专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20090137662A1 SYNERGY OF DOPAMINE D2 AND ADENOSINE A2 RECEPTORS ACTIVATES PKA SIGNALING VIA BETA/GAMMA DIMERS 审中-公开
标题翻译：多巴胺D2和腺苷A2受体的协同作用激活PKA信号通过BETA / GAMMA DIMERS
公开(公告)号：US20090137662A1
公开(公告)日：2009-05-28
申请号：US10550331
申请日：2003-03-27
申请人： Adrienne S. Gordon , Ivan F. Diamond , Lina Yao
发明人： Adrienne S. Gordon , Ivan F. Diamond , Lina Yao
IPC分类号： A61K31/352 , C12Q1/02 , C12Q1/68
CPC分类号： A61K45/06
摘要： This invention pertains to the discovery that a dopamine receptor agonist can activate PKA signaling and/or can act synergistically with an adenosine receptor to activate such signaling. In various embodiments, this invention exploits the synergy between the dopamine receptor pathway and an adenosine receptor pathway to provide methods of mitigating one or more symptoms produced by the chronic consumption of a substance of abuse or to mitigate one or more physiological and/or behavioral symptoms associated with cessation of chronic consumption of a substance of abuse. In certain embodiments, the methods involve administering to the mammal an effective amount of an adenosine receptor antagonist; and an effective amount of a dopamine receptor antagonist; where the effective amount of the adenosine receptor antagonist is lower than the effective amount of an adenosine receptor antagonist administered without said dopamine receptor antagonist.
摘要翻译：本发明涉及多巴胺受体激动剂可以激活PKA信号传导和/或与腺苷受体协同作用以激活这种信号传递的发现。在各种实施方案中，本发明利用多巴胺受体途径和腺苷受体途径之间的协同作用来提供减轻慢性消耗滥用物质产生的一种或多种症状或减轻一种或多种生理和/或行为症状的方法与停止滥用药物的长期消费有关。在某些实施方案中，所述方法包括向哺乳动物施用有效量的腺苷受体拮抗剂; 和有效量的多巴胺受体拮抗剂; 其中腺苷受体拮抗剂的有效量低于没有所述多巴胺受体拮抗剂而给予的腺苷受体拮抗剂的有效量。

IPRDB

热门服务

关于我们

友情链接

联系方式