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1. 发明授权

US4888338A 5-Methoxy alkyl ammonium tetrahydrofurans and tetrahydrothiophenes as anti-PAF agents 失效
标题翻译：作为抗PAF剂的5-甲氧基烷基铵四氢呋喃和四氢噻吩
公开(公告)号：US4888338A
公开(公告)日：1989-12-19
申请号：US199939
申请日：1988-05-27
申请人： Jean-Jacques Godfroid , Pierre Braquet
发明人： Jean-Jacques Godfroid , Pierre Braquet
IPC分类号： A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/44 , A61K31/443 , A61K31/4433 , A61P7/02 , A61P9/08 , A61P37/00 , A61P37/08 , C07D307/12 , C07D333/16 , C07D405/12 , C07D409/12
CPC分类号： C07D405/12 , C07D307/12 , C07D333/16 , C07D409/12
摘要： This invention relates to new tetrahydrofurans and tetrahydrothiophenes of the general formula: ##STR1## wherein X stands for O or S, m is an integer from 1 to 12 and A is a pyridinium or an ammonium salt, to a preparation process of said compounds and to therapeutic compositions of matter containing the same.
摘要翻译：本发明涉及以下通式的新的四氢呋喃和四氢噻吩：其中X代表O或S，m是1至12的整数，A是吡啶鎓或铵盐，所述化合物的制备方法和涉及包含其的物质的治疗组合物。

2. 发明授权

US4888337A 5-oxy derivatives of tetrahydrofuran 失效
标题翻译：四氢呋喃的5-氧基衍生物
公开(公告)号：US4888337A
公开(公告)日：1989-12-19
申请号：US144238
申请日：1988-01-15
申请人： Jean-Jacques Godfroid , Francoise Heymans , Pierre Braquet
发明人： Jean-Jacques Godfroid , Francoise Heymans , Pierre Braquet
IPC分类号： A61K31/325 , A61K31/34 , A61K31/341 , A61K31/425 , A61K31/44 , A61K31/443 , A61K31/445 , A61K31/47 , A61P7/02 , A61P11/00 , C07D307/20 , C07D307/94 , C07D405/12 , C07D417/12
CPC分类号： C07D405/12 , C07D307/20 , C07D307/94 , C07D417/12
摘要： This invention relates to:(a) new tetrahydrofuran derivatives having the general formula I: ##STR1## wherein either each of R and R' independently represents a hydrogen atom or various hydrocarbon substituents and A represents either a nitrogen containing ring or an alkylammonium salt or an alkylaminoacid rest;(b) a process for the preparation of said compounds and(c) therapeutic compositions containing said compounds as an active ingredient.
摘要翻译：本发明涉及：（a）具有通式I的新的四氢呋喃衍生物：其中R和R'各自独立地表示氢原子或各种烃取代基，A表示含氮环或烷基铵盐或烷基氨基酸残基; （b）制备所述化合物的方法和（c）含有所述化合物作为活性成分的治疗组合物。

3. 发明授权

US5017588A 5-(.omega.-ammonio acyloxy methylene) tetrahydrofurans and tetrahydrothiophenes and a therapeutic composition containing same 失效
标题翻译： 5-（ω-氨基酰氧基亚甲基）四氢呋喃和四氢噻吩以及含有它们的治疗组合物
公开(公告)号：US5017588A
公开(公告)日：1991-05-21
申请号：US485448
申请日：1990-02-27
申请人： Jean-Jacques Godfroid , Pierre Braquet , Francoise Heymans
发明人： Jean-Jacques Godfroid , Pierre Braquet , Francoise Heymans
IPC分类号： A61K31/44 , A61K31/443 , A61K31/4433 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P25/28 , A61P37/06 , A61P43/00 , C07D405/12 , C07D409/12
CPC分类号： C07D405/12 , C07D409/12
摘要： This invention relates to new tetrahydrofurans and tetrahydrothiophenes of the general formula ##STR1## wherein X stands for O or S, .eta. is an integer from 1 to 6, R stands for various hydrocarbon substituents and Z.sup..crclbar. is a pharmaceutically acceptable anion, to a preparation process of said compounds and to therapeutic compositions of matter containing the same.
摘要翻译：本发明涉及通式为“IMAGE”的新的四氢呋喃和四氢噻吩，其中X代表O或S，η是1至6的整数，R代表各种烃取代基，Z（ - ）是药学上可接受的阴离子，所述化合物的制备方法和含有该化合物的物质的治疗组合物。

4. 发明授权

US5019576A 2-substituted N,N'-ditrimethoxybenzoyl piperazines and therapeutic compositions containing them 失效
标题翻译： 2-取代的N，N'-二甲氧基苯甲酰基哌嗪和含有它们的治疗组合物
公开(公告)号：US5019576A
公开(公告)日：1991-05-28
申请号：US506421
申请日：1990-04-09
申请人： Pierre Braquet , Eduardo Pirotzky , Jean-Jacques Godfroid , Francoise Heymans
发明人： Pierre Braquet , Eduardo Pirotzky , Jean-Jacques Godfroid , Francoise Heymans
IPC分类号： A61K31/495 , A61P7/02 , A61P11/08 , A61P37/08 , C07D241/04 , C07D241/12 , C07D295/192
CPC分类号： C07D295/192 , C07D241/04
摘要： This invention relates to piperazine derivatives of the general formula I ##STR1## wherein --(CH.sub.2).sub.n -- represents a straight or branched chain alkyl group having from n=1 to n=20 carbon atoms, and R represents a hydrogen atom, a branched alkyl group, a cycloalkyl group having from 5 to 10 carbon atoms, a phenyl group, optionally substituted by one or several chlorine atoms, methyl or methoxy groups, or straight or branched chain alkenyl groups having from 3 to 11 carbon atoms, to a preparation process of said compounds and to therapeutic compositions containing them as an active ingredient.
摘要翻译：本发明涉及通式I的哌嗪衍生物，其中 - （CH 2）n - 表示具有n = 1至n = 20的直链或支链烷基，R代表氢原子，具有5至10个碳原子的环烷基，任选被一个或几个氯原子取代的苯基，甲基或甲氧基，或具有3至11个碳原子的直链或支链烯基，至所述化合物和含有它们作为活性成分的治疗组合物的制备方法。

5. 发明授权

US4923870A 2-Carbonyl substituted N,N'-di-(trimethoxygenzoyl)piperazines, process for preparing the same and therapeutical compounds containing them 失效
标题翻译： 2-羰基取代的N，N'-二（三甲氧基羰基）哌嗪，其制备方法和含有它们的治疗化合物
公开(公告)号：US4923870A
公开(公告)日：1990-05-08
申请号：US418114
申请日：1989-10-06
申请人： Pierre Braquet , Georges Dive , Jean-Jacques Godfroid , Francoise Heymans , Eduardo Pirotzky
发明人： Pierre Braquet , Georges Dive , Jean-Jacques Godfroid , Francoise Heymans , Eduardo Pirotzky
IPC分类号： A61K31/495 , A61P7/02 , A61P9/08 , A61P9/10 , A61P29/00 , C07D241/04
CPC分类号： C07D241/04
摘要： This invention relates to piperazine derivatives having the general formula I: ##STR1## wherein Y stands for ##STR2## and Z represents various substituents, to be a preparation process of said compounds and to therapeutic compositions containing them as an active ingredient.
摘要翻译：本发明涉及具有通式I的哌嗪衍生物：其中Y代表“IMAGE”，Z代表各种取代基，作为所述化合物的制备方法和含有它们作为活性成分的治疗组合物。

6. 发明授权

US4904693A Octahydro indenofuran derivatives and their therapeutic compositions 失效
标题翻译：八氢吲哚呋喃衍生物及其治疗组合物
公开(公告)号：US4904693A
公开(公告)日：1990-02-27
申请号：US267438
申请日：1988-11-04
申请人： Pierre Braquet , Andre Esanu
发明人： Pierre Braquet , Andre Esanu
IPC分类号： C07D307/94 , A61K31/365 , A61P11/08 , A61P37/08 , C07D307/77 , C07D307/93
CPC分类号： C07D307/93
摘要： This invention relates to indenofuran derivatives of the formula: ##STR1## wherein R stands for H or for a ##STR2## group optionally substituted on the phenyl ring by Alk, OH or OAlk, Alk being a lower straight or branched alkyl group up to C.sub.5, to the preparation of these compounds and to therapeutic compositions containing the same in the field of anaphylaxis.
摘要翻译：本发明涉及下式的茚诺呋喃衍生物：其中R代表H或任选在苯环上被Alk，OH或OAlk取代的基团，Alk是直至C5的低级直链或支链烷基，涉及这些化合物的制备及其在过敏反应领域中含有该组合物的治疗组合物。

7. 发明授权

US5246701A Method for inhibiting production of IgE by using IL-9 inhibitors 失效
标题翻译：使用IL-9抑制剂抑制IgE产生的方法
公开(公告)号：US5246701A
公开(公告)日：1993-09-21
申请号：US807260
申请日：1991-12-13
申请人： Bernard Dugas , Catherine Druez , Pierre Braquet , Jean M. Mencia-Huerta , Catherine Uyttenhove , Jean-Christophe Renauld , Jacques Van Snick
发明人： Bernard Dugas , Catherine Druez , Pierre Braquet , Jean M. Mencia-Huerta , Catherine Uyttenhove , Jean-Christophe Renauld , Jacques Van Snick
IPC分类号： A61K38/00 , A61K38/17 , A61K38/20 , C07K14/715 , C07K16/24
CPC分类号： C07K16/247 , C07K14/7155 , C07K16/244 , A61K38/00 , Y10S424/805
摘要： A method for inhibiting production of IgE, and a method for enhancing production of IgG are taught. The methods are linked to the role of interleukin 9 in antibody production. Specifically, production of IgG is potentiated by administering either to a subject or a cell culture a combination of interleukin 4 and interleukin 9. Production of IgE is inhibited by administering an amount of an interleukin 9 inhibitor to a subject.
摘要翻译：教导了抑制IgE产生的方法以及增强IgG产生的方法。该方法与抗体生产中白细胞介素9的作用有关。具体地，通过向受试者或细胞培养物施用白细胞介素4和白介素9的组合来增强IgG的产生。通过向受试者施用一定量的白介素9抑制剂来抑制IgE的产生。

8. 发明授权

US5147856A Method for inhibiting blood vessel blockage using octapeptide compositions 失效
标题翻译：使用八肽组合物抑制血管阻塞的方法
公开(公告)号：US5147856A
公开(公告)日：1992-09-15
申请号：US329854
申请日：1989-03-28
申请人： Peter W. Ramwell , Pierre Braquet
发明人： Peter W. Ramwell , Pierre Braquet
IPC分类号： A61K38/00 , C07K14/655
CPC分类号： C07K14/6555 , A61K38/00
摘要： A method for inhibiting blood vessel blockage in a mammal particularly after a procedure such as angioplasty, an arterial bypass operation or an allograft transplant operation which comprises: administering to a mammal before, during and/or after the procedure an effective blood vessel blockage inhibiting amount of an octapeptide having the formula ##STR1## wherein each A.sub.1 and A.sub.2, independently, is H, C.sub.1-12 alkyl, C.sub.7-10 phenylalkyl, R.sub.1 CO (where R.sub.1 is C.sub.1-20 alkyl, C.sub.3-20 alkenyl, C.sub.3-20 alkinyl, phenyl, naphthyl, or C.sub.7-10 phenylalkyl), or R.sub.2 OCO (where R.sub.2 is C.sub.1-10 alkyl or C.sub.7-10 phenylalkyl), provided that when one of A.sub.1 or A.sub.2 is R.sub.1 CO or R.sub.2 OCO, the other must be H; A.sub.3 is CH.sub.2 A.sub.6 (where A.sub.6 is pentafluorophenyl, naphthyl, pyridyl, or phenyl); A.sub.4 is o-, m- or, more preferably, p-substituted X-Phe (where X is a halogen, H, NH.sub.2, NO.sub.2, OH , or C.sub.1-13 alkyl), pentafluoro-Phe, or .beta.-Nal; A.sub.5 is Thr, Ser, Phe, Val, .alpha.-aminobutyric acid, or Ile; A.sub.7 is Thr, Trp, or .beta.-Nal (and can be either the D- or L-isomer); and Z is NH.sub.2 or OH; or a pharmaceutically acceptable salt thereof.
摘要翻译：一种抑制哺乳动物血管阻塞的方法，特别是在诸如血管成形术，动脉旁路操作或同种异体移植手术的手术之后，包括：在手术之前，期间和/或之后向哺乳动物施用有效的血管阻塞抑制量具有式 + TR LA7Z的八肽，其中每个A1和A2独立地是H，C1-12烷基，C7-10苯基烷基，R1CO（其中R1是C1-20烷基，C3-20烯基，C3- 20个炔基，苯基，萘基或C7-10苯基烷基）或R2OCO（其中R2是C1-10烷基或C7-10苯基烷基），条件是当A1或A2之一为R1CO或R2OCO时，另一个必须为H; A3是CH2A6（其中A6是五氟苯基，萘基，吡啶基或苯基）; A4是邻 - ，间 - 或更优选对取代的X-Phe（其中X是卤素，H，NH 2，NO 2，OH或C 1-13烷基），五氟-Phe或β-Nal; A5是Thr，Ser，Phe，Val，α-氨基丁酸或Ile; A7是Thr，Trp或β-Nal（并且可以是D-或L-异构体）; Z是NH 2或OH; 或其药学上可接受的盐。

9. 发明授权

US4897421A Ophthalmological composition of matter and a method for treatment of ocular inflammation by said composition 失效
标题翻译：物质的眼科学成分和所述组合物治疗眼部炎症的方法
公开(公告)号：US4897421A
公开(公告)日：1990-01-30
申请号：US190761
申请日：1988-05-06
申请人： Pierre Braquet
发明人： Pierre Braquet
IPC分类号： A61K9/00 , A61K9/107 , A61K31/20 , A61P27/02 , C07C57/12
CPC分类号： A61K9/0048 , A61K31/20 , Y10S514/914
摘要： The present invention relates to an ophthalmological composition of matter comprising a suspension of eicosapentaenoic acid in an alkyl cellulose and/or hydroxyalkyl aqueous cellulose solution to be used in any case of ocular inflammation on men and/or on aminals.The invention also relates to the use of said eicosapentaenoic acid and to a method for the treatment of ocular inflammation by the same.
摘要翻译：本发明涉及一种物质的眼科学组合物，其包含二甲基茴香酸在烷基纤维素和/或羟烷基水性纤维素溶液中的悬浮液，用于任何在男性和/或其他人身上发生眼部炎症的情况。本发明还涉及所述二十碳五烯酸的用途和用于治疗眼部炎症的方法。

10. 发明授权

US5492906A Derivatives of thieno-triazolo-diazepine and therapeutic compositions containing them 失效
标题翻译：噻吩并三唑并二氮杂的衍生物和含有它们的治疗组合物
公开(公告)号：US5492906A
公开(公告)日：1996-02-20
申请号：US837580
申请日：1992-02-18
申请人： Pierre Braquet , Andre Esanu , Jean-Pierre Laurent , Alain Rolland
发明人： Pierre Braquet , Andre Esanu , Jean-Pierre Laurent , Alain Rolland
IPC分类号： A61K31/55 , A61P1/00 , A61P11/00 , A61P11/08 , A61P37/08 , C07D495/22
CPC分类号： C07D495/22
摘要： The invention relates to thieno-triazolo-diazepine derivatives of the formula: ##STR1## wherein Y stands for oxygen or sulphur and R stands for various substituents, to a preparation process of said compounds and to therapeutic compositions containing the same. The compounds are particularly interesting as anti-asthmatic, anti-allergic and gastro-intestinal protectors.
摘要翻译：本发明涉及下式的噻吩并三氮唑并二氮杂衍生物：其中Y代表氧或硫，R代表各种取代基，所述化合物的制备方法和含有它们的治疗组合物。这些化合物作为抗哮喘，抗过敏和胃肠保护剂是特别有趣的。

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