基羟基低级烷基，N-二烷基氨基羟基低级烷基，氢; 及其药学上可接受的盐，含有该化合物的药物组合物和制备和使用该化合物的方法。本发明的化合物可用作抗生素。

9. 发明授权

US4360667A (1,2',6'-Tri-N-(2-O-methanesulfonylsalicylidine)-4,5-(2-O-methanesulfonyl salicylaldehyde) oxazolidine-2-O-methanesulfonylfortimicin B 失效
标题翻译：（1,2'，6'-三-N-（2-O-甲磺酰基水杨基）-4,5-（2-O-甲磺酰水杨醛）恶唑烷-2-基 - 甲磺酰基有益霉素B
公开(公告)号：US4360667A
公开(公告)日：1982-11-23
申请号：US266031
申请日：1981-05-22
申请人： John S. Tadanier , Jerry R. Martin , Paulette Collum
发明人： John S. Tadanier , Jerry R. Martin , Paulette Collum
IPC分类号： C07H15/224 , C07H15/22 , A61K31/71
CPC分类号： C07H15/224
摘要： 2-Deoxyfortimicin A, 2-deoxy-4-N-alkyl fortimicins and 2-deoxy-4-N-acyl fortimicins represented by the formula ##STR1## wherein R is selected from the group consisting of acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, an amino acid residue, hydroxyacyl, loweralkyl, aminoloweralkyl, N-monoloweralkylaminoloweralkyl, hydroxyloweralkyl, N-N-diloweralkylaminoloweralkyl or hydroxy-substituted aminoloweralkyl, and the pharmaceutically acceptable salts thereof; intermediates therefor; and pharmaceutical compositions containing the compounds of this invention.
摘要翻译： 2-脱氧有益霉素A，2-脱氧-4-N-烷基苦味蛋白和由式“IMAGE”表示的2-脱氧-4-N-酰基酪氨酸，其中R选自酰基，氨基酰基，N-单低级烷基氨基酰基， N，N-二烷基氨基酰基，羟基取代的酰基酰基，氨基酸残基，羟基酰基，低级烷基，氨基低级烷基，N-单低级烷基氨基低级烷基，羟基低级烷基，N，N-二烷基氨基低级烷基或羟基取代的氨基低级烷基。中间体和含有本发明化合物的药物组合物。

10. 发明授权

US4273924A 2-O-Hydrocarbonsulfonyl-4,5-oxazolidine fortimicin B derivatives 失效
标题翻译： 2-O-烃基磺酰基-4,5-恶唑烷fortimicin B衍生物
公开(公告)号：US4273924A
公开(公告)日：1981-06-16
申请号：US71344
申请日：1979-04-27
申请人： Jerry R. Martin , John S. Tadanier , Paulette Collum
发明人： Jerry R. Martin , John S. Tadanier , Paulette Collum
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/224 , C07H15/22
CPC分类号： C07H15/224 , Y02P20/55
摘要： A new fortimicin antibiotic, 2-deoxyfortimicin B, intermediates useful in the preparation of the compound, methods of making and using the compound and compositions containing 2-deoxyfortimicin B.
摘要翻译：一种新的fortimicin抗生素，2-脱氧好坏疽蛋白B，可用于制备化合物的中间体，制备和使用该化合物的方法和含有2-脱氧好坏疽蛋白B的组合物。

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