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1. 发明申请

US20060030936A1 Method of making a coated medical device 有权
公开(公告)号：US20060030936A1
公开(公告)日：2006-02-09
申请号：US10914012
申请日：2004-08-05
申请人： Jan Weber , Gordon Kocur , Michael Helmus , Maria Palasis
发明人： Jan Weber , Gordon Kocur , Michael Helmus , Maria Palasis
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61F2250/0068 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/606
摘要： Medical devices, such as stents, having a surface, a coating layer comprising a polymer disposed on at least a portion of the surface, and a composition comprising a biologically active material injected into or under the coating layer at one or more locations in the coating layer to form at least one pocket containing a biologically active material are disclosed. The composition may be injected using a nanometer- or micrometer-sized needle. Methods for making such medical devices are also disclosed. Using this method, a precise amount of the biologically active material may be disposed accurately and efficiently on the medical device at predefined locations.

2. 发明授权

US07601382B2 Method of making a coated medical device 有权
标题翻译：制造涂敷医疗器械的方法
公开(公告)号：US07601382B2
公开(公告)日：2009-10-13
申请号：US10914012
申请日：2004-08-05
申请人： Jan Weber , Gordon Kocur , Michael Helmus , Maria Palasis
发明人： Jan Weber , Gordon Kocur , Michael Helmus , Maria Palasis
IPC分类号： A61L33/00 , B05D7/00 , B05D3/10 , A61F2/01
CPC分类号： A61L31/16 , A61F2250/0068 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/606
摘要： Medical devices, such as stents, having a surface, a coating layer comprising a polymer disposed on at least a portion of the surface, and a composition comprising a biologically active material injected into or under the coating layer at one or more locations in the coating layer to form at least one pocket containing a biologically active material are disclosed. The composition may be injected using a nanometer- or micrometer-sized needle. Methods for making such medical devices are also disclosed. Using this method, a precise amount of the biologically active material may be disposed accurately and efficiently on the medical device at predefined locations.
摘要翻译：医疗装置，例如具有表面的支架，包括设置在表面的至少一部分上的聚合物的涂层，以及包含在涂层中的一个或多个位置处注入到涂层内或下的生物活性物质的组合物层以形成至少一个包含生物活性材料的口袋。可以使用纳米或微米尺寸的针注射组合物。还公开了制造这种医疗装置的方法。使用该方法，精确量的生物活性材料可以在预定义的位置处精确而有效地设置在医疗装置上。

3. 发明申请

US20060171980A1 Implantable or insertable medical devices having optimal surface energy 审中-公开
标题翻译：具有最佳表面能的可植入或可插入医疗器械
公开(公告)号：US20060171980A1
公开(公告)日：2006-08-03
申请号：US11048147
申请日：2005-02-01
申请人： Michael Helmus , Paul Valint , Shrirang Ranade
发明人： Michael Helmus , Paul Valint , Shrirang Ranade
IPC分类号： A61F13/00
CPC分类号： A61L27/26 , A61L27/50
摘要： An implantable or insertable medical device is provided that contains at least one polymeric region which comes into contact with a subject upon implantation or insertion of the device into the subject. The polymeric region(s) contain at least one bulk polymer moiety and at least one surface-active polymer moiety that (a) is covalently attached to the bulk polymer moiety/moieties or admixed with the bulk polymer moiety/moieties and (b) is provided in an amount that is effective in providing the polymeric region(s) with a critical surface energy that is between 20 dynes/cm and 30 dynes/cm upon implantation or insertion of the device into the subject.
摘要翻译：提供了一种可植入或可插入的医疗装置，其包含至少一个聚合物区域，该聚合物区域在将装置植入或插入受试者时与受试者接触。聚合物区域包含至少一个本体聚合物部分和至少一个表面活性聚合物部分，（a）共价连接到本体聚合物部分/部分或与本体聚合物部分/部分混合，（b）提供的量可以有效地在聚合物区域植入或插入到受试者中时提供在20达因/厘米至30达因/厘米之间的临界表面能。

4. 发明申请

US20060089705A1 Drug release coated stent 审中-公开
公开(公告)号：US20060089705A1
公开(公告)日：2006-04-27
申请号：US11296764
申请日：2005-12-06
申请人： Ni Ding , Michael Helmus
发明人： Ni Ding , Michael Helmus
IPC分类号： A61F2/90
CPC分类号： A61F2/82 , A61F2/86 , A61F2/90 , A61F2210/0014 , A61F2250/0067 , A61L27/227 , A61L31/10 , A61L31/141 , A61L31/16 , A61L33/0011 , A61L2300/236 , A61L2300/416 , A61L2300/42 , A61L2300/43 , A61L2300/606 , C08L83/04
摘要： The present invention is directed to an expandable stent for implantation in a patient comprising a tubular metal body having open ends and a sidewall structure having openings therein and a coating disposed on a surface of said sidewall structure, said coating comprising a hydrophobic biostable elastomeric material and a biologically active material, wherein said coating continuously conforms to said structure in a manner that preserves said openings.

5. 发明申请

US20070280987A1 Bioactive polymers for imparting bioactive character to hydrophobic medical article surfaces 有权
标题翻译：用于向疏水性医疗用品表面赋予生物活性的生物活性聚合物
公开(公告)号：US20070280987A1
公开(公告)日：2007-12-06
申请号：US11442773
申请日：2006-05-30
申请人： Michael Helmus , Paul Valint , Shrirang Ranade
发明人： Michael Helmus , Paul Valint , Shrirang Ranade
IPC分类号： A61K38/08 , A61K38/06 , A61K38/05 , C08G63/91 , A61K31/727
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/236 , A61L2300/25
摘要： According to an aspect of the present invention, bioactive polymers are provided which have (a) a hydrophilic bioactive portion and (b) at least one hydrophobic polymer group that is linked to the hydrophilic bioactive portion by a covalent linkage that contains a chain transfer agent residue. According to another aspect of the present invention, medical articles are provided with bioactive surface by coating them with a coating material that contains such bioactive polymers.
摘要翻译：根据本发明的一个方面，提供了生物活性聚合物，其具有（a）亲水性生物活性部分和（b）通过含有链转移剂的共价键与亲水生物活性部分连接的至少一个疏水性聚合物基团残留物根据本发明的另一方面，通过用包含这种生物活性聚合物的涂层材料涂覆医疗制品来提供生物活性表面。

6. 发明申请

US20070224235A1 Medical devices having nanoporous coatings for controlled therapeutic agent delivery 审中-公开
标题翻译：具有用于受控治疗剂递送的纳米多孔涂层的医疗装置
公开(公告)号：US20070224235A1
公开(公告)日：2007-09-27
申请号：US11388604
申请日：2006-03-24
申请人： Barron Tenney , Yixin Xu , Michael Helmus
发明人： Barron Tenney , Yixin Xu , Michael Helmus
IPC分类号： A61F2/06
CPC分类号： A61F2/02 , A61F2/30767 , A61F2/82 , A61F2/91 , A61F2002/30677 , A61F2002/3068 , A61F2002/3084 , A61F2210/0076 , A61F2250/0068 , A61L29/146 , A61L29/16 , A61L31/146 , A61L31/16 , A61L2300/00 , A61L2400/12 , A61N1/375 , B82Y30/00
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided which contain (a) one or more depressions that contain at least one therapeutic agent, and (b) a nanoporous coating, disposed over the therapeutic-agent-containing depressions, which regulate transport of species between the therapeutic-agent-containing depressions and the exterior of the device. The implantable or insertable devices are configured to preform a role beyond mere drug delivery, for example, providing mechanical and/or electrical functions within the body, among other functions. An advantage of the present invention is that medical devices may be provided, which release therapeutic agents in quantities far exceeding the void volume within the nanoporous coating, while at the same time providing functionality that extends beyond drug delivery. Such release may further approach or achieve a zero order kinetic drug release profile.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含（a）含有至少一种治疗剂的一种或多种凹陷，和（b）在含治疗剂的凹陷上设置的纳米多孔涂层，其调节物质在含治疗剂的凹陷和装置的外部之间的运输。可植入或可插入的装置被配置为预防仅仅药物递送的作用，例如在体内提供机械和/或电功能等功能。本发明的一个优点是可以提供医疗装置，其释放的量远远超过纳米多孔涂层内的空隙体积，同时提供延伸超出药物递送的功能。这种释放可以进一步接近或实现零级动力学药物释放曲线。

7. 发明申请

US20060204545A1 Drug release regions for medical devices, which include polycyclic-structure-containing polymers 有权
标题翻译：用于医疗器械的药物释放区域，其包括含多环结构的聚合物
公开(公告)号：US20060204545A1
公开(公告)日：2006-09-14
申请号：US11079621
申请日：2005-03-14
申请人： Shrirang Ranade , Michael Helmus , Robert Richard
发明人： Shrirang Ranade , Michael Helmus , Robert Richard
IPC分类号： A61F2/02
CPC分类号： A61L27/50 , A61L27/54 , A61L29/14 , A61L29/16 , A61L31/14 , A61L31/16 , A61L2300/602
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain polymeric release regions that control the release of one or more therapeutic agents. The polymeric release regions, in turn, contain one or more polymers that contain one or more rigid, nonplanar polycyclic molecular structures. The therapeutic agent is disposed beneath or within the polymeric release region.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含控制一种或多种治疗剂的释放的聚合物释放区域。聚合物释放区域又包含一种或多种含有一个或多个刚性非平面多环分子结构的聚合物。治疗剂设置在聚合物释放区域的下方或内部。

8. 发明申请

US20060129215A1 Medical devices having nanostructured regions for controlled tissue biocompatibility and drug delivery 审中-公开
标题翻译：具有用于受控组织生物相容性和药物递送的纳米结构区域的医疗装置
公开(公告)号：US20060129215A1
公开(公告)日：2006-06-15
申请号：US11007867
申请日：2004-12-09
申请人： Michael Helmus , Yixin Xu , Shrirang Ranade
发明人： Michael Helmus , Yixin Xu , Shrirang Ranade
IPC分类号： A61N1/05
CPC分类号： B82Y30/00 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/236 , A61L2300/252 , A61L2300/416 , A61L2300/42 , A61L2300/45 , A61L2300/624 , A61N1/05 , B82Y5/00
摘要： According to certain aspects of the invention, implantable or insertable medical devices are provided that contain one or more nanoporous regions, which may further comprise interconnected nanopores. Other aspects of the invention are directed to implantable or insertable medical devices that contain one or more nanostructured regions, which are formed by a variety of methods. Still other aspects of the invention are directed to implantable or insertable medical devices having nanotextured surface regions, in which cell-adhesion-promoting biomolecules (e.g., glycosaminoglycans, proteoglycans, cell adhesion peptides, and adhesive proteins) are provided on, within or beneath the nanotextured surface regions.
摘要翻译：根据本发明的某些方面，提供了可植入或可插入的医疗装置，其包含一个或多个纳米多孔区域，其可以进一步包括互连的纳米孔。本发明的其它方面涉及含有一个或多个纳米结构区域的可植入或可插入的医疗装置，其通过多种方法形成。本发明的另外其它方面涉及具有纳米纹理表面区域的可植入或可插入的医疗装置，其中提供细胞粘附促进生物分子（例如，糖胺聚糖，蛋白聚糖，细胞粘附肽和粘合蛋白），其中，纳米纹理表面区域。

9. 发明申请

US20060124466A1 Method and apparatus for coating a medical device by electroplating 审中-公开
标题翻译：用于通过电镀涂覆医疗器械的方法和装置
公开(公告)号：US20060124466A1
公开(公告)日：2006-06-15
申请号：US11007297
申请日：2004-12-09
申请人： Yixin Xu , Michael Helmus
发明人： Yixin Xu , Michael Helmus
IPC分类号： C25D15/00
CPC分类号： A61L31/10 , A61L31/082 , A61L31/16 , A61L2300/606 , A61L2420/02 , C09D5/4492 , C25D9/00 , C25D9/02 , C25D15/00
摘要： Methods and apparatuses for coating surfaces of medical devices by electroplating are disclosed. In one embodiment, the invention includes a coating method in which a mixture of a therapeutic agent, and a plating material are electroplated onto the surface of the medical device. The electroplating method may be performed at a relatively low temperature to avoid destruction of the therapeutic agent. In another embodiment, a coating method is disclosed in which the coating is formed by suspending a therapeutic agent in an electrolytic solution and electroplating a plating material onto the medical device wherein the plating material carries the suspended therapeutic agent. Thus, the coating of plating material contains the suspended therapeutic agent. These methods and apparatuses are used to apply one or more coating materials, simultaneously or in sequence by varying the electroplating voltage. In certain embodiments of the invention, the coating materials include therapeutic agents and cationic drugs.
摘要翻译：公开了通过电镀来涂覆医疗装置的表面的方法和装置。在一个实施方案中，本发明包括将治疗剂和电镀材料的混合物电镀在医疗装置的表面上的涂布方法。电镀方法可以在相对低的温度下进行以避免治疗剂的破坏。在另一个实施方案中，公开了一种涂覆方法，其中通过将治疗剂悬浮在电解液中并将电镀材料电镀到医疗装置上而形成涂层，其中电镀材料携带悬浮的治疗剂。因此，电镀材料的涂层含有悬浮治疗剂。这些方法和装置用于通过改变电镀电压同时或依次施加一种或多种涂层材料。在本发明的某些实施方案中，涂层材料包括治疗剂和阳离子药物。

10. 发明申请

US20050080040A1 Treatment of tissue, instruments and work surfaces to remove infectious agents 审中-公开
标题翻译：处理组织，器械和工作表面以去除感染因子
公开(公告)号：US20050080040A1
公开(公告)日：2005-04-14
申请号：US10959549
申请日：2004-10-05
申请人： Crystal Cunanan , Tan Dinh , Christine Loshbaugh , H. Sarner , Michael Helmus
发明人： Crystal Cunanan , Tan Dinh , Christine Loshbaugh , H. Sarner , Michael Helmus
IPC分类号： A61L2/16 , A61L27/36 , A61K31/737 , A61K31/727
CPC分类号： A61L27/3687 , A61L2/16
摘要： The present invention provides methods of inactivating and removing infectious agents from tissues of use in bioprosthetic devices. The methods include the removal and blockage of binding sites on the tissues for the infectious agents. Also provided are methods for blocking a site on an infectious agent that binds to a site on the tissue.
摘要翻译：本发明提供从生物假体装置中使用的组织中灭活和除去感染因子的方法。所述方法包括去除和阻断感染剂组织上的结合位点。还提供了用于阻断结合于组织上的部位的感染剂上的部位的方法。

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