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1. 发明申请

US20050032205A1 In vitro cell culture employing a fibrin network in a flexible gas permeable container 审中-公开
标题翻译：在柔性透气容器中使用纤维蛋白网络的体外细胞培养
公开(公告)号：US20050032205A1
公开(公告)日：2005-02-10
申请号：US10634663
申请日：2003-08-05
申请人： Sidney Smith , Stephen Smith , James Diorio , Susan Young , David Bacehowski , T. Dennehey
发明人： Sidney Smith , Stephen Smith , James Diorio , Susan Young , David Bacehowski , T. Dennehey
IPC分类号： C12M1/00 , C12M3/04 , C12N5/02
CPC分类号： C12M23/24 , C12M23/14 , C12M25/14
摘要： This invention relates to in vitro cell culture employing a fibrin network in a flexible gas permeable container. Specifically, the invention is directed to a cell culture container comprising a flexible, gas permeable material with fibrin matrix which is conducive to the culture of anchorage dependent cells, and the container is suitable for use in closed system in vitro cell culture. The gas permeability of the container is sufficient to permit cellular respiration.
摘要翻译：本发明涉及使用柔性透气性容器中的纤维蛋白网络的体外细胞培养。具体而言，本发明涉及一种细胞培养容器，其包括具有纤维蛋白基质的柔性透气材料，其有利于锚定依赖细胞的培养，并且该容器适用于封闭系统的体外细胞培养。容器的气体渗透性足以允许细胞呼吸。

2. 发明授权

US5858016A Sterile/aseptic connector 失效
标题翻译：无菌/无菌连接器
公开(公告)号：US5858016A
公开(公告)日：1999-01-12
申请号：US914169
申请日：1992-07-14
申请人： David Bacehowski , David Cerny , Dean Glash , Richard Afflerbaugh , Joseph West, Jr.
发明人： David Bacehowski , David Cerny , Dean Glash , Richard Afflerbaugh , Joseph West, Jr.
IPC分类号： A61J1/14 , A61J1/00 , A61J1/10 , A61J1/20 , A61J3/00 , A61M39/14 , B29C65/00 , B29C65/04 , B29C65/74 , B29L22/00 , A61B19/00
CPC分类号： A61J1/2089 , A61M39/143 , B29C65/04 , B29C65/743 , B29C66/1122 , B29C66/43 , B29C66/4312 , B29C66/723 , B29C66/73115 , B29C66/81422 , B29C66/81427 , B29C66/8322 , B29C66/83221 , B29C66/857 , B29C66/8614 , A61J1/10 , A61J1/2027 , B29C2793/0045 , B29C66/71 , B29C66/73143 , B29L2023/007 , B29L2031/7148
摘要： An aseptic/sterile fluid connection between two containers is formed by radio frequency sealing together portions of transfer regions of two containers. Each transfer region has a layer of a relatively high melt temperature material such as a rubber or elastomer positioned between two outer container walls made of a flexible thermoplastic, for example polyvinyl chloride. The transfer regions are placed in registry, and the radio frequency welding fuses together portions of adjacent container outer walls and forms a fluid opening therethrough.
摘要翻译：两个容器之间的无菌/无菌流体连接通过射频密封在一起两个容器的转移区域的部分而形成。每个转移区域具有相对较高的熔融温度材料的层，例如位于由柔性热塑性塑料例如聚氯乙烯制成的两个外部容器壁之间的橡胶或弹性体。转印区域被放置在对准中，并且射频焊接将相邻的容器外壁的部分熔合在一起并形成通过其的流体开口。

3. 发明申请

US20060091155A1 Flexible bag for fluent material dispenser 有权
标题翻译：柔性袋用于流畅的材料分配器
公开(公告)号：US20060091155A1
公开(公告)日：2006-05-04
申请号：US11311601
申请日：2005-12-19
申请人： Hal Danby , Michael Scharf , Julian Swan , David Bacehowski
发明人： Hal Danby , Michael Scharf , Julian Swan , David Bacehowski
IPC分类号： B65D35/56
CPC分类号： B67D1/0037 , B65D77/30 , B65D2231/004 , B67D1/0078 , B67D1/0079 , B67D1/0462 , B67D1/0801 , B67D1/1286 , B67D3/041 , B67D2001/0814 , B67D2210/0006
摘要： A flexible bag having expansible and collapsible cells can be used in a liquid dispenser. A rigid manifold, and in one instance a rigid frame is provided in the bag to keep passages open in use and to isolate one of the cells from the remaining cells. The manifold is capable of altering the volume of one of the cells so that the same bag can be used in different applications.
摘要翻译：具有可膨胀和可折叠细胞的柔性袋可用于液体分配器。刚性歧管，并且在一个实例中，刚性框架设置在袋中以在使用中保持通道开放并且将其中一个电池与剩余的电池隔离。歧管能够改变其中一个电池的体积，使得相同的袋可以在不同的应用中使用。

4. 发明授权

US4417753A Method and apparatus for joining materials 失效
标题翻译：用于连接材料的方法和装置
公开(公告)号：US4417753A
公开(公告)日：1983-11-29
申请号：US265933
申请日：1981-05-21
申请人： David Bacehowski , Paul Measells , Kenneth Zabielski
发明人： David Bacehowski , Paul Measells , Kenneth Zabielski
IPC分类号： B32B1/02 , A61J1/05 , A61J1/10 , B29C35/02 , B29C65/00 , B29C65/02 , B29C65/04 , B29C65/50 , B32B37/00 , B32B43/00 , F16L47/02 , F16L13/02
CPC分类号： A61J1/10 , B29C65/02 , B29C65/5021 , B29C65/5057 , B29C66/1122 , B29C66/5221 , B29C66/52298 , B29C66/5344 , B29C66/712 , B29C66/723 , B29C66/73116 , B29C66/73921 , F16L47/02 , B29C35/0227 , B29C65/04 , B29C65/4895 , B29C66/53262 , B29C66/71 , B29K2105/0085 , B29L2023/22 , B29L2031/7148
摘要： A method and apparatus for joining sealingly incompatible plastic materials is disclosed. A coextruded connector (10) with separate, telescopically related layers (12,14) is affixed to one of the materials. The outer layer (14) of connector (10) is composed of a polymer specifically selected to melt or deform at a temperature lower than that of inner layer (12). The connector is frictionally fit within a second material to be joined and the connection is heated to a temperature sufficient to melt or deform outer layer (14) without melting inner layer (12). Outer layer 14 is thereby securely fused to the second material or blood container.A secondary embodiment is disclosed for joining materials of similar composition. Two coextruded connectors (40,46), having telescopically related layers composed of different polymer materials, are formed, as above, but the layer sequence of each connector is opposite to the other. The connectors (40,46) are sized to frictionally fit one within the other and the layers (42,48) in facing contact are composed of a material selected to melt or deform at a temperature lower than the nonfacing layers (44,50). For joining, the connectors (40,46) are affixed to the materials to be joined and then fit one within the other. The connection is then heated to a temperature sufficient to cause the lower melting, facing layers (42,48) to fuse together.
摘要翻译：公开了一种用于接合密封不兼容的塑料材料的方法和装置。具有单独的可伸缩相关层（12,14）的共挤出连接器（10）被固定到所述材料之一。连接器（10）的外层（14）由特别选择为在比内层（12）的温度低的温度下熔化或变形的聚合物构成。连接器摩擦配合在待接合的第二材料内，并将连接件加热到足以熔化或变形外层（14）而不熔化内层（12）的温度。因此，外层14牢固地熔合到第二材料或血液容器。公开了用于连接具有相似组成的材料的第二实施例。如上所述，形成具有由不同聚合物材料构成的伸缩相关层的两个共挤出连接器（40,46），但是每个连接器的层序列彼此相反。连接器（40,46）的尺寸被设计成摩擦地配合在另一个中，并且面对接触中的层（42,48）由选择成在低于非表面层（44,50）的温度下熔化或变形的材料构成，。为了接合，连接器（40,46）固定到待连接的材料上，然后将其连接在另一个中。然后将连接件加热到足以使较低熔化的面层（42,48）熔合在一起的温度。

5. 发明授权

US4968624A Large volume flexible containers 失效
标题翻译：大容量柔性容器
公开(公告)号：US4968624A
公开(公告)日：1990-11-06
申请号：US342915
申请日：1989-04-25
申请人： David Bacehowski , Arnold Bilstad , Michael R. Keilman
发明人： David Bacehowski , Arnold Bilstad , Michael R. Keilman
IPC分类号： C12M1/00 , C12M3/00
CPC分类号： C12M23/14 , B65D77/065 , B65D81/107 , C12M29/06
摘要： The present invention provides a large volume flexible container capable of containing a fluid to be maintained under sterile conditions. The container comprises an inner liner constructed from a polyolefin that defines an interior of the container and an outer liner constructed from a three-layer laminate. The laminate includes an inner layer constructed from a polyolefin that will, upon the application of sufficient energy, bond to the polyolefin of the inner liner, a middle layer constructed from a barrier material, and an outer layer; the inner liner and outer liner being sealed together along edges of the container. At least one tube member, for accessing the container, extends from a face of the container, and includes an end that is secured to the container, a length of flexible tubing for defining a channel through which fluid can flow, and a connector at a second end. A structure for housing the container is also provided.
摘要翻译：本发明提供一种能够容纳要在无菌条件下保持的流体的大容积柔性容器。容器包括由限定容器内部的聚烯烃构成的内衬层和由三层层压体构成的外衬垫。层压体包括由聚烯烃构成的内层，其将在施加足够的能量时粘合到内衬的聚烯烃上，由阻挡材料构成的中间层和外层; 内衬和外衬层沿容器的边缘密封在一起。用于接近容器的至少一个管构件从容器的表面延伸，并且包括固定到容器的端部，用于限定流体可以流过的通道的一段柔性管道，以及连接器第二端还提供了一种用于容纳容器的结构。

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