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1. 发明申请

US20060204545A1 Drug release regions for medical devices, which include polycyclic-structure-containing polymers 有权
标题翻译：用于医疗器械的药物释放区域，其包括含多环结构的聚合物
公开(公告)号：US20060204545A1
公开(公告)日：2006-09-14
申请号：US11079621
申请日：2005-03-14
申请人： Shrirang Ranade , Michael Helmus , Robert Richard
发明人： Shrirang Ranade , Michael Helmus , Robert Richard
IPC分类号： A61F2/02
CPC分类号： A61L27/50 , A61L27/54 , A61L29/14 , A61L29/16 , A61L31/14 , A61L31/16 , A61L2300/602
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain polymeric release regions that control the release of one or more therapeutic agents. The polymeric release regions, in turn, contain one or more polymers that contain one or more rigid, nonplanar polycyclic molecular structures. The therapeutic agent is disposed beneath or within the polymeric release region.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含控制一种或多种治疗剂的释放的聚合物释放区域。聚合物释放区域又包含一种或多种含有一个或多个刚性非平面多环分子结构的聚合物。治疗剂设置在聚合物释放区域的下方或内部。

2. 发明申请

US20060171985A1 Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility 有权
公开(公告)号：US20060171985A1
公开(公告)日：2006-08-03
申请号：US11048616
申请日：2005-02-01
申请人： Robert Richard , Frederick Strickler , Marlene Schwarz , Rudolf Faust , Shrirang Ranade , Michael Helmus
发明人： Robert Richard , Frederick Strickler , Marlene Schwarz , Rudolf Faust , Shrirang Ranade , Michael Helmus
IPC分类号： A61F2/00
CPC分类号： A61L31/129 , A61L27/48 , A61N1/05
摘要： The present invention relates to phase separated polymeric regions and to their use in conjunction with implantable or insertable medical devices. In some aspects of the invention, phase separated polymeric regions are provided that include (a) at least one biostable polymeric phase and (b) at least one biodisintegrable polymeric phase, which is of nanoscale dimensions and which undergoes biodisintegration such that the phase separated polymeric region becomes a nanoporous polymeric region in vivo. Other aspects of the invention are directed to methods of making implantable or insertable medical devices having at least one nanoporous polymeric region. These methods include (a) providing a phase separated polymeric region comprising a stable polymeric phase and a disintegrable polymeric phase of nanoscale dimensions, (b) selectively removing the disintegrable polymeric phase thereby producing the nanoporous polymeric region. In still other aspects, implantable or insertable medical devices are provided which have phase separated polymeric regions that include (a) at least one block copolymer having at least one biostable polymer block and at least one biodisintegrable polymer block and (b) at least one therapeutic agent which is released in vivo upon implantation or insertion of the medical device.

3. 发明申请

US20060121076A1 Orienting polymer domains for controlled drug delivery 失效
标题翻译：定向聚合物结构域用于受控药物递送
公开(公告)号：US20060121076A1
公开(公告)日：2006-06-08
申请号：US11005852
申请日：2004-12-07
申请人： Shrirang Ranade , Robert Richard , Kinh-Luan (Lenny) Dao , Samuel Gido , Akinbode Isaacs-Sodeye
发明人： Shrirang Ranade , Robert Richard , Kinh-Luan (Lenny) Dao , Samuel Gido , Akinbode Isaacs-Sodeye
IPC分类号： A61F13/00 , B05D3/02 , A61M31/00
CPC分类号： A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/60 , A61L2300/602
摘要： The present invention provides a method for the formation of a medical device that comprises a therapeutic agent and a release region, which regulates the rate at which the therapeutic agent is released from the medical device. The method comprises providing a precursor region that comprises a polymer composition comprising two or more microphase separated polymer domains that are immiscible with one another, and forming said release region by a process that comprises applying an orienting field comprising an electric field, a magnetic field, a mechanical shear field, or a solvent gradient field, or a combination of two or more fields to said precursor region, wherein said field or combination of fields changes the spatial orientation of the microphase separated polymer domains within the release region. The electric, magnetic, mechanical shear or solvent gradient field is of sufficient strength to change the spatial orientation of the microphase separated domains. Moreover, the spatial orientation of the immiscible microphase separated polymer domains affects the rate of release of the therapeutic agent from the medical device. Hence, the present invention is further directed to methods of modulating the rate of release of a therapeutic agent from a medical device. Other aspects of the invention are directed to medical devices formed from the above techniques.
摘要翻译：本发明提供一种形成医疗装置的方法，其包括治疗剂和释放区域，其调节治疗剂从医疗装置释放的速率。该方法包括提供包含聚合物组合物的前体区域，所述聚合物组合物包含彼此不混溶的两个或更多个微相分离的聚合物区域，并且通过包括施加包括电场，磁场的取向场的方法形成所述释放区域，机械剪切场或溶剂梯度场，或两个或更多个场的组合与所述前体区域，其中所述场或场的组合改变了微相分离的聚合物区域在释放区域内的空间取向。电，磁，机械剪切或溶剂梯度场具有足够的强度来改变微相分离域的空间取向。此外，不混溶的微相分离的聚合物区域的空间取向影响治疗剂从医疗装置释放的速率。因此，本发明进一步涉及从医疗装置调节治疗剂的释放速率的方法。本发明的其它方面涉及由上述技术形成的医疗装置。

4. 发明申请

US20050187146A1 Biomaterials for enhanced healing 有权
标题翻译：生物材料增强愈合
公开(公告)号：US20050187146A1
公开(公告)日：2005-08-25
申请号：US10781932
申请日：2004-02-20
申请人： Michael Helmus , Robert Richard , Melissa Dixon
发明人： Michael Helmus , Robert Richard , Melissa Dixon
IPC分类号： A61L27/20 , A61L27/22 , A61K38/16 , A61K31/785
CPC分类号： A61L27/22 , A61L27/20
摘要： The present invention relates to novel biomaterials and methods of using these new biomaterials to facilitate wound healing. The novel biomaterial may be a biocompatible polymer to which at least one bioactive polymer is covalently bonded by graft polymerization, copolymerization or cross-linking. Alternatively, the novel biomaterial may be a polymer blend comprising at least one biocompatible polymer and at least one bioactive polymer.
摘要翻译：本发明涉及使用这些新生物材料以促进伤口愈合的新型生物材料和方法。新型生物材料可以是生物相容性聚合物，至少一种生物活性聚合物通过接枝聚合，共聚或交联共价键合到该聚合物上。或者，新型生物材料可以是包含至少一种生物相容性聚合物和至少一种生物活性聚合物的聚合物共混物。

5. 发明申请

US20060013867A1 Medical devices and materials containing isobutylene copolymer 失效
标题翻译：包含异丁烯共聚物的医疗器械和材料
公开(公告)号：US20060013867A1
公开(公告)日：2006-01-19
申请号：US10894394
申请日：2004-07-19
申请人： Robert Richard , Rudolf Faust
发明人： Robert Richard , Rudolf Faust
IPC分类号： A61K9/70
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/00 , C08L53/02
摘要： The present invention relates to medical devices which contain isobutylene copolymers. The present invention also relates to biocompatible copolymer materials for therapeutic agent delivery comprising a therapeutic-agent-loaded isobutylene copolymer. According to an aspect of the present invention, a medical device is provided, which includes: (a) a substrate and (b) at least one polymeric layer, which contains a copolymer, disposed over all or a portion of the substrate. The copolymer contains one or more polymer chains, within which isobutylene and elevated Tg monomers (and, optionally, other monomers) are incorporated in a random, periodic, statistical or gradient distribution.
摘要翻译：本发明涉及包含异丁烯共聚物的医疗装置。本发明还涉及用于治疗剂递送的生物相容性共聚物材料，其包含负载治疗剂的异丁烯共聚物。根据本发明的一个方面，提供了一种医疗装置，其包括：（a）基底和（b）至少一个包含共聚物的聚合物层，其设置在基底的全部或一部分上。共聚物含有一个或多个聚合物链，其中异丁烯和升高的T单体（和任选地，其它单体）以无规，周期，统计或梯度分布结合。

6. 发明申请

US20050025801A1 Implantable or insertable medical devices containing radiation-treated polymer for improved delivery of therapeutic agent 失效
标题翻译：含有辐射处理聚合物的植入式或可插入医疗装置，用于改善治疗剂的递送
公开(公告)号：US20050025801A1
公开(公告)日：2005-02-03
申请号：US10632054
申请日：2003-07-31
申请人： Robert Richard , Marlene Schwarz
发明人： Robert Richard , Marlene Schwarz
IPC分类号： A61L27/16 , A61L27/34 , A61L27/54 , A61L29/04 , A61L29/08 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/16 , A61N1/08 , A61N1/10
CPC分类号： A61L31/16 , A61L27/16 , A61L27/34 , A61L27/54 , A61L29/041 , A61L29/085 , A61L29/16 , A61L31/048 , A61L31/10 , A61L2300/602 , C08L33/12 , C08L53/02 , C08L25/10 , C08L23/22
摘要： An implantable or insertable medical device which comprises (a) a therapeutic agent and (b) a polymeric release region comprising a polymer. The polymeric release region is treated with a radiation dose that is effective to substantially increase the cumulative release of the therapeutic agent subsequent to administration to a patient. The polymeric release region can be, for example, (a) a carrier region that comprises the therapeutic agent or (b) a barrier region that is disposed over a therapeutic-agent-containing region that comprises the therapeutic agent. The present invention is further directed to methods of forming such medical devices, methods of releasing a therapeutic agent within a patient using such medical devices, and methods of modulating the release of a therapeutic agent from such medical devices.
摘要翻译：一种可植入或可插入的医疗装置，其包括（a）治疗剂和（b）包含聚合物的聚合物释放区域。用辐射剂量处理聚合物释放区域，其有效地大大增加给予患者后治疗剂的累积释放。聚合物释放区可以是例如（a）包含治疗剂的载体区域或（b）设置在包含治疗剂的包含治疗剂的区域上的屏障区域。本发明进一步涉及形成这种医疗装置的方法，使用这种医疗装置在患者体内释放治疗剂的方法，以及调节治疗剂从这些医疗装置释放的方法。

7. 发明申请

US20060013853A1 Medical devices having conductive substrate and covalently bonded coating layer 审中-公开
标题翻译：医疗器械具有导电性基底和共价键合的涂层
公开(公告)号：US20060013853A1
公开(公告)日：2006-01-19
申请号：US10894391
申请日：2004-07-19
申请人： Robert Richard
发明人： Robert Richard
IPC分类号： A61F2/00
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/606
摘要： The present invention provides a medical device comprising an electrically conductive substrate and a coating layer that covers at least a portion of the electrically conductive substrate, wherein the coating layer comprises a polymer that is made by a process that comprises (a) electrochemically linking a initiator to a surface of the electrically conductive substrate and (b) conducting a free radical polymerization reaction in the presence of one or more free radical polymerizable monomers.
摘要翻译：本发明提供一种医疗装置，其包括导电基底和覆盖至少一部分导电基底的涂层，其中该涂层包含通过以下方法制备的聚合物，该方法包括：（a）将引发剂（b）在一种或多种可自由基聚合的单体的存在下进行自由基聚合反应。

8. 发明申请

US20050181014A1 Polymer-filler composites for controlled delivery of therapetic agents from medical articles 有权
标题翻译：用于从医疗制品控制递送治疗剂的聚合物 - 填料复合材料
公开(公告)号：US20050181014A1
公开(公告)日：2005-08-18
申请号：US10777801
申请日：2004-02-12
申请人： Robert Richard
发明人： Robert Richard
IPC分类号： A61L27/34 , A61L27/44 , A61L27/54 , A61L31/10 , A61L31/12 , A61L31/16 , A61F2/00
CPC分类号： A61L31/128 , A61L27/34 , A61L27/446 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/00
摘要： A medical article comprising: (a) a therapeutic agent; and (b) a release region comprising (i) a polymer and (ii) a filler comprising inorganic platelet particles. Upon placement of such a medical article at a position on or within a patient, the release region regulates the rate of release of the therapeutic agent from the medical article to the patient. An example of a filler is one comprising inorganic platelet particles. Examples of medical articles include, for instance, drug delivery patches, and implantable or insertable medical devices. Also described are methods of releasing a therapeutic agent to a patient using such medical articles, and methods of making such medical articles.
摘要翻译：一种医疗制品，其包含：（a）治疗剂; 和（b）释放区域，其包含（i）聚合物和（ii）包含无机血小板颗粒的填料。在将这样的医疗用品放置在患者身上或内部的位置时，释放区域调节治疗剂从医疗用品释放到患者的速率。填料的实例是包含无机血小板颗粒的实例。医疗制品的实例包括例如药物递送贴片以及可植入或可插入的医疗装置。还描述了使用这种医疗制品将治疗剂释放到患者的方法，以及制造这种医疗用品的方法。

9. 发明申请

US20050027283A1 Implantable or insertable medical devices containing silicone copolymer for controlled delivery of therapeutic agent 有权
标题翻译：可植入或可插入的含有共聚物的硅氧烷共聚物，用于治疗剂的控制递送
公开(公告)号：US20050027283A1
公开(公告)日：2005-02-03
申请号：US10632008
申请日：2003-07-31
申请人： Robert Richard , Marlene Schwarz , Frederick Strickler
发明人： Robert Richard , Marlene Schwarz , Frederick Strickler
IPC分类号： A61K9/00 , A61K9/22 , A61L29/06 , A61L29/08 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/16
CPC分类号： A61K9/0024 , A61L29/06 , A61L29/085 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/602 , C08L83/04
摘要： Implantable or insertable medical devices are described. The medical devices comprise (a) a therapeutic agent and (b) a polymeric release region, which controls the release of the therapeutic agent upon administration to a patient. The polymeric release region further comprises a silicone copolymer that contains a plurality of siloxane units and a plurality of non-siloxane units. Also described are methods for administering a therapeutic agent to a patient using the above implantable or insertable medical devices as well as methods of making the above devices.
摘要翻译：描述了可植入或可插入的医疗装置。医疗装置包括（a）治疗剂和（b）聚合物释放区域，其在施用于患者时控制治疗剂的释放。聚合物释放区域还包含含有多个硅氧烷单元和多个非硅氧烷单元的硅氧烷共聚物。还描述了使用上述可植入或可插入医疗装置向患者施用治疗剂的方法以及制备上述装置的方法。

10. 发明授权

US06818172B2 Oriented, cross-linked UHMWPE molding for orthopaedic applications 有权
标题翻译：定向交联UHMWPE成型用于矫形应用
公开(公告)号：US06818172B2
公开(公告)日：2004-11-16
申请号：US09961842
申请日：2001-09-24
申请人： Richard King , Donald E. McNulty , Todd S. Smith , Robert Richard
发明人： Richard King , Donald E. McNulty , Todd S. Smith , Robert Richard
IPC分类号： B29C3508
CPC分类号： B29C43/003 , A61F2/3094 , A61F2/34 , A61F2/389 , A61F2/4081 , A61F2002/30133 , A61F2002/30367 , A61F2002/30403 , A61F2002/30822 , A61F2002/30827 , A61F2002/30878 , A61F2002/30892 , A61F2002/30957 , A61F2002/3412 , A61F2002/4631 , A61F2220/0025 , A61F2220/0033 , A61F2230/0015 , A61F2310/00011 , A61L27/16 , B29C35/08 , B29C2035/085 , B29K2023/0683 , B29K2105/253 , B29K2995/005 , B29K2995/0087 , B29L2031/7532 , C08L23/06
摘要： A process for forming an oriented orthopaedic implant prosthesis bearing, net-shape bearing, or near net-shape bearing includes the step of placing an irradiated UHMWPE preform or puck of a volume sufficient to accommodate the bearing in a compression mold and compression molding the irradiated preform. The molding is accomplished by applying heat and pressure to form the preform into a desired shape. The compression molding induces biaxial orientation in the formed bearing.
摘要翻译：用于形成定向整形外科植入物假体轴承，网状轴承或近网状轴承的方法包括以下步骤：将经辐射的UHMWPE预制件或圆盘放置在足以容纳轴承的压缩模具中并将其压缩成型预制件。通过施加热和压力以将预成型件形成为期望的形状来实现模制。压缩成型在形成的轴承中引起双轴取向。

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