专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20080207610A1 ALDH-2 INHIBITORS IN THE TREATMENT OF ADDICTION 审中-公开
标题翻译： ALDH-2抑制剂在治疗中的应用
公开(公告)号：US20080207610A1
公开(公告)日：2008-08-28
申请号：US12019034
申请日：2008-01-24
申请人： Jeff Zablocki , Matthew Abelman , Michael Organ , Yaroslav Bilokin , Robert Jiang , Elfatih Elzein , Tetsuya Kobayashi , Rao Kalla , Thao Perry , Xiaofen Li , Ivan Diamond , Lina Yao , Peidong Fan , Maria Pia Arolfo , Zhan Jiang
发明人： Jeff Zablocki , Matthew Abelman , Michael Organ , Yaroslav Bilokin , Robert Jiang , Elfatih Elzein , Tetsuya Kobayashi , Rao Kalla , Thao Perry , Xiaofen Li , Ivan Diamond , Lina Yao , Peidong Fan , Maria Pia Arolfo , Zhan Jiang
IPC分类号： A61K31/5377 , C07D311/22 , A61K31/352 , A61P25/30 , C07D413/12 , A61K31/4245
CPC分类号： C07D311/36 , C07D413/12 , C07D413/14 , C07F9/65586
摘要： Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.
摘要翻译：公开了具有式I结构的新型异黄酮衍生物，其可用作用于治疗哺乳动物依赖于成瘾药物的ALDH-2抑制剂，例如对多巴胺产生剂如可卡因，吗啡，苯丙胺，尼古丁和酒精的成瘾。

2. 发明申请

US20090209533A1 ALDH-2 INHIBITORS IN THE TREATMENT OF ADDICTION 有权
标题翻译： ALDH-2抑制剂在治疗中的应用
公开(公告)号：US20090209533A1
公开(公告)日：2009-08-20
申请号：US12371398
申请日：2009-02-13
申请人： Jeff Zablocki , Matthew Abelman , Michael Organ , Yaroslav Bilokin , Elfatih Elzein , Tetsuya Kobayashi , Rao Kalla , Thao Perry , Xiaofen Li , Robert Jiang , Ivan Diamond , Lina Yao , Peidong Fan , Maria Pia Arolfo , Zhan Jiang , Wing Ming Keung , Guoxin Tao
发明人： Jeff Zablocki , Matthew Abelman , Michael Organ , Yaroslav Bilokin , Elfatih Elzein , Tetsuya Kobayashi , Rao Kalla , Thao Perry , Xiaofen Li , Robert Jiang , Ivan Diamond , Lina Yao , Peidong Fan , Maria Pia Arolfo , Zhan Jiang , Wing Ming Keung , Guoxin Tao
IPC分类号： A61K31/352 , C07D417/12 , C07D413/12 , C07D311/22 , A61K31/427 , A61K31/4245 , A61K31/5377 , A61P25/30
CPC分类号： C07D311/36 , C07D413/12 , C07D413/14 , C07F9/65586
摘要： Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.
摘要翻译：公开了具有式I结构的新型异黄酮衍生物，其可用作用于治疗哺乳动物依赖于成瘾药物的ALDH-2抑制剂，例如对多巴胺产生剂如可卡因，吗啡，苯丙胺，尼古丁和酒精的成瘾。

3. 发明授权

US08158810B2 ALDH-2 inhibitors in the treatment of addiction 有权
标题翻译： ALDH-2抑制剂治疗成瘾
公开(公告)号：US08158810B2
公开(公告)日：2012-04-17
申请号：US12371398
申请日：2009-02-13
申请人： Jeff Zablocki , Matthew Abelman , Michael Organ , Yaroslav Bilokin , Elfatih Elzein , Tetsuya Kobayashi , Rao Kalla , Thao Perry , Xiaofen Li , Robert Jiang , Ivan Diamond , Lina Yao , Peidong Fan , Maria Pia Arolfo , Zhan Jiang , Wing Ming Keung , Guoxin Tao
发明人： Jeff Zablocki , Matthew Abelman , Michael Organ , Yaroslav Bilokin , Elfatih Elzein , Tetsuya Kobayashi , Rao Kalla , Thao Perry , Xiaofen Li , Robert Jiang , Ivan Diamond , Lina Yao , Peidong Fan , Maria Pia Arolfo , Zhan Jiang , Wing Ming Keung , Guoxin Tao
IPC分类号： A61K31/35 , C07D307/77
CPC分类号： C07D311/36 , C07D413/12 , C07D413/14 , C07F9/65586
摘要： Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.
摘要翻译：公开了具有式I结构的新型异黄酮衍生物，其可用作用于治疗哺乳动物依赖于成瘾药物的ALDH-2抑制剂，例如对多巴胺产生剂如可卡因，吗啡，苯丙胺，尼古丁和酒精的成瘾。

4. 发明申请

US20080032995A1 ALDH-2 INHIBITORS IN THE TREATMENT OF DRUG ADDICTION 审中-公开
标题翻译： ALDH-2抑制剂治疗药物滥用
公开(公告)号：US20080032995A1
公开(公告)日：2008-02-07
申请号：US11829836
申请日：2007-07-27
申请人： Jeff Zablocki , Matthew Abelman , Michael Organ , Yaroslav Bilokin , Ivan Diamond , Maria Arolfo , Lina Yao , Peidong Fan , Elfatih Elzein , Rao Kalla , Thao Perry , Tetsuya Kobayshi , Xiaofen Lee , Robert Jiang
发明人： Jeff Zablocki , Matthew Abelman , Michael Organ , Yaroslav Bilokin , Ivan Diamond , Maria Arolfo , Lina Yao , Peidong Fan , Elfatih Elzein , Rao Kalla , Thao Perry , Tetsuya Kobayshi , Xiaofen Lee , Robert Jiang
IPC分类号： A61K31/352 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/496 , A61P25/30 , C07D311/04 , C07D405/02 , C07D413/02 , C07D417/02
CPC分类号： C07D413/12 , C07D311/36 , C07D413/14 , C07F9/65586
摘要： Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.
摘要翻译：公开了具有式I结构的新型异黄酮衍生物，其可用作用于治疗哺乳动物依赖于成瘾药物的ALDH-2抑制剂，例如对多巴胺产生剂如可卡因，吗啡，苯丙胺，尼古丁和酒精的成瘾。

5. 发明申请

US20090137662A1 SYNERGY OF DOPAMINE D2 AND ADENOSINE A2 RECEPTORS ACTIVATES PKA SIGNALING VIA BETA/GAMMA DIMERS 审中-公开
标题翻译：多巴胺D2和腺苷A2受体的协同作用激活PKA信号通过BETA / GAMMA DIMERS
公开(公告)号：US20090137662A1
公开(公告)日：2009-05-28
申请号：US10550331
申请日：2003-03-27
申请人： Adrienne S. Gordon , Ivan F. Diamond , Lina Yao
发明人： Adrienne S. Gordon , Ivan F. Diamond , Lina Yao
IPC分类号： A61K31/352 , C12Q1/02 , C12Q1/68
CPC分类号： A61K45/06
摘要： This invention pertains to the discovery that a dopamine receptor agonist can activate PKA signaling and/or can act synergistically with an adenosine receptor to activate such signaling. In various embodiments, this invention exploits the synergy between the dopamine receptor pathway and an adenosine receptor pathway to provide methods of mitigating one or more symptoms produced by the chronic consumption of a substance of abuse or to mitigate one or more physiological and/or behavioral symptoms associated with cessation of chronic consumption of a substance of abuse. In certain embodiments, the methods involve administering to the mammal an effective amount of an adenosine receptor antagonist; and an effective amount of a dopamine receptor antagonist; where the effective amount of the adenosine receptor antagonist is lower than the effective amount of an adenosine receptor antagonist administered without said dopamine receptor antagonist.
摘要翻译：本发明涉及多巴胺受体激动剂可以激活PKA信号传导和/或与腺苷受体协同作用以激活这种信号传递的发现。在各种实施方案中，本发明利用多巴胺受体途径和腺苷受体途径之间的协同作用来提供减轻慢性消耗滥用物质产生的一种或多种症状或减轻一种或多种生理和/或行为症状的方法与停止滥用药物的长期消费有关。在某些实施方案中，所述方法包括向哺乳动物施用有效量的腺苷受体拮抗剂; 和有效量的多巴胺受体拮抗剂; 其中腺苷受体拮抗剂的有效量低于没有所述多巴胺受体拮抗剂而给予的腺苷受体拮抗剂的有效量。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式