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    • 1. 发明授权
    • Tiered therapy cardiac detection system having a global counter
    • 具有全局计数器的分层治疗心脏检测系统
    • US5913878A
    • 1999-06-22
    • US021650
    • 1998-02-10
    • Jean-Cheui HsungMark Stockburger
    • Jean-Cheui HsungMark Stockburger
    • A61N1/362A61N1/39
    • A61N1/3962A61N1/3622
    • A tiered therapy cardiac detection system is provided for a medical device that senses cardiac signals representative of beat-to-beat intervals and delivers at least one therapy in response to a detected cardiac dysrhythmia corresponding to one of a plurality of programmed zones of heart rates. The detection system includes a global counter that counts at least all beat-to-beat intervals indicating a rate greater than a programmed threshold value representative of a minimum heart rate for delivering any therapy once an initial threshold condition is met. A plurality of window memories and parameter memories are provided in the device. Each window memory corresponds to a given one of the zones and stores an indication of whether each of a last N cardiac signals are within that zone. Each parameter memory corresponds to a given one of the zones and stores a programmed trigger value of the global counter required in order for a therapy in that zone to be delivered. Processing circuitry evaluates the global counter, the window memories and the parameter memories on a beat-by-beat basis and indicates that a cardiac dysrhythmia has been detected for a given zone if the global counter exceeds the programmed trigger value for that zone and the indications stored by the window memory for that zone satisfy a predetermined criteria.
    • 提供了一种分层治疗心脏检测系统,用于感测表示搏动间隔时间的心脏信号的医疗装置,并响应于对应于多个程序化心率区之一的检测到的心脏心律失常递送至少一个治疗。 检测系统包括全局计数器,其计数至少所有搏动间隔时间间隔,指示一旦满足初始阈值条件,指示大于表示用于递送任何治疗的最小心率的编程阈值的速率。 在设备中提供多个窗口存储器和参数存储器。 每个窗口存储器对应于给定的一个区域,并且存储每个最后N个心脏信号是否在该区域内的指示。 每个参数存储器对应于给定的一个区域,并且存储所需的全局计数器的编程触发值,以便在该区域中进行治疗。 处理电路以逐拍为基础对全局计数器,窗口存储器和参数存储器进行评估,并且指示如果全局计数器超过该区域的编程触发值,则给定区域已经检测到心脏心律不齐,并且指示 由该区域的窗口存储器存储满足预定标准。
    • 2. 发明授权
    • Defibrillation/cardioversion system with multiple evaluation of heart
condition prior to shock delivery
    • 除颤/心脏复律系统,多次评估心律前的休克
    • US5179945A
    • 1993-01-19
    • US642337
    • 1991-01-17
    • Lloyd Van HofwegenJean-Cheui HsungDaniel Huntwork
    • Lloyd Van HofwegenJean-Cheui HsungDaniel Huntwork
    • A61N1/362A61N1/365A61N1/39
    • A61N1/3956A61N1/3621A61N1/365A61N1/3987
    • An automatic implantable defibrillator/cardioverter having a non-committed defibrillation/cardioversion algorithm. The defibrillator/cardioverter includes an ECG amplifier with automatic gain control (AGC) which detects the electrical activity of the heart for analysis by a cardiac condition detector. Logic is provided which receives input from the ECG amplifier and the cardiac condition detector for analyzing the heart activity. The non-committed defibrillation algorithm sensing begins upon the determination of an arrhythmia. The capacitor is charged while the heart activity is simultaneously monitored. After the capacitor is charged, a check is made on the duration of the last detected R-R interval while so charging the capacitor, and a comparison is made between this R-R interval and a preset value. If the last R-R interval is greater than the preset value, a non-committing period is entered which lasts approximately 2 seconds. The purpose of the non-committing period is to allow detection to monitor the arrhythmia further before making the decision to discharge the capacitor or dump the charge internally. If any R-R interval detected during this interval is less than PCLL, this indicates that the arrhythmia has not reverted and the capacitor charge is delivered to the patients, synchronously with the second R-wave of the fast R-R interval. If no rapid interval is detected during this time, a post intervention (PI) monitoring routine is entered at the end of the non-committing period to further monitor cardiac activity and shock if necessary.
    • 具有非定心除颤/心脏复律算法的自动可植入除颤器/心脏转换器。 除颤器/心律转复器包括具有自动增益控制(AGC)的ECG放大器,其检测心脏的心脏状态检测器进行分析的电活动。 提供逻辑,其接收来自ECG放大器的输入和用于分析心脏活动的心脏状态检测器。 不确定的除颤算法感测从确定心律失常开始。 在同时监测心脏活动的同时对电容器进行充电。 在电容器充电之后,对最后检测到的R-R间隔的持续时间进行检查,同时对电容器进行充电,并且在该R-R间隔和预设值之间进行比较。 如果最后的R-R间隔大于预设值,则输入持续约2秒的非提交期。 非承诺期的目的是允许检测进一步监控心律失常,然后再决定放电电容器或将电荷转移到内部。 如果在该间隔期间检测到的任何R-R间隔小于PCLL,则表明心律不齐没有恢复,电容器电荷与快速R-R间隔的第二R波同步传送给患者。 如果在此期间没有检测到快速间隔,则在非提交期结束时输入后干预(PI)监测程序,以进一步监测心脏活动和休克(如有必要)。
    • 4. 发明授权
    • Deterministic and jitter-free dual-chamber cardiac pacemaker
    • 确定性和无抖动的双室心脏起搏器
    • US06366810B1
    • 2002-04-02
    • US09395432
    • 1999-09-14
    • Sharon JohnsonFrank DroppsJean-Cheui HsungJames Marcotte
    • Sharon JohnsonFrank DroppsJean-Cheui HsungJames Marcotte
    • A61N118
    • A61N1/368
    • A deterministic and jitter-free dual chamber brady pacemaker utilizes both a programmed microprocessor and a hardware state machine, both of which are coupled to a real time clock (RTC), random access memory (RAM) and a common escape interval timer. Time of occurrence (TOC) data representative of the time and nature of atrial and ventricular sensed events and pacing events is stored in the RAM. Escape interval periods are timed by the escape interval timer. The microprocessor is operable in both an active mode and an inactive mode without interrupts. In response to the receipt of wakeup commands, the microprocessor operates in the active mode and uses the TOC data from the RAM to reset the escape interval timer to a desired next event interval. The hardware state machine uses the common escape interval timer for timing timeout events and atrial and ventricular sensed events such that pacing pulses are delivered in a determinate manner.
    • 确定性和无抖动的双室舒适起搏器利用编程的微处理器和硬件状态机,它们都耦合到实时时钟(RTC),随机存取存储器(RAM)和公共逃逸间隔定时器。 代表心房和心室感觉事件和起搏事件的时间和性质的发生时间(TOC)数据存储在RAM中。 逃生间隔时间由转义间隔定时器定时。 微处理器在活动模式和非活动模式下均可操作,无中断。 响应于接收到唤醒命令,微处理器以活动模式操作,并且使用来自RAM的TOC数据将转义间隔定时器重置为期望的下一个事件间隔。 硬件状态机使用公共逃逸间隔定时器来定时超时事件和心房和心室感测事件,使得起搏脉冲以确定的方式被递送。
    • 6. 发明授权
    • Arrhythmia detector using delta modulated turning point morphology of
the ECG wave
    • 心律失常检测器采用Delta调制转折点形态的ECG波
    • US5301677A
    • 1994-04-12
    • US833843
    • 1992-02-06
    • Jean-Cheui Hsung
    • Jean-Cheui Hsung
    • A61B5/0452A61B5/044A61B5/046A61B5/0464A61B5/0468A61N1/37G06F17/00A61B5/0402
    • A61N1/3702A61B5/046A61B5/0464A61B5/0468
    • An arrhythmia detector includes a delta modulator which digitizes the ECG signal and produces a serial digital signal that represents the input ECG signal. A microprocessor classifies the signal as having no slope, positive slope, or negative slope. A finite state machine model in the microprocessor uses the positive slope, negative slope, or no slope information to determine the number of times an isoelectric line segment is present in the ECG signal. By accumulating the line-counts or number of line segments over a two-second period, a determination can be made whether the ECG signal has been in isoelectric line less than a threshold. For two out of three 2 second periods, if the percentage of isoelectric time is less than the ventricular fibrillation threshold then a ventricular fibrillation signal can be generated. For ventricular tachycardia verses supraventricular tachycardia discrimination, a second threshold which relates to the average heart rate observed in a linear formula LC(TH)=b-a*(rate)/30 can be used. If the isoelectric line-count is less than the LC(TH), then VT is declared. The regression coefficient a and b can be found by measuring the line-count and rate pairs in 2 second periods during normal sinus rhythm in periodic basis, for example, 10 data pairs every hour. The delta modulator uses a comparator which receives the ECG signal and a tracking signal to output a series of binary digits. A digital-to-analog converter generates the tracking signal.
    • 心律失常检测器包括增量调制器,其对ECG信号进行数字化并产生表示输入ECG信号的串行数字信号。 微处理器将信号分类为没有斜率,正斜率或负斜率。 微处理器中的有限状态机模型使用正斜率,负斜率或无斜率信息来确定等电点线段在ECG信号中的存在次数。 通过在两秒的时间段内积累行数或行数,可以确定ECG信号是否处于等电位线小于阈值。 对于3个2秒的2次,如果等电时间的百分比小于心室颤动阈值,则可以产生心室颤动信号。 对于室性心动过速与室上性心动过速鉴别,可以使用与线性公式LC(TH)= b-a *(速率)/ 30中观察到的平均心率相关的第二阈值。 如果等电位线计数小于LC(TH),则声明VT。 回归系数a和b可以通过在周期性的正常窦性心律(例如每小时10个数据对)中测量2秒期间的线数和速率对来找到。 增量调制器使用接收ECG信号的比较器和跟踪信号来输出一系列二进制数字。 数模转换器产生跟踪信号。