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1. 发明申请

US20130210811A1 PICOLINAMIDE AND PYRIMIDINE-4-CARBOXAMIDE COMPOUNDS, PROCESS FOR PREPARING AND PHAMACEUTICAL COMPOSITION COMPRISING THE SAME 有权
标题翻译：吡啶酰胺和嘧啶-4-羧酰胺化合物，其制备方法和包含其的药物组合物
公开(公告)号：US20130210811A1
公开(公告)日：2013-08-15
申请号：US13696400
申请日：2011-05-04
申请人： Je Ho Ryu , Shin Ae Kim , Keun Ho Ryu , Jae Sun Kim , Nam Ho Kim , Hye Young Han , Yong Hyuk Kim , Won-No Youn , Yoon-Jung Lee , Hyun Joo Son , Bong-Yong Lee , Sung Hoon Park , Ju Young Lee , Hyun Jung Lee , Hoe Chul Jung , Young Ah Shin , Jung A Lee , Bo Ram Lee , Joon Ho Sa
发明人： Je Ho Ryu , Shin Ae Kim , Keun Ho Ryu , Jae Sun Kim , Nam Ho Kim , Hye Young Han , Yong Hyuk Kim , Won-No Youn , Yoon-Jung Lee , Hyun Joo Son , Bong-Yong Lee , Sung Hoon Park , Ju Young Lee , Hyun Jung Lee , Hoe Chul Jung , Young Ah Shin , Jung A Lee , Bo Ram Lee , Joon Ho Sa
IPC分类号： C07D401/04 , C07D403/14 , C07D403/04 , C07D401/14 , C07D405/14
CPC分类号： C07D401/04 , C07D213/81 , C07D239/557 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14
摘要： Provided are picolinamide and pyrimidine-4-carboxamide compounds, a method for preparing the same, a pharmaceutical composition containing the same, and a medical use using the compound as an agent for preventing, regulating, and treating diseases related to regulation of glucocorticoids by using selective inhibitory activity of the compound for an 11β-HSD1 enzyme. The picolinamide and pyrimidine-4-carboxamide compounds of the present invention are selective inhibitors of human-derived 11β-HSD1 enzymes, and are useful in an agent for preventing, regulating, and treating diseases related to glucocorticoid regulation in which human-derived 11β-HSD1 enzymes are involved, for example, metabolic syndromes such as, type 1 and type 2 diabetes, diabetes later complications, latent autoimmune diabetes adult (LADA), insulin tolerance syndromes, obesity, impaired glucose tolerance (IGT), impaired fasting glucose (IFG), damaged glucose tolerance, dyslipidemia, atherosclerosis, hypertension, etc.
摘要翻译：提供了吡啶酰胺和嘧啶-4-甲酰胺化合物，其制备方法，含有该组合物的药物组合物，以及使用该化合物作为预防，调节和治疗与糖皮质激素调节有关的疾病的药物的用途化合物对11beta-HSD1酶的选择性抑制活性。本发明的吡啶酰胺和嘧啶-4-甲酰胺化合物是人源性11beta-HSD1酶的选择性抑制剂，可用于预防，调节和治疗与糖皮质激素调节相关的疾病的药剂，其中人源性11β- 涉及HSD1酶，例如代谢综合征，如1型和2型糖尿病，糖尿病后期并发症，潜伏性自身免疫性糖尿病成年（LADA），胰岛素耐受综合征，肥胖症，葡萄糖耐量异常（IGT），空腹血糖受损（IFG ），葡萄糖耐量受损，血脂异常，动脉粥样硬化，高血压等。

2. 发明授权

US09096571B2 Picolinamide and pyrimidine-4-carboxamide compounds, process for preparing and pharmaceutical composition comprising the same 有权
标题翻译：吡啶酰胺和嘧啶-4-甲酰胺化合物，其制备方法和包含其的药物组合物
公开(公告)号：US09096571B2
公开(公告)日：2015-08-04
申请号：US13696400
申请日：2011-05-04
申请人： Je Ho Ryu , Shin Ae Kim , Keun Ho Ryu , Jae Sun Kim , Nam Ho Kim , Hye Young Han , Yong Hyuk Kim , Won-No Youn , Yoon-Jung Lee , Hyun Joo Son , Bong-Yong Lee , Sung Hoon Park , Ju Young Lee , Hyun Jung Lee , Hoe Chul Jung , Young Ah Shin , Jung A Lee , Bo Ram Lee , Joon Ho Sa
发明人： Je Ho Ryu , Shin Ae Kim , Keun Ho Ryu , Jae Sun Kim , Nam Ho Kim , Hye Young Han , Yong Hyuk Kim , Won-No Youn , Yoon-Jung Lee , Hyun Joo Son , Bong-Yong Lee , Sung Hoon Park , Ju Young Lee , Hyun Jung Lee , Hoe Chul Jung , Young Ah Shin , Jung A Lee , Bo Ram Lee , Joon Ho Sa
IPC分类号： A61K31/47 , A61K31/55 , A61K31/445 , A61K31/497 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D213/81 , C07D401/06 , C07D401/12 , C07D405/12 , C07D239/557
CPC分类号： C07D401/04 , C07D213/81 , C07D239/557 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14
摘要： Provided are picolinamide and pyrimidine-4-carboxamide compounds, a method for preparing the same, a pharmaceutical composition containing the same, and a medical use using the compound as an agent for preventing, regulating, and treating diseases related to regulation of glucocorticoids by using selective inhibitory activity of the compound for an 11β-HSD1 enzyme. The picolinamide and pyrimidine-4-carboxamide compounds of the present invention are selective inhibitors of human-derived 11β-HSD1 enzymes, and are useful in an agent for preventing, regulating, and treating diseases related to glucocorticoid regulation in which human-derived 11β-HSD1 enzymes are involved, for example, metabolic syndromes such as, type 1 and type 2 diabetes, diabetes later complications, latent autoimmune diabetes adult (LADA), insulin tolerance syndromes, obesity, impaired glucose tolerance (IGT), impaired fasting glucose (IFG), damaged glucose tolerance, dyslipidemia, atherosclerosis, hypertension, etc.
摘要翻译：提供了吡啶酰胺和嘧啶-4-甲酰胺化合物，其制备方法，含有该组合物的药物组合物，以及使用该化合物作为预防，调节和治疗与糖皮质激素调节有关的疾病的药物的用途该化合物对于11-bgr-HSD1酶的选择性抑制活性。本发明的吡啶酰胺和嘧啶-4-甲酰胺化合物是人源性11β-HSD1酶的选择性抑制剂，可用于预防，调节和治疗糖皮质激素调节相关疾病的药剂，其中人源性11β- ; -HSD1酶涉及例如代谢综合征，如1型和2型糖尿病，糖尿病后期并发症，潜伏性自身免疫性糖尿病成人（LADA），胰岛素耐受综合征，肥胖，葡萄糖耐量异常（IGT），空腹血糖受损（IFG），葡萄糖耐量受损，血脂异常，动脉粥样硬化，高血压等。

3. 发明授权

US5932742A Arylsulfonylimidazolone derivatives as an antitumor agent 失效
标题翻译：芳基磺酰基咪唑酮衍生物作为抗肿瘤剂
公开(公告)号：US5932742A
公开(公告)日：1999-08-03
申请号：US212396
申请日：1998-12-16
申请人： Sung June Yoon , Yong Ho Chung , Moon Sun Lee , Dong Rack Choi , Jung A Lee , Hee Soon Lee , Hae Ran Yun , Dug Keun Lee , Eun Yi Moon , Hyun Sook Hwang , Chung Ha Choi , Sang Hun Jung
发明人： Sung June Yoon , Yong Ho Chung , Moon Sun Lee , Dong Rack Choi , Jung A Lee , Hee Soon Lee , Hae Ran Yun , Dug Keun Lee , Eun Yi Moon , Hyun Sook Hwang , Chung Ha Choi , Sang Hun Jung
IPC分类号： A61K31/4178 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61P35/00 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14
CPC分类号： C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14
摘要： The present invention relates to a novel arylsulfonylimidazolone derivative represented by the following formula (I) which shows a superior antineoplastic activity in contrast to the known sulfonylurea antitumor agents as well as little side effect: ##STR1## and its pharmaceutically acceptable salt and stereoisomer, in which - -, R.sub.1, and R.sub.2 are as defined in the specification.
摘要翻译：本发明涉及与已知的磺酰脲类抗肿瘤剂相比具有优异的抗肿瘤活性以及其药学上可接受的盐和立体异构体的下式（I）所示的新型芳基磺酰基咪唑啉酮衍生物，其中+ E ，非 - + EE，R1和R2如规范中所定义。

4. 发明授权

US08048973B2 Transition metal complex, catalyst composition including the same and olefin polymer using catalyst composition 有权
公开(公告)号：US08048973B2
公开(公告)日：2011-11-01
申请号：US13041533
申请日：2011-03-07
申请人： Choong Hoon Lee , Eun Jung Lee , Seungwhan Jung , Boram Lee , Jung A Lee , Bun Yeoul Lee
发明人： Choong Hoon Lee , Eun Jung Lee , Seungwhan Jung , Boram Lee , Jung A Lee , Bun Yeoul Lee
IPC分类号： C08F4/6592 , B01J31/18 , B01J31/22
CPC分类号： C07F17/00 , C07D209/08 , C07D215/12 , C07D215/14 , C08F4/65908 , C08F4/65912 , C08F10/00 , C08F210/16 , C08F2420/02 , Y10S526/943 , C08F4/6592 , C08F210/14 , C08F2500/12 , C08F2500/08 , C08F210/08
摘要： Provided are a novel transition metal complex where a monocyclopentadienyl ligand to which an amido group is introduced is coordinated, a catalyst composition including the same, and an olefin polymer using the catalyst composition. The transition metal complex has a pentagon ring structure having an amido group connected by a phenylene bridge in which a stable bond is formed in the vicinity of a metal site, and thus, a sterically hindered monomer can easily approach the transition metal complex. By using a catalyst composition including the transition metal complex, a linear low density polyolefin copolymer having a high molecular weight and a very low density polyolefin copolymer having a density of 0.910 g/cc or less can be produced in a polymerization of monomers having large steric hindrance. Further, the reactivity for the olefin monomer having large steric hindrance is excellent.

5. 发明授权

US08039671B2 Transition metal complex, catalyst composition including the same and olefin polymer using catalyst composition 有权
标题翻译：过渡金属络合物，包括其的催化剂组合物和使用催化剂组合物的烯烃聚合物
公开(公告)号：US08039671B2
公开(公告)日：2011-10-18
申请号：US13041526
申请日：2011-03-07
申请人： Choong Hoon Lee , Eun Jung Lee , Seungwhan Jung , Boram Lee , Jung A Lee , Bun Yeoul Lee
发明人： Choong Hoon Lee , Eun Jung Lee , Seungwhan Jung , Boram Lee , Jung A Lee , Bun Yeoul Lee
IPC分类号： C07C211/44 , C07C211/48
CPC分类号： C07F17/00 , C07D209/08 , C07D215/12 , C07D215/14 , C08F4/65908 , C08F4/65912 , C08F10/00 , C08F210/16 , C08F2420/02 , Y10S526/943 , C08F4/6592 , C08F210/14 , C08F2500/12 , C08F2500/08 , C08F210/08
摘要： Provided are a novel transition metal complex where a monocyclopentadienyl ligand to which an amido group is introduced is coordinated, a catalyst composition including the same, and an olefin polymer using the catalyst composition. The transition metal complex has a pentagon ring structure having an amido group connected by a phenylene bridge in which a stable bond is formed in the vicinity of a metal site, and thus, a sterically hindered monomer can easily approach the transition metal complex. By using a catalyst composition including the transition metal complex, a linear low density polyolefin copolymer having a high molecular weight and a very low density polyolefin copolymer having a density of 0.910 g/cc or less can be produced in a polymerization of monomers having large steric hindrance. Further, the reactivity for the olefin monomer having large steric hindrance is excellent.
摘要翻译：提供一种新颖的过渡金属络合物，其中引入了酰氨基的单环戊二烯基配位体，包含它们的催化剂组合物和使用该催化剂组合物的烯烃聚合物。过渡金属络合物具有通过在金属部位附近形成稳定的键的亚苯基连接的酰胺基的五
元环结构，因此空间位阻单体容易接近过渡金属络合物。通过使用包含过渡金属络合物的催化剂组合物，可以在具有大立体的单体的聚合中产生具有高分子量的线性低密度聚烯烃共聚物和密度为0.910g / cc以下的极低密度聚烯烃共聚物障碍此外，具有大空间位阻的烯烃单体的反应性优异。

6. 发明授权

US07517940B2 Catalyst composition including transition metal complexes and olefin polymerization using the same 有权
标题翻译：催化剂组合物包括过渡金属配合物和使用其的烯烃聚合
公开(公告)号：US07517940B2
公开(公告)日：2009-04-14
申请号：US11670259
申请日：2007-02-01
申请人： Eunjung Lee , Choong Hoon Lee , Seungwhan Jung , Jung A Lee , Boram Lee
发明人： Eunjung Lee , Choong Hoon Lee , Seungwhan Jung , Jung A Lee , Boram Lee
IPC分类号： C08F4/42 , C07F7/28
CPC分类号： C08F10/00 , C08F4/65908 , C08F4/65912 , C08F210/16 , C08F2410/03 , C08F2420/02 , Y10S526/943 , C08F4/6592 , C08F4/65904 , C08F210/14 , C08F2500/12 , C08F2500/08
摘要： Provided is catalyst composition including a transition metal complex precatalyst represented by Formula 1; a first cocatalyst represented by Formula 2 which is an alkylaluminum compound; and a second cocatalyst represented by Formula 3 which is a salt compound comprising a Bronsted acid cation and a noncoordinating, compatible anion. Here, R1, R2, R3, R4, E, Q1, Q2 and M are defined in the specification. Al(R6)3 Formula 2 Here, R6 is defined in the specification. [L-H]+[ZA4]− Formula 3 Here, L, [L-H]+, Z and A are defined in the specification. A catalyst composition including binuclear transition metal complexes, an alkylaluminum compound, and a salt compound including a Bronsted acid cation, and a noncoordinating, compatible anion, and a method of preparing the catalyst composition are provided.
摘要翻译：提供了包含式1表示的过渡金属络合物预催化剂的催化剂组合物; 由式2表示的作为烷基铝化合物的第一助催化剂; 和由式3表示的第二助催化剂，其是包含布朗斯台德酸阳离子和非配位的相容阴离子的盐化合物。这里，在说明书中定义了R1，R2，R3，R4，E，Q1，Q2和M。 <？in-line-formula description =“In-line Formulas”end =“lead”？> Al（R6）3 Formula 2 <？in-line-formula description =“In-line Formulas”end =“tail”？ >这里，R6在规范中定义。 <？in-line-formula description =“In-line Formulas”end =“lead”？> [LH] + [ZA4] - Formula 3 <？in-line-formula description =“In-line Formulas”end = 尾“？>这里，L，[LH] +，Z和A在说明书中定义。提供了包含双核过渡金属配合物，烷基铝化合物和包含布朗斯台德酸阳离子和非配位相容性阴离子的盐化合物的催化剂组合物和制备该催化剂组合物的方法。

7. 发明授权

US5929103A Arylsulfonylimidazolone derivatives as an antitumor agent 失效
标题翻译：芳基磺酰基咪唑酮衍生物作为抗肿瘤剂
公开(公告)号：US5929103A
公开(公告)日：1999-07-27
申请号：US915726
申请日：1997-08-21
申请人： Sung June Yoon , Yong Ho Chung , Moon Sun Lee , Dong Rack Choi , Jung A Lee , Hee Soon Lee , Hae Ran Yun , Dug Keun Lee , Eun Yi Moon , Hyun Sook Hwang , Chung Ha Choi , Sang Hun Jung
发明人： Sung June Yoon , Yong Ho Chung , Moon Sun Lee , Dong Rack Choi , Jung A Lee , Hee Soon Lee , Hae Ran Yun , Dug Keun Lee , Eun Yi Moon , Hyun Sook Hwang , Chung Ha Choi , Sang Hun Jung
IPC分类号： A61K31/4178 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61P35/00 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , A61K31/415
CPC分类号： C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14
摘要： The present invention relates to a novel arylsulfonylimidazolone derivative represented by the following formula (I) which shows a superior antineoplastic activity in contrast to the known sulfonylurea antitumor agents as well as little side effect: ##STR1## and its pharmaceutically acceptable salt and stereoisomer, in which ----, R.sub.1, and R.sub.2 are as defined in the specification.
摘要翻译：本发明涉及与已知的磺酰脲类抗肿瘤剂相比具有优异的抗肿瘤活性以及其药学上可接受的盐和立体异构体的下式（I）所示的新型芳基磺酰基咪唑啉酮衍生物，其中+ E ，非+ EE，R1和R2如说明书中所定义。

8. 发明授权

US08017413B2 Field emission array having carbon microstructure and method of manufacturing the same 失效
标题翻译：具有碳微观结构的场发射阵列及其制造方法
公开(公告)号：US08017413B2
公开(公告)日：2011-09-13
申请号：US12450965
申请日：2008-07-01
申请人： Seung Seob Lee , Seok Woo Lee , Jung A Lee
发明人： Seung Seob Lee , Seok Woo Lee , Jung A Lee
IPC分类号： H01L21/00
CPC分类号： H01J1/3044 , H01J3/022 , H01J9/025 , H01J31/127 , H01J63/02 , H01J2201/30415 , H01J2201/30453 , H01J2203/0228 , H01J2329/0418 , H01J2329/0444 , H01J2329/4626
摘要： Provided is a method for manufacturing a field emission array with a carbon microstructure. The method includes: a photomask attachment step of attaching a photomask with a pattern groove to one surface of a transparent substrate; a photoresist attachment step of attaching a negative photoresist to one surface of the photomask; an exposure step of irradiating light toward the opposite surface of the transparent substrate from the photomask to cure a portion of the negative photoresist with the light irradiated on the negative photoresist through the pattern groove; a developing step of removing an uncured portion of the negative photoresist while leaving the cured portion of the negative photoresist as a microstructure; a pyrolysis step of heating and carbonizing the microstructure thus obtained; and a cathode attachment step of attaching a voltage-supplying cathode to the surface of the transparent substrate on which the microstructure is formed.
摘要翻译：提供一种制造具有碳微观结构的场致发射阵列的方法。该方法包括：光掩模附着步骤，其将具有图案凹槽的光掩模附着到透明基板的一个表面; 将负性光致抗蚀剂附着到光掩模的一个表面的光致抗蚀剂附着步骤; 曝光步骤，从所述光掩模向所述透明基板的相对表面照射光，以通过所述图案凹槽照射在所述负性光致抗蚀剂上的光来固化所述负性光致抗蚀剂的一部分; 去除负性光致抗蚀剂的未固化部分同时留下负性光致抗蚀剂的固化部分作为微结构的显影步骤; 对由此获得的微结构进行加热和碳化的热解步骤; 以及将电压供给阴极安装在其上形成微结构的透明基板的表面上的阴极附着步骤。

9. 发明申请

US20110089396A1 FIELD EMISSION ARRAY HAVING CARBON MICROSTRUCTURE AND METHOD OF MANUFACTURING THE SAME 失效
标题翻译：具有碳微结构的场发射阵列及其制造方法
公开(公告)号：US20110089396A1
公开(公告)日：2011-04-21
申请号：US12450965
申请日：2008-07-01
申请人： Seung Seob Lee , Seok Woo Lee , Jung A Lee
发明人： Seung Seob Lee , Seok Woo Lee , Jung A Lee
IPC分类号： H01L29/16 , H01L21/28 , H01L21/66
CPC分类号： H01J1/3044 , H01J3/022 , H01J9/025 , H01J31/127 , H01J63/02 , H01J2201/30415 , H01J2201/30453 , H01J2203/0228 , H01J2329/0418 , H01J2329/0444 , H01J2329/4626
摘要： Provided is a method for manufacturing a field emission array with a carbon microstructure. The method includes: a photomask attachment step of attaching a photomask with a pattern groove to one surface of a transparent substrate; a photoresist attachment step of attaching a negative photoresist to one surface of the photomask; an exposure step of irradiating light toward the opposite surface of the transparent substrate from the photomask to cure a portion of the negative photoresist with the light irradiated on the negative photoresist through the pattern groove; a developing step of removing an uncured portion of the negative photoresist while leaving the cured portion of the negative photoresist as a microstructure; a pyrolysis step of heating and carbonizing the microstructure thus obtained; and a cathode attachment step of attaching a voltage-supplying cathode to the surface of the transparent substrate on which the microstructure is formed.
摘要翻译：提供一种制造具有碳微观结构的场致发射阵列的方法。该方法包括：光掩模附着步骤，其将具有图案凹槽的光掩模附着到透明基板的一个表面; 将负性光致抗蚀剂附着到光掩模的一个表面的光致抗蚀剂附着步骤; 曝光步骤，从所述光掩模向所述透明基板的相对表面照射光，以通过所述图案凹槽照射在所述负性光致抗蚀剂上的光来固化所述负性光致抗蚀剂的一部分; 去除负性光致抗蚀剂的未固化部分同时留下负性光致抗蚀剂的固化部分作为微结构的显影步骤; 对由此获得的微结构进行加热和碳化的热解步骤; 以及将电压供给阴极安装在其上形成微结构的透明基板的表面上的阴极附着步骤。

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