专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06608883B2 Automated sample handling for X-ray crystallography 有权
标题翻译：自动样品处理X射线晶体学
公开(公告)号：US06608883B2
公开(公告)日：2003-08-19
申请号：US10144277
申请日：2002-05-10
申请人： Jeffrey A. Olson , Ronald B. Jones , Vicki L. Nienaber , Steven W. Muchmore , Jeffrey Y. Pan , Jonathan Greer
发明人： Jeffrey A. Olson , Ronald B. Jones , Vicki L. Nienaber , Steven W. Muchmore , Jeffrey Y. Pan , Jonathan Greer
IPC分类号： G01N2320
CPC分类号： G01N23/20 , Y10T436/25
摘要： Method for mounting a sample comprising a crystal for X-ray crystallographic analysis, a method for aligning a sample comprising a crystal for X-ray crystallographic analysis, which sample is mounted on a positioning device, and a method for determining the structure of a sample containing a crystal by means of X-ray crystallography. The method includes activating a robot so that the tool retrieves the crystal holder, receives a sufficient amount of a fluid to maintain the crystal in the crystal holder at a temperature not in excess of about 160 degrees K, transfers the retrieved crystal holder to a positioning device, and mounts the transferred crystal holder on the positioning device, whereby the crystal in the retrieved crystal holder is maintained at a temperature not in excess of about 160 degrees K.
摘要翻译：用于安装包括用于X射线晶体学分析的晶体的样品的方法，将包含用于X射线晶体学分析的晶体的样品对准的方法，该样品安装在定位装置上，以及用于确定样品结构的方法通过X射线晶体学包含晶体。该方法包括激活机器人，使得工具检索晶体保持器，接收足够量的流体以将晶体保持在不超过约160度K的温度下，将检索到的晶体保持器传送到定位装置，并将转移的晶体保持器安装在定位装置上，由此将回收的晶体保持器中的晶体保持在不超过约160度K的温度。

2. 发明授权

US06404849B1 Automated sample handling for X-ray crystallography 有权
标题翻译：自动样品处理X射线晶体学
公开(公告)号：US06404849B1
公开(公告)日：2002-06-11
申请号：US09372134
申请日：1999-08-11
申请人： Jeffrey A. Olson , Ronald B. Jones , Vicki L. Nienaber , Steven W. Muchmore , Jeffrey Y. Pan , Jonathan Greer
发明人： Jeffrey A. Olson , Ronald B. Jones , Vicki L. Nienaber , Steven W. Muchmore , Jeffrey Y. Pan , Jonathan Greer
IPC分类号： G01N2320
CPC分类号： G01N23/20 , Y10T436/25
摘要： Method and apparatus for mounting a sample comprising a crystal for X-ray crystallographic analysis, a method for aligning a sample comprising a crystal for X-ray crystallographic analysis, which sample is mounted on a positioning device, and a method for determining the structure of a sample containing a crystal by means of X-ray crystallography.
摘要翻译：用于安装包括用于X射线晶体学分析的晶体的样品的方法和装置，用于将包含用于X射线晶体学分析的晶体的样品对准的方法，该样品安装在定位装置上，以及用于确定通过X射线晶体学包含晶体的样品。

3. 发明授权

US06297021B1 Ligand screening and design by X-ray crystallography 有权
标题翻译：配体筛选和X射线晶体学设计
公开(公告)号：US06297021B1
公开(公告)日：2001-10-02
申请号：US09263904
申请日：1999-03-05
申请人： Vicki L. Nienaber , Jonathan Greer , Celerino Abad-Zapatero , Daniel W. Norbeck
发明人： Vicki L. Nienaber , Jonathan Greer , Celerino Abad-Zapatero , Daniel W. Norbeck
IPC分类号： G01N3353
CPC分类号： G01N33/6845 , C07K2299/00 , C30B7/00 , G01N23/20 , G01N33/68 , G01N33/6803 , G01N33/6842 , G01N2333/9723 , G01N2500/00
摘要： X-ray crystallography can be used to screen compounds that are not known ligands of a target biomolecule for their ability to bind the target biomolecule. The method includes obtaining a crystal of a target biomolecule; exposing the target biomolecule crystal to one or more test samples; and obtaining an X-ray crystal diffraction pattern to determine whether a ligand/receptor complex is formed. The target is exposed to the test samples by either co-crystallizing a biomolecule in the presence of one or more test samples or soaking the biomolecule crystal in a solution of one or more test samples. In another embodiment, structural information from ligand/receptor complexes are used to design ligands that bind tighter, that bind more specifically, that have better biological activity or that have better safety profile. A further embodiment of the invention comprises identifying or designing biologically-active moieties by the instant process. In a further embodiment, a biomolecule crystal having an easily accessible active site is formed by co-crystallizing the biomolecule with a degradable ligand and degrading the ligand.
摘要翻译：可以使用X射线晶体学来筛选目标生物分子的未知配体的化合物，以获得其结合目标生物分子的能力。该方法包括获得目标生物分子的晶体; 将目标生物分子晶体暴露于一个或多个测试样品; 并获得X射线晶体衍射图以确定是否形成配体/受体复合物。靶通过在一个或多个测试样品存在下共生结晶生物分子或将生物分子晶体浸泡在样品中而暴露于测试样品一个或多个测试样品的溶液。在另一个实施方案中，使用来自配体/受体复合物的结构信息来设计更紧密结合的配体，更具体地说，具有更好的生物活性或具有更好的安全性的配体。本发明的另一个实施方案包括鉴定或设计生物活性在另一个实施方案中，具有易于接近的活性位点的生物分子晶体通过使生物分子与可降解配体共结晶并降解配体而形成。

4. 发明授权

US06495562B1 Naphthamidine urokinase inhibitors 有权
标题翻译：萘普生尿激酶抑制剂
公开(公告)号：US06495562B1
公开(公告)日：2002-12-17
申请号：US09842382
申请日：2001-04-25
申请人： Milan Bruncko , Christopher Robin Dalton , Vincent Louis Giranda , Jianchun Gong , Willian J. McClellan , Vicki L. Nienaber , Todd Warren Rockway , Daryl Richard Sauer , Moshe Weitzberg
发明人： Milan Bruncko , Christopher Robin Dalton , Vincent Louis Giranda , Jianchun Gong , Willian J. McClellan , Vicki L. Nienaber , Todd Warren Rockway , Daryl Richard Sauer , Moshe Weitzberg
IPC分类号： C07D21302
CPC分类号： C07D401/06 , C07D217/04 , C07D405/04
摘要： Compounds having the formula are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions, methods for the preparation of urokinase-inhibitors, and a method of inhibiting urokinase in a mammal.
摘要翻译：具有该化学式的化合物是尿激酶的抑制剂，并且可用于治疗尿激酶起作用的疾病。还公开了尿激酶抑制组合物，尿激酶抑制剂的制备方法和抑制哺乳动物尿激酶的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式