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1. 发明授权

US4952812A Irradiation of blood products 失效
标题翻译：血液制品的照射
公开(公告)号：US4952812A
公开(公告)日：1990-08-28
申请号：US346202
申请日：1989-05-02
申请人： Jeffrey E. Miripol , Arnold Bilstad , John Foley , Dean Glash , William R. Bratten
发明人： Jeffrey E. Miripol , Arnold Bilstad , John Foley , Dean Glash , William R. Bratten
IPC分类号： A61J3/00 , A61K35/14 , A61L2/00 , A61L2/10 , A61M1/36
CPC分类号： A61M1/3681 , A61L2/0011 , A61M1/3616
摘要： A thin film or layer of white blood cells, such as the contaminating white cells in a platelet concentrate, is irradiated with ultraviolet radiation predominately of a wavelength of 280 to 320 nanometers, and preferably at an intensity of 4 to 20 milliwatts per square cm. to provide a total energy exposure of typically 800 to 20,000 millijoules per square cm. of ultraviolet radiation. The white blood cells so produced substantially lose their capability to set off an immune reaction in an alloimmunized patient. The white blood cells may preferably be placed into such film in a flat, flexible bag made of poly(ethylene-vinyl acetate) plastic, with the flat, flexible bag being stretched in a direction normal to the path of ultraviolet radiation. Novel irradiating devices are also disclosed.
摘要翻译：用血小板浓缩物中的污染白细胞的薄膜或白细胞层照射紫外线，主要是波长为280至320纳米，优选强度为4至20毫瓦每平方厘米。以提供通常为800至20,000毫焦耳/平方厘米的总能量暴露。的紫外线辐射。如此产生的白血球大大丧失了在同种异体免疫的患者中引发免疫反应的能力。白血细胞可以优选地放置在由聚（乙烯 - 乙酸乙烯酯）塑料制成的平坦柔性袋中的这种膜中，其中平的柔性袋沿着垂直于紫外线辐射的方向被拉伸。还公开了新颖的照射装置。

2. 发明授权

US4866282A Irradiation of blood products 失效
标题翻译：血液制品的照射
公开(公告)号：US4866282A
公开(公告)日：1989-09-12
申请号：US156637
申请日：1988-02-17
申请人： Jeffrey E. Miripol , Arnold Bilstad , John Foley , Dean Glash
发明人： Jeffrey E. Miripol , Arnold Bilstad , John Foley , Dean Glash
IPC分类号： A61M1/36
CPC分类号： A61M1/3681 , A61M1/3616
摘要： A thin film of white blood cells is irradiated with ultraviolet radiation predominately of a wavelength of 280 to 320 nanometers, and preferably at an intensity of 4 to 15 milliwatts per square cm. At such a radiation intensity it is not necessary to agitate the thin film of white blood cells to accomplish the purposes of this invention. The white blood cells so processed substantially lose their capability to set off an immune reaction in an alloimmunized patient. The white blood cells may preferably be placed into such film in a flat, flexible bag made of poly(ethylene-vinyl acetate) plastic, with the flat, flexible bag being stretched in a direction normal to the path of ultraviolet radiation.
摘要翻译：用紫外线辐射主要为280〜320nm的波长的白细胞的薄膜，优选为4〜15毫瓦每平方厘米的强度。在这样的辐射强度下，不需要搅动白细胞的薄膜来实现本发明的目的。如此处理的白细胞基本上丧失了在同种异体免疫的患者中引起免疫反应的能力。白血细胞可以优选地放置在由聚（乙烯 - 乙酸乙烯酯）塑料制成的平坦柔性袋中的这种膜中，其中平的柔性袋沿着垂直于紫外线辐射的方向被拉伸。

3. 发明授权

US4726949A Irradiation of blood products 失效
标题翻译：血液制品的照射
公开(公告)号：US4726949A
公开(公告)日：1988-02-23
申请号：US900217
申请日：1986-08-26
申请人： Jeffrey E. Miripol , Arnold Bilstad , John Foley , Dean Glash
发明人： Jeffrey E. Miripol , Arnold Bilstad , John Foley , Dean Glash
IPC分类号： A61K35/14 , A61M1/36
CPC分类号： A61M1/3681 , A61M1/3616
摘要： A thin film of white blood cells is irradiated with ultraviolet radiation predominately of a wavelength of 280 to 320 nanometers, and preferably at an intensity of 4 to 15 milliwatts per square cm. At such a radiation intensity it is not necessary to agitate the thin film of white blood cells to accomplish the purposes of this invention. The white blood cells so processed substantially lose their capability to set off an immune reaction in an alloimmunized patient. The white blood cells may preferably be placed into such film in a flat, flexible bag made of poly(ethylene-vinyl acetate) plastic, with the flat, flexible bag being stretched in a direction normal to the path of ultraviolet radiation.
摘要翻译：用紫外线辐射主要为280〜320nm的波长的白细胞的薄膜，优选为4〜15毫瓦每平方厘米的强度。在这样的辐射强度下，不需要搅动白细胞的薄膜来实现本发明的目的。如此处理的白细胞基本上丧失了在同种异体免疫的患者中引起免疫反应的能力。白血细胞可以优选地放置在由聚（乙烯 - 乙酸乙烯酯）塑料制成的平坦柔性袋中的这种膜中，其中平的柔性袋沿着垂直于紫外线辐射的方向被拉伸。

4. 发明授权

US5858016A Sterile/aseptic connector 失效
标题翻译：无菌/无菌连接器
公开(公告)号：US5858016A
公开(公告)日：1999-01-12
申请号：US914169
申请日：1992-07-14
申请人： David Bacehowski , David Cerny , Dean Glash , Richard Afflerbaugh , Joseph West, Jr.
发明人： David Bacehowski , David Cerny , Dean Glash , Richard Afflerbaugh , Joseph West, Jr.
IPC分类号： A61J1/14 , A61J1/00 , A61J1/10 , A61J1/20 , A61J3/00 , A61M39/14 , B29C65/00 , B29C65/04 , B29C65/74 , B29L22/00 , A61B19/00
CPC分类号： A61J1/2089 , A61M39/143 , B29C65/04 , B29C65/743 , B29C66/1122 , B29C66/43 , B29C66/4312 , B29C66/723 , B29C66/73115 , B29C66/81422 , B29C66/81427 , B29C66/8322 , B29C66/83221 , B29C66/857 , B29C66/8614 , A61J1/10 , A61J1/2027 , B29C2793/0045 , B29C66/71 , B29C66/73143 , B29L2023/007 , B29L2031/7148
摘要： An aseptic/sterile fluid connection between two containers is formed by radio frequency sealing together portions of transfer regions of two containers. Each transfer region has a layer of a relatively high melt temperature material such as a rubber or elastomer positioned between two outer container walls made of a flexible thermoplastic, for example polyvinyl chloride. The transfer regions are placed in registry, and the radio frequency welding fuses together portions of adjacent container outer walls and forms a fluid opening therethrough.
摘要翻译：两个容器之间的无菌/无菌流体连接通过射频密封在一起两个容器的转移区域的部分而形成。每个转移区域具有相对较高的熔融温度材料的层，例如位于由柔性热塑性塑料例如聚氯乙烯制成的两个外部容器壁之间的橡胶或弹性体。转印区域被放置在对准中，并且射频焊接将相邻的容器外壁的部分熔合在一起并形成通过其的流体开口。

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