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1. 发明授权

US5047354A Thromboxane B.sub.2 assay for coronary artery thrombosis 失效
标题翻译：冠状动脉血栓形成的血栓烷B2测定
公开(公告)号：US5047354A
公开(公告)日：1991-09-10
申请号：US114924
申请日：1987-10-30
申请人： Marie L. Foegh , Peter W. Ramwell
发明人： Marie L. Foegh , Peter W. Ramwell
IPC分类号： G01N33/88
CPC分类号： G01N33/88 , Y10S436/811 , Y10S436/815
摘要： This invention is directed to the use of thromboxane as an early indicator for coronary artery thrombosis (acute myocardial infarction), and assays for detecting thromboxane B.sub.2 or a metabolite of TXB.sub.2 or TXA.sub.2.
摘要翻译：本发明涉及使用血栓烷作为冠状动脉血栓形成（急性心肌梗塞）的早期指标，以及用于检测血栓素B2或TXB2或TXA2的代谢物的测定法。

2. 发明授权

US3993057A Intrauterine device that bioerodes in response to the environment of the uterus and method of using 失效
标题翻译：子宫内装置响应于子宫的环境和使用方法进行生物反应
公开(公告)号：US3993057A
公开(公告)日：1976-11-23
申请号：US578727
申请日：1975-05-19
申请人： Peter W. Ramwell
发明人： Peter W. Ramwell
IPC分类号： A61F6/14 , A61K9/00 , A61F5/46
CPC分类号： A61K9/0039 , A61F6/144
摘要： An intrauterine device for administering drug locally to the uterus at a controlled rate for a prolonged period of time is disclosed. The device contains a body of polymer capable of bioeroding in the environment of the uterus over a prolonged period of time. This body has the drug dispersed throughout so that as the body gradually bioerodes, it slowly releases the dispersed drug. In a preferred embodiment, the device releases a uterine contraction-inducing prostaglandin locally to the uterus at a controlled rate over a prolonged period of time.
摘要翻译：公开了一种子宫内装置，其以受控的速率长时间地向子宫内施用药物。该装置包含能够在更长时间内在子宫环境中进行生物编码的聚合物体。这种身体使药物分散在一起，使得随着身体逐渐生物化，它缓慢释放分散的药物。在优选的实施方案中，该装置在长时间内以受控的速率将子宫收缩诱导前列腺素局部释放到子宫。

3. 发明授权

US5002965A Use of ginkgolides to prevent reperfusion injury in organ transplantation 失效
标题翻译：使用银杏内酯来预防器官移植中的再灌注损伤
公开(公告)号：US5002965A
公开(公告)日：1991-03-26
申请号：US349035
申请日：1989-05-09
申请人： Peter W. Ramwell , Marie L. Foegh
发明人： Peter W. Ramwell , Marie L. Foegh
IPC分类号： A61K31/365 , A61K36/16
CPC分类号： A61K31/365 , A61K36/16
摘要： A living tissue or living cell preservation solution comprising an effective amount of a ginkgolide to reduce reperfusion injury in living tissue which has been stored therein and a substance or mixture or substances present in an amount sufficient to produce an osmotic pressure in said solution approximately equal to the osmotic pressure or mammalian cell and a method for preventing or reducing reperfusion injury in transplanted mammalian organs, which comprises contacting an organ prior to reperfusion with an effective amount of a ginkgolide to reduce reperfusion injury in said organ.
摘要翻译：一种活组织或活细胞保存溶液，其包含有效量的银杏内酯以减少已经存储在其中的活组织中的再灌注损伤，以及以足以在所述溶液中产生渗透压的量的物质或混合物或物质近似等于渗透压或哺乳动物细胞，以及用于预防或减少移植的哺乳动物器官中的再灌注损伤的方法，其包括在再灌注之前使器官与有效量的银杏内酯接触以减少所述器官中的再灌注损伤。

4. 发明授权

US5147856A Method for inhibiting blood vessel blockage using octapeptide compositions 失效
标题翻译：使用八肽组合物抑制血管阻塞的方法
公开(公告)号：US5147856A
公开(公告)日：1992-09-15
申请号：US329854
申请日：1989-03-28
申请人： Peter W. Ramwell , Pierre Braquet
发明人： Peter W. Ramwell , Pierre Braquet
IPC分类号： A61K38/00 , C07K14/655
CPC分类号： C07K14/6555 , A61K38/00
摘要： A method for inhibiting blood vessel blockage in a mammal particularly after a procedure such as angioplasty, an arterial bypass operation or an allograft transplant operation which comprises: administering to a mammal before, during and/or after the procedure an effective blood vessel blockage inhibiting amount of an octapeptide having the formula ##STR1## wherein each A.sub.1 and A.sub.2, independently, is H, C.sub.1-12 alkyl, C.sub.7-10 phenylalkyl, R.sub.1 CO (where R.sub.1 is C.sub.1-20 alkyl, C.sub.3-20 alkenyl, C.sub.3-20 alkinyl, phenyl, naphthyl, or C.sub.7-10 phenylalkyl), or R.sub.2 OCO (where R.sub.2 is C.sub.1-10 alkyl or C.sub.7-10 phenylalkyl), provided that when one of A.sub.1 or A.sub.2 is R.sub.1 CO or R.sub.2 OCO, the other must be H; A.sub.3 is CH.sub.2 A.sub.6 (where A.sub.6 is pentafluorophenyl, naphthyl, pyridyl, or phenyl); A.sub.4 is o-, m- or, more preferably, p-substituted X-Phe (where X is a halogen, H, NH.sub.2, NO.sub.2, OH , or C.sub.1-13 alkyl), pentafluoro-Phe, or .beta.-Nal; A.sub.5 is Thr, Ser, Phe, Val, .alpha.-aminobutyric acid, or Ile; A.sub.7 is Thr, Trp, or .beta.-Nal (and can be either the D- or L-isomer); and Z is NH.sub.2 or OH; or a pharmaceutically acceptable salt thereof.
摘要翻译：一种抑制哺乳动物血管阻塞的方法，特别是在诸如血管成形术，动脉旁路操作或同种异体移植手术的手术之后，包括：在手术之前，期间和/或之后向哺乳动物施用有效的血管阻塞抑制量具有式 + TR LA7Z的八肽，其中每个A1和A2独立地是H，C1-12烷基，C7-10苯基烷基，R1CO（其中R1是C1-20烷基，C3-20烯基，C3- 20个炔基，苯基，萘基或C7-10苯基烷基）或R2OCO（其中R2是C1-10烷基或C7-10苯基烷基），条件是当A1或A2之一为R1CO或R2OCO时，另一个必须为H; A3是CH2A6（其中A6是五氟苯基，萘基，吡啶基或苯基）; A4是邻 - ，间 - 或更优选对取代的X-Phe（其中X是卤素，H，NH 2，NO 2，OH或C 1-13烷基），五氟-Phe或β-Nal; A5是Thr，Ser，Phe，Val，α-氨基丁酸或Ile; A7是Thr，Trp或β-Nal（并且可以是D-或L-异构体）; Z是NH 2或OH; 或其药学上可接受的盐。

5. 发明授权

US3932656A Article of manufacture for instant release of anti-aggregation and non-thrombogenic agents to biological media 失效
标题翻译：将抗凝血和非血栓形成剂即时释放到生物媒体的制造条款
公开(公告)号：US3932656A
公开(公告)日：1976-01-13
申请号：US426444
申请日：1973-12-20
申请人： Peter W. Ramwell , Hideo Shio , Jane E. Shaw
发明人： Peter W. Ramwell , Hideo Shio , Jane E. Shaw
IPC分类号： A61K31/557 , A61L33/00 , C07C405/00 , A61K9/00 , A61K31/19 , A61K31/195 , A61K31/725
CPC分类号： A61K31/715 , A61K31/557 , A61L33/0041 , C07C405/00 , Y10S514/861
摘要： Polymeric materials having at least one exposed surface rendered as a release means for platelet aggregation inhibiting agent by serving as a reservoir for release of aggregation inhibiting prostaglandin. The polymeric surface can also be both platelet aggregation agent releasing and non-thrombogenic agent releasing by having together on the polymeric surface an aggregation inhibiting prostaglandin and an anti-coagulant which are easily released from the surface when in close contact with the blood, plasma or platelets.
摘要翻译：具有至少一个暴露表面的聚合材料作为用于释放聚集抑制性前列腺素的储存器而作为血小板聚集抑制剂的释放装置。聚合物表面也可以是通过在聚合物表面上聚合抑制性前列腺素和抗凝血剂一起释放血小板聚集剂释放和非血栓形成剂释放，当与血液，血浆或血浆等紧密接触时容易从表面释放血小板

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